Scholars@Duke
Andrea T. Deyrup

Andrea T. Deyrup

Professor of Pathology
Pathology
andrea.deyrup@duke.edu
Rm 206AM Davison Bldg, Box 3712 Med Ctr, Durham, NC 27710
DUMC 3712, Durham, NC 27710

Selected Publications

Racial Biology and Medical Misconceptions.

Journal Article N Engl J Med · February 10, 2022 Full text Link to item Cite

VCL-ALK renal cell carcinoma in children with sickle-cell trait: the eighth sickle-cell nephropathy?

Journal Article Am J Surg Pathol · June 2014 We report the third case of a renal cell carcinoma bearing a fusion of the vinculin (VCL) and anaplastic lymphoma kinase (ALK) genes. Like the 2 other reported cases, this neoplasm occurred in a young patient (6 y old) with sickle-cell trait and demonstrat ... Full text Link to item Cite

Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas.

Journal Article Am J Surg Pathol · September 2013 The term "spindle cell liposarcoma" has been applied to liposarcomas (LPSs) composed predominantly or exclusively of spindled cells. These tumors have been considered variants of well-differentiated LPS (WDL), myxoid LPS, and spindle cell lipoma, suggestin ... Full text Link to item Cite

Skeletal Metastasis

Journal Article Surgical Pathology Clinics · March 1, 2012 The most commonly diagnosed tumor in the skeleton represents metastatic disease. Metastatic carcinoma should be the first consideration in older patients with atypical radiologic findings or clinical features suggestive of a bone lesion. The primary goal i ... Full text Cite

Anatomic tumor location influences the success of contemporary limb-sparing surgery and radiation among adults with soft tissue sarcomas of the extremities.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2012 PURPOSE: To examine the influence of anatomic location in the upper extremity (UE) vs. lower extremity (LE) on the presentation and outcomes of adult soft tissue sarcomas (STS). METHODS AND MATERIALS: From 2001 to 2008, 118 patients underwent limb-sparing ... Full text Link to item Cite

Epithelioid Lesions

Journal Article Surgical Pathology Clinics · September 1, 2011 Epithelioid variants have been described for most mesenchymal tumors, including leiomyosarcoma, pleomorphic liposarcoma, epithelioid fibrous histiocytoma, and myxofibrosarcoma. Soft tissue tumors that commonly show epithelioid morphology include epithelioi ... Full text Cite

Pediatric cutaneous angiosarcomas: a clinicopathologic study of 10 cases.

Journal Article Am J Surg Pathol · January 2011 Cutaneous angiosarcomas are rare tumors, which predominantly arise in the sun-exposed skin of the head and neck of adult and elderly patients. Rarely, these tumors can be seen in children. We identified cutaneous angiosarcomas in 10 children and assessed c ... Full text Link to item Cite

Smooth Muscle Tumors

Journal Article · December 1, 2010 Full text Cite

Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin.

Journal Article Oncogene · September 24, 2009 The development of pulmonary metastasis is the major cause of death in osteosarcoma, and its molecular basis is poorly understood. In this study, we show that beta4 integrin is highly expressed in human osteosarcoma cell lines and tumor samples. Furthermor ... Full text Link to item Cite

Smooth Muscle Tumors

Chapter · August 4, 2009 Full text Cite

Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases.

Journal Article Am J Surg Pathol · February 2009 Angiosarcomas are rare tumors that predominantly affect adult and elderly patients and pursue an aggressive clinical course with high mortality. Although angiosarcomas are well described in a variety of clinical settings, they have been incompletely charac ... Full text Link to item Cite

Aggressive (epithelioid) osteoblastoma arising in soft tissue.

Journal Article Int J Surg Pathol · July 2008 Aggressive (epithelioid) osteoblastoma arising in soft tissue has never been described. It is important to differentiate this benign osteoblastoma, a potentially locally aggressive tumor, from extraskeletal osteosarcoma. This report describes an aggressive ... Full text Link to item Cite

Atypical vascular lesions after surgery and radiation of the breast: a clinicopathologic study of 32 cases analyzing histologic heterogeneity and association with angiosarcoma.

Journal Article Am J Surg Pathol · June 2008 We report the clinicopathologic study of 32 cases of atypical vascular lesions (AVLs) after surgery and radiation of the breast, which were referred to us in consultation over a 17-year period. The patients, all women, ranged in age from 41 to 95 years (me ... Full text Link to item Cite

Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases.

