Michael August Blazing | Scholars@Duke

Michael August Blazing
Associate Professor of Medicine

General focus: My research interests are in primary and secondary prevention of cardiovascular disease. Specifically, I am looking at compliance issues within the cardiology division and in the University as a whole with regard to evidence based treatment and secondary prevention of cardiovascular disease. I am using both retrospective and prospective collection of discharge data to try and analyze these trends. In the future, we hope to begin clinical trials with regard to various issues which are outstanding in primary and secondary prevention. Some of the issues include treatment of hypercholesterolemia in elderly patients, differences between the various statins with regard to affects on lipid profiles, and early treatment of hypercholesterolemia after MI.

As part of my work, I have served as a consultant with various drug companies with regard to focusing on active issues and treatment of hypercholesterolemia.

Key words: Primary prevention, secondary prevention, hyperlipidemia, homocysteine, and hypertension.

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Cardiology, Medicine 2007

Contact Information

7412HOSP North, Durham, NC 27710
Duke Box 3126, Durham, NC 27710
blazi001@mc.duke.edu (919) 681-3945

Background
Education, Training, & Certifications
- M.D., University of California, San Francisco, School of Medicine 1987
Duke Appointment History
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2005 - 2007
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 1998 - 2005
- Associate in the Department of Medicine, Medicine, Cardiology, Medicine 1995 - 1998
Research
Selected Grants
- Radiation-Induced Cardiopulmonary Injury in Humans awarded by National Institutes of Health 1996 - 2008
- Anxiety, Depression, and Non-Cardiac Chest Pain awarded by National Institutes of Health 2001 - 2007
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Cholesterol Treatment Trialists' Collaboration, . "Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials." Lancet (London, England) 393, no. 10170 (February 2019): 407-415. Full Text
  - Sharma, A, Sun, J-L, Lokhnygina, Y, Roe, MT, Ahmad, T, Desai, NR, and Blazing, MA. "Patient Phenotypes, Cardiovascular Risk, and Ezetimibe Treatment in Patients After Acute Coronary Syndromes (from IMPROVE-IT)." The American Journal of Cardiology (January 25, 2019). Full Text
  - Navar, AM, Roe, MT, White, JA, Cannon, CP, Lokhnygina, Y, Newby, LK, Giugliano, RP, Tershakovec, AM, Braunwald, E, Califf, RM, and Blazing, MA. "Medication Discontinuation in the IMPROVE-IT Trial." Circulation. Cardiovascular Quality and Outcomes 12, no. 1 (January 2019): e005041-null. Full Text
  - Bonaca, MP, Gutierrez, JA, Cannon, C, Giugliano, R, Blazing, M, Park, J-G, White, J, Tershakovec, A, and Braunwald, E. "Polyvascular disease, type 2 diabetes, and long-term vascular risk: a secondary analysis of the IMPROVE-IT trial." The Lancet. Diabetes & Endocrinology 6, no. 12 (December 2018): 934-943. Full Text
  - Fudim, M, Ganesh, A, Green, C, Jones, WS, Blazing, MA, DeVore, AD, Felker, GM, Kiefer, TL, Kong, DF, Boortz-Marx, RL, Hernandez, AF, and Patel, MR. "Splanchnic nerve block for decompensated chronic heart failure: splanchnic-HF." European Heart Journal 39, no. 48 (December 2018): 4255-4256. Full Text
  - Ambrosy, AP, Cerbin, LP, Fudim, M, Clare, RM, Lokhnygina, Y, Braunwald, E, Califf, RM, Cannon, CP, Tershakovec, AM, Roe, MT, and Blazing, MA. "Natural History of Patients Postacute Coronary Syndrome Based on Heart Failure Status." The American Journal of Cardiology 122, no. 9 (November 2018): 1451-1458. Full Text
  - Simon, TG, Corey, KE, Cannon, CP, Blazing, M, Park, J-G, O'Donoghue, ML, Chung, RT, and Giugliano, RP. "The nonalcoholic fatty liver disease (NAFLD) fibrosis score, cardiovascular risk stratification and a strategy for secondary prevention with ezetimibe." International Journal of Cardiology 270 (November 2018): 245-252. Full Text
  - Yang, S, Tsiatis, AA, and Blazing, M. "Modeling survival distribution as a function of time to treatment discontinuation: A dynamic treatment regime approach." Biometrics 74, no. 3 (September 2018): 900-909. Full Text
