Scholars@Duke
Brinnae Bent

Brinnae Bent

Executive in Residence in the Engineering Graduate and Professional Programs
Engineering Graduate and Professional Programs

Selected Publications

Goodbye Electronic Health Record?

Journal Article Stud Health Technol Inform · August 31, 2022 The Electronic Health Record has failed to meet its intended purpose. We propose a new approach focusing on the use of data for health and health care. The first step is to create a repository of all patient data with data storage independent of data use. ... Full text Link to item Cite

Demographic Imbalances Resulting From the Bring-Your-Own-Device Study Design.

Journal Article JMIR Mhealth Uhealth · April 8, 2022 Digital health technologies, such as smartphones and wearable devices, promise to revolutionize disease prevention, detection, and treatment. Recently, there has been a surge of digital health studies where data are collected through a bring-your-own-devic ... Full text Link to item Cite

Physiologic Response to the Pfizer-BioNTech COVID-19 Vaccine Measured Using Wearable Devices: Prospective Observational Study.

Journal Article JMIR formative research · August 2021 BackgroundThe Pfizer-BioNTech COVID-19 vaccine uses a novel messenger RNA technology to elicit a protective immune response. Short-term physiologic responses to the vaccine have not been studied using wearable devices.ObjectiveWe aim to c ... Full text Cite

Flexible, high-resolution thin-film electrodes for human and animal neural research.

Journal Article J Neural Eng · June 17, 2021 Objective.Brain functions such as perception, motor control, learning, and memory arise from the coordinated activity of neuronal assemblies distributed across multiple brain regions. While major progress has been made in understanding the function of indi ... Full text Link to item Cite

Engineering digital biomarkers of interstitial glucose from noninvasive smartwatches.

Journal Article NPJ Digit Med · June 2, 2021 Prediabetes affects one in three people and has a 10% annual conversion rate to type 2 diabetes without lifestyle or medical interventions. Management of glycemic health is essential to prevent progression to type 2 diabetes. However, there is currently no ... Full text Link to item Cite

Sufficient sampling for kriging prediction of cortical potential in rat, monkey, and human µECoG.

Journal Article J Neural Eng · March 8, 2021 Objective. Large channel count surface-based electrophysiology arrays (e.g. µECoG) are high-throughput neural interfaces with good chronic stability. Electrode spacing remains ad hoc due to redundancy and nonstationarity of field dynamics. Here, we establi ... Full text Link to item Cite

Digital Medicine Community Perspectives and Challenges: Survey Study.

Journal Article JMIR mHealth and uHealth · February 2021 BackgroundThe field of digital medicine has seen rapid growth over the past decade. With this unfettered growth, challenges surrounding interoperability have emerged as a critical barrier to translating digital medicine into practice. In order to ... Full text Cite

Biosignal Compression Toolbox for Digital Biomarker Discovery.

Journal Article Sensors (Basel, Switzerland) · January 2021 A critical challenge to using longitudinal wearable sensor biosignal data for healthcare applications and digital biomarker development is the exacerbation of the healthcare "data deluge," leading to new data storage and organization challenges and costs. ... Full text Cite

Cgmquantify: Python and R Software Packages for Comprehensive Analysis of Interstitial Glucose and Glycemic Variability from Continuous Glucose Monitor Data.

Journal Article IEEE open journal of engineering in medicine and biology · January 2021 Goal: Continuous glucose monitoring (CGM) is commonly used in Type 1 diabetes management by clinicians and patients and in diabetes research to understand how factors of longitudinal glucose and glucose variability relate to disease onset and severi ... Full text Cite

Wearables in the SARS-CoV-2 Pandemic: What Are They Good for?

