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Andrada Delia Neacsiu

Associate Professor in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
2400 Pratt Street, North Pavilion (102505), 6th Floor, Room # 6044, Durham, NC 27710
2400 Pratt Street, North Pavilion (102505), Durham, NC 27710

Selected Publications


An experimental examination of neurostimulation and cognitive restructuring as potential components for Misophonia interventions.

Journal Article J Affect Disord · April 1, 2024 Misophonia is a disorder of decreased tolerance to certain aversive, repetitive common sounds, or to stimuli associated with these sounds. Two matched groups of adults (29 participants with misophonia and 30 clinical controls with high emotion dysregulatio ... Full text Link to item Cite

Network-level dynamics underlying a combined rTMS and psychotherapy treatment for major depressive disorder: An exploratory network analysis.

Journal Article Int J Clin Health Psychol · 2023 BACKGROUND: Despite the growing use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for depression, there is a limited understanding of the mechanisms of action and how potential treatment-related brain changes help to characterize tr ... Full text Open Access Link to item Cite

Mechanisms of change in treatments for transdiagnostic emotion dysregulation: The roles of skills use, perceived control and mindfulness.

Journal Article Clin Psychol Psychother · 2023 Emotion dysregulation (ED) is a key target for change among empirically supported treatments for emotional disorders, including dialectical behaviour therapy skills training (DBT-ST), yet how treatments improve ED is poorly understood. Using data from a ra ... Full text Link to item Cite

Enhancing cognitive restructuring with concurrent fMRI-guided neurostimulation for emotional dysregulation-A randomized controlled trial.

Journal Article J Affect Disord · March 15, 2022 BACKGROUND: Transdiagnostic clinical emotional dysregulation is a key component of many mental health disorders and offers an avenue to address multiple disorders with one transdiagnostic treatment. In the current study, we pilot an intervention that combi ... Full text Link to item Cite

Multilevel associations of daily skill use and effectiveness with anxiety, depression, and stress in a transdiagnostic sample undergoing dialectical behavior therapy skills training.

Journal Article Cogn Behav Ther · March 2022 Dialectical Behavior Therapy (DBT) is effective at treating disorders of emotion dysregulation. However, it is unclear which mechanisms contribute to these effects. The aim of this study was to characterize the within-person associations of two theoretical ... Full text Link to item Cite

Enhancing Cognitive Restructuring with Concurrent Repetitive Transcranial Magnetic Stimulation: A Transdiagnostic Randomized Controlled Trial.

Journal Article Psychother Psychosom · 2022 INTRODUCTION: Emotional dysregulation constitutes a serious public health problem in need of novel transdiagnostic treatments. OBJECTIVE: To this aim, we developed and tested a one-time intervention that integrates behavioral skills training with concurren ... Full text Link to item Cite

The neurobiology of misophonia and implications for novel, neuroscience-driven interventions.

Journal Article Front Neurosci · 2022 Decreased tolerance in response to specific every-day sounds (misophonia) is a serious, debilitating disorder that is gaining rapid recognition within the mental health community. Emerging research findings suggest that misophonia may have a unique neural ... Full text Link to item Cite

Enhancing Cognitive Restructuring with Concurrent Repetitive Transcranial Magnetic Stimulation: A Transdiagnostic Randomized Controlled Trial

Journal Article · 2021 Introduction Emotional dysregulation constitutes a serious public health problem in need of novel transdiagnostic treatments. Objective To this aim, we developed and tested a one-time intervention that integrates behavioral skills trainin ... Full text Cite

Examining the Role of Lateral Parietal Cortex in Emotional Distancing Using TMS.