  - Giugliano, RP, Cannon, CP, Blazing, MA, Nicolau, JC, Corbalán, R, Špinar, J, Park, J-G, White, JA, Bohula, EA, Braunwald, E, and IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial) Investigators, . "Benefit of Adding Ezetimibe to Statin Therapy on Cardiovascular Outcomes and Safety in Patients With Versus Without Diabetes Mellitus: Results From IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)." Circulation 137, no. 15 (April 2018): 1571-1582. Full Text
  - Bohula, EA, Wiviott, SD, Giugliano, RP, Blazing, MA, Park, J-G, Murphy, SA, White, JA, Mach, F, Van de Werf, F, Dalby, AJ, White, HD, Tershakovec, AM, Cannon, CP, and Braunwald, E. "Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary Syndrome in IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)." Circulation 136, no. 25 (December 2017): 2440-2450. Full Text
  - Kato, ET, Cannon, CP, Blazing, MA, Bohula, E, Guneri, S, White, JA, Murphy, SA, Park, J-G, Braunwald, E, and Giugliano, RP. "Efficacy and Safety of Adding Ezetimibe to Statin Therapy Among Women and Men: Insight From IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)." Journal of the American Heart Association 6, no. 11 (November 18, 2017). Full Text
  - Stanifer, JW, Charytan, DM, White, J, Lokhnygina, Y, Cannon, CP, Roe, MT, and Blazing, MA. "Benefit of Ezetimibe Added to Simvastatin in Reduced Kidney Function." Journal of the American Society of Nephrology : Jasn 28, no. 10 (October 2017): 3034-3043. Full Text Open Access Copy
  - Fanaroff, AC, Roe, MT, Clare, RM, Lokhnygina, Y, Navar, AM, Giugliano, RP, Wiviott, SD, Tershakovec, AM, Braunwald, E, and Blazing, MA. "Competing Risks of Cardiovascular Versus Noncardiovascular Death During Long-Term Follow-Up After Acute Coronary Syndromes." Journal of the American Heart Association 6, no. 9 (September 18, 2017). Full Text
  - Giugliano, RP, Wiviott, SD, Blazing, MA, De Ferrari, GM, Park, J-G, Murphy, SA, White, JA, Tershakovec, AM, Cannon, CP, and Braunwald, E. "Long-term Safety and Efficacy of Achieving Very Low Levels of Low-Density Lipoprotein Cholesterol : A Prespecified Analysis of the IMPROVE-IT Trial." Jama Cardiology 2, no. 5 (May 2017): 547-555. Full Text
  - Pokharel, Y, Chinnakondepalli, K, Vilain, K, Wang, K, Mark, DB, Davies, G, Blazing, MA, Giugliano, RP, Braunwald, E, Cannon, CP, Cohen, DJ, and Magnuson, EA. "Impact of Ezetimibe on the Rate of Cardiovascular-Related Hospitalizations and Associated Costs Among Patients With a Recent Acute Coronary Syndrome: Results From the IMPROVE-IT Trial (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)." Circulation. Cardiovascular Quality and Outcomes 10, no. 5 (May 2017). Full Text
  - Bohula, EA, Morrow, DA, Giugliano, RP, Blazing, MA, He, P, Park, J-G, Murphy, SA, White, JA, Kesaniemi, YA, Pedersen, TR, Brady, AJ, Mitchel, Y, Cannon, CP, and Braunwald, E. "Atherothrombotic Risk Stratification and Ezetimibe for Secondary Prevention." Journal of the American College of Cardiology 69, no. 8 (February 2017): 911-921. Full Text
  - Blazing, MA, Giugliano, RP, de Lemos, JA, Cannon, CP, Tonkin, A, Ballantyne, CM, Lewis, BS, Musliner, TA, Tershakovec, AM, Lokhnygina, Y, White, JA, Reist, C, McCagg, A, and Braunwald, E. "On-treatment analysis of the Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT)." American Heart Journal 182 (December 2016): 89-96. Full Text
  - Eisen, A, Cannon, CP, Blazing, MA, Bohula, EA, Park, J-G, Murphy, SA, White, JA, Giugliano, RP, Braunwald, E, and IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial) Investigators, . "The benefit of adding ezetimibe to statin therapy in patients with prior coronary artery bypass graft surgery and acute coronary syndrome in the IMPROVE-IT trial." European Heart Journal 37, no. 48 (December 2016): 3576-3584. Full Text
  - Murphy, SA, Cannon, CP, Blazing, MA, Giugliano, RP, Tershakovec, AM, and Braunwald, E. "Reply: Personalize and Optimize Lipid-Lowering Therapies." Journal of the American College of Cardiology 68, no. 3 (July 2016): 326-null. (Letter) Full Text
  - Murphy, SA, Cannon, CP, Blazing, MA, Giugliano, RP, Tershakovec, AM, and Braunwald, E. "Reply: Adding Ezetimibe to Simvastatin for the Secondary Prevention of Cardiovascular Disease: Is it Useful?." Journal of the American College of Cardiology 67, no. 25 (June 2016): 3025-3026. (Letter) Full Text
