Overview
Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center. Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and complement-mediated diseases. Dr. Arepally’s long-standing research program investigates the immune pathogenesis of heparin induced thrombocytopenia (HIT). Current laboratory efforts focus on the role of complement activation in antibody production and thrombosis in HIT, studies of complement inhibitors for immune-complex mediated diseases and diagnostic biomarkers of platelet activation.
Current Appointments & Affiliations
Professor of Medicine
·
2018 - Present
Medicine, Hematology,
Medicine
Associate Professor of Pathology
·
2009 - Present
Pathology,
Clinical Science Departments
Professor of Pathology
·
2018 - Present
Pathology,
Clinical Science Departments
Recent Publications
Targeting PIEZO1-TMEM16F Coupling to Mitigate Sickle Cell Disease Complications.
Journal Article Am J Hematol · December 2025 A deeper understanding of sickle cell disease (SCD) pathophysiology is critical for identifying novel therapeutic targets. A hallmark of SCD is abnormal phosphatidylserine (PS) exposure on sickle red blood cells (RBCs), which contributes to anemia, thrombo ... Full text Open Access Link to item CiteEscherichia coli Type III Secretion System 2 Is Associated With Patient Mortality in Bloodstream Infections.
Journal Article J Infect Dis · November 14, 2025 BACKGROUND: Escherichia coli has an extensive accessory genome, though its role in affecting patient mortality is unknown. METHODS: We performed whole genome sequencing with E. coli bacteremia isolates. Pan-genome analysis was used to identify flexible gen ... Full text Link to item CiteStructural and functional changes underlying activation of monocytes in heparin-induced thrombocytopenia.
Journal Article J Thromb Haemost · May 2025 BACKGROUND: Heparin-induced thrombocytopenia (HIT) is an antibody-mediated disorder associated with thrombosis developing in response to anticoagulation with heparin. Monocytes targeted by HIT antibodies contribute to the prothrombotic state, but structura ... Full text Link to item CiteRecent Grants
2/3 CTSA K12 Program at Duke University
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030The role of cerebrospinal fluid complement activation in delirium and post-intensive care unit long-term cognitive impairment
ResearchAdvisor · Awarded by National Institute on Aging · 2024 - 2029Mid-Atlantic praGmatic NETwork for Inclusive Clinical trials in emergency care (MAGNETIC)
ResearchCollaborator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2028View All Grants
Education, Training & Certifications
Vanderbilt University ·
1989
M.D.