Scholars@Duke
Bruno Chumpitazi

Bruno Chumpitazi

Instructor Temporary in the Department of Pediatrics
Pediatrics, Gastroenterology, Hepatology and Nutrition
bruno.chumpitazi@duke.edu
2400 Pratt Street, Room 8012, Durham, NC 27705
2400 Pratt Street, Room 8012, Durham, NC 27705

Selected Publications

Ineffective esophageal motility: Characterization and outcomes across pediatric neurogastroenterology and motility centers in the United States.

Journal Article J Pediatr Gastroenterol Nutr · September 2024 OBJECTIVES: Ineffective esophageal motility (IEM) on high-resolution manometry (HRM) is not consistently associated with specific clinical syndromes or outcomes. We evaluated the prevalence, clinical features, management, and outcomes of pediatric IEM pati ... Full text Link to item Cite

Factors Associated With Adherence to a Low Fermentable Carbohydrate Diet in Children With Functional Gastrointestinal Disorders.

Journal Article J Acad Nutr Diet · June 2024 BACKGROUND: The low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet (LFD) has been associated with reduced symptomology in pediatric functional gastrointestinal disorders (FGIDs). The LFD is a complex dietary interven ... Full text Link to item Cite

Avoidant/restrictive food intake disorder prevalence is high in children with gastroparesis and functional dyspepsia.

Journal Article Neurogastroenterol Motil · May 2024 BACKGROUND: Avoidant/restrictive food intake disorder (ARFID) prevalence in children with gastroparesis (Gp) and/or functional dyspepsia (FD) is unknown. We aimed to identify ARFID prevalence and trajectory over 2 months in children with Gp, FD, and health ... Full text Link to item Cite

Genetic and acquired sucrase-isomaltase deficiency: A clinical review.

Journal Article J Pediatr Gastroenterol Nutr · April 2024 Genetic sucrase-isomaltase deficiency (GSID) is an inherited deficiency in the ability to digest sucrose and potentially starch due to mutations in the sucrase-isomaltase (SI) gene. Congenital sucrase-isomaltase deficiency is historically considered to be ... Full text Link to item Cite

Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis.

Journal Article iScience · March 15, 2024 Gastrointestinal immune cells, particularly muscularis macrophages (MM) interact with the enteric nervous system and influence gastrointestinal motility. Here we determine the human gastric muscle immunome and its changes in patients with idiopathic gastro ... Full text Link to item Cite

Relationships among intragastric meal distribution during gastric emptying scintigraphy, water consumption during water load satiety testing, and symptoms of gastroparesis.

Journal Article Am J Physiol Gastrointest Liver Physiol · November 1, 2023 Gastric emptying scintigraphy (GES) measures total gastric retention after a solid meal and can assess intragastric meal distribution (IMD). Water load satiety test (WLST) measures gastric capacity. Both IMD immediately after meal ingestion [ratio of proxi ... Full text Link to item Cite

Diagnostic Utility of Mucosal Biopsies Taken During Colonoscopy-Guided Colonic Manometry Catheter Placement.

Journal Article J Pediatr Gastroenterol Nutr · November 1, 2023 OBJECTIVES: The diagnostic utility of mucosal biopsies taken during colonoscopy-guided colonic manometry catheter placement is unknown. The aims of our study were to determine the frequency and histopathology results of mucosal biopsies during these proced ... Full text Link to item Cite

A pilot genome-wide association study meta-analysis of gastroparesis.

Journal Article United European Gastroenterol J · October 2023 BACKGROUND: Gastroparesis (GP) is characterized by delayed gastric emptying in the absence of mechanical obstruction. OBJECTIVE: Genetic predisposition may play a role; however, investigation at the genome-wide level has not been performed. METHODS: We car ... Full text Link to item Cite

Many pediatric patients with gastroparesis do not receive dietary education.