  - Nissen, SE, Stroes, E, Dent-Acosta, RE, Rosenson, RS, Lehman, SJ, Sattar, N, Preiss, D, Bruckert, E, Ceška, R, Lepor, N, Ballantyne, CM, Gouni-Berthold, I, Elliott, M, Brennan, DM, Wasserman, SM, Somaratne, R, Scott, R, Stein, EA, and GAUSS-3 Investigators, . "Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance: The GAUSS-3 Randomized Clinical Trial." Jama 315, no. 15 (April 2016): 1580-1590. Full Text
  - Bohula, EA, Giugliano, RP, Cannon, CP, Zhou, J, Murphy, SA, White, J, Tershakovec, AM, Blazing, MA, and Braunwald, E. "Response to Letter Regarding Article, "Achievement of Dual Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein Targets More Frequent With the Addition of Ezetimibe to Simvastatin and Associated With Better Outcomes in IMPROVE-IT"." Circulation 133, no. 13 (March 2016): e463-. (Letter) Full Text
  - Murphy, SA, Cannon, CP, Blazing, MA, Giugliano, RP, White, JA, Lokhnygina, Y, Reist, C, Im, K, Bohula, EA, Isaza, D, Lopez-Sendon, J, Dellborg, M, Kher, U, Tershakovec, AM, and Braunwald, E. "Reduction in Total Cardiovascular Events With Ezetimibe/Simvastatin Post-Acute Coronary Syndrome: The IMPROVE-IT Trial." Journal of the American College of Cardiology 67, no. 4 (February 2016): 353-361. Full Text
  - Cannon, CP, Blazing, MA, and Braunwald, E. "Ezetimibe plus a Statin after Acute Coronary Syndromes." The New England Journal of Medicine 373, no. 15 (October 2015): 1476-1477. (Letter) Full Text
  - Bohula, EA, Giugliano, RP, Cannon, CP, Zhou, J, Murphy, SA, White, JA, Tershakovec, AM, Blazing, MA, and Braunwald, E. "Achievement of dual low-density lipoprotein cholesterol and high-sensitivity C-reactive protein targets more frequent with the addition of ezetimibe to simvastatin and associated with better outcomes in IMPROVE-IT." Circulation 132, no. 13 (September 2015): 1224-1233. Full Text
  - Tricoci, P, D'Andrea, DM, Gurbel, PA, Yao, Z, Cuchel, M, Winston, B, Schott, R, Weiss, R, Blazing, MA, Cannon, L, Bailey, A, Angiolillo, DJ, Gille, A, Shear, CL, Wright, SD, and Alexander, JH. "Infusion of Reconstituted High-Density Lipoprotein, CSL112, in Patients With Atherosclerosis: Safety and Pharmacokinetic Results From a Phase 2a Randomized Clinical Trial." Journal of the American Heart Association 4, no. 8 (August 25, 2015): e002171-null. Full Text
  - Cannon, CP, Blazing, MA, Giugliano, RP, McCagg, A, White, JA, Theroux, P, Darius, H, Lewis, BS, Ophuis, TO, Jukema, JW, De Ferrari, GM, Ruzyllo, W, De Lucca, P, Im, K, Bohula, EA, Reist, C, Wiviott, SD, Tershakovec, AM, Musliner, TA, Braunwald, E, Califf, RM, and IMPROVE-IT Investigators, . "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes." The New England Journal of Medicine 372, no. 25 (June 3, 2015): 2387-2397. Full Text
  - Cholesterol Treatment Trialists' (CTT) Collaboration, , Fulcher, J, O'Connell, R, Voysey, M, Emberson, J, Blackwell, L, Mihaylova, B, Simes, J, Collins, R, Kirby, A, Colhoun, H, Braunwald, E, La Rosa, J, Pedersen, TR, Tonkin, A, Davis, B, Sleight, P, Franzosi, MG, Baigent, C, and Keech, A. "Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials." Lancet (London, England) 385, no. 9976 (April 2015): 1397-1405. Full Text
  - Blazing, MA, Giugliano, RP, Cannon, CP, Musliner, TA, Tershakovec, AM, White, JA, Reist, C, McCagg, A, Braunwald, E, and Califf, RM. "Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: final baseline characteristics of the IMPROVE-IT study population." American Heart Journal 168, no. 2 (August 2014): 205-12.e1. Full Text
  - "Inflammation and atherosclerosis: Disease modulating therapies." Current Treatment Options in Cardiovascular Medicine 15, no. 6 (December 1, 2013): 681-695. (Review) Full Text
  - Patel, MJ, and Blazing, MA. "Inflammation and atherosclerosis: disease modulating therapies." Curr Treat Options Cardiovasc Med 15, no. 6 (December 2013): 681-695. Full Text Link to Item
  - Cholesterol Treatment Trialists' (CTT) Collaborators, , Mihaylova, B, Emberson, J, Blackwell, L, Keech, A, Simes, J, Barnes, EH, Voysey, M, Gray, A, Collins, R, and Baigent, C. "The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials." Lancet (London, England) 380, no. 9841 (August 2012): 581-590. Full Text
  - Cholesterol Treatment Trialists' (CTT) Collaboration, , Emberson, JR, Kearney, PM, Blackwell, L, Newman, C, Reith, C, Bhala, N, Holland, L, Peto, R, Keech, A, Collins, R, Simes, J, and Baigent, C. "Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy." Plos One 7, no. 1 (January 19, 2012): e29849-null. Full Text
