Anne Frances Buckley | Scholars@Duke

Anne Frances Buckley
Assistant Professor of Pathology

My basic research focus is on neurogenic stem cells and their involvement in brain development and brain tumors. I work in mouse models using inducible in vivo genetic systems, live imaging, and tissue culture, in addition to histological and biochemical methods.
My clinical research interests include neuromuscular diseases. I collaborate with colleagues at Duke on basic and translational research in this area.

Current Appointments & Affiliations

Assistant Professor of Pathology, Pathology, Clinical Science Departments 2021
Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021

Contact Information

Dept of Pathology, Box 3712, Durham, NC 27710
anne.buckley@duke.edu (919) 684-2533

Background
Education, Training, & Certifications
- Neuropathology Fellow, Pathology, Duke University 2008
- Fellow, Neuropathology, Pathology, University of California San Francisco, School of Medicine 2006 - 2007
- Fellow, Surgical Pathology, Pathology, University of California San Francisco, School of Medicine 2005 - 2006
- Resident, Anatomic Pathology, Pathology, University of California San Francisco, School of Medicine 2003 - 2005
- M.D., The University of Chicago 2003
- Ph.D., The University of Chicago 2001
Previous Appointments & Affiliations
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2012 - 2020
- Medical Instructor in the Department of Pathology, Pathology, Clinical Science Departments 2008 - 2012
- Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2008
Expertise
Subject Headings
Research
Selected Grants
- Promoting Podocyte Protective Natriuretic Peptide Signaling in Proteinuric Kidney Diseases awarded by Department of Defense 2019 - 2022
- Targeting TRPC6 to treat focal segmental glomerulosclerosis (FSGS) awarded by Amgen, Inc. 2016 - 2019
- Supplemental Funding for Phase 1/2 study of Clenbuterol for the Treatment of Pompe Disease awarded by Roivant Sciences, Inc. 2015 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kumar, Reeti, Vahakn Keskinyan, Megan Chryst Stangl, Brandon M. Lane, Anne F. Buckley, Laura Barisoni, David N. Howell, and Rasheed A. Gbadegesin. “Case Report: Unusual Aggregation of Different Glomerulopathies in a Family Resolved by Genetic Testing and Reverse Phenotyping.” Front Pediatr 10 (2022): 826330. https://doi.org/10.3389/fped.2022.826330.
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  - Wang, Liming, Yuping Tang, Anne F. Buckley, and Robert F. Spurney. “Blockade of the natriuretic peptide clearance receptor attenuates proteinuria in a mouse model of focal segmental glomerulosclerosis.” Physiol Rep 9, no. 21 (November 2021): e15095. https://doi.org/10.14814/phy2.15095.
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  - Jug, Rachel, Adam L. Booth, Anne F. Buckley, Jordan Newell, Joshua Kesterson, Jerad M. Gardner, Lerna Ozcan, et al. “Multisite Quality Improvement Study of a Patient-Pathologist Consultation Program.” Am J Clin Pathol 155, no. 6 (May 18, 2021): 887–94. https://doi.org/10.1093/ajcp/aqaa202.
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  - Pittman, Patricia D., William T. Harrison, and Anne F. Buckley. “Adult atypical teratoid/rhabdoid tumor (AT/RT): A case of mistaken identity.” Clin Neuropathol 40, no. 1 (January 2021): 62–63. https://doi.org/10.5414/NP301306.
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  - Ahn, Janice S., Maureen Petersen, Allan H. Friedman, Edward M. López, Thomas J. Cummings, Anne F. Buckley, and Giselle Y. López. “Eosinophilic globules in a classic ependymoma: evidence of a possible secretory role.” Ultrastruct Pathol 44, no. 4–6 (November 20, 2020): 511–18. https://doi.org/10.1080/01913123.2020.1843578.