Journal Article Cogn Affect Behav Neurosci · October 2020 We recently proposed a neurocognitive model of distancing-an emotion regulation tactic-with a focus on the lateral parietal cortex. Although this brain area has been implicated in both cognitive control and self-projection processes during distancing, fMRI ... Full text Open Access Link to item Cite

Blinded by our emotions: The impact of borderline personality disorder and affect on emotion recognition sensitivity

Journal Article Journal of Experimental Psychopathology · January 1, 2019 Previous studies have demonstrated abnormalities in emotion recognition within individuals diagnosed with borderline personality disorder (BPD). However, it is yet unknown how much these abnormalities can be attributed to emotional states or affect. Theref ... Full text Cite

On the Concurrent Use of Self-System Therapy and Functional Magnetic Resonance Imaging-Guided Transcranial Magnetic Stimulation as Treatment for Depression.

Journal Article J ECT · December 2018 OBJECTIVES: Despite the growing use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for unipolar depression, its typical effect sizes have been modest, and methodological and conceptual challenges remain regarding how to optimize its ... Full text Open Access Link to item Cite

Changes in Problematic Anger, Shame, and Disgust in Anxious and Depressed Adults Undergoing Treatment for Emotion Dysregulation.

Journal Article Behav Ther · May 2018 Emotion dysregulation, the pervasive difficulty managing negative emotions, is a core problem across mood and anxiety disorders. Anger, shame, and disgust are particularly problematic emotions, impacting both disorder severity and treatment outcome. We pre ... Full text Link to item Cite

Suicidal Behavior and Problems with Emotion Regulation.

Journal Article Suicide Life Threat Behav · February 2018 We examined in two independent samples whether: (1) difficulties with emotion regulation predict suicide ideation and (2) depressed adults with a history of attempting suicide report and exhibit more emotion dysregulation compared to healthy and depressed ... Full text Link to item Cite

Challenging assumptions from emotion dysregulation psychological treatments.

Journal Article J Affect Disord · September 2017 BACKGROUND: Contemporary treatments assume that the inability to downregulate negative emotional arousal is a key problem in the development and maintenance of psychopathology and that lack of effective regulation efforts and a preference to use maladaptiv ... Full text Link to item Cite

Understanding borderline personality disorder across sociocultural groups: Findings, issues, and future directions

Journal Article Current Psychiatry Reviews · September 1, 2017 Background: In recent years, there have been significant advancements in understanding the etiology, assessment, and treatment of borderline personality disorder [BPD]. However, the influence of culture has not been carefully considered. The present review ... Full text Cite

Reprint of ''Using neuroimaging to individualize TMS treatment for depression: Toward a new paradigm for imaging-guided intervention''.

Journal Article Neuroimage · May 1, 2017 The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than ... Full text Open Access Link to item Cite

Using neuroimaging to individualize TMS treatment for depression: Toward a new paradigm for imaging-guided intervention.

Journal Article Neuroimage · March 1, 2017 The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than ... Full text Open Access Link to item Cite

Die Dialectical Behavior Therapy Ways of Coping Checklist (DBT-WCCL)

Journal Article Diagnostica · January 2017 Zusammenfassung. Ziel dieser Arbeit war die Erprobung und Validierung einer deutschen Version der Dialectical Behavior Therapy Ways of Coping Checklist (DBT-WCCL, Neacsiu, Rizui, Vitaliano, Lynch & Linehan, 2010 ), einem Fragebogen zur Erhebun ... Full text Cite

Emotional Reactivity to Personally-Relevant and Standardized Sounds in Borderline Personality Disorder

Journal Article Cognitive Therapy and Research · June 1, 2016 Theoretical conceptualizations highlight emotional reactivity as a core problem for borderline personality disorder (BPD); however, empirical work investigating emotional reactivity in BPD has produced mixed and inconclusive findings. The current study aim ... Full text Cite

An experimental examination of neurostimulation and cognitive restructuring as potential components for Misophonia interventions.

Journal Article J Affect Disord · April 1, 2024 Misophonia is a disorder of decreased tolerance to certain aversive, repetitive common sounds, or to stimuli associated with these sounds. Two matched groups of adults (29 participants with misophonia and 30 clinical controls with high emotion dysregulatio ... Full text Link to item Cite

Network-level dynamics underlying a combined rTMS and psychotherapy treatment for major depressive disorder: An exploratory network analysis.

