Scholars@Duke
Anne Cherry

Anne Cherry

Associate Professor of Anesthesiology
Anesthesiology
anne.cherry@duke.edu
DUMC Box 3094, Durham, NC 27710
DUMC Box 3094, Durham, NC 27710

Selected Publications

Right Ventricle-Pulmonary Artery Coupling in Patients Undergoing Cardiac Interventions.

Journal Article Curr Cardiol Rep · June 2024 PURPOSE OF REVIEW: This review aims to summarize the fundamentals of RV-PA coupling, its non-invasive means of measurement, and contemporary understanding of RV-PA coupling in cardiac surgery, cardiac interventions, and congenital heart disease. RECENT FIN ... Full text Link to item Cite

Abstract 14318: Right Ventriculo- Arterial Coupling Assessment by High-Fidelity Hemodynamic Measurements in Patients Undergoing Left Ventricular Assist Device Implantation

Conference Circulation · November 7, 2023 Background: The changes in RV function after LVAD placement are not fully understood. RV- PA coupling, defined as the ratio of RV end-systolic to arterial elastances (E ES Full text Cite

The Role of Recipient Thyroid Hormone Supplementation in Primary Graft Dysfunction After Heart Transplantation: A Propensity-Adjusted Analysis.

Journal Article J Cardiothorac Vasc Anesth · November 2023 OBJECTIVES: To investigate whether recipient administration of thyroid hormone (liothyronine [T3]) is associated with reduced rates of primary graft dysfunction (PGD) after orthotopic heart transplantation. DESIGN: Retrospective cohort study. SETTING: Sing ... Full text Link to item Cite

Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery.

Journal Article Circulation · October 24, 2023 BACKGROUND: Right ventricular failure (RVF) is a leading driver of morbidity and death after major cardiac surgery for advanced heart failure, including orthotopic heart transplantation and left ventricular assist device implantation. Inhaled pulmonary-sel ... Full text Open Access Link to item Cite

Mitochondrial transplantation in cardiac surgical patients: optimism, caveats, and outstanding questions.

Journal Article Curr Opin Anaesthesiol · February 1, 2023 PURPOSE OF REVIEW: Mitochondria satisfy the high metabolic demand of the heart, and also play major roles in reactive oxygen species signaling, calcium buffering, and regulation of cell death. Mitochondrial damage or dysfunction can drive diseases seen in ... Full text Link to item Cite

Identification of Trajectory-Based Acute Kidney Injury Phenotypes Among Cardiac Surgery Patients.

Journal Article Ann Thorac Surg · December 2022 BACKGROUND: Acute kidney injury (AKI) is a common and serious complication of cardiac surgical procedures for which unrecognized heterogeneity may underpin poor success in identifying effective therapies. We aimed to identify phenotypically similar groups ... Full text Link to item Cite

Predictive capabilities of the European registry for patients with mechanical circulatory support right-sided heart failure risk score after left ventricular assist device implantation.

Journal Article J Cardiothorac Vasc Anesth · October 2022 OBJECTIVES: The prediction of right heart failure (RHF) after left ventricular assist device (LVAD) implantation remains a challenge. Recently, risk scores were derived from analysis of the European Registry for Patients with Mechanical Circulatory Support ... Full text Link to item Cite

Editorial: cardiovascular anaesthesiology.

Journal Article Curr Opin Anaesthesiol · February 1, 2022 Full text Link to item Cite

Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant: A Randomized Clinical Trial.

Journal Article JAMA Surg · January 1, 2022 IMPORTANCE: Inhaled nitric oxide (iNO) is commonly administered for selectively inhaled pulmonary vasodilation and prevention of oxidative injury after lung transplant (LT). Inhaled epoprostenol (iEPO) has been introduced worldwide as a cost-saving alterna ... Full text Open Access Link to item Cite

Patient- and Ventilator-Specific Modeling to Drive the Use and Development of 3D Printed Devices for Rapid Ventilator Splitting During the COVID-19 Pandemic

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2022 In the early days of the COVID-19 pandemic, there was a pressing need for an expansion of the ventilator capacity in response to the COVID19 pandemic. Reserved for dire situations, ventilator splitting is complex, and has previously been limited to patient ... Full text Cite

Renal-Resistive Index for Prediction of Acute Kidney Injury in the Setting of Aortic Insufficiency.

