Patricia Lynn Ashley | Scholars@Duke

Patricia Lynn Ashley
Associate Professor of Pediatrics

My current clinical time is divided between inpatient and outpatient care of infants who graduate from the ICN or TCN. In addition, I am a provider in our Transitions program for the most medically fragile and complex infants that we care for.
My research interests center on how Nutrition influences growth and development, primarily in infants born extremely premature. Through a combination of clinical research and basic science involving study of the microbiome and metabolome, we are seeking new answers regarding how to optimize growth, development, and eventual long term outcomes for these infants.
I also have taken on administrative and regulatory roles involving research over the last three years when I became a member of the IRB. More recently I have taken on the role of Director for the Children's Clinical Research Unit.

Current Research Interests

My research interests center on how Nutrition influences growth and development, primarily in infants born extremely premature. Through a combination of clinical research and basic science involving study of the microbiome and metabolome, we are seeking new answers regarding how to optimize growth, development, and eventual long term outcomes for these infants.

Current Appointments & Affiliations

Associate Professor of Pediatrics, Pediatrics, Neonatology, Pediatrics 2021

Contact Information

2400 Pratt Street, 8th Floor, Durham, NC 27705
Box 102509, Durham, NC 27710
ashle022@mc.duke.edu (919) 681-3501

Background
Education, Training, & Certifications
- Resident, Pediatrics, University of Texas at Dallas 1991 - 1994
- M.D., University of Texas at Dallas 1991
- Ph.D., University of Texas at Dallas 1984
Previous Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Neonatology, Pediatrics 2018 - 2020
- Assistant Professor of Pediatrics, Pediatrics, Neonatology, Pediatrics 2011 - 2018
- Medical Instructor in the Department of Pediatrics, Pediatrics, Neonatology, Pediatrics 2009 - 2011
- Clinical Associate in the Department of Pediatrics, Pediatrics, Neonatology, Pediatrics 2002 - 2009
Leadership & Clinical Positions at Duke
- Director, Children's Clinical Research Unit
Research
Selected Grants
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lowe, Jean, Janell F. Fuller, Allison G. Dempsey, Barbara Do, Carla M. Bann, Abhik Das, Kathryn E. Gustafson, et al. “Cortisol awakening response and developmental outcomes at 6-7 years in children born extremely preterm.” Pediatr Res 93, no. 3 (February 2023): 689–95. https://doi.org/10.1038/s41390-022-02113-9.
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  - Salas, Ariel A., Waldemar A. Carlo, Barbara T. Do, Edward F. Bell, Abhik Das, Krisa P. Van Meurs, Brenda B. Poindexter, et al. “Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth.” J Pediatr 237 (October 2021): 148-153.e3. https://doi.org/10.1016/j.jpeds.2021.06.026.
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  - Laptook, Abbot R., Seetha Shankaran, Patrick Barnes, Nancy Rollins, Barbara T. Do, Nehal A. Parikh, Shannon Hamrick, et al. “Limitations of Conventional Magnetic Resonance Imaging as a Predictor of Death or Disability Following Neonatal Hypoxic-Ischemic Encephalopathy in the Late Hypothermia Trial.” J Pediatr 230 (March 2021): 106-111.e6. https://doi.org/10.1016/j.jpeds.2020.11.015.
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  - Brumbaugh, Jane E., Edward F. Bell, Scott F. Grey, Sara B. DeMauro, Betty R. Vohr, Heidi M. Harmon, Carla M. Bann, et al. “Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia.” J Pediatr 219 (April 2020): 152-159.e5. https://doi.org/10.1016/j.jpeds.2019.12.028.
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  - Harmon, Heidi M., Erik A. Jensen, Sylvia Tan, Aasma S. Chaudhary, Jonathan L. Slaughter, Edward F. Bell, Myra H. Wyckoff, et al. “Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes.” J Perinatol 40, no. 4 (April 2020): 616–27. https://doi.org/10.1038/s41372-020-0594-4.