  - Preiss, D, Seshasai, SRK, Welsh, P, Murphy, SA, Ho, JE, Waters, DD, DeMicco, DA, Barter, P, Cannon, CP, Sabatine, MS, Braunwald, E, Kastelein, JJP, de Lemos, JA, Blazing, MA, Pedersen, TR, Tikkanen, MJ, Sattar, N, and Ray, KK. "Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis." Jama 305, no. 24 (June 2011): 2556-2564. Full Text
  - Keefe, FJ, Shelby, RA, Somers, TJ, Varia, I, Blazing, M, Waters, SJ, McKee, D, Silva, S, She, L, Blumenthal, JA, O'Connor, J, Knowles, V, Johnson, P, and Bradley, L. "Effects of coping skills training and sertraline in patients with non-cardiac chest pain: a randomized controlled study." Pain 152, no. 4 (April 2011): 730-741. Full Text
  - Baigent, C, Blackwell, L, Emberson, J, Holland, LE, Reith, C, Bhala, N, Peto, R, Barnes, EH, Keech, A, Simes, J, Collins, R, De Lemos, J, Braunwald, E, Blazing, M, Murphy, S, Downs, JR, Gotto, A, Clearfield, M, Holdaas, H, Gordon, D, Davis, B, Koren, M, Dahlof, B, Poulter, N, Sever, P, Knopp, RH, Fellström, B, Jardine, A, Schmieder, R, Zannad, F, Goldbourt, U, Kaplinsky, E, Colhoun, HM, Betteridge, DJ, Durrington, PN, Hitman, GA, Fuller, J, Neil, A, Wanner, C, Krane, V, Sacks, F, Moyé, L, Pfeffer, M, Hawkins, CM, Barter, P, Tavazzi, L, Maggioni, A, Marchioli, R, Tognoni, G, Franzosi, MG, Bloomfield, H, Robins, S, Armitage, J, Parish, S, Sleight, P, Pedersen, TR, Ridker, PM, Holman, R, Meade, T, MacMahon, S, Marschner, I, Tonkin, A, Shaw, J, Serruys, PW, Nakamura, H, Knatterud, G, Furberg, C, Byington, R, Macfarlane, P, Cobbe, S, Ford, I, Murphy, M, Blauw, GJ, Packard, C, Shepherd, J, Kjekshus, J, Pedersen, T, Wilhelmsen, L, Cannon, C, Bowman, L, Baxter, A, and Landray, M. "Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170 000 participants in 26 randomised trials." The Lancet 376, no. 9753 (November 13, 2010): 1670-1681. Full Text
  - Kong, MH, Shaw, LK, O'Connor, C, Califf, RM, Blazing, MA, and Al-Khatib, SM. "Is rhythm-control superior to rate-control in patients with atrial fibrillation and diastolic heart failure?." Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 15, no. 3 (July 2010): 209-217. Full Text
  - Califf, RM, Lokhnygina, Y, Cannon, CP, Stepanavage, ME, McCabe, CH, Musliner, TA, Pasternak, RC, Blazing, MA, Giugliano, RP, Harrington, RA, and Braunwald, E. "An update on the IMProved reduction of outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design." American Heart Journal 159, no. 5 (May 2010): 705-709. Full Text
  - Blazing, M. "Statins - Is there potential for uncovering new benefits (or detriments)?." Cardiovascular Therapeutics 28, no. 2 (2010): 67-69. Full Text
  - Mielniczuk, LM, Pfeffer, MA, Lewis, EF, Blazing, MA, de Lemos, JA, Mohanavelu, S, Rouleau, J, Fox, K, Pedersen, TR, and Califf, RM. "Acute decline in renal function, inflammation, and cardiovascular risk after an acute coronary syndrome." Clinical Journal of the American Society of Nephrology : Cjasn 4, no. 11 (November 2009): 1811-1817. Full Text
  - Shelby, RA, Somers, TJ, Keefe, FJ, Silva, SG, McKee, DC, She, L, Waters, SJ, Varia, I, Riordan, YB, Knowles, VM, Blazing, M, Blumenthal, JA, and Johnson, P. "Pain catastrophizing in patients with noncardiac chest pain: relationships with pain, anxiety, and disability." Psychosomatic Medicine 71, no. 8 (October 2009): 861-868. Full Text
  - Califf, RM, Harrington, RA, and Blazing, MA. "Premature release of data from clinical trials of ezetimibe." The New England Journal of Medicine 361, no. 7 (August 2009): 712-717. Full Text
  - Alexander, KP, Blazing, MA, Rosenson, RS, Hazard, E, Aronow, WS, Smith, SC, and Ohman, EM. "Management of hyperlipidemia in older adults." J Cardiovasc Pharmacol Ther 14, no. 1 (March 2009): 49-58. (Review) Full Text Link to Item
  - Cannon, CP, Giugliano, RP, Blazing, MA, Harrington, RA, Peterson, JL, Sisk, CM, Strony, J, Musliner, TA, McCabe, CH, Veltri, E, Braunwald, E, Califf, RM, and IMPROVE-IT Investigators, . "Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes." American Heart Journal 156, no. 5 (November 2008): 826-832. Full Text