Journal Article BMC Gastroenterol · July 17, 2023 BACKGROUND: Gastroparesis is delayed gastric emptying in the absence of obstruction; dietary modifications are first-line treatment. However, we do not know the factors related to provision of dietary recommendations. METHODS: We sought to determine how of ... Full text Link to item Cite

Gastrointestinal Symptoms Profile in Gastroparesis Compared to Other Functional and Organic Gastrointestinal Diseases.

Journal Article J Pediatr Gastroenterol Nutr · July 1, 2023 OBJECTIVES: The primary objective was to compare the patient-reported gastrointestinal symptoms profiles of pediatric patients with gastroparesis to pediatric patients with 1 of 7 other functional gastrointestinal disorders and organic gastrointestinal dis ... Full text Link to item Cite

Functional response to a microbial synbiotic in the gastrointestinal system of children: a randomized clinical trial.

Journal Article Pediatr Res · June 2023 BACKGROUND: Oral microbial therapy has been studied as an intervention for a range of gastrointestinal disorders. Though research suggests that microbial exposure may affect the gastrointestinal system, motility, and host immunity in a pediatric population ... Full text Link to item Cite

Characteristics and outcomes of patients with gastroparesis using enteral and/or exclusive parenteral nutrition.

Journal Article JPEN J Parenter Enteral Nutr · May 2023 BACKGROUND: Patients with gastroparesis (Gp) may need enteral nutrition (EN) or exclusive parenteral nutrition (PN). Among patients with Gp, we aimed to (1) identify the frequency of EN and exclusive PN use and (2) explore characteristics of patients using ... Full text Link to item Cite

Perspective: Assessing Tolerance to Nondigestible Carbohydrate Consumption.

Journal Article Adv Nutr · December 22, 2022 Human intestinal enzymes do not hydrolyze nondigestible carbohydrates (NDCs), and thus, they are not digested and absorbed in the small intestine. Instead, NDCs are partially to completely fermented by the intestinal microbiota. Select NDCs are associated ... Full text Link to item Cite

Progress in Gastroparesis - A Narrative Review of the Work of the Gastroparesis Clinical Research Consortium.

Journal Article Clin Gastroenterol Hepatol · December 2022 The Gastroparesis Clinical Research Consortium is a multicenter coalition created and funded by the National Institutes of Diabetes and Digestive and Kidney Disorders, with a mission to advance understanding of the pathophysiology of gastroparesis and deve ... Full text Link to item Cite

Dietary Interventions for Gastroparesis: A Systematic Review.

Journal Article Adv Nutr · October 2, 2022 Gastroparesis (Gp) is a delay in gastric emptying in the absence of a mechanical obstruction and has the capacity to cause symptoms that significantly impact a patient's quality of life. Dietary interventions are the first-line treatment in Gp, but the eff ... Full text Link to item Cite

Children with functional abdominal pain disorders successfully decrease FODMAP food intake on a low FODMAP diet with modest improvements in nutritional intake and diet quality.

Journal Article Neurogastroenterol Motil · October 2022 BACKGROUND: We sought to determine how a low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet (LFD) affected high FODMAP food intake, nutrient intake, and diet quality in children with functional abdominal pain disorders ... Full text Link to item Cite

Gastrointestinal Symptoms Profile in Pediatric Patients With Gastroparesis Compared to Healthy Controls.

Journal Article J Pediatr Gastroenterol Nutr · August 1, 2022 OBJECTIVES: The primary objective was to compare the patient-reported gastrointestinal symptoms profiles of pediatric patients with gastroparesis to matched healthy controls using the Pediatric Quality of Life Inventory™ (PedsQL™) Gastrointestinal Symptoms ... Full text Link to item Cite

Pediatric Rome IV diagnosis agreement is greater than agreement on diagnostic testing.

Journal Article Neurogastroenterol Motil · August 2022 BACKGROUND: Pediatric Rome IV criteria are used to diagnose childhood functional gastrointestinal disorders (FGIDs). This study of pediatric gastroenterology physicians measured their agreement in (1) Making a pediatric Rome IV FGID diagnosis; and (2) Diag ... Full text Link to item Cite

Pediatric Aspects of Nutrition Interventions for Disorders of Gut-Brain Interaction.

