Anne Frances Buckley | Scholars@Duke

Anne Frances Buckley
Assistant Professor of Pathology

My basic research focus is on neurogenic stem cells and their involvement in brain development and brain tumors. I work in mouse models using inducible in vivo genetic systems, live imaging, and tissue culture, in addition to histological and biochemical methods.
My clinical research interests include neuromuscular diseases. I collaborate with colleagues at Duke on basic and translational research in this area.

Current Appointments & Affiliations

Assistant Professor of Pathology, Pathology, Clinical Science Departments 2021
Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021

Contact Information

Dept of Pathology, Box 3712, Durham, NC 27710
anne.buckley@duke.edu (919) 684-2533

Background
Education, Training, & Certifications
- Neuropathology Fellow, Pathology, Duke University 2008
- Fellow, Neuropathology, Pathology, University of California San Francisco, School of Medicine 2006 - 2007
- Fellow, Surgical Pathology, Pathology, University of California San Francisco, School of Medicine 2005 - 2006
- Resident, Anatomic Pathology, Pathology, University of California San Francisco, School of Medicine 2003 - 2005
- M.D., The University of Chicago 2003
- Ph.D., The University of Chicago 2001
Previous Appointments & Affiliations
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2012 - 2020
- Medical Instructor in the Department of Pathology, Pathology, Clinical Science Departments 2008 - 2012
- Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2008
Expertise
Subject Headings
Research
Selected Grants
- Promoting Podocyte Protective Natriuretic Peptide Signaling in Proteinuric Kidney Diseases awarded by Department of Defense 2019 - 2022
- Targeting TRPC6 to treat focal segmental glomerulosclerosis (FSGS) awarded by Amgen, Inc. 2016 - 2019
- Supplemental Funding for Phase 1/2 study of Clenbuterol for the Treatment of Pompe Disease awarded by Roivant Sciences, Inc. 2015 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Wu, Zhichao, Sharika Rajan, Hye-Jung Chung, Mark Raffeld, Pavalan Panneer Selvam, Leonille Schweizer, Arie Perry, et al. “Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions.” Acta Neuropathol 144, no. 6 (December 2022): 1175–78. https://doi.org/10.1007/s00401-022-02508-2.
    Full Text Link to Item
  - Enam, Syed Faaiz, Cem Y. Kilic, Jianxi Huang, Brian J. Kang, Reed Chen, Connor S. Tribble, Ekaterina Ilich, et al. “Cytostatic hypothermia and its impact on glioblastoma and survival.” Sci Adv 8, no. 47 (November 25, 2022): eabq4882. https://doi.org/10.1126/sciadv.abq4882.
    Full Text Link to Item
  - Vaios, Eugene J., Kristen A. Batich, Anne F. Buckley, Anastasie Dunn-Pirio, Mallika P. Patel, John P. Kirkpatrick, Ranjit Goudar, and Katherine B. Peters. “Addendum: Resolution of radiation necrosis with bevacizumab following radiation therapy for primary CNS lymphoma.” Oncotarget 13 (October 20, 2022): 1165. https://doi.org/10.18632/oncotarget.28292.
    Full Text Link to Item
  - Lai, Dulcie, Meethila Gade, Edward Yang, Hyun Yong Koh, Jinfeng Lu, Nicole M. Walley, Anne F. Buckley, et al. “Somatic variants in diverse genes leads to a spectrum of focal cortical malformations.” Brain 145, no. 8 (August 27, 2022): 2704–20. https://doi.org/10.1093/brain/awac117.
    Full Text Link to Item
  - Kumar, Reeti, Vahakn Keskinyan, Megan Chryst Stangl, Brandon M. Lane, Anne F. Buckley, Laura Barisoni, David N. Howell, and Rasheed A. Gbadegesin. “Case Report: Unusual Aggregation of Different Glomerulopathies in a Family Resolved by Genetic Testing and Reverse Phenotyping.” Front Pediatr 10 (2022): 826330. https://doi.org/10.3389/fped.2022.826330.