  - Brilakis, ES, de Lemos, JA, Cannon, CP, Wiviott, SD, Murphy, SA, Morrow, DA, Sabatine, MS, Banerjee, S, Blazing, MA, Califf, RM, and Braunwald, E. "Outcomes of patients with acute coronary syndrome and previous coronary artery bypass grafting (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy [PROVE IT-TIMI 22] and the Aggrastat to Zocor [A to Z] trials)." The American Journal of Cardiology 102, no. 5 (September 2008): 552-558. Full Text
  - Mielniczuk, LM, Pfeffer, MA, Lewis, EF, Blazing, MA, de Lemos, JA, Shui, A, Mohanavelu, S, Califf, RM, and Braunwald, E. "Estimated glomerular filtration rate, inflammation, and cardiovascular events after an acute coronary syndrome." American Heart Journal 155, no. 4 (April 2008): 725-731. Full Text
  - McLean, DS, Ravid, S, Blazing, M, Gersh, B, Shui, A, and Cannon, CP. "Effect of statin dose on incidence of atrial fibrillation: data from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) and Aggrastat to Zocor (A to Z) trials." American Heart Journal 155, no. 2 (February 2008): 298-302. Full Text
  - de Lemos, JA, Morrow, DA, Blazing, MA, Jarolim, P, Wiviott, SD, Sabatine, MS, Califf, RM, and Braunwald, E. "Serial measurement of monocyte chemoattractant protein-1 after acute coronary syndromes: results from the A to Z trial." Journal of the American College of Cardiology 50, no. 22 (November 13, 2007): 2117-2124. Full Text
  - Murphy, SA, Cannon, CP, Wiviott, SD, de Lemos, JA, Blazing, MA, McCabe, CH, Califf, RM, and Braunwald, E. "Effect of intensive lipid-lowering therapy on mortality after acute coronary syndrome (a patient-level analysis of the Aggrastat to Zocor and Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 trials)." The American Journal of Cardiology 100, no. 7 (October 2007): 1047-1051. Full Text
  - Prosnitz, RG, Hubbs, JL, Evans, ES, Zhou, S-M, Yu, X, Blazing, MA, Hollis, DR, Tisch, A, Wong, TZ, Borges-Neto, S, Hardenbergh, PH, and Marks, LB. "Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: analysis of data 3 to 6 years after treatment." Cancer 110, no. 8 (October 2007): 1840-1850. Full Text
  - Martin, MG, Ardati, AK, Dunlay, SM, Abernethy, AP, and Blazing, MA. "Small cell lung cancer presenting as a paraneoplastic syndrome characterized by recurrent episodic hypotension and bradycardia: case report." Chest 131, no. 1 (January 2007): 290-293. Full Text Link to Item
  - Evans, ES, Prosnitz, RG, Yu, X, Zhou, S-M, Hollis, DR, Wong, TZ, Light, KL, Hardenbergh, PH, Blazing, MA, and Marks, LB. "Impact of patient-specific factors, irradiated left ventricular volume, and treatment set-up errors on the development of myocardial perfusion defects after radiation therapy for left-sided breast cancer." International Journal of Radiation Oncology, Biology, Physics 66, no. 4 (November 2006): 1125-1134. Full Text
  - de Lemos, JA, Wiviott, SD, Murphy, SA, Blazing, MA, Lewis, EF, Califf, RM, Pfeffer, MA, and Braunwald, E. "Evaluation of the National Cholesterol Education Program Adult Treatment Panel III algorithm for selecting candidates for statin therapy: insights from the A to Z trial." The American Journal of Cardiology 98, no. 6 (September 2006): 739-742. Full Text
  - Morrow, DA, de Lemos, JA, Sabatine, MS, Wiviott, SD, Blazing, MA, Shui, A, Rifai, N, Califf, RM, and Braunwald, E. "Clinical relevance of C-reactive protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to-Zocor Trial." Circulation 114, no. 4 (July 17, 2006): 281-288. Full Text
  - Briel, M, Schwartz, GG, Thompson, PL, de Lemos, JA, Blazing, MA, van Es, G-A, Kayikçioglu, M, Arntz, H-R, den Hartog, FR, Veeger, NJGM, Colivicchi, F, Dupuis, J, Okazaki, S, Wright, RS, Bucher, HC, and Nordmann, AJ. "Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trials." Jama 295, no. 17 (May 2006): 2046-2056. Full Text
  - Wiviott, SD, de Lemos, JA, Cannon, CP, Blazing, M, Murphy, SA, McCabe, CH, Califf, R, and Braunwald, E. "A tale of two trials: a comparison of the post-acute coronary syndrome lipid-lowering trials A to Z and PROVE IT-TIMI 22." Circulation 113, no. 11 (March 13, 2006): 1406-1414. Full Text
  - Morrow, DA, de Lemos, JA, Blazing, MA, Sabatine, MS, Murphy, SA, Jarolim, P, White, HD, Fox, KAA, Califf, RM, Braunwald, E, and Investigators, . "Prognostic value of serial B-type natriuretic peptide testing during follow-up of patients with unstable coronary artery disease." Jama 294, no. 22 (December 2005): 2866-2871. Full Text