Journal Article Am J Gastroenterol · June 1, 2022 Dietary factors may play an important role in the generation of symptoms in children with disorders of gut-brain interaction (DGBIs). Although dietary modification may provide successful treatment, there is a relative paucity of controlled trials that have ... Full text Link to item Cite

Peppermint oil effects on the gut microbiome in children with functional abdominal pain.

Journal Article Clin Transl Sci · April 2022 Peppermint oil (PMO) is effective in the treatment of functional abdominal pain disorders, but its mechanism of action is unclear. Evidence suggests PMO has microbicidal activity. We investigated the effect of three different doses of PMO on gut microbiome ... Full text Link to item Cite

Randomised trial: Peppermint oil (menthol) pharmacokinetics in children and effects on gut motility in children with functional abdominal pain.

Journal Article Br J Clin Pharmacol · March 2022 AIMS: Little is known regarding the pharmacokinetics and pharmacodynamics of menthol, the active ingredient in peppermint oil (PMO). Our aim was to investigate the pharmacokinetics of menthol at 3 dose levels in children and determine their effects on gut ... Full text Link to item Cite

Multidisciplinary Care for Refractory Pediatric Functional Abdominal Pain Decreases Emergency and Inpatient Utilization.

Journal Article J Pediatr Gastroenterol Nutr · February 1, 2022 Children with refractory functional abdominal pain (FAP) experience functional disability and may utilize emergency department (ED) and/or inpatient services. Whether multidisciplinary programs which help care for children with refractory FAP affect acute ... Full text Link to item Cite

Gastric accommodation: Physiology, diagnostic modalities, clinical relevance, and therapies.

Journal Article Neurogastroenterol Motil · December 2021 BACKGROUND: Gastric accommodation is an essential gastric motor function which occurs following ingestion of a meal. Impaired gastric fundic accommodation (IFA) is associated with dyspeptic symptoms. Gastric accommodation is mediated by the vagal pathway w ... Full text Link to item Cite

Multisite Pain Is Highly Prevalent in Children with Functional Abdominal Pain Disorders and Is Associated with Increased Morbidity.

Journal Article J Pediatr · September 2021 OBJECTIVES: To characterize the types of multisite pain experienced by children with functional abdominal pain disorders (FAPDs) and to examine differences in psychosocial distress, functional disability, and health-related quality of life in children with ... Full text Link to item Cite

PedsQL™ Gastroparesis Symptoms Module Domain and Item Development: Qualitative Methods.

Journal Article J Pediatr Gastroenterol Nutr · August 1, 2021 OBJECTIVES: Like adults, children suffer from gastroparesis; however, there are currently no validated instruments to determine the impact of gastroparesis in pediatric patients. The objective of this study was to develop the items and domains to support t ... Full text Link to item Cite

Pediatric Tracheal Lobular Capillary Hemangioma: A Case Report and Review of the Literature.

Journal Article Laryngoscope · August 2021 Chronic cough is a common complaint in the pediatric population and can have many different etiologies. We present a rare case of a tracheal lobular capillary hemangioma (LCH), also known as pyogenic granuloma, causing chronic cough in a child. In this cas ... Full text Link to item Cite

Clinical Characterization of Pediatric Gastroparesis Using a Four-hour Gastric Emptying Scintigraphy Standard.

Journal Article J Pediatr Gastroenterol Nutr · June 1, 2021 OBJECTIVES: Four-hour gastric emptying scintigraphy (GES) is the recommended method to identify both adult and childhood gastroparesis (GP). Previous pediatric studies have, however, not used this standard. We sought to determine the characteristics and ou ... Full text Link to item Cite

Functional Dyspepsia and Gastroparesis in Tertiary Care are Interchangeable Syndromes With Common Clinical and Pathologic Features.

Journal Article Gastroenterology · May 2021 BACKGROUND: The aim of this study was to clarify the pathophysiology of functional dyspepsia (FD), a highly prevalent gastrointestinal syndrome, and its relationship with the better-understood syndrome of gastroparesis. METHODS: Adult patients with chronic ... Full text Link to item Cite

Meal-Induced Symptoms in Children with Dyspepsia-Relationships to Sex and the Presence of Gastroparesis.

