Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Post-Doctoral Fellowship, Gene Therapy Center, University of North Carolina - Chapel Hill 2005 - 2009
  • Ph.D., The Hebrew University of Jerusalem (Israel) 2005
  • M.Sc., The Hebrew University of Jerusalem (Israel) 1998
  • Ph.D., Grodno State Medical University (Republic of Belarus) 1995
• 

  Duke Appointment History

  • Assistant Research Professor in the Department of Neurobiology, Neurobiology, Basic Science Departments 2016 - 2019
• Research
• 

  Selected Grants

  • Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's disease awarded by National Institutes of Health 2020 - 2025
  • Production of Adeno-Associated Vectors (AAVs) for Kallyope awarded by Kallyope, Inc 2019 - 2021
  • Production of lentiviral vectors (LVs) awarded by Falcon Therapeutics 2018 - 2019
  • Production of Adeno-Associated Vectors (AAVs) awarded by Kallyope, Inc 2018
• 

  External Relationships

  • CLAIRIgen
  • Seelos Therapeutics
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Tagliafierro, Lidia, Ekaterina Ilich, Malik Moncalvo, Jeffrey Gu, Ahila Sriskanda, Carole Grenier, Susan K. Murphy, Ornit Chiba-Falek, and Boris Kantor. “Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models.” J Vis Exp, no. 145 (March 29, 2019). https://doi.org/10.3791/59241.
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    • Kantor, Boris, Lidia Tagliafierro, Jeffrey Gu, Madison E. Zamora, Ekaterina Ilich, Carole Grenier, Zhiqing Y. Huang, Susan Murphy, and Ornit Chiba-Falek. “Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.” Mol Ther 26, no. 11 (November 7, 2018): 2638–49. https://doi.org/10.1016/j.ymthe.2018.08.019.
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    • Vijayraghavan, Sriram, and Boris Kantor. “A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells.” J Vis Exp, no. 130 (December 12, 2017). https://doi.org/10.3791/56915.
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    • Ortinski, Pavel I., Bernadette O’Donovan, Xiaoyu Dong, and Boris Kantor. “Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing.” Mol Ther Methods Clin Dev 5 (June 16, 2017): 153–64. https://doi.org/10.1016/j.omtm.2017.04.002.
       Full Text  Open Access Copy  Link to Item

  • Conference Papers

    • Asmus, Natalie, Malik Moncalvo, Wendy Dong, Ekaterina Ilich, Carmel Falek, Joseph Rittiner, Domenic Tringali, et al. “Epigenetic Downregulation of ApoE4 for Alzheimer's Disease.” In Molecular Therapy, 28:430–430, 2020.
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    • Chiba-Falek, Ornit, Domenic Tringali, Young Yun, Malik Molcavno, Angela Wei, Joseph Rittiner, Natalie Asmus, et al. “Allele Specific Knockdown of APOE e4 Expression: A Novel Platform for Precision Gene Therapy in Alzheimer's Disease.” In Molecular Therapy, 28:323–24, 2020.
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    • Kantor, Boris, Joseph Rittiner, Malik Moncalvo, Ekaterina Ilich, Wendy Dong, Natalie Asmus, Carmel Falek, et al. “Development of Lentiviral Platform for Allele-Specific Targeted Down-Regulation of APOEe4 Expression: Epigenetic Therapy for Precision Medicine in Alzheimer's Disease.” In Molecular Therapy, 28:431–32, 2020.
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    • Wei, Angela, Domenic Tringali, Natalie Asmus, Anna Yang, Boris Kantor, Misha Angrist, and Ornit Chiba-Falek. “An Isogenic hiPSC-Derived Model System for Establishing Gene Therapy Approaches in Alzheimer's Disease.” In Molecular Therapy, 28:481–481, 2020.
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    • Yang, Anna, Ornit Chiba-Falek, Boris Kantor, Angela Wei, Natalie Asmus, and Misha Angrist. “Implications of Gene Therapy for Alzheimer's.” In Molecular Therapy, 28:322–23, 2020.
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    • Chiba-Falek, Ornit, Lidia Tagliafierro, Ekaterina Ilich, Ahila Sriskanda, and Boris Kantor. “The New Epigenome-Editing Approach for Targeting Dysregulated SNCA Expression: Novel Target Validation for Next-Generation Drug Discovery.” In Molecular Therapy, 27:35–35. CELL PRESS, 2019.
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    • Kantor, Boris, Ekaterina Ilich, Lidia Tagliafierro, and Ornit Chiba-Falek. “Integrase-Deficient Lentiviral Vector for Efficient CRISPR/Cas9-Mediated Gene and Epigenome-Editing Applications.” In Molecular Therapy, 27:101–101. CELL PRESS, 2019.
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    • Lubbe, D., J. D. Altman, B. Kantor, D. R. Holmes, R. S. Schwartz, and B. J. Gersh. “By what mechanism does glucose-insulin-potassium improve survival following myocardial infarction?” In Journal of the American College of Cardiology, 37:353A-353A. ELSEVIER SCIENCE INC, 2001.
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• Teaching & Mentoring
• 

  Recent Courses

  • NEUROBIO 393: Research Independent Study 2020
  • NEUROSCI 495: Research Independent Study 3 2020
  • NEUROBIO 393: Research Independent Study 2019
  • NEUROSCI 494: Research Independent Study 2 2019
• Scholarly, Clinical, & Service Activities
• 

  Outreach & Engaged Scholarship

  • Bass Connections Team Leader. Gene Therapy for Alzheimer's Disease and Ethical Aspects of Genome Editing. 2020 - 2021  2020 - 2021
  • Bass Connections Team Leader. Gene Therapy in Alzheimer's Disease: Novel Therapies and Ethical Aspects of Somatic Gene Editing. 2019 - 2020  2019 - 2020

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