  - Marks, LB, Yu, X, Prosnitz, RG, Zhou, S-M, Hardenbergh, PH, Blazing, M, Hollis, D, Lind, P, Tisch, A, Wong, TZ, and Borges-Neto, S. "The incidence and functional consequences of RT-associated cardiac perfusion defects." International Journal of Radiation Oncology, Biology, Physics 63, no. 1 (September 2005): 214-223. Full Text
  - Blazing, M. "Statin therapy-Time to turn the focus from efficacy to implementation?." American Heart Journal 149, no. 3 (2005): 381-383. Full Text
  - Crouse, JR. "High-dose statins in acute coronary syndromes." Jama 293, no. 1 (January 2005): 36-null. (Letter) Full Text
  - Das, SK, Baydush, AH, Zhou, S, Miften, M, Yu, X, Craciunescu, O, Oldham, M, Light, K, Wong, T, Blazing, M, Borges-Neto, S, Dewhirst, MW, and Marks, LB. "Predicting radiotherapy-induced cardiac perfusion defects." Med Phys 32, no. 1 (January 2005): 19-27. Full Text Link to Item
  - Goyal, A, and Blazing, M. "Should we measure C-reactive protein levels to ascertain the adequacy of statin therapy in patients who are at very high risk for a coronary heart disease event?." American Heart Journal 150, no. 4 (2005): 650-651. Full Text
  - De Lemos, JA, Blazing, MA, and Wiviott, SD. "Early intensive simvastatin may reduce CVD morbidity and mortality." Journal of Family Practice 53, no. 12 (December 1, 2004): 954-955. (Review)
  - Jiang, W, Kuchibhatla, M, Cuffe, MS, Christopher, EJ, Alexander, JD, Clary, GL, Blazing, MA, Gaulden, LH, Califf, RM, Krishnan, RR, and O'Connor, CM. "Prognostic value of anxiety and depression in patients with chronic heart failure." Circulation 110, no. 22 (November 22, 2004): 3452-3456. Full Text
  - Kanna, B, and Sharma, P. "Enoxaparin vs unfractionated heparin in acute coronary syndrome." Jama 292, no. 16 (October 2004): 1952-null. (Letter) Full Text
  - de Lemos, JA, Blazing, MA, Wiviott, SD, Brady, WE, White, HD, Fox, KAA, Palmisano, J, Ramsey, KE, Bilheimer, DW, Lewis, EF, Pfeffer, M, Califf, RM, Braunwald, E, and Investigators, . "Enoxaparin versus unfractionated heparin in patients treated with tirofiban, aspirin and an early conservative initial management strategy: results from the A phase of the A-to-Z trial." European Heart Journal 25, no. 19 (October 2004): 1688-1694. Full Text
  - de Lemos, JA, Blazing, MA, Wiviott, SD, Lewis, EF, Fox, KAA, White, HD, Rouleau, J-L, Pedersen, TR, Gardner, LH, Mukherjee, R, Ramsey, KE, Palmisano, J, Bilheimer, DW, Pfeffer, MA, Califf, RM, Braunwald, E, and Investigators, . "Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial." Jama 292, no. 11 (September 2004): 1307-1316. Full Text
  - Hedayati, SS, Jiang, W, O'Connor, CM, Kuchibhatla, M, Krishnan, KR, Cuffe, MS, Blazing, MA, and Szczech, LA. "The association between depression and chronic kidney disease and mortality among patients hospitalized with congestive heart failure." Am J Kidney Dis 44, no. 2 (August 2004): 207-215. Link to Item
  - Blazing, MA, de Lemos, JA, White, HD, Fox, KAA, Verheugt, FWA, Ardissino, D, DiBattiste, PM, Palmisano, J, Bilheimer, DW, Snapinn, SM, Ramsey, KE, Gardner, LH, Hasselblad, V, Pfeffer, MA, Lewis, EF, Braunwald, E, Califf, RM, and 'A to Z' Investigators, . "Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes who receive tirofiban and aspirin: a randomized controlled trial." Jama 292, no. 1 (July 2004): 55-64. Full Text
  - Petersen, JL, Mahaffey, KW, Hasselblad, V, Antman, EM, Cohen, M, Goodman, SG, Langer, A, Blazing, MA, Le-Moigne-Amrani, A, de Lemos, JA, Nessel, CC, Harrington, RA, Ferguson, JJ, Braunwald, E, and Califf, RM. "Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-Segment elevation acute coronary syndromes: a systematic overview." Jama 292, no. 1 (July 2004): 89-96. (Review) Full Text
  - Ballantyne, CM, Blazing, MA, King, TR, Brady, WE, and Palmisano, J. "Efficacy and safety of ezetimibe co-administered with simvastatin compared with atorvastatin in adults with hypercholesterolemia." The American Journal of Cardiology 93, no. 12 (June 2004): 1487-1494. Full Text
  - Ballantyne, CM, Blazing, MA, Hunninghake, DB, Davidson, MH, Yuan, Z, DeLucca, P, Ramsey, KE, Hustad, CM, and Palmisano, J. "Effect on high-density lipoprotein cholesterol of maximum dose simvastatin and atorvastatin in patients with hypercholesterolemia: results of the Comparative HDL Efficacy and Safety Study (CHESS)." American Heart Journal 146, no. 5 (November 2003): 862-869. Full Text