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  - Lin, Yi-Yu, Ian Belle, Maria Blasi, Min-Nung Huang, Anne F. Buckley, Wes Rountree, Mary E. Klotman, Andrea Cara, and Donatella Negri. “Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity.” Mol Ther Methods Clin Dev 17 (June 12, 2020): 532–44. https://doi.org/10.1016/j.omtm.2020.03.008.
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  - Taylor, Gregory A., Hsin-I Huang, Brian E. Fee, Nourhan Youssef, Mark L. Jewell, Viviana Cantillana, Alexi A. Schoenborn, et al. “Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.” Plos Pathog 16, no. 5 (May 2020): e1008553. https://doi.org/10.1371/journal.ppat.1008553.
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  - Harrison, William T., Thomas Bouldin, Anne Buckley, Januario Estrada, Roger McLendon, and Kimberly Janssen. “Sudden Unexpected Death in a Child From an Anaplastic Ependymoma.” Am J Forensic Med Pathol 40, no. 3 (September 2019): 275–78. https://doi.org/10.1097/PAF.0000000000000480.
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  - Eisenberg, A., J. Mersereau, A. F. Buckley, and L. Gratian. “Multiple Pituitary Adenomas with Functional Follicle-Stimulating Hormone Secretion Leading to Ovarian Hyperstimulation Syndrome.” Aace Clinical Case Reports 5, no. 2 (March 1, 2019): e159–63. https://doi.org/10.4158/ACCR-2018-0474.
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  - Wang, Liming, Jae-Hyung Chang, Anne F. Buckley, and Robert F. Spurney. “Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.” Kidney Int 95, no. 2 (February 2019): 321–32. https://doi.org/10.1016/j.kint.2018.09.026.
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  - Kang, Jennifer H., Anne F. Buckley, Seema Nagpal, Nancy Fischbein, and Katherine B. Peters. “A Diffuse Leptomeningeal Glioneuronal Tumor Without Diffuse Leptomeningeal Involvement: Detailed Molecular and Clinical Characterization.” J Neuropathol Exp Neurol 77, no. 9 (September 1, 2018): 751–56. https://doi.org/10.1093/jnen/nly053.
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  - Wang, Liming, Anne F. Buckley, and Robert F. Spurney. “Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).” Sci Rep 8, no. 1 (August 16, 2018): 12286. https://doi.org/10.1038/s41598-018-30115-3.
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  - Tan, Queenie K-G, Allyn McConkie-Rosell, Jane Juusola, Kathryn E. Gustafson, Carolyn E. Pizoli, Anne F. Buckley, and Yong-Hui Jiang. “The importance of managing the patient and not the gene: expanded phenotype of GLE1-associated arthrogryposis.” Cold Spring Harb Mol Case Stud 3, no. 6 (November 2017). https://doi.org/10.1101/mcs.a002063.
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  - Torok, Rachel D., Stephanie L. Austin, Chanika Phornphutkul, Kathleen M. Rotondo, Deeksha Bali, Gregory H. Tatum, Stephanie B. Wechsler, Anne F. Buckley, and Priya S. Kishnani. “PRKAG2 mutations presenting in infancy.” J Inherit Metab Dis 40, no. 6 (November 2017): 823–30. https://doi.org/10.1007/s10545-017-0072-0.
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  - Wang, Liming, Yonggang Sha, Jingyi Bai, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.” Am J Physiol Renal Physiol 313, no. 2 (August 1, 2017): F430–39. https://doi.org/10.1152/ajprenal.00614.2016.
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  - Mori, Mari, Lauren A. Bailey, Januario Estrada, Catherine W. Rehder, Jennifer S. Li, Joseph G. Rogers, Deeksha S. Bali, Anne F. Buckley, and Priya S. Kishnani. “Severe Cardiomyopathy as the Isolated Presenting Feature in an Adult with Late-Onset Pompe Disease: A Case Report.” Jimd Rep 31 (2017): 79–83. https://doi.org/10.1007/8904_2016_563.