Journal Article J Pediatr · April 2021 OBJECTIVES: To test the hypothesis that in children with dyspepsia, prospective symptom severity following ingestion of a meal would correlate with percent gastric retention, and those ultimately diagnosed with gastroparesis would report worse symptoms. ST ... Full text Link to item Cite

Outcomes of Non-anesthesiologist-Administered Propofol in Pediatric Gastroenterology Procedures

Journal Article Frontiers in Pediatrics · February 2, 2021 Background and Aims: Non-anesthesiologist-administered propofol (NAAP) has been found to have an acceptable safety profile in adult endoscopy, but its use remains controversial and pediatric data is limited. Our aim was to examine the safety and efficacy o ... Full text Cite

Fructan-sensitive children with irritable bowel syndrome have distinct gut microbiome signatures.

Journal Article Aliment Pharmacol Ther · February 2021 BACKGROUND: Dietary fructans may worsen gastrointestinal symptoms in children with irritable bowel syndrome (IBS). AIM: To determine whether gut microbiome composition and function are associated with childhood IBS fructan-induced symptoms. METHODS: Faecal ... Full text Link to item Cite

Development and Assessment of a Pictographic Pediatric Constipation Action Plan.

Journal Article J Pediatr · February 2021 OBJECTIVE: To assess the Uniformed Services Constipation Action Plan (USCAP) as an evidence-based, personalized, clinical action tool with pictograms to aid clinicians and families in the management of functional constipation. STUDY DESIGN: The USCAP facil ... Full text Link to item Cite

Development of a multidisciplinary colorectal and pelvic health program: Program implementation and clinical impact.

Journal Article J Pediatr Surg · November 2020 INTRODUCTION: Pediatric patients with complex colorectal and genitourinary conditions often require coordinated multidisciplinary care; however, this coordinated care can be hard to structure and deliver. The purpose of this paper is to review the developm ... Full text Link to item Cite

Does a Minority of Children With Functional Gastrointestinal Disorders Receive Formal Diet Advice?

Journal Article JPEN J Parenter Enteral Nutr · November 2020 BACKGROUND: Diet therapies may be recommended for pediatric functional gastrointestinal disorders (FGIDs). However, little is known about the frequency with which diet therapy is recommended in FGIDs. Our aims were to determine and contrast the frequency a ... Full text Link to item Cite

Proceedings of the 2018 Advances In Motility and In NeuroGastroenterology: AIMING for the Future Single Topic Symposium.

Journal Article J Pediatr Gastroenterol Nutr · August 2020 OBJECTIVES: Motility and functional disorders are common in children and often debilitating, yet these disorders remain challenging to treat effectively. At the 2018 Annual North American Society for Pediatric Gastroenterology, Hepatology and Nutrition mee ... Full text Link to item Cite

Endoscopic Ultrasound in an Adolescent With Rectal Adenocarcinoma and Lynch Syndrome

Journal Article Journal of Pediatric Gastroenterology and Nutrition · June 1, 2020 Full text Cite

Routine disaccharidase testing: are we there yet?

Journal Article Curr Opin Gastroenterol · March 2020 PURPOSE OF REVIEW: Disaccharidase testing, as applied to the evaluation of gastrointestinal disturbances is available but it is not routinely considered in the diagnostic work-up. The purpose of this review was to determine if disaccharidase testing is cli ... Full text Link to item Cite

The gut microbiome as a predictor of low fermentable oligosaccharides disaccharides monosaccharides and polyols diet efficacy in functional bowel disorders.

Journal Article Curr Opin Gastroenterol · March 2020 PURPOSE OF REVIEW: Fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAP) dietary restriction ameliorates irritable bowel syndrome (IBS) symptoms; however, not all individuals with IBS respond. Given the gut microbiome's role in ca ... Full text Link to item Cite

Literature Review: Dietary Intervention Adherence and Adherence Barriers in Functional Gastrointestinal Disorder Studies.