  - Blazing, MA, and Crawford, LE. "Enhanced External Counterpulsation (EECP): enough evidence to support this and the next wave?." Am Heart J 146, no. 3 (September 2003): 383-384. Full Text Link to Item
  - Yu, X, Prosnitz, RR, Zhou, S, Hardenberg, PH, Tisch, A, Blazing, MA, Borges-Neto, S, Hollis, D, Wong, T, and Marks, LB. "Symptomatic cardiac events following radiation therapy for left-sided breast cancer: possible association with radiation therapy-induced changes in regional perfusion." Clin Breast Cancer 4, no. 3 (August 2003): 193-197. Link to Item
  - Fischi, MC, Trichon, B, Velazquez, E, Blazing, M, and O’Conner, C. "Making Two Wrongs Right – Case of Using a Patient’s Diabetes insipidus to Treat HisHeart Failure: Experience with Vasopress in Antagonists from Animal Studies and Clinical Trials." Heart Drug 3, no. 2 (2003): 107-112. Full Text
  - Duvall, WL, Blazing, MA, Saxena, S, and Guyton, JR. "Targeting cardiovascular risk associated with both low density and high density lipoproteins using statin–niacin combination therapy." European Journal of Cardiovascular Prevention &Amp; Rehabilitation 9, no. 6 (January 1, 2002): 339-347. Full Text
  - Hardenbergh, P, Munley, M, Hu, C, Hollis, D, Light, K, Blazing, M, Borges-Neto, S, Prosnitz, L, and Marks, L. "Doxorubicin-based chemotherapy and radiation increase cardiac perfusion changes in patients treated for left-sided breast cancer." Breast Cancer Research and Treatment 69, no. 3 (December 1, 2001): 231-null.
  - Whellan, DJ, Gaulden, L, Gattis, WA, Granger, B, Russell, SD, Blazing, MA, Cuffe, MS, and O'Connor, CM. "The benefit of implementing a heart failure disease management program." Arch Intern Med 161, no. 18 (October 8, 2001): 2223-2228. Link to Item
  - Blazing, MA, De Lemos, JA, Dyke, CK, Califf, RM, Bilheimer, D, and Braunwald, E. "The A-to-Z Trial: Methods and rationale for a single trial investigating combined use of low-molecular-weight heparin with the glycoprotein IIb/IIIa inhibitor tirofiban and defining the efficacy of early aggressive simvastatin therapy." American Heart Journal 142, no. 2 (August 2001): 211-217. Full Text
  - Jiang, W, Alexander, J, Christopher, E, Kuchibhatla, M, Gaulden, LH, Cuffe, MS, Blazing, MA, Davenport, C, Califf, RM, Krishnan, RR, and O'Connor, CM. "Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure." Archives of Internal Medicine 161, no. 15 (August 2001): 1849-1856. Full Text
  - Kong, DF, Blazing, MA, and O'Connor, CM. "Advances in the approach to acute coronary syndromes." Hosp Pract (1995) 35, no. 4 (April 15, 2000): 61-64. (Review) Link to Item
  - Guyton, JR, Blazing, MA, Hagar, J, Kashyap, ML, Knopp, RH, McKenney, JM, Nash, DT, and Nash, SD. "Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol." Archives of Internal Medicine 160, no. 8 (2000): 1177-1184.
  - Blazing, MA, and O'Connor, CM. "Evidence supporting secondary prevention strategies." Curr Opin Cardiol 14, no. 4 (July 1999): 303-309. (Review) Link to Item
  - Kong, DF, Blazing, MA, and O'Connor, CM. "The health care burden of unstable angina." Cardiol Clin 17, no. 2 (May 1999): 247-261. (Review) Link to Item
  - Orloff, DG, Blazing, MA, and O'Connor, CM. "Atherosclerotic disease in non-insulin-dependent diabetes mellitus: Role of abnormal lipids and the place for lipid-altering therapies." American Heart Journal 138, no. 5 I (January 1, 1999). Full Text
  - Channon, KM, Qian, H, Neplioueva, V, Blazing, MA, Olmez, E, Shetty, GA, Youngblood, SA, Pawloski, J, McMahon, T, Stamler, JS, and George, SE. "In vivo gene transfer of nitric oxide synthase enhances vasomotor function in carotid arteries from normal and cholesterol-Fed rabbits." Circulation 98, no. 18 (November 3, 1998): 1905-1911. Link to Item
  - Channon, KM, Qian, HS, Youngblood, SA, Olmez, E, Shetty, GA, Neplioueva, V, Blazing, MA, and George, SE. "Acute host-mediated endothelial injury after adenoviral gene transfer in normal rabbit arteries: impact on transgene expression and endothelial function." Circ Res 82, no. 12 (June 29, 1998): 1253-1262. Link to Item
  - Channon, KM, Qian, HS, Neplioueva, V, Blazing, MA, Olmez, E, Shetty, GA, Pawloski, J, Mc Mahon, T, Stamler, JS, and George, SE. "Nitric oxide synthase gene transfer corrects deficient endothelial vasmotor function in hypercholesterolaemic rabbits." Heart 79, no. SUPPL. 1 (May 1, 1998).