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  - McGowan, Elisabeth C., Abbot R. Laptook, Jean Lowe, Myriam Peralta-Carcelen, Dhuly Chowdhury, Rosemary D. Higgins, Susan R. Hintz, et al. “Developmental Outcomes of Extremely Preterm Infants with a Need for Child Protective Services Supervision.” Journal of Pediatrics 215 (December 1, 2019): 41-+. https://doi.org/10.1016/j.jpeds.2019.01.063.
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  - McGowan, Elisabeth C., Abbot R. Laptook, Jean Lowe, Myriam Peralta-Carcelen, Dhuly Chowdhury, Rosemary D. Higgins, Susan R. Hintz, Betty R. Vohr, and Betty R. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. “Developmental Outcomes of Extremely Preterm Infants with a Need for Child Protective Services Supervision.” J Pediatr 215 (December 2019): 41-49.e4. https://doi.org/10.1016/j.jpeds.2019.07.063.
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  - Hansen, Adam W., Mullai Murugan, He Li, Michael M. Khayat, Liwen Wang, Jill Rosenfeld, B Kim Andrews, et al. “A Genocentric Approach to Discovery of Mendelian Disorders.” Am J Hum Genet 105, no. 5 (November 7, 2019): 974–86. https://doi.org/10.1016/j.ajhg.2019.09.027.
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  - Younge, Noelle E., Christopher B. Newgard, C Michael Cotten, Ronald N. Goldberg, Michael J. Muehlbauer, James R. Bain, Robert D. Stevens, et al. “Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure.” Sci Rep 9, no. 1 (June 3, 2019): 8167. https://doi.org/10.1038/s41598-019-44547-y.
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  - Brumbaugh, Jane E., Nellie I. Hansen, Edward F. Bell, Amaanti Sridhar, Waldemar A. Carlo, Susan R. Hintz, Betty R. Vohr, et al. “Outcomes of Extremely Preterm Infants With Birth Weight Less Than 400 g.” Jama Pediatr 173, no. 5 (May 1, 2019): 434–45. https://doi.org/10.1001/jamapediatrics.2019.0180.
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  - Helbig, Katherine L., Robert J. Lauerer, Jacqueline C. Bahr, Ivana A. Souza, Candace T. Myers, Betül Uysal, Niklas Schwarz, et al. “De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias.” Am J Hum Genet 104, no. 3 (March 7, 2019): 562. https://doi.org/10.1016/j.ajhg.2019.02.015.
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  - Meyers, J. M., S. Tan, E. F. Bell, A. F. Duncan, R. Guillet, B. J. Stoll, C. T. D’Angio, and C. T. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. “Neurodevelopmental outcomes among extremely premature infants with linear growth restriction.” J Perinatol 39, no. 2 (February 2019): 193–202. https://doi.org/10.1038/s41372-018-0259-8.
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  - Khan, Tahir N., Kamal Khan, Azita Sadeghpour, Hannah Reynolds, Yezmin Perilla, Marie T. McDonald, William B. Gallentine, et al. “Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies.” Am J Hum Genet 104, no. 1 (January 3, 2019): 94–111. https://doi.org/10.1016/j.ajhg.2018.11.017.
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  - Duncan, Andrea F., Carla M. Bann, Allison Dempsey, Myriam Peralta-Carcelen, Susan Hintz, and Susan Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network. “Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm.” J Pediatr 204 (January 2019): 148-156.e4. https://doi.org/10.1016/j.jpeds.2018.08.059.
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  - Lowe, Jean R., Janell F. Fuller, Barbara T. Do, Betty R. Vohr, Abhik Das, Susan R. Hintz, Kristi L. Watterberg, Rosemary D. Higgins, Rosemary D. Eunice Kennedy Shriver National Institute of Child Health, and Rosemary D. Human Development Neonatal Research Network. “Behavioral problems are associated with cognitive and language scores in toddlers born extremely preterm.” Early Hum Dev 128 (January 2019): 48–54. https://doi.org/10.1016/j.earlhumdev.2018.11.007.
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  - Vohr, Betty R., Roy Heyne, Carla M. Bann, Abhik Das, Rosemary D. Higgins, Susan R. Hintz, and Susan R. Eunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network. “Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort.” J Pediatr 200 (September 2018): 132-139.e3. https://doi.org/10.1016/j.jpeds.2018.04.073.