    Full Text Link to Item
  - Shalita, Chidyaonga, Eric W. Sankey, Stephen M. Bergin, John McManigle, Anne F. Buckley, Rodney Radtke, Claudia Torres, Guy L. Dear, and Eric M. Thompson. “Successful Neonatal, Intraoperative Neuromonitoring in the Surgical Correction of a Thoracic Dermal Sinus Tract: Technical Note.” Pediatr Neurosurg 57, no. 4 (2022): 295–300. https://doi.org/10.1159/000524924.
    Full Text Link to Item
  - Vaios, Eugene J., Kristen A. Batich, Anne F. Buckley, Anastasie Dunn-Pirio, Mallika P. Patel, John P. Kirkpatrick, Ranjit Goudar, and Katherine B. Peters. “Resolution of radiation necrosis with bevacizumab following radiation therapy for primary CNS lymphoma.” Oncotarget 13 (2022): 576–82. https://doi.org/10.18632/oncotarget.28222.
    Full Text Link to Item
  - Maheswaranathan, Mithu, Anne F. Buckley, Andrew B. Cutler, Lisa Criscione-Schreiber, and Ankoor Shah. “Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Syndrome, a Central Nervous System Vasculitis Mimic.” Arthritis Rheumatol 73, no. 12 (December 2021): 2239. https://doi.org/10.1002/art.41922.
    Full Text Link to Item
  - Wang, Liming, Yuping Tang, Anne F. Buckley, and Robert F. Spurney. “Blockade of the natriuretic peptide clearance receptor attenuates proteinuria in a mouse model of focal segmental glomerulosclerosis.” Physiol Rep 9, no. 21 (November 2021): e15095. https://doi.org/10.14814/phy2.15095.
    Full Text Link to Item
  - Jug, Rachel, Adam L. Booth, Anne F. Buckley, Jordan Newell, Joshua Kesterson, Jerad M. Gardner, Lerna Ozcan, et al. “Multisite Quality Improvement Study of a Patient-Pathologist Consultation Program.” Am J Clin Pathol 155, no. 6 (May 18, 2021): 887–94. https://doi.org/10.1093/ajcp/aqaa202.
    Full Text Link to Item
  - Pittman, Patricia D., William T. Harrison, and Anne F. Buckley. “Adult atypical teratoid/rhabdoid tumor (AT/RT): A case of mistaken identity.” Clin Neuropathol 40, no. 1 (2021): 62–63. https://doi.org/10.5414/NP301306.
    Full Text Link to Item
  - Ahn, Janice S., Maureen Petersen, Allan H. Friedman, Edward M. López, Thomas J. Cummings, Anne F. Buckley, and Giselle Y. López. “Eosinophilic globules in a classic ependymoma: evidence of a possible secretory role.” Ultrastruct Pathol 44, no. 4–6 (November 20, 2020): 511–18. https://doi.org/10.1080/01913123.2020.1843578.
    Full Text Link to Item
  - Lin, Yi-Yu, Ian Belle, Maria Blasi, Min-Nung Huang, Anne F. Buckley, Wes Rountree, Mary E. Klotman, Andrea Cara, and Donatella Negri. “Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity.” Mol Ther Methods Clin Dev 17 (June 12, 2020): 532–44. https://doi.org/10.1016/j.omtm.2020.03.008.
    Full Text Link to Item
  - Taylor, Gregory A., Hsin-I Huang, Brian E. Fee, Nourhan Youssef, Mark L. Jewell, Viviana Cantillana, Alexi A. Schoenborn, et al. “Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.” Plos Pathog 16, no. 5 (May 2020): e1008553. https://doi.org/10.1371/journal.ppat.1008553.
    Full Text Link to Item
  - “Corrigendum to "Wang L, Chang J-H, Buckley AF, Spurney RF. Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice." Kidney Int. 2019;95:321-332.” Kidney International 97, no. 4 (April 2020): 808–9. https://doi.org/10.1016/j.kint.2020.01.004.
    Full Text
  - Harrison, William T., Thomas Bouldin, Anne Buckley, Januario Estrada, Roger McLendon, and Kimberly Janssen. “Sudden Unexpected Death in a Child From an Anaplastic Ependymoma.” Am J Forensic Med Pathol 40, no. 3 (September 2019): 275–78. https://doi.org/10.1097/PAF.0000000000000480.
