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Angela Roger

Assistant Professor in Pediatrics
Pediatrics, Pulmonary and Sleep Medicine
DUMC Box 2644, Durham, NC 27710
203 Research Drive, MSRB1, Room 141, Durham, NC 27705

Current Appointments & Affiliations


Assistant Professor in Pediatrics · 2024 - Present Pediatrics, Pulmonary and Sleep Medicine, Pediatrics

Recent Publications


GAA deficiency disrupts distal airway cells in Pompe disease.

Journal Article Am J Physiol Lung Cell Mol Physiol · September 1, 2023 Pompe disease is an autosomal recessive glycogen storage disease caused by mutations in the gene that encodes acid alpha-glucosidase (GAA)-an enzyme responsible for hydrolyzing lysosomal glycogen. GAA deficiency results in systemic lysosomal glycogen accum ... Full text Link to item Cite

Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing.

Journal Article Nat Commun · October 10, 2022 Recombinant adeno-associated viral (AAV) vectors are a promising gene delivery platform, but ongoing clinical trials continue to highlight a relatively narrow therapeutic window. Effective clinical translation is confounded, at least in part, by difference ... Full text Link to item Cite

Respiratory dysfunction in a mouse model of spinocerebellar ataxia type 7.

Journal Article Dis Model Mech · July 1, 2021 Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder caused by a CAG repeat expansion in the coding region of the ataxin-7 gene. Infantile-onset SCA7 patients display extremely large repeat expansions (>200 CAGs) and exh ... Full text Link to item Cite
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Recent Grants


Respiratory Characterization of DMD Mouse Models

ResearchPost Doctoral Trainee · Awarded by Sarepta Therapeutics, Inc. · 2019 - 2027

Novel Adjunctive Therapies for Pompe Disease

ResearchPrincipal Investigator · Awarded by National Heart, Lung, and Blood Institute · 2024 - 2027

Novel Adjunctive Therapies for Pompe Disease

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2023

View All Grants

Education, Training & Certifications


University of Florida, College of Medicine · 2017 Ph.D.
University of Florida · 2012 B.S.