Journal Article J Clin Gastroenterol · March 2020 Dietary management is key in controlling functional gastrointestinal disorders (FGIDs) symptoms. However, the degree to which patients with FGIDs in clinical studies adhere to dietary recommendations is unknown. Our aim was to evaluate adherence, dietary e ... Full text Link to item Cite

Childhood gastroparesis is a unique entity in need of further investigation.

Journal Article Neurogastroenterol Motil · March 2020 BACKGROUND: Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for ... Full text Link to item Cite

Hypomorphic SI genetic variants are associated with childhood chronic loose stools.

Journal Article PLoS One · 2020 OBJECTIVE: The SI gene encodes the sucrase-isomaltase enzyme, a disaccharidase expressed in the intestinal brush border. Hypomorphic SI variants cause recessive congenital sucrase-isomaltase deficiency (CSID) and related gastrointestinal (GI) symptoms. Amo ... Full text Link to item Cite

Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome.

Journal Article J Mol Diagn · May 2019 Accurate diagnosis and stratification of children with irritable bowel syndrome (IBS) remain challenging. Given the central role of recurrent abdominal pain in IBS, we evaluated the relationships of pediatric IBS and abdominal pain with intestinal microbes ... Full text Link to item Cite

High-resolution manometric guidance during laparoscopic Heller myotomy: Impact on quality of life and symptom severity for children with achalasia.

Journal Article J Pediatr Surg · May 2019 BACKGROUND: High-resolution esophageal manometry (HREM) during laparoscopic Heller myotomy (LHM) with fundoplication for achalasia allows tailoring of myotomy length and wrap tightness. The purpose of this study is to quantify long-term postoperative sympt ... Full text Link to item Cite

Assessment of Quality and Readability of Internet Dietary Information on Irritable Bowel Syndrome.

Journal Article Clin Gastroenterol Hepatol · February 2019 Diet plays an important role for patients with irritable bowel syndrome (IBS). For medical conditions such as IBS, the Internet is a primary source of health information.1 However, recent evidence suggests that Internet health information may have several ... Full text Link to item Cite

Update on Dietary Management of Childhood Functional Abdominal Pain Disorders.

Journal Article Gastroenterol Clin North Am · December 2018 Diet plays a significant role for children with functional abdominal pain disorders. A large majority of these children identify at least 1 food that exacerbates their symptoms. Malabsorbed carbohydrates may have both direct and microbiome-mediated physiol ... Full text Link to item Cite

Evaluation of FODMAP Carbohydrates Content in Selected Foods in the United States.

Journal Article J Pediatr · August 2018 We analyzed the fermentable oligosaccharide, disaccharide, monosaccharide, and polyols (FODMAP) content of several foods potentially low in FODMAP which are commonly consumed by children. We determined that several processed foods (eg, gluten-free baked pr ... Full text Link to item Cite

Demographic and Clinical Correlates of Mucosal Disaccharidase Deficiencies in Children With Functional Dyspepsia.

Journal Article J Pediatr Gastroenterol Nutr · June 2018 BACKGROUND: A subset of children with functional gastrointestinal disorders (FGIDs), which includes functional dyspepsia, may have duodenal disaccharidase deficiencies. OBJECTIVES: To determine the frequency, demographics, and clinical characteristics asso ... Full text Link to item Cite

13C-Labeled-Starch Breath Test in Congenital Sucrase-isomaltase Deficiency.

Journal Article J Pediatr Gastroenterol Nutr · June 2018 BACKGROUND AND HYPOTHESES: Human starch digestion is a multienzyme process involving 6 different enzymes: salivary and pancreatic α-amylase; sucrase and isomaltase (from sucrose-isomaltase [SI]), and maltase and glucoamylase (from maltase-glucoamylase [MGA ... Full text Link to item Cite

Fidget Spinner Ingestions in Children-A Problem that Spun Out of Nowhere.