Journal Article J Cardiothorac Vasc Anesth · December 2021 Acute kidney injury (AKI) is a common postoperative complication after cardiac surgery with cardiopulmonary bypass (CPB), and leads to significant morbidity, mortality, and cost. Although early recognition and management of AKI may reduce the burden of ren ... Full text Link to item Cite

Preservation of Renal Function

Chapter · January 1, 2021 Acute kidney injury (AKI) remains a frequent and serious complication of surgical procedures and critical illness that is consistently associated with worse outcomes and increased long-term morbidity and mortality. Much work has gone into finding kidney pr ... Full text Cite

Sirtuin-1 expression and activity is diminished in aged liver grafts.

Journal Article Sci Rep · July 17, 2020 The cellular mechanisms underlying impaired function of aged liver grafts have not been fully elucidated, but mitochondrial dysfunction appears to be contributory. Sirtuin1 has been identified as a key mediator of mitochondrial recovery following ischemia- ... Full text Link to item Cite

Intraoperative renal resistive index threshold as an acute kidney injury biomarker.

Journal Article J Clin Anesth · May 2020 STUDY OBJECTIVE: The lag in creatinine-mediated diagnosis of cardiac surgery-associated acute kidney injury (AKI) may be impeding the development of renoprotection therapies. Postoperative renal resistive index (RRI) measured by transabdominal Doppler ultr ... Full text Link to item Cite

3D TEE-Applications for Daily Practice (canceled)

Conference · April 21, 2020 Discussion of applications for 3D TEE in the Operating Room. ... Open Access Cite

Mitral Regurgitation: A Team-Based Approach to Decision-Making PBLD (Canceled)

Conference · April 21, 2020 A worksheet created for a PBLD workshop that was to be a part of the Society of Cardiovascular Anesthesiologists Annual Meeting, for a discussion of important elements of diagnosis, imging, and management of functional mitral regurgitation in the operating ... Open Access Cite

EUROMACS-RHF Risk Score and 3D Echocardiography as Predictors of Right Heart Failure after Left Ventricular Assist Device Implantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Right heart failure (RHF) after LVAD implantation is associated with significant morbidity and mortality. Recently, the EUROMACS-RHF risk score was developed to predict postoperative RHF in this setting. In a single-center analysis, we assessed th ... Full text Cite

Renal Failure and Dialysis

Chapter · January 1, 2020 Acute kidney injury (AKI) is a common and serious complication of cardiac surgery. The spectrum of cardiac surgery-associated AKI (CS-AKI) ranges from transient loss of renal reserve, through AKI, to long-term irreversible renal failure requiring renal rep ... Full text Cite

Mitochondrial Dysfunction in Cardiac Surgery.

Journal Article Anesthesiol Clin · December 2019 Mitochondria are key to the cellular response to energetic demand, but are also vital to reactive oxygen species signaling, calcium hemostasis, and regulation of cell death. Cardiac surgical patients with diabetes, heart failure, advanced age, or cardiomyo ... Full text Link to item Cite

Intraoperative Renal Resistive Index as an Acute Kidney Injury Biomarker: Development and Validation of an Automated Analysis Algorithm.

Journal Article J Cardiothorac Vasc Anesth · October 2018 OBJECTIVE: Intraoperative Doppler-determined renal resistive index (RRI) is a promising early acute kidney injury (AKI) biomarker. As RRI continues to be studied, its clinical usefulness and robustness in research settings will be linked to the ease, effic ... Full text Link to item Cite

The Association of Aortic Valve Pathology With Renal Resistive Index as a Kidney Injury Biomarker.

Journal Article Ann Thorac Surg · July 2018 BACKGROUND: Acute kidney injury (AKI) is a common serious complication after cardiac surgery. Doppler-determined renal resistive index (RRI) is a promising early AKI biomarker in this population. However, the relationship between aortic valve pathology (in ... Full text Link to item Cite

Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.