    Full Text Link to Item
  - Eisenberg, Adva, Jennifer Mersereau, Anne F. Buckley, and Lauren Gratian. “MULTIPLE PITUITARY ADENOMAS WITH FUNCTIONAL FOLLICLE-STIMULATING HORMONE SECRETION LEADING TO OVARIAN HYPERSTIMULATION SYNDROME.” Aace Clinical Case Reports 5, no. 2 (March 2019): e159–63. https://doi.org/10.4158/accr-2018-0474.
    Full Text
  - Wang, Liming, Jae-Hyung Chang, Anne F. Buckley, and Robert F. Spurney. “Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.” Kidney Int 95, no. 2 (February 2019): 321–32. https://doi.org/10.1016/j.kint.2018.09.026.
    Full Text Link to Item
  - Kang, Jennifer H., Anne F. Buckley, Seema Nagpal, Nancy Fischbein, and Katherine B. Peters. “A Diffuse Leptomeningeal Glioneuronal Tumor Without Diffuse Leptomeningeal Involvement: Detailed Molecular and Clinical Characterization.” J Neuropathol Exp Neurol 77, no. 9 (September 1, 2018): 751–56. https://doi.org/10.1093/jnen/nly053.
    Full Text Link to Item
  - Wang, Liming, Anne F. Buckley, and Robert F. Spurney. “Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).” Sci Rep 8, no. 1 (August 16, 2018): 12286. https://doi.org/10.1038/s41598-018-30115-3.
    Full Text Link to Item
  - Tan, Queenie K-G, Allyn McConkie-Rosell, Jane Juusola, Kathryn E. Gustafson, Carolyn E. Pizoli, Anne F. Buckley, and Yong-Hui Jiang. “The importance of managing the patient and not the gene: expanded phenotype of GLE1-associated arthrogryposis.” Cold Spring Harb Mol Case Stud 3, no. 6 (November 2017). https://doi.org/10.1101/mcs.a002063.
    Full Text Link to Item
  - Torok, Rachel D., Stephanie L. Austin, Chanika Phornphutkul, Kathleen M. Rotondo, Deeksha Bali, Gregory H. Tatum, Stephanie B. Wechsler, Anne F. Buckley, and Priya S. Kishnani. “PRKAG2 mutations presenting in infancy.” J Inherit Metab Dis 40, no. 6 (November 2017): 823–30. https://doi.org/10.1007/s10545-017-0072-0.
    Full Text Link to Item
  - Wang, Liming, Yonggang Sha, Jingyi Bai, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.” Am J Physiol Renal Physiol 313, no. 2 (August 1, 2017): F430–39. https://doi.org/10.1152/ajprenal.00614.2016.
    Full Text Link to Item
  - Buckley, Anne F. “Mitochondrial disorders: The need for precision ultrastructural analysis in clinical diagnosis.” Ultrastruct Pathol 41, no. 1 (January 2017): 76. https://doi.org/10.1080/01913123.2016.1269482.
    Full Text Link to Item
  - Mori, Mari, Lauren A. Bailey, Januario Estrada, Catherine W. Rehder, Jennifer S. Li, Joseph G. Rogers, Deeksha S. Bali, Anne F. Buckley, and Priya S. Kishnani. “Severe Cardiomyopathy as the Isolated Presenting Feature in an Adult with Late-Onset Pompe Disease: A Case Report.” Jimd Rep 31 (2017): 79–83. https://doi.org/10.1007/8904_2016_563.
    Full Text Link to Item
  - Badea, Alexandra, Lauren Kane, Robert J. Anderson, Yi Qi, Mark Foster, Gary P. Cofer, Neil Medvitz, et al. “The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease.” Neuroimage 142 (November 15, 2016): 498–511. https://doi.org/10.1016/j.neuroimage.2016.08.014.
    Full Text Link to Item
  - Rudemiller, Nathan P., Mehul B. Patel, Jian-Dong Zhang, Alexander D. Jeffs, Norah S. Karlovich, Robert Griffiths, Matthew J. Kan, Anne F. Buckley, Michael D. Gunn, and Steven D. Crowley. “C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration.” Am J Pathol 186, no. 11 (November 2016): 2846–56. https://doi.org/10.1016/j.ajpath.2016.07.015.