Journal Article J Pediatr · June 2018 The Consumer Product Safety Risk Management System's injury and potential injury database records 13 cases of fidget spinner ingestion since 2016. In addition to a database query, we report 3 additional cases of fidget spinner ingestion to describe patient ... Full text Link to item Cite

Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional disorders.

Journal Article Aliment Pharmacol Ther · March 2018 BACKGROUND: Peppermint oil has been used for centuries as a treatment for gastrointestinal ailments. It has been shown to have several effects on gastrointestinal physiology relevant to clinical care and management. AIM: To review the literature on pepperm ... Full text Link to item Cite

Fructans Exacerbate Symptoms in a Subset of Children With Irritable Bowel Syndrome.

Journal Article Clin Gastroenterol Hepatol · February 2018 BACKGROUND & AIMS: Dietary fructans exacerbate symptoms in some, but not all, adults with irritable bowel syndrome (IBS). We sought to determine whether fructans worsen symptoms in children with IBS and whether clinical and psychosocial factors, and/or gas ... Full text Link to item Cite

Physical Therapy for Fecal Incontinence in Children with Pelvic Floor Dyssynergia.

Journal Article J Pediatr · November 2017 OBJECTIVES: To determine the efficacy of physical therapy (PT) for fecal incontinence in children with pelvic floor dyssynergia (PFD). STUDY DESIGN: Retrospective chart review of children with PFD completing >1 PT session for fecal incontinence at a quater ... Full text Link to item Cite

Diagnostic approach to constipation impacts pediatric emergency department disposition.

Journal Article Am J Emerg Med · October 2017 OBJECTIVES: Constipation is a common cause of abdominal pain in children presenting to the emergency department (ED). The objectives of this study were to determine the diagnostic evaluation undertaken for constipation and to assess the association of the ... Full text Link to item Cite

Low FODMAP Dietary Food Lists are Often Discordant.

Journal Article Am J Gastroenterol · April 2017 Full text Link to item Cite

Lactulose Breath Test Gas Production in Childhood IBS Is Associated With Intestinal Transit and Bowel Movement Frequency.

Journal Article J Pediatr Gastroenterol Nutr · April 2017 OBJECTIVES: In adults with irritable bowel syndrome (IBS), bacterial gas production (colonic fermentation) is related to both symptom generation and intestinal transit. Whether gas production affects symptom generation, psychosocial distress, or intestinal ... Full text Link to item Cite

Factors influencing drainage setting and cost for cutaneous abscesses among pediatric patients.

Journal Article Am J Emerg Med · February 2017 OBJECTIVE: To evaluate the clinical and microbiological factors associated with skin and soft tissue infections drained in the emergency department (ED) vs operative drainage (OD) in a tertiary care children's hospital. METHODS: This was a cross-sectional ... Full text Link to item Cite

Stooling Characteristics in Children With Irritable Bowel Syndrome.

Journal Article Clin Gastroenterol Hepatol · January 2017 Full text Link to item Cite

Childhood Irritable Bowel Syndrome Characteristics Are Related to Both Sex and Pubertal Development.

Journal Article J Pediatr · January 2017 OBJECTIVE: To determine the relationship of both pubertal development and sex to childhood irritable bowel syndrome (IBS) clinical characteristics including gastrointestinal symptoms (eg, abdominal pain) and psychological factors. STUDY DESIGN: Cross-secti ... Full text Link to item Cite

Intramural esophageal bronchogenic cyst mimicking achalasia in a toddler.

Journal Article Pediatr Surg Int · January 2017 Bronchogenic cysts are congenital malformations of the tracheobronchial tree. We describe a 20-month-old male who presented with persistent non-bilious emesis; manometry and imaging were consistent with esophageal achalasia. During a planned laparoscopic H ... Full text Link to item Cite

Self-Perceived Food Intolerances Are Common and Associated with Clinical Severity in Childhood Irritable Bowel Syndrome.

Journal Article J Acad Nutr Diet · September 2016 BACKGROUND: Adults with irritable bowel syndrome (IBS) frequently identify foods as exacerbating their gastrointestinal symptoms. In children with IBS, the prevalence of perceived food intolerances and their impact are unknown. OBJECTIVE: Our aim was to de ... Full text Link to item Cite

Soap Suds Enemas Are Efficacious and Safe for Treating Fecal Impaction in Children With Abdominal Pain.

