Anne Frances Buckley | Scholars@Duke

Anne Frances Buckley
Assistant Professor of Pathology

My basic research focus is on neurogenic stem cells and their involvement in brain development and brain tumors. I work in mouse models using inducible in vivo genetic systems, live imaging, and tissue culture, in addition to histological and biochemical methods.
My clinical research interests include neuromuscular diseases. I collaborate with colleagues at Duke on basic and translational research in this area.

Current Appointments & Affiliations

Assistant Professor of Pathology, Pathology, Clinical Science Departments 2012
Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016

Contact Information

anne.buckley@duke.edu (919) 684-2533

Background
Education, Training, & Certifications
- Neuropathology Fellow, Pathology, Duke University 2008
- Fellow, Neuropathology, Pathology, University of California, San Francisco, School of Medicine 2006 - 2007
- Fellow, Surgical Pathology, Pathology, University of California, San Francisco, School of Medicine 2005 - 2006
- Resident, Anatomic Pathology, Pathology, University of California, San Francisco, School of Medicine 2003 - 2005
- M.D., University of Chicago 2003
- Ph.D., University of Chicago 2001
Duke Appointment History
- Medical Instructor in the Department of Pathology, Pathology, Clinical Science Departments 2008 - 2012
- Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2008
Expertise
Subject Headings
Research
Selected Grants
- Targeting TRPC6 to treat focal segmental glomerulosclerosis (FSGS) awarded by Amgen, Inc. 2016 - 2018
- An integrated and diverse genomic medicine program for undiagnosed diseases awarded by National Institutes of Health 2014 - 2018
- Supplemental Funding for Phase 1/2 study of Clenbuterol for the Treatment of Pompe Disease awarded by Roivant Sciences, Inc. 2015 - 2016
Publications & Artistic Works
Selected Publications
- Book Sections
  - Buckley, AF, McLendon, RE, Wikstrand, CJ, and Bigner, DD. "Biomarker discovery in central nervous system neoplasms: Past, present and future." In Tumors of the Central Nervous System: Astrocytomas, Hemangioblastomas, and Gangliogliomas, 107-119. January 1, 2012. Full Text
- Conference Papers
  - Bailey, LA, Mori, M, Bali, D, Buckley, AF, and Kishnani, PS. "Late onset Pompe disease case review: Severe isolated hypertrophic cardiomyopathy." February 2016. Full Text
- Journal Articles
  - Torok, RD, Austin, SL, Phornphutkul, C, Rotondo, KM, Bali, D, Tatum, GH, Wechsler, SB, Buckley, AF, and Kishnani, PS. "PRKAG2 mutations presenting in infancy." Journal of inherited metabolic disease (August 11, 2017). Full Text
  - Wang, L, Sha, Y, Bai, J, Eisner, W, Sparks, MA, Buckley, AF, and Spurney, RF. "Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease." American journal of physiology. Renal physiology 313, no. 2 (August 2017): F430-F439. Full Text
  - Mori, M, Bailey, LA, Estrada, J, Rehder, CW, Li, JS, Rogers, JG, Bali, DS, Buckley, AF, and Kishnani, PS. "Severe Cardiomyopathy as the Isolated Presenting Feature in an Adult with Late-Onset Pompe Disease: A Case Report." JIMD reports 31 (January 2017): 79-83. Full Text
  - Badea, A, Kane, L, Anderson, RJ, Qi, Y, Foster, M, Cofer, GP, Medvitz, N, Buckley, AF, Badea, AK, Wetsel, WC, and Colton, CA. "The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease." NeuroImage 142 (November 2016): 498-511. Full Text
  - Somarelli, JA, Schaeffer, D, Marengo, MS, Bepler, T, Rouse, D, Ware, KE, Hish, AJ, Zhao, Y, Buckley, AF, Epstein, JI, Armstrong, AJ, Virshup, DM, and Garcia-Blanco, MA. "Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways." Oncogene 35, no. 33 (August 2016): 4302-4311. Full Text Open Access Copy
  - McKinnon, EL, Rand, AJ, Selim, MA, Fuchs, HE, Buckley, AF, and Cummings, TJ. "Rhabdomyomatous mesenchymal hamartoma presenting as a sacral skin tag in two neonates with spinal dysraphism." Journal of cutaneous pathology 42, no. 10 (October 2015): 774-778. Full Text
  - Wang, L, Jirka, G, Rosenberg, PB, Buckley, AF, Gomez, JA, Fields, TA, Winn, MP, and Spurney, RF. "Gq signaling causes glomerular injury by activating TRPC6." The Journal of clinical investigation 125, no. 5 (May 2015): 1913-1926. Full Text