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  - Badea, Alexandra, Lauren Kane, Robert J. Anderson, Yi Qi, Mark Foster, Gary P. Cofer, Neil Medvitz, et al. “The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease.” Neuroimage 142 (November 15, 2016): 498–511. https://doi.org/10.1016/j.neuroimage.2016.08.014.
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  - Rudemiller, Nathan P., Mehul B. Patel, Jian-Dong Zhang, Alexander D. Jeffs, Norah S. Karlovich, Robert Griffiths, Matthew J. Kan, Anne F. Buckley, Michael D. Gunn, and Steven D. Crowley. “C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration.” Am J Pathol 186, no. 11 (November 2016): 2846–56. https://doi.org/10.1016/j.ajpath.2016.07.015.
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  - Somarelli, J. A., D. Schaeffer, M. S. Marengo, T. Bepler, D. Rouse, K. E. Ware, A. J. Hish, et al. “Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.” Oncogene 35, no. 33 (August 18, 2016): 4302–11. https://doi.org/10.1038/onc.2015.497.
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  - McKinnon, Elizabeth L., Andrew J. Rand, M Angelica Selim, Herbert E. Fuchs, Anne F. Buckley, and Thomas J. Cummings. “Rhabdomyomatous mesenchymal hamartoma presenting as a sacral skin tag in two neonates with spinal dysraphism.” J Cutan Pathol 42, no. 10 (October 2015): 774–78. https://doi.org/10.1111/cup.12538.
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  - Wang, Liming, Grant Jirka, Paul B. Rosenberg, Anne F. Buckley, Jose A. Gomez, Timothy A. Fields, Michelle P. Winn, and Robert F. Spurney. “Gq signaling causes glomerular injury by activating TRPC6.” J Clin Invest 125, no. 5 (May 2015): 1913–26. https://doi.org/10.1172/JCI76767.
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  - Weitzel, Douglas H., Artak Tovmasyan, Kathleen A. Ashcraft, Zrinka Rajic, Tin Weitner, Chunlei Liu, Wei Li, et al. “Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.” Mol Cancer Ther 14, no. 1 (January 2015): 70–79. https://doi.org/10.1158/1535-7163.MCT-14-0343.
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  - Zhang, Jian-dong, Mehul B. Patel, Robert Griffiths, Paul C. Dolber, Phillip Ruiz, Matthew A. Sparks, Johannes Stegbauer, et al. “Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis.” J Clin Invest 124, no. 5 (May 2014): 2198–2203. https://doi.org/10.1172/JCI61368.
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  - Koeberl, Dwight D., Stephanie Austin, Laura E. Case, Edward C. Smith, Anne F. Buckley, Sarah P. Young, Deeksha Bali, and Priya S. Kishnani. “Adjunctive albuterol enhances the response to enzyme replacement therapy in late-onset Pompe disease.” Faseb J 28, no. 5 (May 2014): 2171–76. https://doi.org/10.1096/fj.13-241893.
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  - Wang, Liming, Yuping Tang, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.” Biochem Biophys Res Commun 444, no. 4 (February 21, 2014): 622–27. https://doi.org/10.1016/j.bbrc.2014.01.115.
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  - Buckley, Anne F., and Edward H. Bossen. “Skeletal muscle microvasculature in the diagnosis of neuromuscular disease.” J Neuropathol Exp Neurol 72, no. 10 (October 2013): 906–18. https://doi.org/10.1097/NEN.0b013e3182a7f0b8.
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  - Prater, Sean N., Trusha T. Patel, Anne F. Buckley, Hanna Mandel, Eugene Vlodavski, Suhrad G. Banugaria, Erin J. Feeney, Nina Raben, and Priya S. Kishnani. “Skeletal muscle pathology of infantile Pompe disease during long-term enzyme replacement therapy.” Orphanet J Rare Dis 8 (June 20, 2013): 90. https://doi.org/10.1186/1750-1172-8-90.
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  - Pei, Yanxin, Colin E. Moore, Jun Wang, Alok K. Tewari, Alexey Eroshkin, Yoon-Jae Cho, Hendrik Witt, et al. “An animal model of MYC-driven medulloblastoma.” Cancer Cell 21, no. 2 (February 14, 2012): 155–67. https://doi.org/10.1016/j.ccr.2011.12.021.