Journal Article Am J Surg Pathol · June 2008 Epithelioid hemangioendothelioma (EHE) of soft tissue is a distinctive vascular tumor that has been variously considered a tumor of borderline malignancy and low-grade angiosarcoma. The majority of cases are associated with low mortality, but some metastas ... Full text Link to item Cite

Epstein-Barr virus-associated epithelial and mesenchymal neoplasms.

Journal Article Hum Pathol · April 2008 Epstein-Barr virus (EBV) is a ubiquitous human pathogen that usually maintains a harmonious relationship with its host. Rarely, this host-virus balance is perturbed, causing a diverse group of malignancies in both immunocompetent and immunosuppressed patie ... Full text Link to item Cite

Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases.

Journal Article Am J Surg Pathol · January 2008 Angiosarcomas have traditionally been considered high-grade lesions for which histologic features and grading have played no role in prognostication and, consequently, they have been excluded from the American Joint Committee on Cancer staging system. We h ... Full text Link to item Cite

Sarcomas arising in Paget disease of bone: a clinicopathologic analysis of 70 cases.

Journal Article Arch Pathol Lab Med · June 2007 CONTEXT: Sarcomatous transformation is a rare complication of Paget disease of bone. Prognosis in patients with other types of sarcomas arising in bone has improved in the last several decades because of therapeutic advances. However, because of the rarity ... Full text Link to item Cite

Epithelioid and epithelial neoplasms of bone.

Journal Article Arch Pathol Lab Med · February 2007 CONTEXT: Epithelioid and epithelial neoplasms seen in bone are rare and include epithelioid variants of vascular lesions, osteoblastoma, osteosarcoma, chordoma, and chondroblastoma as well as adamantinoma and metastatic carcinoma. OBJECTIVE: To provide an ... Full text Link to item Cite

Pathology quiz case 1. Laryngeal myxoma.

Journal Article Arch Otolaryngol Head Neck Surg · January 2007 Full text Link to item Cite

Alveolar soft-part sarcoma: a review and update.

Journal Article J Clin Pathol · November 2006 Alveolar soft-part sarcoma (ASPS) is a rare, distinctive sarcoma, typically occurring in young patients. Although it displays a relatively indolent clinical course, the ultimate prognosis is poor and is often characterised by late metastases. Recently, our ... Full text Link to item Cite

Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients.

Journal Article Am J Surg Pathol · January 2006 Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) are rare lesions that occur in immunocompromised patients. Because they have not been fully characterized pathologically or at the molecular level, we have studied 29 tumors from 19 patients, the ... Full text Link to item Cite

Estrogen receptor-beta expression in extraabdominal fibromatoses: an analysis of 40 cases.

Journal Article Cancer · January 1, 2006 BACKGROUND: Early experiments using ligand-binding assays demonstrated the presence of estrogen receptor (ER) in fibromatoses. These findings were not confirmed by later studies using immunohistochemical analysis. METHODS: To verify the expression of ERs i ... Full text Link to item Cite

Grading of soft tissue sarcomas: the challenge of providing precise information in an imprecise world.

Journal Article Histopathology · January 2006 By identifying patients at greatest risk for distant metastasis and, hence, most likely to benefit from adjuvant therapy, the grading of sarcomas has been one of the most important contributions pathologists have made to the treatment of sarcomas. Over the ... Full text Link to item Cite

Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma.

Journal Article Cancer Lett · November 8, 2005 While most osteosarcoma patients have metastatic or micrometastatic lesions, less than 15% of them have clinically detectable metastatic diseases at presentation. To identify potential markers that may predict osteosarcoma metastasis, we analyzed the expre ... Full text Link to item Cite

Paraganglioma-like dermal melanocytic tumor: a unique entity distinct from cellular blue nevus, clear cell sarcoma, and cutaneous melanoma.

Journal Article Am J Surg Pathol · December 2004 We are reporting a previously undescribed primary dermal melanocytic tumor identified by reviewing all dermal melanocytic tumors referred in consultation that did not qualify histologically as a previously described entity. From these cases, 8 were remarka ... Full text Link to item Cite

Estrogen receptor beta expression in vascular neoplasia: an analysis of 53 benign and malignant cases.

