Overview
Dr. Bowes Rickman is a highly accomplished translational scientist whose research efforts over two decades have been focused on the molecular/cell biology and pathobiology of age-related macular degeneration (AMD). In an effort to better understand the pathophysiology of AMD, she has created a number of murine models that recapitulate many aspects of human AMD and point the way toward eventual treatments for AMD. Among many cited seminal contributions is her discovery of a connection between complement and lipoprotein metabolism and AMD and the development of a murine model that closely mirrors findings in humans. Using these models, Dr. Bowes Rickman has dissected disease mechanisms that contribute to AMD risk, and tested multiple novel therapeutic targets for its treatment.
Current Appointments & Affiliations
George and Geneva Boguslavsky Distinguished Professor of Eye Research
·
2021 - Present
Ophthalmology, Vitreoretinal Diseases & Surgery,
Ophthalmology
Professor of Ophthalmology
·
2018 - Present
Ophthalmology, Vitreoretinal Diseases & Surgery,
Ophthalmology
Professor in Cell Biology
·
2020 - Present
Cell Biology,
Basic Science Departments
Recent Publications
Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision.
Journal Article bioRxiv · September 1, 2025 UNLABELLED: Oct4, Sox2, and Klf4 (OSK) Yamanaka factors induce pluripotency and reverse age-related epigenetic changes, yet the mechanisms by which they promote rejuvenation remain poorly explored. Oxidative stress contributes to CNS aging and retinal pigm ... Full text Link to item CiteTruncated complement factor H Y402 gene therapy rescues C3 glomerulonephritis.
Journal Article Mol Ther · August 6, 2025 There are no effective therapies for patients with dry age-related macular degeneration (AMD) or C3 glomerulonephritis (C3G). Unfortunately, past efforts to treat C3G using exogenous human complement factor H (CFH) found limited success due to immune rejec ... Full text Link to item CiteOptimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse.
Journal Article J Vis Exp · July 25, 2025 The conventional method of material delivery to the subretinal space in the mouse involves dual perforation of the neural retina, which causes extensive surgical damage. This leads to variability in the subsequent outcome measures of the visual function, s ... Full text Link to item CiteRecent Grants
Swept Source (SS-) OCT system for Ex-Vivo Imaging, and specialized human postmortem full tissue sample package preparation
ResearchPrincipal Investigator · Awarded by Janssen Research & Development, LLC · 2024 - 2028Gene therapy targeting CFH and lipoprotein dynamics in AMD
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2028Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027View All Grants
Education, Training & Certifications
University of California, Los Angeles ·
1989
Ph.D.
University of California, Los Angeles ·
1983
B.A.