Anne Frances Buckley
Assistant Professor of Pathology
My basic research focus is on neurogenic stem cells and their involvement in brain development and brain tumors. I work in mouse models using inducible in vivo genetic systems, live imaging, and tissue culture, in addition to histological and biochemical methods.
My clinical research interests include neuromuscular diseases. I collaborate with colleagues at Duke on basic and translational research in this area.
My clinical research interests include neuromuscular diseases. I collaborate with colleagues at Duke on basic and translational research in this area.
Current Appointments & Affiliations
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2012
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016
Contact Information
- Dept of Pathology, Box 3712, Durham, NC 27710
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anne.buckley@duke.edu
(919) 684-2533
- Background
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Education, Training, & Certifications
- Neuropathology Fellow, Pathology, Duke University 2008
- Fellow, Neuropathology, Pathology, University of California San Francisco, School of Medicine 2006 - 2007
- Fellow, Surgical Pathology, Pathology, University of California San Francisco, School of Medicine 2005 - 2006
- Resident, Anatomic Pathology, Pathology, University of California San Francisco, School of Medicine 2003 - 2005
- M.D., The University of Chicago 2003
- Ph.D., The University of Chicago 2001
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Duke Appointment History
- Medical Instructor in the Department of Pathology, Pathology, Clinical Science Departments 2008 - 2012
- Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2008
- Expertise
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Subject Headings
- Adolescent
- Adult
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- Biopsy
- Cell Division
- Cell Line, Tumor
- Cell Proliferation
- Cell Transformation, Neoplastic
- Cerebellar Neoplasms
- Cerebellum
- Child
- Diabetes Mellitus
- Diagnosis, Differential
- Disease Models, Animal
- Epithelial Cells
- Female
- Fibrosis
- Flow Cytometry
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Glioma
- Hepatocytes
- Humans
- Imidazoles
- Immunohistochemistry
- Infant
- Iodine Radioisotopes
- Kidney
- Kidney Diseases
- Liver Neoplasms
- Macrophages
- Male
- Medulloblastoma
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Microsurgery
- Microvessels
- Middle Aged
- Morpholines
- Muscle, Skeletal
- Neoplasm Recurrence, Local
- Neoplasms, Nerve Tissue
- Neoplasms, Second Primary
- Neural Stem Cells
- Neuroma, Acoustic
- Neuromuscular Diseases
- Phosphatidylinositol 3-Kinases
- Pilot Projects
- Proto-Oncogene Proteins c-myc
- Radiosurgery
- Reagent Kits, Diagnostic
- Receptor, Epidermal Growth Factor
- TOR Serine-Threonine Kinases
- Time Factors
- Tissue Distribution
- Treatment Outcome
- Research
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Selected Grants
- Promoting Podocyte Protective Natriuretic Peptide Signaling in Proteinuric Kidney Diseases awarded by Department of Defense 2019 - 2022
- Targeting TRPC6 to treat focal segmental glomerulosclerosis (FSGS) awarded by Amgen, Inc. 2016 - 2019
- Supplemental Funding for Phase 1/2 study of Clenbuterol for the Treatment of Pompe Disease awarded by Roivant Sciences, Inc. 2015 - 2016
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Lin, Yi-Yu, Ian Belle, Maria Blasi, Min-Nung Huang, Anne F. Buckley, Wes Rountree, Mary E. Klotman, Andrea Cara, and Donatella Negri. “Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity.” Molecular Therapy. Methods & Clinical Development 17 (June 2020): 532–44. https://doi.org/10.1016/j.omtm.2020.03.008.Full Text
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Taylor, Gregory A., Hsin-I Huang, Brian E. Fee, Nourhan Youssef, Mark L. Jewell, Viviana Cantillana, Alexi A. Schoenborn, et al. “Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.” Plos Pathog 16, no. 5 (May 2020): e1008553. https://doi.org/10.1371/journal.ppat.1008553.Full Text Link to Item
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Harrison, William T., Thomas Bouldin, Anne Buckley, Januario Estrada, Roger McLendon, and Kimberly Janssen. “Sudden Unexpected Death in a Child From an Anaplastic Ependymoma.” Am J Forensic Med Pathol 40, no. 3 (September 2019): 275–78. https://doi.org/10.1097/PAF.0000000000000480.Full Text Link to Item
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Wang, Liming, Jae-Hyung Chang, Anne F. Buckley, and Robert F. Spurney. “Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.” Kidney International 95, no. 2 (February 2019): 321–32. https://doi.org/10.1016/j.kint.2018.09.026.Full Text
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Kang, Jennifer H., Anne F. Buckley, Seema Nagpal, Nancy Fischbein, and Katherine B. Peters. “A Diffuse Leptomeningeal Glioneuronal Tumor Without Diffuse Leptomeningeal Involvement: Detailed Molecular and Clinical Characterization.” J Neuropathol Exp Neurol 77, no. 9 (September 1, 2018): 751–56. https://doi.org/10.1093/jnen/nly053.Full Text Link to Item
