Boris Kantor | Scholars@Duke

Boris Kantor
Associate Research Professor of Neurobiology

Kantor Lab, the Duke University Viral Vector Core, facilitates the use of virus-mediated tools for gene transfer by investigators across diverse fields of study such as systems neuroscience, stem cell biology, metabolism, aging, cancer biology and others. Services are open to researchers within the Duke University Medical Center, Duke University, as well as outside investigators, worldwide.

Current Appointments & Affiliations

Associate Research Professor of Neurobiology, Neurobiology, Basic Science Departments 2019
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2019

Contact Information

Box 3209, Durham, NC 27710
Bryan Research Building, 311 Research Drive Room 213, Durham, NC 27710
boris.kantor@duke.edu (919) 681-1068

Background
Education, Training, & Certifications
- Post-Doctoral Fellowship, Gene Therapy Center, University of North Carolina - Chapel Hill 2005 - 2009
- Ph.D., The Hebrew University of Jerusalem (Israel) 2005
- M.Sc., The Hebrew University of Jerusalem (Israel) 1998
- Ph.D., Grodno State Medical University (Republic of Belarus) 1995
Duke Appointment History
- Assistant Research Professor in the Department of Neurobiology, Neurobiology, Basic Science Departments 2016 - 2019
Research
Selected Grants
- Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's disease awarded by National Institutes of Health 2020 - 2025
- Production of Adeno-Associated Vectors (AAVs) for Kallyope awarded by Kallyope, Inc 2019 - 2021
- Production of lentiviral vectors (LVs) awarded by Falcon Therapeutics 2018 - 2019
- Production of Adeno-Associated Vectors (AAVs) awarded by Kallyope, Inc 2018
External Relationships
- Seelos Therapeutics
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Hunanyan, Arsen S., Boris Kantor, Ram S. Puranam, Courtney Elliott, Angela McCall, Justin Dhindsa, Promila Pagadala, et al. “Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3Mashl/+, Mouse Model of Alternating Hemiplegia of Childhood.” Hum Gene Ther 32, no. 7–8 (April 2021): 405–19. https://doi.org/10.1089/hum.2020.191.
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  - MacDougall, Gabriella, Logan Y. Brown, Boris Kantor, and Ornit Chiba-Falek. “The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models.” Mol Ther 29, no. 3 (March 3, 2021): 949–72. https://doi.org/10.1016/j.ymthe.2021.01.001.
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  - Yang, Anna, Boris Kantor, and Ornit Chiba-Falek. “APOE: The New Frontier in the Development of a Therapeutic Target towards Precision Medicine in Late-Onset Alzheimer's.” Int J Mol Sci 22, no. 3 (January 27, 2021). https://doi.org/10.3390/ijms22031244.
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  - Brown, Logan Y., Wendy Dong, and Boris Kantor. “An Improved Protocol for the Production of Lentiviral Vectors.” Star Protoc 1, no. 3 (December 18, 2020): 100152. https://doi.org/10.1016/j.xpro.2020.100152.
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  - Chen, Vivian, Malik Moncalvo, Dominic Tringali, Lidia Tagliafierro, Ahila Shriskanda, Ekaterina Ilich, Wendy Dong, Boris Kantor, and Ornit Chiba-Falek. “The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations.” Hum Mol Genet 29, no. 18 (November 4, 2020): 3107–21. https://doi.org/10.1093/hmg/ddaa183.
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  - Angrist, Misha, Anna Yang, Boris Kantor, and Ornit Chiba-Falek. “Good problems to have? Policy and societal implications of a disease-modifying therapy for presymptomatic late-onset Alzheimer's disease.” Life Sci Soc Policy 16, no. 1 (October 12, 2020): 11. https://doi.org/10.1186/s40504-020-00106-2.
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  - Uchitel, Julie, Boris Kantor, Edward C. Smith, and Mohamad A. Mikati. “Viral-Mediated Gene Replacement Therapy in the Developing Central Nervous System: Current Status and Future Directions.” Pediatr Neurol 110 (September 2020): 5–19. https://doi.org/10.1016/j.pediatrneurol.2020.04.010.
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  - Rittiner, Joseph Edward, Malik Moncalvo, Ornit Chiba-Falek, and Boris Kantor. “Gene-Editing Technologies Paired With Viral Vectors for Translational Research Into Neurodegenerative Diseases.” Front Mol Neurosci 13 (2020): 148. https://doi.org/10.3389/fnmol.2020.00148.
