Boris Kantor
Associate Research Professor of Neurobiology
Kantor Lab, the Duke University Viral Vector Core, facilitates the use of virus-mediated tools for gene transfer by investigators across diverse fields of study such as systems neuroscience, stem cell biology, metabolism, aging, cancer biology and others. Services are open to researchers within the Duke University Medical Center, Duke University, as well as outside investigators, worldwide.
Current Appointments & Affiliations
- Associate Research Professor of Neurobiology, Neurobiology, Basic Science Departments 2019
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2019
Contact Information
- Box 3209, Durham, NC 27710
- Bryan Research Building, 311 Research Drive Room 213, Durham, NC 27710
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boris.kantor@duke.edu
(919) 681-1068
- Background
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Education, Training, & Certifications
- Postdoctoral Fellowship, Gene Therapy Center, University of North Carolina - Chapel Hill 2005 - 2009
- Ph.D., The Hebrew University of Jerusalem (Israel) 2005
- M.Sc., The Hebrew University of Jerusalem (Israel) 1998
- Ph.D., Grodno State Medical University (Republic of Belarus) 1995
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Previous Appointments & Affiliations
- Assistant Research Professor in the Department of Neurobiology, Neurobiology, Basic Science Departments 2016 - 2019
- Research
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Selected Grants
- Untangling the diversity in the genetic architecture of late-onset Alzheimer's disease using single cell multi-omics awarded by National Institutes of Health 2022 - 2025
- A novel gene-therapy strategy for Parkinson's disease (PD): Epigenome editing mediated-regulation of SNCA expression awarded by Michael J. Fox Foundation for Parkinson's Research 2022 - 2024
- Seelos SRA-PD Model Vectors Generation for CRO SLS004 awarded by Seelos Therapeutics 2022 - 2024
- Seelos SRA 009- Amplification and preparation of Adeno-associated vectors (AAVs) for production awarded by Seelos Therapeutics 2022 - 2023
- Production of Adeno-Associated Vectors (AAVs) for Kallyope awarded by Kallyope, Inc 2019 - 2023
- Production of lentiviral vectors (LVs) awarded by Falcon Therapeutics 2018 - 2019
- Production of Adeno-Associated Vectors (AAVs) awarded by Kallyope, Inc 2018
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External Relationships
- CLAIRIgene
- Seelos Therapeutics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Rittiner, Joseph, Mohanapriya Cumaran, Sahil Malhotra, and Boris Kantor. “Therapeutic modulation of gene expression in the disease state: Treatment strategies and approaches for the development of next-generation of the epigenetic drugs.” Front Bioeng Biotechnol 10 (2022): 1035543. https://doi.org/10.3389/fbioe.2022.1035543.Full Text Link to Item
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Dong, Wendy, and Boris Kantor. “Lentiviral Vectors for Delivery of Gene-Editing Systems Based on CRISPR/Cas: Current State and Perspectives.” Viruses 13, no. 7 (July 1, 2021). https://doi.org/10.3390/v13071288.Full Text Link to Item
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Hunanyan, Arsen S., Boris Kantor, Ram S. Puranam, Courtney Elliott, Angela McCall, Justin Dhindsa, Promila Pagadala, et al. “Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3Mashl/+, Mouse Model of Alternating Hemiplegia of Childhood.” Hum Gene Ther 32, no. 7–8 (April 2021): 405–19. https://doi.org/10.1089/hum.2020.191.Full Text Link to Item
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MacDougall, Gabriella, Logan Y. Brown, Boris Kantor, and Ornit Chiba-Falek. “The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models.” Mol Ther 29, no. 3 (March 3, 2021): 949–72. https://doi.org/10.1016/j.ymthe.2021.01.001.Full Text Link to Item
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Yang, Anna, Boris Kantor, and Ornit Chiba-Falek. “APOE: The New Frontier in the Development of a Therapeutic Target towards Precision Medicine in Late-Onset Alzheimer's.” Int J Mol Sci 22, no. 3 (January 27, 2021). https://doi.org/10.3390/ijms22031244.Full Text Link to Item
