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Darell Doty Bigner

E. L. and Lucille F. Jones Cancer Distinguished Research Professor, in the School of Medicine
Neurosurgery
Duke Box 3156, Durham, NC 27710
177 Med Sci Res Bldg, Durham, NC 27710

Selected Grants


PRECLINICAL THERAPEUTIC SCREENING FOR NEW THERAPIES FOR GLIOBLASTOMA MULTIFORME

ResearchInvestigator · Awarded by Jewish Communal Fund · 2022 - 2026

PRECLINICAL THERAPEUTIC SCREENING FOR NEW THERAPIES FOR GLIOBLASTOMA MULTIFORME

ResearchPrincipal Investigator · Awarded by Jewish Communal Fund · 2007 - 2026

PVSRIPO in melanoma

ResearchCo-Mentor · Awarded by National Cancer Institute · 2020 - 2025

Duke CTSA (TL1) Year 5

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024

Regional Oncolytic Poliovirus Immunotherapy for Breast Cancer

ResearchCollaborator · Awarded by Department of Defense · 2016 - 2024

Reviving cancer immune surveillance with CD4 T cell help

ResearchMentor · Awarded by National Institutes of Health · 2021 - 2023

Translational Research in Surgical Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2002 - 2022

Validation of Novel Therapeutic Approach for Leptomeningeal Metastases

ResearchCo Investigator · Awarded by Minnetronix, Inc · 2016 - 2022

Oncolytic Polovirus, Immunotoxin, and Checkpoint Inhibitor Therapy of Gliomas

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2022

Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma?

ResearchCollaborator · Awarded by National Institutes of Health · 2019 - 2022

Phase-1 clinical trial of PVSRIPO oncolytic immunotherapy in pediatric HGG

Clinical TrialCo Investigator · Awarded by Solving Kids' Cancer · 2016 - 2021

A novel sustained-release immunotoxin for treatment of glioblastoma multiforme

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2021

Cancer Immunotherapy Through Intratumoral Activation of Recall Responses

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2021

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Anti-tumor efficacy of EGFR-targeting immunotoxin in combination with CCNU or PD-L1 blockade in glioma mouse models

FellowshipPrincipal Investigator · Awarded by National Cancer Center · 2018 - 2020

The Role of IDH1 Mutations in Gliomagenesis and Metabolism

ResearchCollaborator · Awarded by National Institutes of Health · 2009 - 2020

Systemically administrered EGRFvIII-targeted bispecific antibody as an immunotherapeutic for glioblastoma.

FellowshipCollaborator · Awarded by National Institutes of Health · 2015 - 2019

Vaccine Immunotoxin and Radioimmunotherapy of Primary and Metastatic CNS Tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2018

Targeting Translation Control in Malignant Glioma

ResearchCollaborator · Awarded by National Institutes of Health · 2007 - 2018

A Genetically Modified Poliovirus and Immunotoxin for Malignant Brain Tumors

ResearchPrincipal Investigator · Awarded by Brain Tumor Research Charity · 2013 - 2017

Determining the maximum tolerated dose of a recombinant immunotoxin targeting wildtype EGFR and Mutant EGFRvIII

ResearchPrincipal Investigator · Awarded by Uncle Kory Foundation · 2016 - 2017

Oncolytic PVSRIPO Expressing Tumor Antigens as a Cancer Vaccine

ResearchSignificant Contributor · Awarded by Oligo Nation · 2016 - 2017

Enhancing dendritic cell migration to drive potent anti-tumor immune responses

FellowshipMentor · Awarded by National Institutes of Health · 2013 - 2017

Immunosequencing of poliovirus and immunotoxin treated brain tumor samples

ResearchPrincipal Investigator · Awarded by Uncle Kory Foundation · 2015 - 2016

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1998 - 2016

Oncolytic Poliovirus Immunotherapy of Malignant Glioma

ResearchPrincipal Investigator · Awarded by The Slomo and Cindy Silvian Foundation, Inc · 2014 - 2015

Clinical Oncology Research Career Development Program

ResearchMentor · Awarded by National Institutes of Health · 2009 - 2015

Oncolytic Virotherapy of Meningeal Cancer

ResearchCollaborator · Awarded by National Institutes of Health · 2009 - 2015

SRC on Primary Tumors of the CNS

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1999 - 2015

Adoptive Immunotherapy for GBM During Hematopoietic Recovery from Temozolomide

Clinical TrialCollaborator · Awarded by National Institutes of Health · 2009 - 2014

Targeting EGFRvIII in Brain Tumors with Bispecific Antibodies

FellowshipCollaborator · Awarded by National Institutes of Health · 2013 - 2014

Modulation of the blood-tumor barrier through targeted suppression of claudin 5

ResearchMentor · Awarded by National Institutes of Health · 2011 - 2013

Reversal of CMV-specific immune deficits in patients with glioblastoma

Clinical TrialCollaborator · Awarded by National Institutes of Health · 2009 - 2013

