Anne Frances Buckley | Scholars@Duke

Anne Frances Buckley
Assistant Professor of Pathology

My basic research focus is on neurogenic stem cells and their involvement in brain development and brain tumors. I work in mouse models using inducible in vivo genetic systems, live imaging, and tissue culture, in addition to histological and biochemical methods.
My clinical research interests include neuromuscular diseases. I collaborate with colleagues at Duke on basic and translational research in this area.

Current Appointments & Affiliations

Assistant Professor of Pathology, Pathology, Clinical Science Departments 2012
Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016

Contact Information

Dept of Pathology, Box 3712, Durham, NC 27710
anne.buckley@duke.edu (919) 684-2533

Background
Education, Training, & Certifications
- Neuropathology Fellow, Pathology, Duke University 2008
- Fellow, Neuropathology, Pathology, University of California, San Francisco, School of Medicine 2006 - 2007
- Fellow, Surgical Pathology, Pathology, University of California, San Francisco, School of Medicine 2005 - 2006
- Resident, Anatomic Pathology, Pathology, University of California, San Francisco, School of Medicine 2003 - 2005
- M.D., University of Chicago 2003
- Ph.D., University of Chicago 2001
Duke Appointment History
- Medical Instructor in the Department of Pathology, Pathology, Clinical Science Departments 2008 - 2012
- Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2008
Expertise
Subject Headings
Research
Selected Grants
- An integrated and diverse genomic medicine program for undiagnosed diseases awarded by National Institutes of Health 2014 - 2022
- Targeting TRPC6 to treat focal segmental glomerulosclerosis (FSGS) awarded by Amgen, Inc. 2016 - 2019
- Supplemental Funding for Phase 1/2 study of Clenbuterol for the Treatment of Pompe Disease awarded by Roivant Sciences, Inc. 2015 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Wang, L, Chang, J-H, Buckley, AF, and Spurney, RF. "Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice." Kidney International 95, no. 2 (February 2019): 321-332. Full Text
  - Kang, JH, Buckley, AF, Nagpal, S, Fischbein, N, and Peters, KB. "A Diffuse Leptomeningeal Glioneuronal Tumor Without Diffuse Leptomeningeal Involvement: Detailed Molecular and Clinical Characterization." Journal of Neuropathology and Experimental Neurology 77, no. 9 (September 2018): 751-756. Full Text
  - Wang, L, Buckley, AF, and Spurney, RF. "Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1)." Scientific Reports 8, no. 1 (August 16, 2018): 12286-null. Full Text
  - Tan, QK-G, McConkie-Rosell, A, Juusola, J, Gustafson, KE, Pizoli, CE, Buckley, AF, and Jiang, Y-H. "The importance of managing the patient and not the gene: expanded phenotype of GLE1-associated arthrogryposis." Cold Spring Harbor Molecular Case Studies 3, no. 6 (November 21, 2017). Full Text
  - Torok, Rachel D., Stephanie L. Austin, Chanika Phornphutkul, Kathleen M. Rotondo, Deeksha Bali, Gregory H. Tatum, Stephanie B. Wechsler, Anne F. Buckley, and Priya S. Kishnani. “PRKAG2 mutations presenting in infancy..” Journal of Inherited Metabolic Disease 40, no. 6 (November 2017): 823–30. https://doi.org/10.1007/s10545-017-0072-0.
    Full Text
  - Wang, L, Sha, Y, Bai, J, Eisner, W, Sparks, MA, Buckley, AF, and Spurney, RF. "Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease." American Journal of Physiology. Renal Physiology 313, no. 2 (August 2017): F430-F439. Full Text