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Gu, Jeffrey, Julio Barrera, Young Yun, Susan K. Murphy, Thomas G. Beach, Randy L. Woltjer, Geidy E. Serrano, Boris Kantor, and Ornit Chiba-Falek. “Cell-Type Specific Changes in DNA Methylation of SNCA Intron 1 in Synucleinopathy Brains.” Front Neurosci 15 (2021): 652226. https://doi.org/10.3389/fnins.2021.652226.Full Text Link to Item
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Brown, Logan Y., Wendy Dong, and Boris Kantor. “An Improved Protocol for the Production of Lentiviral Vectors.” Star Protoc 1, no. 3 (December 18, 2020): 100152. https://doi.org/10.1016/j.xpro.2020.100152.Full Text Link to Item
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Chen, Vivian, Malik Moncalvo, Dominic Tringali, Lidia Tagliafierro, Ahila Shriskanda, Ekaterina Ilich, Wendy Dong, Boris Kantor, and Ornit Chiba-Falek. “The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations.” Hum Mol Genet 29, no. 18 (November 4, 2020): 3107–21. https://doi.org/10.1093/hmg/ddaa183.Full Text Link to Item
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Angrist, Misha, Anna Yang, Boris Kantor, and Ornit Chiba-Falek. “Good problems to have? Policy and societal implications of a disease-modifying therapy for presymptomatic late-onset Alzheimer's disease.” Life Sci Soc Policy 16, no. 1 (October 12, 2020): 11. https://doi.org/10.1186/s40504-020-00106-2.Full Text Link to Item
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Uchitel, Julie, Boris Kantor, Edward C. Smith, and Mohamad A. Mikati. “Viral-Mediated Gene Replacement Therapy in the Developing Central Nervous System: Current Status and Future Directions.” Pediatr Neurol 110 (September 2020): 5–19. https://doi.org/10.1016/j.pediatrneurol.2020.04.010.Full Text Link to Item
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Rittiner, Joseph Edward, Malik Moncalvo, Ornit Chiba-Falek, and Boris Kantor. “Gene-Editing Technologies Paired With Viral Vectors for Translational Research Into Neurodegenerative Diseases.” Front Mol Neurosci 13 (2020): 148. https://doi.org/10.3389/fnmol.2020.00148.Full Text Link to Item
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Tagliafierro, Lidia, Ekaterina Ilich, Malik Moncalvo, Jeffrey Gu, Ahila Sriskanda, Carole Grenier, Susan K. Murphy, Ornit Chiba-Falek, and Boris Kantor. “Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models.” J Vis Exp, no. 145 (March 29, 2019). https://doi.org/10.3791/59241.Full Text Link to Item
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Kantor, Boris, Lidia Tagliafierro, Jeffrey Gu, Madison E. Zamora, Ekaterina Ilich, Carole Grenier, Zhiqing Y. Huang, Susan Murphy, and Ornit Chiba-Falek. “Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.” Mol Ther 26, no. 11 (November 7, 2018): 2638–49. https://doi.org/10.1016/j.ymthe.2018.08.019.Full Text Link to Item
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Vijayraghavan, Sriram, and Boris Kantor. “A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells.” J Vis Exp, no. 130 (December 12, 2017). https://doi.org/10.3791/56915.Full Text Open Access Copy Link to Item
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Manuel, Allison M., Michael D. Walla, Adam Faccenda, Stephanie L. Martin, Ross M. Tanis, Gerardo G. Piroli, Julie Adam, et al. “Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes.” Antioxid Redox Signal 27, no. 16 (December 1, 2017): 1281–96. https://doi.org/10.1089/ars.2016.6853.Full Text Link to Item
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Ortinski, Pavel I., Bernadette O’Donovan, Xiaoyu Dong, and Boris Kantor. “Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing.” Mol Ther Methods Clin Dev 5 (June 16, 2017): 153–64. https://doi.org/10.1016/j.omtm.2017.04.002.Full Text Open Access Copy Link to Item
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Titus, Mark A., Brian Zeithaml, Boris Kantor, Xiangping Li, Karin Haack, Dominic T. Moore, Elizabeth M. Wilson, James L. Mohler, and Tal Kafri. “Dominant-negative androgen receptor inhibition of intracrine androgen-dependent growth of castration-recurrent prostate cancer.” Plos One 7, no. 1 (2012): e30192. https://doi.org/10.1371/journal.pone.0030192.Full Text Link to Item