Journal Article J Pediatr Gastroenterol Nutr · July 2016 OBJECTIVES: Constipation is a common cause of pediatric abdominal pain and emergency department (ED) presentation. Despite the high prevalence, there is a dearth of clinical information and wide practice variation in childhood constipation management in th ... Full text Link to item Cite

Bristol Stool Form Scale reliability and agreement decreases when determining Rome III stool form designations.

Journal Article Neurogastroenterol Motil · March 2016 BACKGROUND: Rater reproducibility of the Bristol Stool Form Scale (BSFS), which categorizes stools into one of seven types, is unknown. We sought to determine reliability and agreement by individual stool type and when responses are categorized by Rome III ... Full text Link to item Cite

Dietary Carbohydrates and Childhood Functional Abdominal Pain.

Journal Article Ann Nutr Metab · 2016 Childhood functional gastrointestinal disorders (FGIDs) affect a large number of children throughout the world. Carbohydrates (which provide the majority of calories consumed in the Western diet) have been implicated both as culprits for the etiology of sy ... Full text Link to item Cite

Letter: avoid FODMAPs or follow simple tips--authors' reply.

Journal Article Aliment Pharmacol Ther · December 2015 Full text Link to item Cite

Editorial: Predicting response to a low FODMAP diet in children - Authors' reply

Journal Article Alimentary Pharmacology and Therapeutics · September 1, 2015 Full text Cite

Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome.

Journal Article Aliment Pharmacol Ther · August 2015 BACKGROUND: A low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet can ameliorate symptoms in adult irritable bowel syndrome (IBS) within 48 h. AIM: To determine the efficacy of a low FODMAP diet in childhood IBS and w ... Full text Link to item Cite

Gastric emptying scintigraphy results in children are affected by age, anthropometric factors, and study duration.

Journal Article Neurogastroenterol Motil · March 2015 BACKGROUND: A standardized 4-h adult-based gastric emptying scintigraphy (GES) protocol is increasingly being used in children to evaluate for gastroparesis. We sought to determine the effect of age, anthropometrics, and study duration on GES results using ... Full text Link to item Cite

Subtypes of irritable bowel syndrome in children and adolescents.

Journal Article Clin Gastroenterol Hepatol · September 2014 BACKGROUND & AIMS: Pharmacologic treatments for irritable bowel syndrome (IBS) and medical management of symptoms are increasingly based on IBS subtype, so it is important to accurately differentiate patients. Few studies have classified subtypes of pediat ... Full text Link to item Cite

Relationship of gastrointestinal symptoms and psychosocial distress to gastric retention in children.

Journal Article J Pediatr · July 2014 OBJECTIVES: To determine whether gastrointestinal (GI) symptoms (abdominal pain, nonpain GI symptoms, nausea) and/or psychosocial distress differ between children with/without gastroparesis and whether the severity of GI symptoms and/or psychosocial distre ... Full text Link to item Cite

Child and parent perceived food-induced gastrointestinal symptoms and quality of life in children with functional gastrointestinal disorders.

Journal Article J Acad Nutr Diet · March 2014 It is unknown whether children with functional gastrointestinal (GI) disorders identify specific foods that exacerbate their GI symptoms. The objectives of this study were to determine the perceived role of food on GI symptoms and to determine the impact o ... Full text Link to item Cite

Decreased relative diagnostic yield of esophagogastroduodenoscopy in children with gastroparesis.

Journal Article J Clin Gastroenterol · March 2014 BACKGROUND: Esophagogastroduodenoscopy (EGD) and gastric emptying scintigraphy (GES) are commonly performed in the evaluation of children with upper gastrointestinal symptoms. It has been presumed, but not clarified, that gastroparesis increases the likeli ... Full text Link to item Cite

Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome.