Journal Article Int J Clin Health Psychol · 2023 BACKGROUND: Despite the growing use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for depression, there is a limited understanding of the mechanisms of action and how potential treatment-related brain changes help to characterize tr ... Full text Open Access Link to item Cite

Mechanisms of change in treatments for transdiagnostic emotion dysregulation: The roles of skills use, perceived control and mindfulness.

Journal Article Clin Psychol Psychother · 2023 Emotion dysregulation (ED) is a key target for change among empirically supported treatments for emotional disorders, including dialectical behaviour therapy skills training (DBT-ST), yet how treatments improve ED is poorly understood. Using data from a ra ... Full text Link to item Cite

Enhancing cognitive restructuring with concurrent fMRI-guided neurostimulation for emotional dysregulation-A randomized controlled trial.

Journal Article J Affect Disord · March 15, 2022 BACKGROUND: Transdiagnostic clinical emotional dysregulation is a key component of many mental health disorders and offers an avenue to address multiple disorders with one transdiagnostic treatment. In the current study, we pilot an intervention that combi ... Full text Link to item Cite

Multilevel associations of daily skill use and effectiveness with anxiety, depression, and stress in a transdiagnostic sample undergoing dialectical behavior therapy skills training.

Journal Article Cogn Behav Ther · March 2022 Dialectical Behavior Therapy (DBT) is effective at treating disorders of emotion dysregulation. However, it is unclear which mechanisms contribute to these effects. The aim of this study was to characterize the within-person associations of two theoretical ... Full text Link to item Cite

Enhancing Cognitive Restructuring with Concurrent Repetitive Transcranial Magnetic Stimulation: A Transdiagnostic Randomized Controlled Trial.

Journal Article Psychother Psychosom · 2022 INTRODUCTION: Emotional dysregulation constitutes a serious public health problem in need of novel transdiagnostic treatments. OBJECTIVE: To this aim, we developed and tested a one-time intervention that integrates behavioral skills training with concurren ... Full text Link to item Cite

The neurobiology of misophonia and implications for novel, neuroscience-driven interventions.

Journal Article Front Neurosci · 2022 Decreased tolerance in response to specific every-day sounds (misophonia) is a serious, debilitating disorder that is gaining rapid recognition within the mental health community. Emerging research findings suggest that misophonia may have a unique neural ... Full text Link to item Cite

Enhancing Cognitive Restructuring with Concurrent Repetitive Transcranial Magnetic Stimulation: A Transdiagnostic Randomized Controlled Trial

Journal Article · 2021 Introduction Emotional dysregulation constitutes a serious public health problem in need of novel transdiagnostic treatments. Objective To this aim, we developed and tested a one-time intervention that integrates behavioral skills trainin ... Full text Cite

Examining the Role of Lateral Parietal Cortex in Emotional Distancing Using TMS.

Journal Article Cogn Affect Behav Neurosci · October 2020 We recently proposed a neurocognitive model of distancing-an emotion regulation tactic-with a focus on the lateral parietal cortex. Although this brain area has been implicated in both cognitive control and self-projection processes during distancing, fMRI ... Full text Open Access Link to item Cite

Blinded by our emotions: The impact of borderline personality disorder and affect on emotion recognition sensitivity

Journal Article Journal of Experimental Psychopathology · January 1, 2019 Previous studies have demonstrated abnormalities in emotion recognition within individuals diagnosed with borderline personality disorder (BPD). However, it is yet unknown how much these abnormalities can be attributed to emotional states or affect. Theref ... Full text Cite

On the Concurrent Use of Self-System Therapy and Functional Magnetic Resonance Imaging-Guided Transcranial Magnetic Stimulation as Treatment for Depression.

Journal Article J ECT · December 2018 OBJECTIVES: Despite the growing use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for unipolar depression, its typical effect sizes have been modest, and methodological and conceptual challenges remain regarding how to optimize its ... Full text Open Access Link to item Cite

Changes in Problematic Anger, Shame, and Disgust in Anxious and Depressed Adults Undergoing Treatment for Emotion Dysregulation.