Journal Article JMIR mHealth and uHealth · December 2020 Recently, companies such as Apple Inc, Fitbit Inc, and Garmin Ltd have released new wearable blood oxygenation measurement technologies. Although the release of these technologies has great potential for generating health-related information, it is importa ... Full text Cite

Wearables in the SARS-CoV-2 Pandemic: What Are They Good for? (Preprint)

Journal Article · October 19, 2020 UNSTRUCTUREDRecently, companies such as Apple Inc, Fitbit Inc, and Garmin Ltd have released new wearable blood oxygenation measurement technologies. Although the release of these technolo ... Full text Cite

Digital Medicine Community Perspectives and Challenges: Survey Study (Preprint)

Journal Article · September 24, 2020 BACKGROUNDThe field of digital medicine has seen rapid growth over the past decade. With this unfettered growth, challenges surrounding interoperability have emerged as a critical barrier ... Full text Cite

Optimizing sampling rate of wrist-worn optical sensors for physiologic monitoring.

Journal Article Journal of clinical and translational science · August 2020 IntroductionPersonalized medicine has exposed wearable sensors as new sources of biomedical data which are expected to accrue annual data storage costs of approximately $7.2 trillion by 2020 (>2000 exabytes). To improve the usability of wearable d ... Full text Cite

The digital biomarker discovery pipeline: An open-source software platform for the development of digital biomarkers using mHealth and wearables data.

Journal Article Journal of clinical and translational science · July 2020 IntroductionDigital health is rapidly expanding due to surging healthcare costs, deteriorating health outcomes, and the growing prevalence and accessibility of mobile health (mHealth) and wearable technology. Data from Biometric Monitoring Technol ... Full text Cite

EventDTW: An Improved Dynamic Time Warping Algorithm for Aligning Biomedical Signals of Nonuniform Sampling Frequencies.

Journal Article Sensors (Basel, Switzerland) · May 2020 The dynamic time warping (DTW) algorithm is widely used in pattern matching and sequence alignment tasks, including speech recognition and time series clustering. However, DTW algorithms perform poorly when aligning sequences of uneven sampling frequencies ... Full text Cite

Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates.

Journal Article Science translational medicine · April 2020 Long-lasting, high-resolution neural interfaces that are ultrathin and flexible are essential for precise brain mapping and high-performance neuroprosthetic systems. Scaling to sample thousands of sites across large brain regions requires integrating power ... Full text Cite

Investigating sources of inaccuracy in wearable optical heart rate sensors.

Journal Article NPJ Digit Med · 2020 As wearable technologies are being increasingly used for clinical research and healthcare, it is critical to understand their accuracy and determine how measurement errors may affect research conclusions and impact healthcare decision-making. Accuracy of w ... Full text Open Access Link to item Cite

Verification, analytical validation, and clinical validation (V3): the foundation of determining fit-for-purpose for Biometric Monitoring Technologies (BioMeTs).

Journal Article NPJ digital medicine · January 2020 Digital medicine is an interdisciplinary field, drawing together stakeholders with expertize in engineering, manufacturing, clinical science, data science, biostatistics, regulatory science, ethics, patient advocacy, and healthcare policy, to name a few. A ... Full text Cite

Simultaneous Recording and Stimulation Instrumentation for Closed Loop Spinal Cord Stimulation

Conference International IEEE/EMBS Conference on Neural Engineering, NER · May 16, 2019 Chronic neuropathic pain is a debilitating disorder. Many patients receive pain relief when implanted with a Spinal Cord Stimulation (SCS) system. However, there is currently no way to automatically determine the most effective parameters to use in stimula ... Full text Cite

Long-term recording reliability of liquid crystal polymer µECoG arrays.

Journal Article Journal of neural engineering · December 2018 ObjectiveThe clinical use of microsignals recorded over broad cortical regions is largely limited by the chronic reliability of the implanted interfaces.ApproachWe evaluated the chronic reliability of novel 61-channel micro-electrocortico ... Full text Cite

A Novel µECoG Electrode Interface for Comparison of Local and Common Averaged Referenced Signals.

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · July 2018 Micro-electrocorticography (µECoG) is a minimally invasive neural interface that allows for recording from the surface of the brain with high spatial and temporal resolution [1], [2]. However, discerning multi-unit and local field potential (LFP) activity ... Full text Cite

3D Printed Cranial Window System for Chronic μECoG Recording.

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · July 2018 Chronic studies of flexible μECoG electrodes and the electrode-brain interface have been limited by the inability to assess tissue response over time. The electrophysiological system presented here combines epidural microelectrocorticographic (μECoG) recor ... Full text Cite