  - Mori, Mari, Lauren A. Bailey, Januario Estrada, Catherine W. Rehder, Jennifer S. Li, Joseph G. Rogers, Deeksha S. Bali, Anne F. Buckley, and Priya S. Kishnani. “Severe Cardiomyopathy as the Isolated Presenting Feature in an Adult with Late-Onset Pompe Disease: A Case Report..” Jimd Reports 31 (January 2017): 79–83. https://doi.org/10.1007/8904_2016_563.
    Full Text
  - Badea, Alexandra, Lauren Kane, Robert J. Anderson, Yi Qi, Mark Foster, Gary P. Cofer, Neil Medvitz, et al. “The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease..” Neuroimage 142 (November 2016): 498–511. https://doi.org/10.1016/j.neuroimage.2016.08.014.
    Full Text
  - Rudemiller, NP, Patel, MB, Zhang, J-D, Jeffs, AD, Karlovich, NS, Griffiths, R, Kan, MJ, Buckley, AF, Gunn, MD, and Crowley, SD. "C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration." The American Journal of Pathology 186, no. 11 (November 2016): 2846-2856. Full Text Open Access Copy
  - Somarelli, J. A., D. Schaeffer, M. S. Marengo, T. Bepler, D. Rouse, K. E. Ware, A. J. Hish, et al. “Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways..” Oncogene 35, no. 33 (August 2016): 4302–11. https://doi.org/10.1038/onc.2015.497.
    Full Text Open Access Copy
  - McKinnon, Elizabeth L., Andrew J. Rand, M Angelica Selim, Herbert E. Fuchs, Anne F. Buckley, and Thomas J. Cummings. “Rhabdomyomatous mesenchymal hamartoma presenting as a sacral skin tag in two neonates with spinal dysraphism..” Journal of Cutaneous Pathology 42, no. 10 (October 2015): 774–78. https://doi.org/10.1111/cup.12538.
    Full Text
  - Wang, L, Jirka, G, Rosenberg, PB, Buckley, AF, Gomez, JA, Fields, TA, Winn, MP, and Spurney, RF. "Gq signaling causes glomerular injury by activating TRPC6." The Journal of Clinical Investigation 125, no. 5 (May 2015): 1913-1926. Full Text
  - Weitzel, DH, Tovmasyan, A, Ashcraft, KA, Rajic, Z, Weitner, T, Liu, C, Li, W, Buckley, AF, Prasad, MR, Young, KH, Rodriguiz, RM, Wetsel, WC, Peters, KB, Spasojevic, I, Herndon, JE, Batinic-Haberle, I, and Dewhirst, MW. "Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+." Molecular Cancer Therapeutics 14, no. 1 (January 2015): 70-79. Full Text
  - Koeberl, DD, Austin, S, Case, LE, Smith, EC, Buckley, AF, Young, SP, Bali, D, and Kishnani, PS. "Adjunctive albuterol enhances the response to enzyme replacement therapy in late-onset Pompe disease." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 28, no. 5 (May 2014): 2171-2176. Full Text Open Access Copy
  - Zhang, J-D, Patel, MB, Griffiths, R, Dolber, PC, Ruiz, P, Sparks, MA, Stegbauer, J, Jin, H, Gomez, JA, Buckley, AF, Lefler, WS, Chen, D, and Crowley, SD. "Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis." J Clin Invest 124, no. 5 (May 2014): 2198-2203. Full Text Link to Item
  - Sparks, MA, Buckley, AF, and Spurney, RF. "Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice." Biochemical and Biophysical Research Communications 444, no. 4 (February 21, 2014): 622-627. Full Text
  - Wang, Liming, Yuping Tang, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice..” Biochemical and Biophysical Research Communications 444, no. 4 (February 2014): 622–27. https://doi.org/10.1016/j.bbrc.2014.01.115.
    Full Text
  - Buckley, Anne F., and Edward H. Bossen. “Skeletal muscle microvasculature in the diagnosis of neuromuscular disease..” Journal of Neuropathology and Experimental Neurology 72, no. 10 (October 2013): 906–18. https://doi.org/10.1097/nen.0b013e3182a7f0b8.