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  - Hintz, Susan R., Betty R. Vohr, Carla M. Bann, H Gerry Taylor, Abhik Das, Kathryn E. Gustafson, Kimberly Yolton, et al. “Preterm Neuroimaging and School-Age Cognitive Outcomes.” Pediatrics 142, no. 1 (July 2018). https://doi.org/10.1542/peds.2017-4058.
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  - Adams-Chapman, Ira, Roy J. Heyne, Sara B. DeMauro, Andrea F. Duncan, Susan R. Hintz, Athina Pappas, Betty R. Vohr, et al. “Neurodevelopmental Impairment Among Extremely Preterm Infants in the Neonatal Research Network.” Pediatrics 141, no. 5 (May 2018). https://doi.org/10.1542/peds.2017-3091.
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  - Sarkar, Subrata, Seetha Shankaran, John Barks, Barbara T. Do, Abbot R. Laptook, Abhik Das, Namasivayam Ambalavanan, et al. “Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age.” J Pediatr 195 (April 2018): 59-65.e3. https://doi.org/10.1016/j.jpeds.2017.12.010.
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  - Pappas, Athina, Ira Adams-Chapman, Seetha Shankaran, Scott A. McDonald, Barbara J. Stoll, Abbot R. Laptook, Waldemar A. Carlo, et al. “Neurodevelopmental and Behavioral Outcomes in Extremely Premature Neonates With Ventriculomegaly in the Absence of Periventricular-Intraventricular Hemorrhage.” Jama Pediatr 172, no. 1 (January 1, 2018): 32–42. https://doi.org/10.1001/jamapediatrics.2017.3545.
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  - James, Jennifer, David Munson, Sara B. DeMauro, John C. Langer, April R. Dworetz, Girija Natarajan, Margarita Bidegain, et al. “Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support.” J Pediatr 190 (November 2017): 118-123.e4. https://doi.org/10.1016/j.jpeds.2017.05.056.
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  - Younge, Noelle, Ricki F. Goldstein, Carla M. Bann, Susan R. Hintz, Ravi M. Patel, P Brian Smith, Edward F. Bell, et al. “Survival and Neurodevelopmental Outcomes among Periviable Infants.” N Engl J Med 376, no. 7 (February 16, 2017): 617–28. https://doi.org/10.1056/NEJMoa1605566.
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  - Navarrete, Cristina T., Lisa A. Wrage, Waldemar A. Carlo, Michele C. Walsh, Wade Rich, Marie G. Gantz, Abhik Das, et al. “Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth.” J Pediatr 176 (September 2016): 62-68.e4. https://doi.org/10.1016/j.jpeds.2016.05.070.
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  - Younge, Noelle, P Brian Smith, Kathryn E. Gustafson, William Malcolm, Patricia Ashley, C Michael Cotten, Ronald N. Goldberg, and Ricki F. Goldstein. “Improved survival and neurodevelopmental outcomes among extremely premature infants born near the limit of viability.” Early Hum Dev 95 (April 2016): 5–8. https://doi.org/10.1016/j.earlhumdev.2016.01.015.
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  - Seigel, Jonathan K., P Brian Smith, Patricia L. Ashley, C Michael Cotten, Claudia C. Herbert, Beth A. King, Angela R. Maynor, Sara Neill, James Wynn, and Margarita Bidegain. “Early administration of oropharyngeal colostrum to extremely low birth weight infants.” Breastfeed Med 8, no. 6 (December 2013): 491–95. https://doi.org/10.1089/bfm.2013.0025.
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  - Cox, D. R., T. Trouillot, P. L. Ashley, M. Brabant, and P. Coffino. “A functional mouse ornithine decarboxylase gene (Odc) maps to chromosome 12: further evidence of homoeology between mouse chromosome 12 and the short arm of human chromosome 2.” Cytogenet Cell Genet 48, no. 2 (1988): 92–94. https://doi.org/10.1159/000132597.
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  - Ashley, P. L., J. Ellison, K. A. Sullivan, H. R. Bourne, and D. R. Cox. “Chromosomal assignment of the murine Gi alpha and Gs alpha genes. Implications for the obese mouse.” J Biol Chem 262, no. 31 (November 5, 1987): 15299–301.
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  - Lovett, M., D. Goldgaber, P. Ashley, D. R. Cox, D. C. Gajdusek, and C. J. Epstein. “The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16.” Biochem Biophys Res Commun 144, no. 2 (April 29, 1987): 1069–75. https://doi.org/10.1016/s0006-291x(87)80073-6.