  - Gachhui, R, Abu-Soud, HM, Ghosha, DK, Presta, A, Blazing, MA, Mayer, B, George, SE, and Stuehr, DJ. "Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras." The Journal of Biological Chemistry 273, no. 10 (March 1998): 5451-5454. Full Text
  - Channon, KM, Fulton, GJ, Gray, JL, Annex, BH, Shetty, GA, Blazing, MA, Peters, KG, Hagen, PO, and George, SE. "Efficient adenoviral gene transfer to early venous bypass grafts: comparison with native vessels." Cardiovasc Res 35, no. 3 (September 1997): 505-513. Link to Item
  - "In vivo pulmonary artery adenoviral gene transfer of nitric oxide synthase enhances pulmonary nitric oxide production." Heart 77, no. SUPPL. 1 (May 1, 1997).
  - Channon, KM, Blazing, MA, Pawloski, J, McMahon, T, Olmez, E, Shetty, GA, Stamler, JS, and George, SE. "In vivo adenoviral gene transfer of nitric oxide synthase augments or restores vascular no production." Heart 77, no. SUPPL. 1 (May 1, 1997).
  - Channon, KM, Youngblood, SA, Olmez, E, Shetty, GA, Blazing, MA, and George, SE. "Optimising adenoviral vascular gene transfer in vivo: Impact of early acute inflammation on transgene expression and vasomotor function." Heart 77, no. SUPPL. 1 (May 1, 1997).
  - Davies, MG, Annex, BH, Fulton, GJ, Denning, SM, Taylor, DA, Blazing, MA, Peters, KG, Channon, KM, George, SE, and Hagen, PO. "Alteration of Arterial Vasomotor Function in Vitro by Gene Transfer with a Replication-Deficient Adenovirus." Vascular and Endovascular Surgery 31, no. 2 (January 1, 1997): 131-136. Full Text
  - Gachhui, R, Abu-Soud, HM, Ghosh, DK, Presta, A, Blazing, MA, Mayert, B, George, SE, and Stuehrt, DJ. "Neuronal no synthase interaction with calmodulintroponin C chimeras: Divergent activation of catalytic functions and its relationship to reduction of flavin or heme centers." FASEB Journal 11, no. 9 (1997): A788-.
  - Channon, KM, Blazing, MA, Shetty, GA, Potts, KE, and George, SE. "Adenoviral gene transfer of nitric oxide synthase: high level expression in human vascular cells." Cardiovascular Research 32, no. 5 (November 1996): 962-972. Full Text
  - Channon, KM, Blazing, MA, and George, SE. "Vascular gene transfer." Heart 75, no. 3 (March 1996): 215-217. Link to Item
  - Channon, KM, Fulton, GJ, Shetty, GA, Annex, BH, Blazing, MA, Peters, KG, Hagen, PO, and Georoe, SE. "Adenoviral gene transfer to intact and denuded arteries: A quantitative, comparative study." Journal of Investigative Medicine 44, no. 3 (January 1, 1996).
  - Youngblood, SA, Channon, KM, Shetty, GA, Blazing, MA, and George, SE. "In-vivo vs. ex-vivo adenoviral gene transfer to rabbit carotid artery: A comparative study of transgene expression." Journal of Investigative Medicine 44, no. 3 (January 1, 1996).
  - Su, Z, Blazing, MA, Fan, D, and George, SE. "The calmodulin-nitric oxide synthase interaction. Critical role of the calmodulin latch domain in enzyme activation." J Biol Chem 270, no. 49 (December 8, 1995): 29117-29122. Link to Item
  - Schwarz, JK, Bassing, CH, Kovesdi, I, Datto, MB, Blazing, M, George, S, Wang, XF, and Nevins, JR. "Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression." Proc Natl Acad Sci U S A 92, no. 2 (January 17, 1995): 483-487. Link to Item
  - Blazing, MA, and Morris, JJ. "Atrial fibrillation: conventional wisdom reappraised." Heart Dis Stroke 1, no. 2 (March 1992): 78-84. (Review) Link to Item
  - Ulrich, SK, and Blazing, MA. "Ethical dilemmas in emergency practice." Topics in Emergency Medicine 13, no. 3 (January 1, 1991): 22-34.
- Conference Papers
  - Evans, E, Yu, X, Prosnitz, R, Zhou, S, Wong, T, Light, K, Hardenbergh, P, Blazing, M, and Marks, L. "SU-FF-J-131: Is There a Relationship Between Body Mass Index, Treatment Set-Up Errors, and the Development of Myocardial Perfusion Defects Following Radiation Therapy for Left-Sided Breast Cancer?." June 2006. Full Text
  - Zeng, J, Zhang, J, Koweek, L, Blazing, M, Zhou, S, and Marks, L. "SU‐FF‐T‐119: Cardiac Dose Heterogeneity and Relationship to Tumor Location in Patients Receiving Radiation for Lung Cancer." January 1, 2006. Full Text

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Conference Papers