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  - Tagliafierro, Lidia, Ekaterina Ilich, Malik Moncalvo, Jeffrey Gu, Ahila Sriskanda, Carole Grenier, Susan K. Murphy, Ornit Chiba-Falek, and Boris Kantor. “Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models.” J Vis Exp, no. 145 (March 29, 2019). https://doi.org/10.3791/59241.
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  - Kantor, Boris, Lidia Tagliafierro, Jeffrey Gu, Madison E. Zamora, Ekaterina Ilich, Carole Grenier, Zhiqing Y. Huang, Susan Murphy, and Ornit Chiba-Falek. “Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.” Mol Ther 26, no. 11 (November 7, 2018): 2638–49. https://doi.org/10.1016/j.ymthe.2018.08.019.
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  - Vijayraghavan, Sriram, and Boris Kantor. “A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells.” J Vis Exp, no. 130 (December 12, 2017). https://doi.org/10.3791/56915.
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  - Ortinski, Pavel I., Bernadette O’Donovan, Xiaoyu Dong, and Boris Kantor. “Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing.” Mol Ther Methods Clin Dev 5 (June 16, 2017): 153–64. https://doi.org/10.1016/j.omtm.2017.04.002.
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- Conference Papers
  - Asmus, Natalie, Malik Moncalvo, Wendy Dong, Ekaterina Ilich, Carmel Falek, Joseph Rittiner, Domenic Tringali, et al. “Epigenetic Downregulation of ApoE4 for Alzheimer's Disease.” In Molecular Therapy, 28:430–430, 2020.
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  - Chiba-Falek, Ornit, Domenic Tringali, Young Yun, Malik Molcavno, Angela Wei, Joseph Rittiner, Natalie Asmus, et al. “Allele Specific Knockdown of APOE e4 Expression: A Novel Platform for Precision Gene Therapy in Alzheimer's Disease.” In Molecular Therapy, 28:323–24, 2020.
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  - Kantor, Boris, Joseph Rittiner, Malik Moncalvo, Ekaterina Ilich, Wendy Dong, Natalie Asmus, Carmel Falek, et al. “Development of Lentiviral Platform for Allele-Specific Targeted Down-Regulation of APOEe4 Expression: Epigenetic Therapy for Precision Medicine in Alzheimer's Disease.” In Molecular Therapy, 28:431–32, 2020.
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  - Wei, Angela, Domenic Tringali, Natalie Asmus, Anna Yang, Boris Kantor, Misha Angrist, and Ornit Chiba-Falek. “An Isogenic hiPSC-Derived Model System for Establishing Gene Therapy Approaches in Alzheimer's Disease.” In Molecular Therapy, 28:481–481, 2020.
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  - Yang, Anna, Ornit Chiba-Falek, Boris Kantor, Angela Wei, Natalie Asmus, and Misha Angrist. “Implications of Gene Therapy for Alzheimer's.” In Molecular Therapy, 28:322–23, 2020.
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  - Chiba-Falek, Ornit, Lidia Tagliafierro, Ekaterina Ilich, Ahila Sriskanda, and Boris Kantor. “The New Epigenome-Editing Approach for Targeting Dysregulated SNCA Expression: Novel Target Validation for Next-Generation Drug Discovery.” In Molecular Therapy, 27:35–35. CELL PRESS, 2019.
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  - Kantor, Boris, Ekaterina Ilich, Lidia Tagliafierro, and Ornit Chiba-Falek. “Integrase-Deficient Lentiviral Vector for Efficient CRISPR/Cas9-Mediated Gene and Epigenome-Editing Applications.” In Molecular Therapy, 27:101–101. CELL PRESS, 2019.
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  - Lubbe, D., J. D. Altman, B. Kantor, D. R. Holmes, R. S. Schwartz, and B. J. Gersh. “By what mechanism does glucose-insulin-potassium improve survival following myocardial infarction?” In Journal of the American College of Cardiology, 37:353A-353A. ELSEVIER SCIENCE INC, 2001.
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Teaching & Mentoring
Recent Courses
Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship
- Bass Connections Team Leader. Gene Therapy for Alzheimer's Disease and Ethical Aspects of Genome Editing. 2020 - 2021 2020 - 2021
- Bass Connections Team Leader. Gene Therapy in Alzheimer's Disease: Novel Therapies and Ethical Aspects of Somatic Gene Editing. 2019 - 2020 2019 - 2020

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers

Recent Courses

Outreach & Engaged Scholarship