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Johnson, Jarrod S., Martina Gentzsch, Liqun Zhang, Carla M. P. Ribeiro, Boris Kantor, Tal Kafri, Raymond J. Pickles, and R Jude Samulski. “AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.” Plos Pathog 7, no. 5 (May 2011): e1002053. https://doi.org/10.1371/journal.ppat.1002053.Full Text Link to Item
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Kantor, B., M. Bayer, H. Ma, J. Samulski, C. Li, T. McCown, and T. Kafri. “Notable reduction in illegitimate integration mediated by a PPT-deleted, nonintegrating lentiviral vector.” Molecular Therapy 19, no. 3 (January 1, 2011): 547–56. https://doi.org/10.1038/mt.2010.277.Full Text
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Monahan, P. E., C. D. Lothrop, J. Sun, M. L. Hirsch, T. Kafri, B. Kantor, R. Sarkar, D. M. Tillson, J. R. Elia, and R. J. Samulski. “Proteasome inhibitors enhance gene delivery by AAV virus vectors expressing large genomes in hemophilia mouse and dog models: A strategy for broad clinical application.” Molecular Therapy 18, no. 11 (January 1, 2010): 1907–16. https://doi.org/10.1038/mt.2010.170.Full Text
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Kantor, Boris, Hong Ma, Jennifer Webster-Cyriaque, Paul E. Monahan, and Tal Kafri. “Epigenetic activation of unintegrated HIV-1 genomes by gut-associated short chain fatty acids and its implications for HIV infection.” Proc Natl Acad Sci U S A 106, no. 44 (November 3, 2009): 18786–91. https://doi.org/10.1073/pnas.0905859106.Full Text Link to Item
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Bayer, Matthew, Boris Kantor, Adam Cockrell, Hong Ma, Brian Zeithaml, Xiangping Li, Thomas McCown, and Tal Kafri. “A large U3 deletion causes increased in vivo expression from a nonintegrating lentiviral vector.” Mol Ther 16, no. 12 (December 2008): 1968–76. https://doi.org/10.1038/mt.2008.199.Full Text Link to Item
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Razin, Aharon, and Boris Kantor. “DNA methylation in epigenetic control of gene expression.” Prog Mol Subcell Biol 38 (2005): 151–67. https://doi.org/10.1007/3-540-27310-7_6.Full Text Link to Item
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Kantor, Boris, Yotam Kaufman, Kirill Makedonski, Aharon Razin, and Ruth Shemer. “Establishing the epigenetic status of the Prader-Willi/Angelman imprinting center in the gametes and embryo.” Hum Mol Genet 13, no. 22 (November 15, 2004): 2767–79. https://doi.org/10.1093/hmg/ddh290.Full Text Link to Item
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Kantor, Boris, Kirill Makedonski, Yael Green-Finberg, Ruth Shemer, and Aharon Razin. “Control elements within the PWS/AS imprinting box and their function in the imprinting process.” Hum Mol Genet 13, no. 7 (April 1, 2004): 751–62. https://doi.org/10.1093/hmg/ddh085.Full Text Link to Item
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Kantor, Boris, Kirill Makedonski, Ruth Shemer, and Aharon Razin. “Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo.” Gene Expr Patterns 3, no. 6 (December 2003): 697–702. https://doi.org/10.1016/j.modgep.2003.07.003.Full Text Link to Item
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Green Finberg, Yael, Boris Kantor, Alon Y. Hershko, and Aharon Razin. “Characterization of the human Snrpn minimal promoter and cis elements within it.” Gene 304 (January 30, 2003): 201–6. https://doi.org/10.1016/s0378-1119(02)01212-x.Full Text Link to Item
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Temkin, Vladislav, Boris Kantor, Vivian Weg, Mor-Li Hartman, and Francesca Levi-Schaffer. “Tryptase activates the mitogen-activated protein kinase/activator protein-1 pathway in human peripheral blood eosinophils, causing cytokine production and release.” J Immunol 169, no. 5 (September 1, 2002): 2662–69. https://doi.org/10.4049/jimmunol.169.5.2662.Full Text Link to Item
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Hershko, A. Y., Y. Finberg, B. Kantor, R. Shemer, and A. Razin. “The mouse Snrpn minimal promoter and its human orthologue: activity and imprinting.” Genes Cells 6, no. 11 (November 2001): 967–75. https://doi.org/10.1046/j.1365-2443.2001.00474.x.Full Text Link to Item