Journal Article Gut Microbes · 2014 We sought to determine whether a low fermentable substrate diet (LFSD) decreases abdominal pain frequency in children with irritable bowel syndrome (IBS) and to identify potential microbial factors related to diet efficacy. Pain symptoms, stooling characte ... Full text Link to item Cite

Interprovider variation of celiac disease testing in childhood chronic abdominal pain.

Journal Article BMC Gastroenterol · October 14, 2013 BACKGROUND: To determine within one tertiary care center: 1) the variation between providers in testing for celiac disease in children with chronic abdominal pain; 2) the characteristics of those children who were more likely to be tested, and 3) the preva ... Full text Link to item Cite

Concomitant gastroparesis negatively affects children with functional gallbladder disease.

Journal Article J Pediatr Gastroenterol Nutr · June 2012 OBJECTIVES: The aim of the present study was to determine whether concomitant gastroparesis and biliary dyskinesia (BD) occur in children, and if so, to determine whether concomitant gastroparesis affects clinical outcome in children with BD. METHODS: We c ... Full text Link to item Cite

Clinical characteristics and risk factors for symptomatic pediatric gallbladder disease.

Journal Article Pediatrics · January 2012 OBJECTIVE: Our center previously reported its experience with pediatric gallbladder disease and cholecystectomies from 1980 to 1996. We aimed to determine the current clinical characteristics and risk factors for symptomatic pediatric gallbladder disease a ... Full text Link to item Cite

Defecation disorders in children after surgery for Hirschsprung disease.

Journal Article J Pediatr Gastroenterol Nutr · July 2011 BACKGROUND AND OBJECTIVE: The majority of children with Hirschsprung disease (HD) after corrective surgery (CS) develop protracted defecation disorders (DDs) such as constipation, fecal incontinence, and/or enterocolitis. The aim of this investigation was ... Full text Link to item Cite

Reliability and validity of a modified bristol stool form scale for children

Journal Article Journal of Pediatrics · January 1, 2011 Objectives: This study sought to: evaluate the ability of children to reliably use a modified Bristol Stool Form Scale for Children (mBSFS-C), evaluate criterion-related validity of the mBSFS-C, and identify the lower age limit for mBSFS-C use. Study desig ... Full text Cite

Authors' response

Journal Article Journal of Pediatric Gastroenterology and Nutrition · January 1, 2011 Full text Cite

Creation and initial evaluation of a Stool Form Scale for children.

Journal Article J Pediatr · October 2010 OBJECTIVE: To develop a pediatric stool form rating scale and determine its interrater reliability, intrarater reliability, and agreement among pediatric gastroenterologists. STUDY DESIGN: An ordinal stool scale with 5 categorical stool form types was crea ... Full text Link to item Cite

Taeniasis in an adolescent with chronic anemia.

Journal Article J Pediatr Gastroenterol Nutr · April 2010 Full text Link to item Cite

Absent smooth muscle actin immunoreactivity of the small bowel muscularis propria circular layer in association with chromosome 15q11 deletion in megacystis-microcolon-intestinal hypoperistalsis syndrome.

Journal Article Pediatr Dev Pathol · 2010 Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS; OMIM%249210) is a rare and severe form of congenital intestinal and urinary dysfunction and malformation. Histologic studies suggest that the predominant intestinal manifestation is smooth m ... Full text Link to item Cite

Long-term clinical outcome after botulinum toxin injection in children with nonrelaxing internal anal sphincter.

Journal Article Am J Gastroenterol · April 2009 OBJECTIVES: Children with surgically repaired Hirschsprung's disease (HD) and those with internal anal sphincter (IAS) achalasia may develop obstructive gastrointestinal symptoms and/or enterocolitis due to a functional obstruction caused by an inability o ... Full text Link to item Cite

Pediatric gastrointestinal motility disorders: Challenges and a clinical update

Journal Article Gastroenterology and Hepatology · February 1, 2008 Pediatric gastrointestinal motility disorders are common and can range from relatively benign conditions such as functional constipation to more serious disorders such as achalasia, Hirschsprung disease, and intestinal pseudoobstruction. Performing and int ... Cite