  - Weitzel, DH, Tovmasyan, A, Ashcraft, KA, Rajic, Z, Weitner, T, Liu, C, Li, W, Buckley, AF, Prasad, MR, Young, KH, Rodriguiz, RM, Wetsel, WC, Peters, KB, Spasojevic, I, Herndon, JE, Batinic-Haberle, I, and Dewhirst, MW. "Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+." Molecular cancer therapeutics 14, no. 1 (January 2015): 70-79. Full Text
  - Koeberl, DD, Austin, S, Case, LE, Smith, EC, Buckley, AF, Young, SP, Bali, D, and Kishnani, PS. "Adjunctive albuterol enhances the response to enzyme replacement therapy in late-onset Pompe disease." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28, no. 5 (May 2014): 2171-2176. Full Text Open Access Copy
  - Zhang, J-D, Patel, MB, Griffiths, R, Dolber, PC, Ruiz, P, Sparks, MA, Stegbauer, J, Jin, H, Gomez, JA, Buckley, AF, Lefler, WS, Chen, D, and Crowley, SD. "Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis." The Journal of clinical investigation 124, no. 5 (May 2014): 2198-2203. Full Text
  - Wang, L, Tang, Y, Eisner, W, Sparks, MA, Buckley, AF, and Spurney, RF. "Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice." Biochemical and Biophysical Research Communications 444, no. 4 (February 21, 2014): 622-627. Full Text
  - Wang, L, Tang, Y, Eisner, W, Sparks, MA, Buckley, AF, and Spurney, RF. "Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice." Biochemical and biophysical research communications 444, no. 4 (February 2014): 622-627. Full Text
  - Buckley, AF, and Bossen, EH. "Skeletal muscle microvasculature in the diagnosis of neuromuscular disease." J Neuropathol Exp Neurol 72, no. 10 (October 2013): 906-918. (Review) Full Text Link to Item
  - Prater, SN, Patel, TT, Buckley, AF, Mandel, H, Vlodavski, E, Banugaria, SG, Feeney, EJ, Raben, N, and Kishnani, PS. "Skeletal muscle pathology of infantile Pompe disease during long-term enzyme replacement therapy. (Published online)" Orphanet J Rare Dis 8 (June 20, 2013): 90-. Full Text Open Access Copy Link to Item
  - Pei, Y, Moore, CE, Wang, J, Tewari, AK, Eroshkin, A, Cho, Y-J, Witt, H, Korshunov, A, Read, T-A, Sun, JL, Schmitt, EM, Miller, CR, Buckley, AF, McLendon, RE, Westbrook, TF, Northcott, PA, Taylor, MD, Pfister, SM, Febbo, PG, and Wechsler-Reya, RJ. "An animal model of MYC-driven medulloblastoma." Cancer Cell 21, no. 2 (February 14, 2012): 155-167. Full Text Link to Item
  - Zalutsky, MR, Boskovitz, A, Kuan, C-T, Pegram, CN, Ayriss, J, Wikstrand, CJ, Buckley, AF, Lipp, ES, Herndon, JE, McLendon, RE, and Bigner, DD. "Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors." Nucl Med Biol 39, no. 1 (January 2012): 23-34. Full Text Link to Item
  - de Ipolyi, AR, Yang, I, Buckley, A, Barbaro, NM, Cheung, SW, and Parsa, AT. "Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case report." Neurosurgery 62, no. 5 (May 2008): E1164-E1165. Full Text Link to Item
  - Buckley, AF, Burgart, LJ, Sahai, V, and Kakar, S. "Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinoma." Am J Clin Pathol 129, no. 2 (February 2008): 245-251. Full Text Link to Item
  - Lee, TJ, Glastonbury, CM, Buckley, AF, Eisele, DW, and Hawkins, RA. "Perineural spread of melanoma demonstrated by F-18 FDG PET With MRI and pathologic correlation." Clin Nucl Med 33, no. 2 (February 2008): 106-108. Full Text Link to Item
  - Buckley, AF, and Kakar, S. "Comparison of the Dako EGFR pharmDx kit and Zymed EGFR antibody for assessment of EGFR status in colorectal adenocarcinoma." Appl Immunohistochem Mol Morphol 15, no. 3 (September 2007): 305-309. Full Text Link to Item
  - Buckley, AF, Burgart, LJ, and Kakar, S. "Epidermal growth factor receptor expression and gene copy number in fibrolamellar hepatocellular carcinoma." Hum Pathol 37, no. 4 (April 2006): 410-414. Full Text Link to Item
  - Buckley, AF, Kuo, CT, and Leiden, JM. "Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway." Nat Immunol 2, no. 8 (August 2001): 698-704. Full Text Link to Item
- Other Articles
  - Somarelli, JA, Somarelli, JA, Schaeffer, D, Schaeffer, D, Marengo, MS, Marengo, MS, Bepler, T, Bepler, T, Rouse, D, Buckley, AF, Epstein, JI, Armstrong, AJ, Garcia-Blanco, MA, and Garcia-Blanco, MA. "Abstract SS02-02: A long walk from FGFR2 alternative splicing to cancer progression." Cancer Epidemiology Biomarkers & Prevention 23, no. 11 Supplement (November 2014): SS02-02-SS02-02. Full Text

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Grants

Selected Publications

Book Sections

Conference Papers

Journal Articles

Other Articles