Journal Article Mod Pathol · November 2004 The importance of estrogen in vascular neoplasia is suggested by a predilection for women and a tendency for rapid growth during pregnancy. Although early experiments using radioligand assays demonstrated estrogen receptor (ER) expression, these findings w ... Full text Link to item Cite

Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery.

Journal Article Gene Ther · September 2004 Efficacious bone regeneration could revolutionize the clinical management of bone and musculoskeletal disorders. Although several bone morphogenetic proteins (BMPs) (mostly BMP-2 and BMP-7) have been shown to induce bone formation, it is unclear whether th ... Full text Link to item Cite

Leiomyosarcoma of the kidney: a clinicopathologic study.

Journal Article Am J Surg Pathol · February 2004 Leiomyosarcoma of kidney is a rare lesion for which limited data are available. Cases coded as leiomyosarcoma of the kidney from three institutions were reviewed. These cases comprised 3 men and 7 women, 40 to 75 years of age. Immunohistochemistry was perf ... Full text Link to item Cite

Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases.

Journal Article Cancer · August 15, 2003 BACKGROUND: The results of a recent study demonstrated an association between myoid differentiation and an adverse prognosis in adult patients with pleomorphic sarcoma, as determined by 5-year metastasis-free survival rates. METHODS: To confirm the importa ... Full text Link to item Cite

Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma.

Journal Article Int J Cancer · December 1, 2002 The molecular events that precede the development of osteosarcoma, the most common primary malignancy of bone, are unclear, and concurrent molecular and genetic alterations associated with its pathogenesis have yet to be identified. Recent studies suggest ... Full text Link to item Cite

Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase.

Journal Article J Biol Chem · October 8, 1999 The sulfurylase domain of the mouse bifunctional enzyme ATP sulfurylase/adenosine 5'-phosphosulfate (APS) kinase contains HXXH and PP-loop motifs. To elucidate the functional importance of these motifs and of conserved arginines and histidines, chemical mo ... Full text Link to item Cite

Activity and stability of recombinant bifunctional rearranged and monofunctional domains of ATP-sulfurylase and adenosine 5'-phosphosulfate kinase.

Journal Article J Biol Chem · April 16, 1999 Murine adenosine 3'-phosphate 5'-phosphosulfate (PAPS) synthetase consists of a COOH-terminal ATP-sulfurylase domain covalently linked through a nonhomologous intervening sequence to an NH2-terminal adenosine 5'-phosphosulfate (APS) kinase domain forming a ... Full text Link to item Cite

A member of a family of sulfate-activating enzymes causes murine brachymorphism.

Journal Article Proc Natl Acad Sci U S A · July 21, 1998 Sulfation is critical to the function of a wide variety of biomolecules. This common modification requires the enzymatic synthesis of an activated sulfate donor, phosphoadenosine-phosphosulfate (PAPS). In higher organisms PAPS synthesis is catalyzed by a b ... Full text Link to item Cite

Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme.

Journal Article J Biol Chem · April 17, 1998 The P-loop is a common motif found in ATP- and GTP-binding proteins. The recently cloned murine ATP-sulfurylase/adenosine 5'-phosphosulfate (APS) kinase contains a P-loop (residues 59-66) in the APS kinase portion of the bifunctional protein. A series of e ... Full text Link to item Cite

Sulfate activation and transport in mammals: system components and mechanisms.

Journal Article Chem Biol Interact · February 20, 1998 Extensive studies on the mammalian sulfate-activating enzymes and PAPS translocase have enhanced our understanding of the overall pathway of sulfate activation and utilization. Isolation of the PAPS-synthesizing activities from rat chondrosarcoma and prepa ... Full text Link to item Cite

Expression and functional analysis of the murine brain atp sulfurylase/adenosine 5'-phosphosulfate (APS) kinase enzyme a

Journal Article FASEB Journal · December 1, 1997 The sulfate activation pathway in higher organisms consists of a bifunrtional ATP sulfurylàse/APS kinasc enzyme; in contrast, lower organisms have each activity on a separate polypeptide. ATP sulfurylase/ APS kinase isolated from rat chondrosarcoma has als ... Cite

The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase.

Journal Article J Biol Chem · December 8, 1995 Biosynthesis of the activated sulfate donor, adenosine 3'-phosphate 5'-phosphosulfate, involves the sequential action of two enzyme activities: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and free sulfate, a ... Full text Link to item Cite