Overview
Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center. Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and complement-mediated diseases. Dr. Arepally’s long-standing research program investigates the immune pathogenesis of heparin induced thrombocytopenia (HIT). Current laboratory efforts focus on the role of complement activation in antibody production and thrombosis in HIT, studies of complement inhibitors for immune-complex mediated diseases and diagnostic biomarkers of platelet activation.
Current Appointments & Affiliations
Professor of Medicine
·
2018 - Present
Medicine, Hematology,
Medicine
Associate Professor of Pathology
·
2009 - Present
Pathology,
Clinical Science Departments
Professor of Pathology
·
2018 - Present
Pathology,
Clinical Science Departments
Recent Publications
Escherichia coli Type III Secretion System 2 (ETT2) is Associated with Patient Mortality in Bloodstream Infections.
Journal Article J Infect Dis · May 22, 2025 BACKGROUND: Escherichia coli has an extensive accessory genome, though its role in impacting patient mortality is unknown. METHODS: We performed whole genome sequencing with E. coli bloodstream infection isolates from inpatients at Duke University. Pan-gen ... Full text Link to item CiteStructural and functional changes underlying activation of monocytes in heparin-induced thrombocytopenia.
Journal Article J Thromb Haemost · May 2025 BACKGROUND: Heparin-induced thrombocytopenia (HIT) is an antibody-mediated disorder associated with thrombosis developing in response to anticoagulation with heparin. Monocytes targeted by HIT antibodies contribute to the prothrombotic state, but structura ... Full text Link to item CiteComplement activation as a biomarker for platelet-activating antibodies in heparin-induced thrombocytopenia.
Journal Article J Thromb Haemost · March 2025 BACKGROUND: Immunoglobulin G antibodies (Abs) to platelet factor 4 (PF4) complexed to heparin (PF4/H) commonly occur after H exposure but cause life-threatening complications of H-induced thrombocytopenia (HIT) in only a few patients. Presently, only plate ... Full text Link to item CiteRecent Grants
The role of cerebrospinal fluid complement activation in delirium and post-intensive care unit long-term cognitive impairment
ResearchAdvisor · Awarded by National Institutes of Health · 2024 - 2029Mid-Atlantic praGmatic NETwork for Inclusive Clinical trials in emergency care (MAGNETIC)
ResearchCollaborator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2028Stimulating Access to Research in Residency (StARR) - NHLBI
Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2018 - 2028View All Grants
Education, Training & Certifications
Vanderbilt University ·
1989
M.D.