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Wang, Liming, Anne F. Buckley, and Robert F. Spurney. “Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).” Sci Rep 8, no. 1 (August 16, 2018): 12286. https://doi.org/10.1038/s41598-018-30115-3.Full Text Link to Item
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Tan, Queenie K-G, Allyn McConkie-Rosell, Jane Juusola, Kathryn E. Gustafson, Carolyn E. Pizoli, Anne F. Buckley, and Yong-Hui Jiang. “The importance of managing the patient and not the gene: expanded phenotype of GLE1-associated arthrogryposis.” Cold Spring Harb Mol Case Stud 3, no. 6 (November 2017). https://doi.org/10.1101/mcs.a002063.Full Text Link to Item
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Torok, Rachel D., Stephanie L. Austin, Chanika Phornphutkul, Kathleen M. Rotondo, Deeksha Bali, Gregory H. Tatum, Stephanie B. Wechsler, Anne F. Buckley, and Priya S. Kishnani. “PRKAG2 mutations presenting in infancy.” J Inherit Metab Dis 40, no. 6 (November 2017): 823–30. https://doi.org/10.1007/s10545-017-0072-0.Full Text Link to Item
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Wang, Liming, Yonggang Sha, Jingyi Bai, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.” Am J Physiol Renal Physiol 313, no. 2 (August 1, 2017): F430–39. https://doi.org/10.1152/ajprenal.00614.2016.Full Text Link to Item
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Mori, Mari, Lauren A. Bailey, Januario Estrada, Catherine W. Rehder, Jennifer S. Li, Joseph G. Rogers, Deeksha S. Bali, Anne F. Buckley, and Priya S. Kishnani. “Severe Cardiomyopathy as the Isolated Presenting Feature in an Adult with Late-Onset Pompe Disease: A Case Report.” Jimd Rep 31 (2017): 79–83. https://doi.org/10.1007/8904_2016_563.Full Text Link to Item
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Badea, Alexandra, Lauren Kane, Robert J. Anderson, Yi Qi, Mark Foster, Gary P. Cofer, Neil Medvitz, et al. “The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease.” Neuroimage 142 (November 15, 2016): 498–511. https://doi.org/10.1016/j.neuroimage.2016.08.014.Full Text Link to Item
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Rudemiller, Nathan P., Mehul B. Patel, Jian-Dong Zhang, Alexander D. Jeffs, Norah S. Karlovich, Robert Griffiths, Matthew J. Kan, Anne F. Buckley, Michael D. Gunn, and Steven D. Crowley. “C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration.” Am J Pathol 186, no. 11 (November 2016): 2846–56. https://doi.org/10.1016/j.ajpath.2016.07.015.Full Text Open Access Copy Link to Item
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Somarelli, J. A., D. Schaeffer, M. S. Marengo, T. Bepler, D. Rouse, K. E. Ware, A. J. Hish, et al. “Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.” Oncogene 35, no. 33 (August 18, 2016): 4302–11. https://doi.org/10.1038/onc.2015.497.Full Text Open Access Copy Link to Item
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McKinnon, Elizabeth L., Andrew J. Rand, M Angelica Selim, Herbert E. Fuchs, Anne F. Buckley, and Thomas J. Cummings. “Rhabdomyomatous mesenchymal hamartoma presenting as a sacral skin tag in two neonates with spinal dysraphism.” J Cutan Pathol 42, no. 10 (October 2015): 774–78. https://doi.org/10.1111/cup.12538.Full Text Link to Item
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Wang, Liming, Grant Jirka, Paul B. Rosenberg, Anne F. Buckley, Jose A. Gomez, Timothy A. Fields, Michelle P. Winn, and Robert F. Spurney. “Gq signaling causes glomerular injury by activating TRPC6.” J Clin Invest 125, no. 5 (May 2015): 1913–26. https://doi.org/10.1172/JCI76767.Full Text Link to Item
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Weitzel, Douglas H., Artak Tovmasyan, Kathleen A. Ashcraft, Zrinka Rajic, Tin Weitner, Chunlei Liu, Wei Li, et al. “Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.” Mol Cancer Ther 14, no. 1 (January 2015): 70–79. https://doi.org/10.1158/1535-7163.MCT-14-0343.Full Text Link to Item
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Koeberl, Dwight D., Stephanie Austin, Laura E. Case, Edward C. Smith, Anne F. Buckley, Sarah P. Young, Deeksha Bali, and Priya S. Kishnani. “Adjunctive albuterol enhances the response to enzyme replacement therapy in late-onset Pompe disease.” Faseb J 28, no. 5 (May 2014): 2171–76. https://doi.org/10.1096/fj.13-241893.Full Text Open Access Copy Link to Item
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Zhang, Jian-dong, Mehul B. Patel, Robert Griffiths, Paul C. Dolber, Phillip Ruiz, Matthew A. Sparks, Johannes Stegbauer, et al. “Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis.” J Clin Invest 124, no. 5 (May 2014): 2198–2203. https://doi.org/10.1172/JCI61368.Full Text Link to Item