    Full Text Open Access Copy Link to Item
  - Somarelli, J. A., D. Schaeffer, M. S. Marengo, T. Bepler, D. Rouse, K. E. Ware, A. J. Hish, et al. “Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.” Oncogene 35, no. 33 (August 18, 2016): 4302–11. https://doi.org/10.1038/onc.2015.497.
    Full Text Open Access Copy Link to Item
  - McKinnon, Elizabeth L., Andrew J. Rand, M Angelica Selim, Herbert E. Fuchs, Anne F. Buckley, and Thomas J. Cummings. “Rhabdomyomatous mesenchymal hamartoma presenting as a sacral skin tag in two neonates with spinal dysraphism.” J Cutan Pathol 42, no. 10 (October 2015): 774–78. https://doi.org/10.1111/cup.12538.
    Full Text Link to Item
  - Wang, Liming, Grant Jirka, Paul B. Rosenberg, Anne F. Buckley, Jose A. Gomez, Timothy A. Fields, Michelle P. Winn, and Robert F. Spurney. “Gq signaling causes glomerular injury by activating TRPC6.” J Clin Invest 125, no. 5 (May 2015): 1913–26. https://doi.org/10.1172/JCI76767.
    Full Text Link to Item
  - Weitzel, Douglas H., Artak Tovmasyan, Kathleen A. Ashcraft, Zrinka Rajic, Tin Weitner, Chunlei Liu, Wei Li, et al. “Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.” Mol Cancer Ther 14, no. 1 (January 2015): 70–79. https://doi.org/10.1158/1535-7163.MCT-14-0343.
    Full Text Link to Item
  - Zhang, Jian-dong, Mehul B. Patel, Robert Griffiths, Paul C. Dolber, Phillip Ruiz, Matthew A. Sparks, Johannes Stegbauer, et al. “Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis.” J Clin Invest 124, no. 5 (May 2014): 2198–2203. https://doi.org/10.1172/JCI61368.
    Full Text Link to Item
  - Koeberl, Dwight D., Stephanie Austin, Laura E. Case, Edward C. Smith, Anne F. Buckley, Sarah P. Young, Deeksha Bali, and Priya S. Kishnani. “Adjunctive albuterol enhances the response to enzyme replacement therapy in late-onset Pompe disease.” Faseb J 28, no. 5 (May 2014): 2171–76. https://doi.org/10.1096/fj.13-241893.
    Full Text Open Access Copy Link to Item
  - Wang, Liming, Yuping Tang, William Eisner, Matthew A. Sparks, Anne F. Buckley, and Robert F. Spurney. “Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.” Biochem Biophys Res Commun 444, no. 4 (February 21, 2014): 622–27. https://doi.org/10.1016/j.bbrc.2014.01.115.
    Full Text Link to Item
  - Buckley, Anne F., and Edward H. Bossen. “Skeletal muscle microvasculature in the diagnosis of neuromuscular disease.” J Neuropathol Exp Neurol 72, no. 10 (October 2013): 906–18. https://doi.org/10.1097/NEN.0b013e3182a7f0b8.
    Full Text Link to Item
  - Prater, Sean N., Trusha T. Patel, Anne F. Buckley, Hanna Mandel, Eugene Vlodavski, Suhrad G. Banugaria, Erin J. Feeney, Nina Raben, and Priya S. Kishnani. “Skeletal muscle pathology of infantile Pompe disease during long-term enzyme replacement therapy.” Orphanet J Rare Dis 8 (June 20, 2013): 90. https://doi.org/10.1186/1750-1172-8-90.
    Full Text Open Access Copy Link to Item
  - Pei, Yanxin, Colin E. Moore, Jun Wang, Alok K. Tewari, Alexey Eroshkin, Yoon-Jae Cho, Hendrik Witt, et al. “An animal model of MYC-driven medulloblastoma.” Cancer Cell 21, no. 2 (February 14, 2012): 155–67. https://doi.org/10.1016/j.ccr.2011.12.021.
    Full Text Link to Item
  - Zalutsky, Michael R., Abraham Boskovitz, Chien-Tsun Kuan, Charles N. Pegram, Joanne Ayriss, Carol J. Wikstrand, Anne F. Buckley, et al. “Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors.” Nucl Med Biol 39, no. 1 (January 2012): 23–34. https://doi.org/10.1016/j.nucmedbio.2011.06.005.
    Full Text Link to Item