Journal Article Anesth Analg · October 2017 BACKGROUND: Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting (CABG) surgery are associated w ... Full text Open Access Link to item Cite

Hypercapnia in diving: a review of CO₂ retention in submersed exercise at depth.

Journal Article Undersea Hyperb Med · 2017 Carbon dioxide (CO₂) retention, or hypercapnia, is a known risk of diving that can cause mental and physical impairments leading to life-threatening accidents. Often, such accidents occur due to elevated inspired carbon dioxide. For instance, in cases of C ... Full text Open Access Link to item Cite

Swimming-Induced Pulmonary Edema: Pathophysiology and Risk Reduction With Sildenafil.

Journal Article Circulation · March 8, 2016 BACKGROUND: Swimming-induced pulmonary edema (SIPE) occurs during swimming or scuba diving, often in young individuals with no predisposing conditions, and its pathophysiology is poorly understood. This study tested the hypothesis that pulmonary artery and ... Full text Open Access Link to item Cite

Heme Oxygenase-1 Is Cardioprotective Against Hyperoxia

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle.

Journal Article Am J Physiol Lung Cell Mol Physiol · October 15, 2015 The heme oxygenase-1 (HO-1)/carbon monoxide (CO) system induces mitochondrial biogenesis, but its biological impact in human skeletal muscle is uncertain. The enzyme system generates CO, which stimulates mitochondrial proliferation in normal muscle. Here w ... Full text Link to item Cite

Regulation of mitochondrial biogenesis and its intersection with inflammatory responses.

Journal Article Antioxid Redox Signal · April 20, 2015 SIGNIFICANCE: Mitochondria play a vital role in cellular homeostasis and are susceptible to damage from inflammatory mediators released by the host defense. Cellular recovery depends, in part, on mitochondrial quality control programs, including mitochondr ... Full text Link to item Cite

Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis.

Journal Article J Biol Chem · January 3, 2014 A key transcriptional regulator of cell metabolism, the peroxisome proliferator-activated receptor γ co-activator 1-α (PPARGC-1-α or PGC-1α), also regulates mitochondrial biogenesis, but its role in antioxidant gene regulation is not well understood. Here, ... Full text Link to item Cite

The future of cardiothoracic anesthesia.

Journal Article Anesthesiol Clin · June 2013 The future of cardiothoracic anesthesia, simply stated, depends on establishing and maintaining a unique and differentiated quality and identity that promotes and contributes positive value to patients, surgical colleagues, and health system administrators ... Full text Link to item Cite

PGC-1α and the Mitochondrial Antioxidant Response during Sepsis

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans.

Journal Article Am J Physiol Heart Circ Physiol · July 2009 Given that the physiology of heme oxygenase-1 (HO-1) encompasses mitochondrial biogenesis, we tested the hypothesis that the HO-1 product, carbon monoxide (CO), activates mitochondrial biogenesis in skeletal muscle and enhances maximal oxygen uptake (Vo(2m ... Full text Link to item Cite

Pulmonary gas exchange in diving.

Journal Article J Appl Physiol (1985) · February 2009 Diving-related pulmonary effects are due mostly to increased gas density, immersion-related increase in pulmonary blood volume, and (usually) a higher inspired Po(2). Higher gas density produces an increase in airways resistance and work of breathing, and ... Full text Link to item Cite

Effects of head and body cooling on hemodynamics during immersed prone exercise at 1 ATA.

Journal Article J Appl Physiol (1985) · February 2009 Immersion pulmonary edema (IPE) is a condition with sudden onset in divers and swimmers suspected to be due to pulmonary arterial or venous hypertension induced by exercise in cold water, although it does occur even with adequate thermal protection. We tes ... Full text Link to item Cite

Predictors of increased PaCO2 during immersed prone exercise at 4.7 ATA.

Journal Article J Appl Physiol (1985) · January 2009 During diving, arterial Pco(2) (Pa(CO(2))) levels can increase and contribute to psychomotor impairment and unconsciousness. This study was designed to investigate the effects of the hypercapnic ventilatory response (HCVR), exercise, inspired Po(2), and ex ... Full text Link to item Cite