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Wang, Liming, Yuping Tang, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.” Biochem Biophys Res Commun 444, no. 4 (February 21, 2014): 622–27. https://doi.org/10.1016/j.bbrc.2014.01.115.Full Text Link to Item
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Buckley, Anne F., and Edward H. Bossen. “Skeletal muscle microvasculature in the diagnosis of neuromuscular disease.” J Neuropathol Exp Neurol 72, no. 10 (October 2013): 906–18. https://doi.org/10.1097/NEN.0b013e3182a7f0b8.Full Text Link to Item
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Prater, Sean N., Trusha T. Patel, Anne F. Buckley, Hanna Mandel, Eugene Vlodavski, Suhrad G. Banugaria, Erin J. Feeney, Nina Raben, and Priya S. Kishnani. “Skeletal muscle pathology of infantile Pompe disease during long-term enzyme replacement therapy.” Orphanet J Rare Dis 8 (June 20, 2013): 90. https://doi.org/10.1186/1750-1172-8-90.Full Text Open Access Copy Link to Item
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Pei, Yanxin, Colin E. Moore, Jun Wang, Alok K. Tewari, Alexey Eroshkin, Yoon-Jae Cho, Hendrik Witt, et al. “An animal model of MYC-driven medulloblastoma.” Cancer Cell 21, no. 2 (February 14, 2012): 155–67. https://doi.org/10.1016/j.ccr.2011.12.021.Full Text Link to Item
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Zalutsky, Michael R., Abraham Boskovitz, Chien-Tsun Kuan, Charles N. Pegram, Joanne Ayriss, Carol J. Wikstrand, Anne F. Buckley, et al. “Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors.” Nucl Med Biol 39, no. 1 (January 2012): 23–34. https://doi.org/10.1016/j.nucmedbio.2011.06.005.Full Text Link to Item
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Ipolyi, Amy R. de, Isaac Yang, Anne Buckley, Nicholas M. Barbaro, Steven W. Cheung, and Andrew T. Parsa. “Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case report.” Neurosurgery 62, no. 5 (May 2008): E1164–65. https://doi.org/10.1227/01.neu.0000325880.13494.f2.Full Text Link to Item
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Buckley, Anne F., Lawrence J. Burgart, Vaibhav Sahai, and Sanjay Kakar. “Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinoma.” Am J Clin Pathol 129, no. 2 (February 2008): 245–51. https://doi.org/10.1309/WF10QAAED3PP93BH.Full Text Link to Item
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Lee, Theodore J., Christine M. Glastonbury, Anne F. Buckley, David W. Eisele, and Randall A. Hawkins. “Perineural spread of melanoma demonstrated by F-18 FDG PET With MRI and pathologic correlation.” Clin Nucl Med 33, no. 2 (February 2008): 106–8. https://doi.org/10.1097/RLU.0b013e31815ef7be.Full Text Link to Item
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Buckley, Anne F., and Sanjay Kakar. “Comparison of the Dako EGFR pharmDx kit and Zymed EGFR antibody for assessment of EGFR status in colorectal adenocarcinoma.” Appl Immunohistochem Mol Morphol 15, no. 3 (September 2007): 305–9. https://doi.org/10.1097/01.pai.0000213141.47277.bf.Full Text Link to Item
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Buckley, Anne F., Lawrence J. Burgart, and Sanjay Kakar. “Epidermal growth factor receptor expression and gene copy number in fibrolamellar hepatocellular carcinoma.” Hum Pathol 37, no. 4 (April 2006): 410–14. https://doi.org/10.1016/j.humpath.2005.12.009.Full Text Link to Item
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Buckley, A. F., C. T. Kuo, and J. M. Leiden. “Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway.” Nat Immunol 2, no. 8 (August 2001): 698–704. https://doi.org/10.1038/90633.Full Text Link to Item
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Book Sections
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Buckley, A. F., R. E. McLendon, C. J. Wikstrand, and D. D. Bigner. “Biomarker discovery in central nervous system neoplasms: Past, present and future.” In Tumors of the Central Nervous System: Astrocytomas, Hemangioblastomas, and Gangliogliomas, 5:107–19, 2012. https://doi.org/10.1007/978-94-007-2019-0_13.Full Text
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Other Articles
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Somarelli, Jason A., Daneen Schaeffer, Mathew S. Marengo, Tristan Bepler, Douglas Rouse, Anne F. Buckley, Jonathan I. Epstein, Andrew J. Armstrong, and Mariano A. Garcia-Blanco. “Abstract SS02-02: A long walk from FGFR2 alternative splicing to cancer progression.” Cell, Molecular, and Tumor Biology. American Association for Cancer Research, November 2014. https://doi.org/10.1158/1538-7755.disp13-ss02-02.Full Text
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Conference Papers
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Bailey, Lauren A., Mari Mori, Deeksha Bali, Anne F. Buckley, and Priya S. Kishnani. “Late onset Pompe disease case review: Severe isolated hypertrophic cardiomyopathy.” In Molecular Genetics and Metabolism, 117:S24–S24. Elsevier BV, 2016. https://doi.org/10.1016/j.ymgme.2015.12.189.Full Text
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