  - Ipolyi, Amy R. de, Isaac Yang, Anne Buckley, Nicholas M. Barbaro, Steven W. Cheung, and Andrew T. Parsa. “Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case report.” Neurosurgery 62, no. 5 (May 2008): E1164–65. https://doi.org/10.1227/01.neu.0000325880.13494.f2.
    Full Text Link to Item
  - Buckley, Anne F., Lawrence J. Burgart, Vaibhav Sahai, and Sanjay Kakar. “Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinoma.” Am J Clin Pathol 129, no. 2 (February 2008): 245–51. https://doi.org/10.1309/WF10QAAED3PP93BH.
    Full Text Link to Item
  - Lee, Theodore J., Christine M. Glastonbury, Anne F. Buckley, David W. Eisele, and Randall A. Hawkins. “Perineural spread of melanoma demonstrated by F-18 FDG PET With MRI and pathologic correlation.” Clin Nucl Med 33, no. 2 (February 2008): 106–8. https://doi.org/10.1097/RLU.0b013e31815ef7be.
    Full Text Link to Item
  - Buckley, Anne F., and Sanjay Kakar. “Comparison of the Dako EGFR pharmDx kit and Zymed EGFR antibody for assessment of EGFR status in colorectal adenocarcinoma.” Appl Immunohistochem Mol Morphol 15, no. 3 (September 2007): 305–9. https://doi.org/10.1097/01.pai.0000213141.47277.bf.
    Full Text Link to Item
  - Buckley, Anne F., Lawrence J. Burgart, and Sanjay Kakar. “Epidermal growth factor receptor expression and gene copy number in fibrolamellar hepatocellular carcinoma.” Hum Pathol 37, no. 4 (April 2006): 410–14. https://doi.org/10.1016/j.humpath.2005.12.009.
    Full Text Link to Item
  - Buckley, A. F., C. T. Kuo, and J. M. Leiden. “Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway.” Nat Immunol 2, no. 8 (August 2001): 698–704. https://doi.org/10.1038/90633.
    Full Text Link to Item
- Book Sections
  - Buckley, A. F., R. E. McLendon, C. J. Wikstrand, and D. D. Bigner. “Biomarker discovery in central nervous system neoplasms: Past, present and future.” In Tumors of the Central Nervous System: Astrocytomas, Hemangioblastomas, and Gangliogliomas, 5:107–19, 2012. https://doi.org/10.1007/978-94-007-2019-0_13.
    Full Text
- Other Articles
  - Somarelli, Jason A., Daneen Schaeffer, Mathew S. Marengo, Tristan Bepler, Douglas Rouse, Anne F. Buckley, Jonathan I. Epstein, Andrew J. Armstrong, and Mariano A. Garcia-Blanco. “Abstract SS02-02: A long walk from FGFR2 alternative splicing to cancer progression.” Cancer Epidemiology, Biomarkers &Amp; Prevention. American Association for Cancer Research (AACR), November 1, 2014. https://doi.org/10.1158/1538-7755.disp13-ss02-02.
    Full Text
- Conference Papers
  - Austin, Stephanie L., Rachel D. Torok, Chanika Phornphutkul, Kathleen Rotondo, Anne F. Buckley, Gregory H. Tatum, Stephanie B. Wechsler, and Priya S. Kishnani. “PRKAG2 as a mimicker of Pompe disease.” In Molecular Genetics and Metabolism, 120:S23–S23. Elsevier BV, 2017. https://doi.org/10.1016/j.ymgme.2016.11.029.
    Full Text
  - Ha, Christine I., Ankit K. Desai, Justin Waterfield, Zoheb B. Kazi, Stephanie L. Austin, Edward H. Bossen, Priya S. Kishnani, and Anne F. Buckley. “Outside the fiber: interstitial pathology of skeletal muscle in infantile Pompe disease.” In Molecular Genetics and Metabolism, 120:S60–61. Elsevier BV, 2017. https://doi.org/10.1016/j.ymgme.2016.11.136.
    Full Text
  - Bailey, Lauren A., Mari Mori, Deeksha Bali, Anne F. Buckley, and Priya S. Kishnani. “Late onset Pompe disease case review: Severe isolated hypertrophic cardiomyopathy.” In Molecular Genetics and Metabolism, 117:S24–S24. Elsevier BV, 2016. https://doi.org/10.1016/j.ymgme.2015.12.189.
    Full Text

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Other Articles

Conference Papers