Bin Ni

Journal Article Open Forum Infect Dis · July 2024 We evaluated use of maribavir (MBV) for treatment of 15 episodes of refractory/resistant cytomegalovirus infection in 13 solid organ transplant recipients. Treatment failure due to treatment-emergent MBV resistance or early virological recurrence after MBV ... Full text Link to item Cite

Cutting Edge: Cytosolic Receptor AIM2 Is Induced by Peroxisome Proliferator-activated Receptor γ following Mycobacterium tuberculosis Infection of Human Macrophages but Does Not Contribute to IL-1β Release.

Journal Article Journal of immunology (Baltimore, Md. : 1950) · March 2024 AIM2 (absent in melanoma 2), an inflammasome component, mediates IL-1β release in murine macrophages and cell lines. AIM2 and IL-1β contribute to murine control of Mycobacterium tuberculosis (M.tb) infection, but AIM2's impact in human macrophages, the pri ... Full text Cite

SARS-CoV-2 vaccine safety and immunogenicity in patients with hematologic malignancies, transplantation, and cellular therapies.

Journal Article Blood reviews · November 2022 Individuals with hematological malignancies and hematopoietic stem cell transplant (HCT) recipients are immunologically heterogenous groups with varying degrees of immunosuppression at increased risk of severe disease and mortality from SARS-CoV-2 infectio ... Full text Cite

Avoidance of Emergency Care in the Southeastern United States During the COVID-19 Pandemic.

Journal Article Open Forum Infect Dis · May 2022 In a low-income cohort in the Southeastern United States, 5% of participants avoided emergency medical care during the coronavirus disease 2019 pandemic, primarily due to fear and visitor restrictions. Younger age, self-perceived lower health status, lack ... Full text Link to item Cite

Vaccine protection and how we measure it.

Journal Article Transplant infectious disease : an official journal of the Transplantation Society · December 2021 Full text Cite

Disruption of medical care among individuals in the southeastern United States during the COVID-19 pandemic.

Journal Article J Public Health Res · September 24, 2021 BACKGROUND: Widespread disruptions of medical care to mitigate COVID-19 spread and reduce burden on healthcare systems may have deleterious public health consequences. DESIGN AND METHODS: To examine factors contributing to healthcare interruptions during t ... Full text Link to item Cite

Effect of Early Post-Transplantation Tacrolimus Concentration on the Risk of Acute Graft-Versus-Host Disease in Allogenic Stem Cell Transplantation.

Journal Article Cancers · February 2021 Acute graft versus host disease (aGVHD) remains a leading cause of morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HSCT). Tacrolimus (TAC), a calcineurin inhibitor that prevents T-cell activation, is commonly used as a GVHD p ... Full text Cite

Efficacy of Autologous Stem Cell Transplantation for the Treatment of Multiple Myeloma in HIV-Positive Patients

Journal Article OBM Transplantation · January 1, 2021 Prior to the advent of anti-retroviral therapy (ART), autologous stem cell transplant (ASCT) was relatively contraindicated for multiple myeloma (MM) patients with human immunodeficiency virus (HIV) due to issues associated with stem cell harvest and the r ... Full text Cite

M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1.

Journal Article Cell reports · October 2017 Despite its prominent role as a C-type lectin (CTL) pattern recognition receptor, mannose receptor (MR, CD206)-specific signaling molecules and pathways are unknown. The MR is highly expressed on human macrophages, regulating endocytosis, phagocytosis, and ... Full text Cite

Macrophage immunoregulatory pathways in tuberculosis.

Journal Article Seminars in immunology · December 2014 Macrophages, the major host cells harboring Mycobacterium tuberculosis (M.tb), are a heterogeneous cell type depending on their tissue of origin and host they are derived from. Significant discord in macrophage responses to M.tb exists due to differences i ... Full text Cite

Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a.

Journal Article Journal of immunology (Baltimore, Md. : 1950) · November 2014 IFN-γ-activated macrophages play an essential role in controlling intracellular pathogens; however, macrophages also serve as the cellular home for the intracellular pathogen Mycobacterium tuberculosis. Based on previous evidence that M. tuberculosis can m ... Full text Cite

Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · October 2011 Contact of Mycobacterium tuberculosis (M.tb) with the immune system requires interactions between microbial surface molecules and host pattern recognition receptors. Major M.tb-exposed cell envelope molecules, such as lipomannan (LM), contain subtle struct ... Full text Cite

Microscale hydrogels for medicine and biology: Synthesis characteristics and applications

Journal Article Journal of Mechanics of Materials and Structures · January 1, 2007 Microscale hydrogels with dimensions of 200 μm or less are powerful tools for various biomedical applications such as tissue engineering, drug delivery, and biosensors, due to their size, biocompatibility, and their controllable biological, chemical, and m ... Full text Cite

A controlled-release strategy for the generation of cross-linked hydrogel microstructures.

Journal Article Journal of the American Chemical Society · November 2006 Microscale hydrogels of controlled sizes and shapes are useful for cell-based screening, in vitro diagnostics, tissue engineering, and drug delivery. However, the rapid cross-linking of many chemically and pH cross-linkable hydrogel materials prevents the ... Full text Cite