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Aristobulo Loaiza

Adjunct Instructor in the Engineering Graduate and Professional Programs
Engineering Graduate and Professional Programs

Current Appointments & Affiliations


Adjunct Instructor in the Engineering Graduate and Professional Programs · 2022 - Present Engineering Graduate and Professional Programs, Pratt School of Engineering

Recent Publications


Folding dynamics of phenylalanine hydroxylase depends on the enzyme's metallation state: the native metal, iron, protects against aggregate intermediates.

Journal Article European biophysics journal : EBJ · August 2011 Phenylalanine hydroxylase (PAH), a non-heme iron enzyme, is responsible for the phenylalanine conversion to tyrosine. Its malfunction causes phenylketonuria (PKU). To better understand how protein structure and folding profiles are affected by the metal co ... Full text Cite

Kinetics of thermal unfolding of phenylalanine hydroxylase variants containing different metal cofactors (FeII, CoII, and ZnII) and their isokinetic relationship.

Journal Article Inorganic chemistry · June 2008 The kinetics of thermal unfolding of apo- and holo-Chromobacterium violaceum phenylalanine hydroxylase (cPAH) was investigated using circular dichroism (CD) over the temperature range 44-76 degrees C. In addition to the native cofactor (FeII), the unfoldin ... Full text Cite
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Education, Training & Certifications


Purdue University · 2008 Ph.D.