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  - Ashley, P. L., and R. J. MacDonald. “Tissue-specific expression of kallikrein-related genes in the rat.” Biochemistry 24, no. 17 (August 13, 1985): 4520–27. https://doi.org/10.1021/bi00338a006.
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  - Ashley, P. L., and R. J. MacDonald. “Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin.” Biochemistry 24, no. 17 (August 13, 1985): 4512–20. https://doi.org/10.1021/bi00338a005.
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  - John, M. E., M. C. John, P. Ashley, R. J. MacDonald, E. R. Simpson, and M. R. Waterman. “Identification and characterization of cDNA clones specific for cholesterol side-chain cleavage cytochrome P-450.” Proc Natl Acad Sci U S A 81, no. 18 (September 1984): 5628–32. https://doi.org/10.1073/pnas.81.18.5628.
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  - Griffin, B. W., and P. L. Ashley. “Evidence for a radical mechanism of halogenation of monochlorodimedone catalyzed by chloroperoxidase.” Arch Biochem Biophys 233, no. 1 (August 15, 1984): 188–96. https://doi.org/10.1016/0003-9861(84)90616-7.
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  - Ashley, P. L., and R. J. MacDonald. “Synthesis of single-stranded hybridization probes from reusable DNA templates bound to solid support.” Anal Biochem 140, no. 1 (July 1984): 95–103. https://doi.org/10.1016/0003-2697(84)90138-6.
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  - John, M. E., M. C. John, P. Ashley, R. J. MacDonald, E. R. Simpson, and M. R. Waterman. “Identification and characterization of cDNA clones specific for cholesterol side-chain cleavage cytochrome P-450.” Proceedings of the National Academy of Sciences of the United States of America 81, no. 18 I (1984): 5628–32.
  - Swift, G. H., J. C. Dagorn, P. L. Ashley, S. W. Cummings, and R. J. MacDonald. “Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid sequence of the encoded preproenzyme.” Proc Natl Acad Sci U S A 79, no. 23 (December 1982): 7263–67. https://doi.org/10.1073/pnas.79.23.7263.
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  - Ashley, P. L., and B. W. Griffin. “Chloroperoxidase-catalyzed halogenation of antipyrine, a drug substrate of liver microsomal cytochrome P-450.” Arch Biochem Biophys 210, no. 1 (August 1981): 167–78. https://doi.org/10.1016/0003-9861(81)90177-6.
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  - Ashley, P. L., and B. W. Griffin. “Involvement of radical species in the oxidation of aminopyrine and 4-aminoantipyrine by cumene hydroperoxide in rat liver microsomes.” Mol Pharmacol 19, no. 1 (January 1981): 146–52.
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  - Ashley, P. L., D. K. Davis, and B. W. Griffin. “Electron acceptor function of O2 in radical N-demethylation reactions catalyzed by hemeproteins.” Biochem Biophys Res Commun 97, no. 2 (November 28, 1980): 660–66. https://doi.org/10.1016/0006-291x(80)90315-0.
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- Book Sections
  - Warren, M. G., K. E. Gustafson, W. F. Malcolm, P. Ashley, D. D. Mago-Shah, and E. B. Heyward. “The care of the premature infant.” In Encyclopedia of Child and Adolescent Health, First Edition, 1:280–94, 2023. https://doi.org/10.1016/B978-0-12-818872-9.00037-6.
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  - “Respiratory Conditions of the Preterm Infant.” In Beyond the NICU: Comprehensive Care of the High-Risk Infant Comprehensive Care of the High-Risk Infant. McGraw Hill Professional, 2014.
  - “Respiratory Conditions of the Preterm Infant.” In Beyond the NICU: Comprehensive Care of the High-Risk Infant Comprehensive Care of the High-Risk Infant. McGraw Hill Professional, 2014.
Teaching & Mentoring
Recent Courses
Advising & Mentoring
- Research projects
  Clinical shadowing
Available to mentor:
- Fellow
- Resident
- Undergraduate

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Education, Training, & Certifications

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

Selected Grants

Selected Publications

Academic Articles

Book Sections

Recent Courses

Advising & Mentoring

Available to mentor: