Andrew Aldridge

Journal Article Curr Opin Neurobiol · December 2024 Epigenetic regulation of the genome is required for cell-type differentiation during organismal development and is especially important to generate the panoply of specialized cell types that comprise the brain. Here, we review how progressive changes in th ... Full text Link to item Cite

Brain-wide correspondence of neuronal epigenomics and distant projections

Journal Article Nature · December 14, 2023 AbstractSingle-cell analyses parse the brain’s billions of neurons into thousands of ‘cell-type’ clusters residing in different brain structures1. Many cell types mediate their functions through targete ... Full text Cite

Single-cell DNA methylation and 3D genome architecture in the human brain.

Journal Article Science (New York, N.Y.) · October 2023 Delineating the gene-regulatory programs underlying complex cell types is fundamental for understanding brain function in health and disease. Here, we comprehensively examined human brain cell epigenomes by probing DNA methylation and chromatin conformatio ... Full text Cite

View All Publications