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  - Zalutsky, Michael R., Abraham Boskovitz, Chien-Tsun Kuan, Charles N. Pegram, Joanne Ayriss, Carol J. Wikstrand, Anne F. Buckley, et al. “Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors.” Nucl Med Biol 39, no. 1 (January 2012): 23–34. https://doi.org/10.1016/j.nucmedbio.2011.06.005.
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  - Ipolyi, Amy R. de, Isaac Yang, Anne Buckley, Nicholas M. Barbaro, Steven W. Cheung, and Andrew T. Parsa. “Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case report.” Neurosurgery 62, no. 5 (May 2008): E1164–65. https://doi.org/10.1227/01.neu.0000325880.13494.f2.
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  - Buckley, Anne F., Lawrence J. Burgart, Vaibhav Sahai, and Sanjay Kakar. “Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinoma.” Am J Clin Pathol 129, no. 2 (February 2008): 245–51. https://doi.org/10.1309/WF10QAAED3PP93BH.
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  - Lee, Theodore J., Christine M. Glastonbury, Anne F. Buckley, David W. Eisele, and Randall A. Hawkins. “Perineural spread of melanoma demonstrated by F-18 FDG PET With MRI and pathologic correlation.” Clin Nucl Med 33, no. 2 (February 2008): 106–8. https://doi.org/10.1097/RLU.0b013e31815ef7be.
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  - Buckley, Anne F., and Sanjay Kakar. “Comparison of the Dako EGFR pharmDx kit and Zymed EGFR antibody for assessment of EGFR status in colorectal adenocarcinoma.” Appl Immunohistochem Mol Morphol 15, no. 3 (September 2007): 305–9. https://doi.org/10.1097/01.pai.0000213141.47277.bf.
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  - Buckley, Anne F., Lawrence J. Burgart, and Sanjay Kakar. “Epidermal growth factor receptor expression and gene copy number in fibrolamellar hepatocellular carcinoma.” Hum Pathol 37, no. 4 (April 2006): 410–14. https://doi.org/10.1016/j.humpath.2005.12.009.
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  - Buckley, A. F., C. T. Kuo, and J. M. Leiden. “Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway.” Nat Immunol 2, no. 8 (August 2001): 698–704. https://doi.org/10.1038/90633.
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- Book Sections
  - Buckley, A. F., R. E. McLendon, C. J. Wikstrand, and D. D. Bigner. “Biomarker discovery in central nervous system neoplasms: Past, present and future.” In Tumors of the Central Nervous System: Astrocytomas, Hemangioblastomas, and Gangliogliomas, 5:107–19, 2012. https://doi.org/10.1007/978-94-007-2019-0_13.
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- Other Articles
  - Somarelli, Jason A., Daneen Schaeffer, Mathew S. Marengo, Tristan Bepler, Douglas Rouse, Anne F. Buckley, Jonathan I. Epstein, Andrew J. Armstrong, and Mariano A. Garcia-Blanco. “Abstract SS02-02: A long walk from FGFR2 alternative splicing to cancer progression.” Cancer Epidemiology, Biomarkers &Amp; Prevention. American Association for Cancer Research (AACR), November 1, 2014. https://doi.org/10.1158/1538-7755.disp13-ss02-02.
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- Conference Papers
  - Bailey, Lauren A., Mari Mori, Deeksha Bali, Anne F. Buckley, and Priya S. Kishnani. “Late onset Pompe disease case review: Severe isolated hypertrophic cardiomyopathy.” In Molecular Genetics and Metabolism, 117:S24–S24. Elsevier BV, 2016. https://doi.org/10.1016/j.ymgme.2015.12.189.
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Education, Training, & Certifications

Previous Appointments & Affiliations

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Other Articles

Conference Papers