Scholars@Duke
Astrid Botty

Astrid Botty

Assistant Professor of Surgery
Surgical Oncology

Selected Publications

High risk surveillance MRI may not be necessary in BRCA1/2 mutation carriers over 70 years old.

Journal Article Breast Cancer Res Treat · June 2025 BACKGROUND: The risk of developing breast cancer up to age 80 for women with BRCA1/2 mutations is approximately 69-72%. The risk estimates, however, become labile in the later years of life. Many older BRCA1/2 mutation carriers who have not developed breas ... Full text Link to item Cite

Risk Stratification for Sentinel Lymph Node Positivity in Older Women With Early-Stage Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2 Neu-Negative Invasive Breast Cancer.

Journal Article JCO Clin Cancer Inform · March 2025 PURPOSE: Guidelines recommend omission of sentinel lymph node biopsy (SLNB) for axillary staging in select patients age 70 years and older with early-stage estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 neu-negative (HER2-) inva ... Full text Link to item Cite

Surgical Perspectives on the Updated ASTRO Guideline on Partial Breast Irradiation for Breast Cancer.

Journal Article Ann Surg Oncol · September 2024 This is an executive summary of the most recent American Society for Radiation Oncology (ASTRO) guidelines on use of partial breast irradiation in early-stage breast cancer.In the conscientious pursuit of "right-sizing" the management of patients with earl ... Full text Link to item Cite

Axillary nodal disease burden is not associated with an elevated 21-gene recurrence score in post-menopausal women presenting with a clinically negative axilla.

Journal Article Am J Surg · July 2024 BACKGROUND: The predictive and prognostic value of the recurrence score (RS) has emphasized the importance of tumor biology and has reduced the prognostic implications of limited nodal burden in post-menopausal women with HR+/HER2-invasive breast cancer (I ... Full text Link to item Cite

Racial/Ethnic Disparities in Pathologic Complete Response and Overall Survival in Patients With Triple-Negative Breast Cancer Treated With Neoadjuvant Chemotherapy.

Journal Article J Clin Oncol · May 10, 2024 PURPOSE: Black women have higher rates of death from triple-negative breast cancer (TNBC) than White women. We hypothesized that pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and overall survival (OS) may vary by race/ethnicity in pa ... Full text Link to item Cite

Society of Surgical Oncology Breast Disease Site Working Group Statement on Contralateral Mastectomy: Indications, Outcomes, and Risks.

Journal Article Ann Surg Oncol · April 2024 Rates of contralateral mastectomy (CM) among patients with unilateral breast cancer have been increasing in the United States. In this Society of Surgical Oncology position statement, we review the literature addressing the indications, risks, and benefits ... Full text Link to item Cite

Elder Abuse

Journal Article Clinics in Geriatric Medicine · February 2019 Full text Cite

The Effect of Insurance and Race on Breast Cancer Tumor Biology and Short-Term Outcomes

Journal Article The American Surgeon™ · July 2018 To determine whether low-income status as demonstrated by insurance type has any association with aggressive tumor biology and breast cancer outcomes. Retrospective review of 535 women with new diagnosis of breast cancer from January 2009 to March ... Full text Cite

Local Recurrence, the Augmented Breast, and the Contralateral Breast

Chapter · September 1, 2017 The book chapter addresses the complex multidisciplinary management of lororegional recurrence (LRR), breast cancer in the augmented breast and breast cancer risk in the contralateral breast ... Cite

Sound preconditioning therapy inhibits ototoxic hearing loss in mice

Journal Article Journal of Clinical Investigation · November 1, 2013 Therapeutic drugs with ototoxic side effects cause significant hearing loss for thousands of patients annually. Two major classes of ototoxic drugs are cisplatin and the aminoglycoside antibiotics, both of which are toxic to mechanosensory hair cells, the ... Full text Cite