Current Appointments & Affiliations
Professor of Neurosurgery
·
2021 - Present
Neurosurgery, Neuro-Oncology,
Neurosurgery
Professor in Neurology
·
2021 - Present
Neurology, General & Community Neurology,
Neurology
Member of the Duke Cancer Institute
·
2003 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Clinical trial of feasibility for mindfulness intervention for patients with newly diagnosed high grade glioma.
Journal Article J Neurooncol · November 5, 2025 PURPOSE: With a bleak prognosis for malignant glioma, maintaining quality of life (QoL) and decreasing distress are essential in patient clinical care. Mindfulness meditation is a mind-body therapy that is being investigated as a non-pharmacological strate ... Full text Link to item CiteA surgical window of opportunity trial evaluating the effect of the PCSK9 inhibitor evolocumab on tumoral MHC-I expression and CD8+ infiltration in glioma.
Journal Article Sci Rep · October 23, 2025 Many cancers evade immunosurveillance by downregulating surface major histocompatibility class (MHC)-I. Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes MHC-I degradation and is elevated in glioma. Evolocumab is a clinically approved PCSK9 in ... Full text Link to item CiteResponse Assessment in Neuro-Oncology (RANO) 2009-2025: Broad scope and implementation-A progress report.
Journal Article Neuro Oncol · October 14, 2025 Since its first activities in 2008 and 2009, the Response Assessment in NeuroOncology (RANO) group has given guidance on response assessment, trial design, and trial procedures to improve and standardize the way clinical trials in neurooncological studies ... Full text Link to item CiteRecent Grants
McCain/Bayh Glioblastoma Consortium
Clinical TrialCo Investigator · Awarded by Department of Defense · 2025 - 2029An open-label, Phase 1b study to evaluate the safety and tolerability of eflornithine plus temozolomide in patients with newly diagnosed glioblastoma
Clinical TrialPrincipal Investigator · Awarded by Orbus Therapeutics, Inc. · 2024 - 2028Comparison of convection enhanced delivery systems in a clinical study of recurrent Grade 3-4 glioma patients
ResearchPrincipal Investigator · Awarded by CreoSalus · 2025 - 2027View All Grants
Education, Training & Certifications
University of Sherbrooke (Canada) ·
1998
M.D.