    Full Text
  - Prater, Sean N., Trusha T. Patel, Anne F. Buckley, Hanna Mandel, Eugene Vlodavski, Suhrad G. Banugaria, Erin J. Feeney, Nina Raben, and Priya S. Kishnani. “Skeletal muscle pathology of infantile Pompe disease during long-term enzyme replacement therapy..” Orphanet Journal of Rare Diseases 8 (June 20, 2013). https://doi.org/10.1186/1750-1172-8-90.
    Full Text Open Access Copy
  - Pei, Yanxin, Colin E. Moore, Jun Wang, Alok K. Tewari, Alexey Eroshkin, Yoon-Jae Cho, Hendrik Witt, et al. “An animal model of MYC-driven medulloblastoma..” Cancer Cell 21, no. 2 (February 2012): 155–67. https://doi.org/10.1016/j.ccr.2011.12.021.
    Full Text
  - Zalutsky, MR, Boskovitz, A, Kuan, C-T, Pegram, CN, Ayriss, J, Wikstrand, CJ, Buckley, AF, Lipp, ES, Herndon, JE, McLendon, RE, and Bigner, DD. "Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors." Nuclear Medicine and Biology 39, no. 1 (January 2012): 23-34. Full Text
  - Ipolyi, Amy R. de, Isaac Yang, Anne Buckley, Nicholas M. Barbaro, Steven W. Cheung, and Andrew T. Parsa. “Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case report..” Neurosurgery 62, no. 5 (May 2008): E1164–65. https://doi.org/10.1227/01.neu.0000325880.13494.f2.
    Full Text
  - Lee, Theodore J., Christine M. Glastonbury, Anne F. Buckley, David W. Eisele, and Randall A. Hawkins. “Perineural spread of melanoma demonstrated by F-18 FDG PET With MRI and pathologic correlation..” Clinical Nuclear Medicine 33, no. 2 (February 2008): 106–8. https://doi.org/10.1097/rlu.0b013e31815ef7be.
    Full Text
  - Buckley, AF, Burgart, LJ, Sahai, V, and Kakar, S. "Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinoma." American Journal of Clinical Pathology 129, no. 2 (February 2008): 245-251. Full Text
  - Buckley, AF, and Kakar, S. "Comparison of the Dako EGFR pharmDx kit and Zymed EGFR antibody for assessment of EGFR status in colorectal adenocarcinoma." Applied Immunohistochemistry & Molecular Morphology : Aimm 15, no. 3 (September 2007): 305-309. Full Text
  - Buckley, AF, Burgart, LJ, and Kakar, S. "Epidermal growth factor receptor expression and gene copy number in fibrolamellar hepatocellular carcinoma." Human Pathology 37, no. 4 (April 2006): 410-414. Full Text
  - Buckley, A. F., C. T. Kuo, and J. M. Leiden. “Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway..” Nature Immunology 2, no. 8 (August 2001): 698–704. https://doi.org/10.1038/90633.
    Full Text
- Book Sections
  - Buckley, AF, McLendon, RE, Wikstrand, CJ, and Bigner, DD. "Biomarker discovery in central nervous system neoplasms: Past, present and future." In Tumors of the Central Nervous System: Astrocytomas, Hemangioblastomas, and Gangliogliomas, 107-119. January 1, 2012. Full Text
- Other Articles
  - Somarelli, JA, Schaeffer, D, Marengo, MS, Bepler, T, Rouse, D, Buckley, AF, Epstein, JI, Armstrong, AJ, and Garcia-Blanco, MA. "Abstract SS02-02: A long walk from FGFR2 alternative splicing to cancer progression." Cell, Molecular, and Tumor Biology (November 2014). Full Text
- Conference Papers
  - Bailey, LA, Mori, M, Bali, D, Buckley, AF, and Kishnani, PS. "Late onset Pompe disease case review: Severe isolated hypertrophic cardiomyopathy." : Elsevier BV, February 2016. Full Text

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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Other Articles

Conference Papers