Journal Article Behav Ther · May 2018 Emotion dysregulation, the pervasive difficulty managing negative emotions, is a core problem across mood and anxiety disorders. Anger, shame, and disgust are particularly problematic emotions, impacting both disorder severity and treatment outcome. We pre ... Full text Link to item Cite

Suicidal Behavior and Problems with Emotion Regulation.

Journal Article Suicide Life Threat Behav · February 2018 We examined in two independent samples whether: (1) difficulties with emotion regulation predict suicide ideation and (2) depressed adults with a history of attempting suicide report and exhibit more emotion dysregulation compared to healthy and depressed ... Full text Link to item Cite

Challenging assumptions from emotion dysregulation psychological treatments.

Journal Article J Affect Disord · September 2017 BACKGROUND: Contemporary treatments assume that the inability to downregulate negative emotional arousal is a key problem in the development and maintenance of psychopathology and that lack of effective regulation efforts and a preference to use maladaptiv ... Full text Link to item Cite

Understanding borderline personality disorder across sociocultural groups: Findings, issues, and future directions

Journal Article Current Psychiatry Reviews · September 1, 2017 Background: In recent years, there have been significant advancements in understanding the etiology, assessment, and treatment of borderline personality disorder [BPD]. However, the influence of culture has not been carefully considered. The present review ... Full text Cite

Reprint of ''Using neuroimaging to individualize TMS treatment for depression: Toward a new paradigm for imaging-guided intervention''.

Journal Article Neuroimage · May 1, 2017 The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than ... Full text Open Access Link to item Cite

Using neuroimaging to individualize TMS treatment for depression: Toward a new paradigm for imaging-guided intervention.

Journal Article Neuroimage · March 1, 2017 The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than ... Full text Open Access Link to item Cite

Die Dialectical Behavior Therapy Ways of Coping Checklist (DBT-WCCL)

Journal Article Diagnostica · January 2017 Zusammenfassung. Ziel dieser Arbeit war die Erprobung und Validierung einer deutschen Version der Dialectical Behavior Therapy Ways of Coping Checklist (DBT-WCCL, Neacsiu, Rizui, Vitaliano, Lynch & Linehan, 2010 ), einem Fragebogen zur Erhebun ... Full text Cite

Emotional Reactivity to Personally-Relevant and Standardized Sounds in Borderline Personality Disorder

Journal Article Cognitive Therapy and Research · June 1, 2016 Theoretical conceptualizations highlight emotional reactivity as a core problem for borderline personality disorder (BPD); however, empirical work investigating emotional reactivity in BPD has produced mixed and inconclusive findings. The current study aim ... Full text Cite

Magnetic Stimulation for Depression: Subconvulsive and Convulsive Approaches

Chapter · March 5, 2016 Treatment-resistant depression remains an important clinical problem in need of novel treatment solutions. Electro-convulsive therapy and transcranial magnetic stimulation are two neuromodulation techniques with promise in the treatment of severe and chron ... Full text Cite

Psychotherapeutic Treatment of Bipolar Depression.

Journal Article Psychiatr Clin North Am · March 2016 The gold standard for treating bipolar depression is based on the combination of mood stabilizers and psychotherapy. Therefore, the authors present evidence-based models and promising approaches for psychotherapy for bipolar depression. Cognitive-behaviora ... Full text Open Access Link to item Cite

Dialectical behavior therapy skills use and emotion dysregulation in personality disorders and psychopathy: a community self-report study.

Journal Article Borderline Personal Disord Emot Dysregul · 2016 BACKGROUND: Emotion dysregulation is a critical transdiagnostic mental health problem that needs to be further examined in personality disorders (PDs). The current study examined dialectical behavior therapy (DBT) skills use, emotion dysregulation, and dys ... Full text Link to item Cite

Dialectical behavior therapy for high suicide risk in individuals with borderline personality disorder: a randomized clinical trial and component analysis.