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Book Sections
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Kantor, B., and O. Chiba-Falek. “Lentiviral vectors as the delivery vehicles for transduction into iPSCs: Shortcomings and benefits.” In Methods in IPSC Technology, 79–100, 2021. https://doi.org/10.1016/B978-0-323-85766-6.00005-X.Full Text
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Kantor, Boris, Rachel M. Bailey, Keon Wimberly, Sahana N. Kalburgi, and Steven J. Gray. “Methods for gene transfer to the central nervous system.,” 87:125–97, 2014. https://doi.org/10.1016/B978-0-12-800149-3.00003-2.Full Text Link to Item
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Kantor, Boris, Thomas McCown, Paola Leone, and Steven J. Gray. “Clinical applications involving CNS gene transfer.,” 87:71–124, 2014. https://doi.org/10.1016/B978-0-12-800149-3.00002-0.Full Text Link to Item
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Conference Papers
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Asmus, Natalie, and Boris Kantor. “CRISPR/Cas9 Inducible Systems for Neurodegenerative Disease.” In Molecular Therapy, 29:415–415, 2021.Link to Item
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Chiba-Falek, Ornit, Ashley Kilgore, Gabriella MacDougall, Joseph Rittiner, and Boris Kantor. “Epigenome-Base Strategies for Efficient and Safe Editing of APOE epsilon 4 Allele: Implications for Alzheimer's Disease.” In Molecular Therapy, 29:200–200, 2021.Link to Item
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Gupta, Ishika, Boris Kantor, Ornit Chiba-Falek, and Misha Angrist. “Policies and Pitfalls: What the Alzheimer's Community Can Learn from the Deployment of Disease-Modifying Therapies for Multiple Sclerosis Patients.” In Molecular Therapy, 29:278–278, 2021.Link to Item
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Kantor, Boris, Wendy Dong, Joseph Rittiner, Jordan Poe, and Ornit Chiba-Falek. “Downregulation of SNCA Expression as a Therapoetic Approach for Parkinson's Disease and Other Synucleinopathies: New Target Validation for Next-Generation Drug Discovery.” In Molecular Therapy, 29:265–66, 2021.Link to Item
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Yang, Anna, Boris Kantor, and Ornit Chiba-Falek. “The New Frontier in the Development of LOAD Therapies Targeting APOE.” In Molecular Therapy, 29:203–203, 2021.Link to Item
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Asmus, Natalie, Malik Moncalvo, Wendy Dong, Ekaterina Ilich, Carmel Falek, Joseph Rittiner, Domenic Tringali, et al. “Epigenetic Downregulation of ApoE4 for Alzheimer's Disease.” In Molecular Therapy, 28:430–430, 2020.Link to Item
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Chiba-Falek, Ornit, Domenic Tringali, Young Yun, Malik Molcavno, Angela Wei, Joseph Rittiner, Natalie Asmus, et al. “Allele Specific Knockdown of APOE e4 Expression: A Novel Platform for Precision Gene Therapy in Alzheimer's Disease.” In Molecular Therapy, 28:323–24, 2020.Link to Item
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Kantor, Boris, Joseph Rittiner, Malik Moncalvo, Ekaterina Ilich, Wendy Dong, Natalie Asmus, Carmel Falek, et al. “Development of Lentiviral Platform for Allele-Specific Targeted Down-Regulation of APOEe4 Expression: Epigenetic Therapy for Precision Medicine in Alzheimer's Disease.” In Molecular Therapy, 28:431–32, 2020.Link to Item
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Wei, Angela, Domenic Tringali, Natalie Asmus, Anna Yang, Boris Kantor, Misha Angrist, and Ornit Chiba-Falek. “An Isogenic hiPSC-Derived Model System for Establishing Gene Therapy Approaches in Alzheimer's Disease.” In Molecular Therapy, 28:481–481, 2020.Link to Item
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Yang, Anna, Ornit Chiba-Falek, Boris Kantor, Angela Wei, Natalie Asmus, and Misha Angrist. “Implications of Gene Therapy for Alzheimer's.” In Molecular Therapy, 28:322–23, 2020.Link to Item