Brain Tumors - Immunological and Biological Studies

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2013

Nuclear EGFR Signaling Network in Human Cancer

ResearchMentor · Awarded by National Institutes of Health · 2006 - 2012

Pre-clinical Translation of Regulatory T-cell Inhibition in Brain Tumors

ResearchCollaborator · Awarded by National Institutes of Health · 2010 - 2012

The Role of OTX2 in Molecular Pathogenesis of Medulloblastoma

ResearchCo Investigator · Awarded by National Institutes of Health · 2006 - 2012

Small Animal PET / CT Molecular Imaging

EquipmentMajor User · Awarded by National Institutes of Health · 2011 - 2012

Meningioma: Risk Factors and Quality of Life

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2006 - 2012

SPORE in Brain Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2004 - 2011

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2010

Temodar Resistance in CNS Tumors

ResearchCollaborator · Awarded by National Institutes of Health · 1992 - 2010

Innovative Assays for Oncogenic Hedgehog Signaling

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2010

Stem Cell-Like Glioma Cells in Angiogenesis

ResearchConsultant · Awarded by National Institutes of Health · 2008 - 2009

TGFbeta-PTEN Interactions in Glioma Biology & Therapy

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2008

Molecular Mechanisms of SPARC Mediated Glioma Invasion

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2008

Phase II Study of 44Gy from 131I-81C6 for CNS Tumors

ResearchCo Investigator · Awarded by National Institutes of Health · 2003 - 2006

High-Resolution CGH Characterization of Brain Tumors

ResearchConsultant · Awarded by National Institutes of Health · 2004 - 2006

Regional AGT Depletion of CNS and Leptomeningeal Tumors

ResearchCollaborator · Awarded by National Institutes of Health · 2002 - 2006

Anti-Tenascin Antibody Constructs

ResearchCo Investigator · Awarded by Department of Energy · 1995 - 2005

GCRC CAP

ResearchMentor · Awarded by National Institutes of Health · 2000 - 2005

Therapy of Temodar plus O6-Benzulguanine in Malignant Glioma

ResearchCo Investigator · Awarded by National Institutes of Health · 2003 - 2005

SPORE in Brain Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2004

Administrative Supplement: SRC on Primary and Metastatic Tumors of the CNS\

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2004

Astatine And Iodine Radiolabeled Monoclonal Antibodies

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1999 - 2004

ZD1839 Therapy of Glioblastoma Multiforme

ResearchCollaborator · Awarded by National Institutes of Health · 2001 - 2003

Development of Novel Tumor Imaging Agents

ResearchCollaborator · Awarded by National Institutes of Health · 2000 - 2003

The Role Of Tgfb In Brain Tumors

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1998 - 2001

Same

ResearchCollaborator · Awarded by National Institutes of Health · 1999 - 2001

Brain Tumors--Immunological and Biological Studies

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1976 - 2001

SRC on Primary and Metastatic Tumors of the CNS

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2001

Administrative Supplement to NS20023-15

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1999 - 2000

Brain Tumors - Immunological And Biological Studies

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 1999

Src On Primary And Matastatic Tumors Of The Cns

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1994 - 1999

Astatine And Iodine Radiolabeled Monoclonal Antibodies

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1994 - 1999

Src On Primary And Metastatic Tumors Of The Cns

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 1999

Comprehensive Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1976 - 1998

Comprehensive Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1976 - 1998

Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1976 - 1998

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 1987 - 1998

Research Training In Neurology-Oncology

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 1992 - 1997

Brain Tumors -- Immunological And Biological Studies

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1994 - 1996

Brain Tumors: Immunological And Biological Studies

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1993 - 1996

Intrathecal Therapy Of Melanoma Neoplastic Meningitis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1993 - 1995

Src On Malignant Human Gliomas And Medulloblastomas

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1993 - 1994

Src On Malignant Human Gliomas And Medulloblastomas

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1992 - 1994

Src On Malignant Human Gliomas And Medulloblastoma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1989 - 1994

Brain Tumors: Immunological And Biological Studies

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1992 - 1993

Brain Tumors; Immunological And Biological Studies

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1990 - 1993

Brain Tumor: Immunological And Biological Studies

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1988 - 1993

Malignant Human Gliomas And Medulloblastoma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1987 - 1989

Malignant Human Gliomas And Medulloblastoma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1985 - 1989

Sixth International Conference On Brain Tumor Research A

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1985 - 1986

External Relationships


  • Istari Oncology Inc.
  • Vimana Inc

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.