Scholars@Duke
Bo Hu

Bo Hu

Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics

Selected Publications

Efficacy and safety of passive immunotherapies targeting amyloid beta in Alzheimer's disease: A systematic review and meta-analysis.

Journal Article PLoS Med · March 2025 BACKGROUND: While recently U.S. FDA-approved anti-amyloid beta (anti-Aβ) monoclonal antibodies (mAbs) offer new treatment approaches for patients suffering from Alzheimer's disease (AD), these medications also carry potential safety concerns and uncertaint ... Full text Link to item Cite

Long-Term Outcomes of Medical Management vs Bariatric Surgery in Type 2 Diabetes

Journal Article JAMA · February 27, 2024 ImportanceRandomized clinical trials of bariatric surgery have been limited in size, type of surgical procedure, and follow-up duration.ObjectiveTo de ... Full text Cite

Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression

Journal Article New England Journal of Medicine · September 7, 2023 Full text Cite

Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression

Journal Article New England Journal of Medicine · June 22, 2023 Full text Cite

Brain single cell transcriptomic profiles in episodic memory phenotypes associated with temporal lobe epilepsy.

Journal Article NPJ Genom Med · November 29, 2022 Memory dysfunction is prevalent in temporal lobe epilepsy (TLE), but little is known about the underlying molecular etiologies. Single-nucleus RNA sequencing technology was used to examine differences in cellular heterogeneity among left (language-dominant ... Full text Link to item Cite

Derivation and Validation of a Risk Factor Model to Identify Medical Inpatients at Risk for Venous Thromboembolism

Journal Article Thrombosis and Haemostasis · July 2022 Abstract Background Venous thromboembolism (VTE) prophylaxis is recommended for hospitalized medical patients at high risk for VTE. Multiple risk assessment models exist, but few have been compared in large datase ... Full text Cite

Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach.

Journal Article Transl Psychiatry · April 4, 2022 We investigated gene-environment effects on structural brain endophenotype in bipolar disorder (BD) using a novel method of combining polygenic risk scores with epigenetic signatures since traditional methods of examining the family history and trauma effe ... Full text Link to item Cite

Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA.

Journal Article Mitochondrion · May 2021 Mitochondrial dysfunction has emerged to be associated with a broad spectrum of diseases, and there is an increasing demand for accurate detection of mitochondrial DNA (mtDNA) variants. Whole genome sequencing (WGS) has been the dominant sequencing approac ... Full text Link to item Cite

Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity.

Journal Article Nat Commun · January 11, 2021 The pathogenesis of ulcerative colitis (UC), a major type of inflammatory bowel disease, remains unknown. No model exists that adequately recapitulates the complexity of clinical UC. Here, we take advantage of induced pluripotent stem cells (iPSCs) to deve ... Full text Open Access Link to item Cite

Integrative analysis of lithium treatment associated effects on brain structure and peripheral gene expression reveals novel molecular insights into mechanism of action

Journal Article Translational Psychiatry · April 6, 2020 AbstractLithium is a highly effective medication for bipolar disorder, but its mechanism of action remains unknown. In this study, brain MRI scans and blood samples for gene expression (total of 110 scans and 109 blood samp ... Full text Cite

A simple method to estimate the time-dependent receiver operating characteristic curve and the area under the curve with right censored data

Journal Article Statistical Methods in Medical Research · August 2018 The time-dependent receiver operating characteristic curve is often used to study the diagnostic accuracy of a single continuous biomarker, measured at baseline, on the onset of a disease condition when the disease onset may occur at different tim ... Full text Cite

Joint multiple imputation for longitudinal outcomes and clinical events that truncate longitudinal follow‐up

Journal Article Statistics in Medicine · July 30, 2016 Longitudinal cohort studies often collect both repeated measurements of longitudinal outcomes and times to clinical events whose occurrence precludes further longitudinal measurements. Although joint modeling of the clinical events and the longitud ... Full text Cite