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Chiba-Falek, Ornit, Lidia Tagliafierro, Ekaterina Ilich, Ahila Sriskanda, and Boris Kantor. “The New Epigenome-Editing Approach for Targeting Dysregulated SNCA Expression: Novel Target Validation for Next-Generation Drug Discovery.” In Molecular Therapy, 27:35–35. CELL PRESS, 2019.Link to Item
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Kantor, Boris, Ekaterina Ilich, Lidia Tagliafierro, and Ornit Chiba-Falek. “Integrase-Deficient Lentiviral Vector for Efficient CRISPR/Cas9-Mediated Gene and Epigenome-Editing Applications.” In Molecular Therapy, 27:101–101. CELL PRESS, 2019.Link to Item
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Kantor, B., R. Shemer, and A. Razin. “The Prader-Willi/Angelman imprinted domain and its control center.” In Cytogenet Genome Res, 113:300–305, 2006. https://doi.org/10.1159/000090845.Full Text Link to Item
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Lubbe, D., J. D. Altman, B. Kantor, D. R. Holmes, R. S. Schwartz, and B. J. Gersh. “By what mechanism does glucose-insulin-potassium improve survival following myocardial infarction?” In Journal of the American College of Cardiology, 37:353A-353A. ELSEVIER SCIENCE INC, 2001.Link to Item
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- Teaching & Mentoring
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Recent Courses
- BRAINSOC 395-1: Bass Connections in Brain and Society: Interdisciplinary Team Projects 2022
- BRAINSOC 395: Bass Connections in Brain and Society: Interdisciplinary Team Projects 2022
- BRAINSOC 395T: Bass Connections in Brain & Society Research Team 2022
- BRAINSOC 396-1: Bass Connections in Brain and Society 2: Interdisciplinary Team Projects 2022
- BRAINSOC 396: Bass Connections in Brain and Society 2: Interdisciplinary Team Projects 2022
- BRAINSOC 396T: Bass Connections in Brain & Society Research Team 2022
- BRAINSOC 397-1: Bass Connections in Brain and Society 3: Interdisciplinary Team Projects 2022
- BRAINSOC 397T: Bass Connections in Brain & Society Research Team 2022
- BRAINSOC 398-1: Bass Connections in Brain and Society 4: Interdisciplinary Team Projects 2022
- BRAINSOC 398: Bass Connections in Brain and Society 4: Interdisciplinary Team Projects 2022
- BRAINSOC 398T: Bass Connections in Brain & Society Research Team 2022
- BRAINSOC 795T: Bass Connections in Brain & Society Research Team 2022
- BRAINSOC 796T: Bass Connections in Brain & Society Research Team 2022
- NEUROSCI 493: Research Independent Study 1 2022
- NEUROSCI 494: Research Independent Study 2 2022
- BRAINSOC 395-1: Bass Connections in Brain and Society: Interdisciplinary Team Projects 2021
- BRAINSOC 395: Bass Connections in Brain and Society: Interdisciplinary Team Projects 2021
- BRAINSOC 395T: Bass Connections in Brain & Society Research Team 2021
- BRAINSOC 396-1: Bass Connections in Brain and Society 2: Interdisciplinary Team Projects 2021
- BRAINSOC 396: Bass Connections in Brain and Society 2: Interdisciplinary Team Projects 2021
- BRAINSOC 396T: Bass Connections in Brain & Society Research Team 2021
- BRAINSOC 397-1: Bass Connections in Brain and Society 3: Interdisciplinary Team Projects 2021
- BRAINSOC 397T: Bass Connections in Brain & Society Research Team 2021
- BRAINSOC 398-1: Bass Connections in Brain and Society 4: Interdisciplinary Team Projects 2021
- BRAINSOC 398: Bass Connections in Brain and Society 4: Interdisciplinary Team Projects 2021
- BRAINSOC 398T: Bass Connections in Brain & Society Research Team 2021
- BRAINSOC 795T: Bass Connections in Brain & Society Research Team 2021
- BRAINSOC 796T: Bass Connections in Brain & Society Research Team 2021
- NEUROBIO 393: Research Independent Study 2021
- NEUROSCI 493: Research Independent Study 1 2021
- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
- Bass Connections Team Leader. Treating Alzheimer's with Gene Therapy and the Ethical, Legal and Social Implications. 2021 - 2022 2021 - 2022
- Bass Connections Team Leader. Gene Therapy for Alzheimer's Disease and Ethical Aspects of Genome Editing. 2020 - 2021 2020 - 2021
- Bass Connections Team Leader. Gene Therapy in Alzheimer's Disease: Novel Therapies and Ethical Aspects of Somatic Gene Editing. 2019 - 2020 2019 - 2020
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