Journal Article JAMA Psychiatry · May 2015 IMPORTANCE: Dialectical behavior therapy (DBT) is an empirically supported treatment for suicidal individuals. However, DBT consists of multiple components, including individual therapy, skills training, telephone coaching, and a therapist consultation tea ... Full text Link to item Cite

Identity disturbance and problems with emotion regulation are related constructs across diagnoses.

Journal Article J Clin Psychol · April 2015 OBJECTIVE: This study examined the relation between identity disturbance and emotion dysregulation in a cross-diagnostic sample. We assessed whether these constructs are related and relevant beyond borderline personality disorder (BPD). METHOD: We recruite ... Full text Link to item Cite

Dialectical behavior therapy skills for transdiagnostic emotion dysregulation: a pilot randomized controlled trial.

Journal Article Behav Res Ther · August 2014 Difficulties with emotions are common across mood and anxiety disorders. Dialectical behavior therapy skills training (DBT-ST) reduces emotion dysregulation in borderline personality disorder (BPD). Preliminary evidence suggests that use of DBT skills medi ... Full text Link to item Cite

A methodological examination of emotion inductions in borderline personality disorder: A comparison of standardized versus idiographic stimuli

Journal Article Journal of Psychopathology and Behavioral Assessment · March 1, 2014 Emotional reactivity is conceptualized as a core feature of borderline personality disorder (BPD) and has been subject to substantial empirical research. The laboratory methods used to elicit emotional reactivity in BPD have varied and findings across stud ... Full text Cite

Impact of dialectical behavior therapy versus community treatment by experts on emotional experience, expression, and acceptance in borderline personality disorder.

Journal Article Behav Res Ther · February 2014 Evidence suggests that heightened negative affectivity is a prominent feature of Borderline Personality Disorder (BPD) that often leads to maladaptive behaviors. Nevertheless, there is little research examining treatment effects on the experience and expre ... Full text Link to item Cite

Emerging Approaches to Counseling Intervention: Dialectical Behavior Therapy

Journal Article The Counseling Psychologist · January 1, 2012 Dialectical Behavior Therapy (DBT) is a comprehensive, multimodal cognitive behavioral treatment originally developed for individuals who met criteria for borderline personality disorder (BPD) who displayed suicidal tendencies. DBT is based on behavioral t ... Full text Cite

Dialectical behavior therapy skills use as a mediator and outcome of treatment for borderline personality disorder.

Journal Article Behav Res Ther · September 2010 A central component of Dialectical Behavior Therapy (DBT) is the teaching of specific behavioral skills with the aim of helping individuals with Borderline Personality Disorder (BPD) replace maladaptive behaviors with skillful behavior. Although existing e ... Full text Link to item Cite

The dialectical behavior therapy ways of coping checklist: development and psychometric properties.

Journal Article J Clin Psychol · June 2010 Skills training is a crucial mode of treatment in dialectical behavioral therapy (DBT; Linehan, 1993b), yet a psychometrically sound measure of DBT skills use does not exist. We adapted the Revised Ways of Coping Checklist (RWCCL; Vitaliano, Russo, Carr, M ... Full text Link to item Cite

The impact of experiential avoidance on the reduction of depression in treatment for borderline personality disorder.

Journal Article Behav Res Ther · August 2009 BACKGROUND: Reducing symptoms of depression is an important target in the treatment of borderline personality disorder (BPD). Although current treatments for BPD are effective in reducing depression, the average post-treatment level of depression remains h ... Full text Link to item Cite

Risk of Unwanted Sex for College Women: Evidence for a Red Zone

Journal Article JOURNAL OF AMERICAN COLLEGE HEALTH · November 1, 2008 Link to item Cite

Risk of unwanted sex for college women: evidence for a red zone.

Journal Article J Am Coll Health · 2008 OBJECTIVE: University and college health and counseling centers frequently warn female students about the red zone-a period early in a student's first year at college during which she may be at higher risk for unwanted sexual experiences (UWS). The authors ... Full text Link to item Cite