Bryan David Kraft | Scholars@Duke

Bryan David Kraft
Adjunct Assistant Professor in the Department of Medicine

Dr. Kraft has a wide variety of clinical and research interests, including sepsis, pneumonia, and acute respiratory distress syndrome (ARDS), and has special expertise in rare lung diseases such as pulmonary fibrosis and pulmonary alveolar proteinosis (PAP). PAP can be congenital, hereditary, autoimmune, or due to occupational exposures (e.g. dusts, fibers, silica).

Dr. Kraft performs whole lung lavage (WLL) at Duke in a state-of-the art hyperbaric chamber within the Duke Center for Hyperbaric Medicine and Environmental Physiology. Performing WLL with hyperbaric oxygen (when necessary) augments oxygen delivery during the procedure, meaning both lungs can be lavaged on the same day, during a single episode of anesthesia.

Dr. Kraft’s research laboratory is devoted to understanding mechanisms of acute lung injury resolution, and uses translational models and clinical patient samples to identify novel pathways of recovery. Dr. Kraft is also an active investigator in clinical trials to develop new therapies for patients with lung diseases.

Current Appointments & Affiliations

Adjunct Assistant Professor in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2021

Contact Information

Box 3315 DUMC, Durham, NC 27710
bryan.kraft@duke.edu (919) 613-6394

Background
Education, Training, & Certifications
- Fellowship, Pulmonary, Allergy, And Critical Care, Duke University School of Medicine 2010 - 2013
- Residency, Internal Medicine, Duke University School of Medicine 2007 - 2010
- M.D., University of Tennessee Health Science Center 2007
Previous Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2021
- Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2016 - 2020
- Medical Instructor in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2013 - 2016
Academic Positions Outside Duke
- Medical Director for Respiratory Therapy, Durham Technical Community College. 2018 - 2019
Recognition
In the News
- MAR 13, 2018 Infectious Diseases Hub
  
  Could carbon monoxide be used to manage sepsis-related lung injury? – an interview with Bryan Kraft, MD
- FEB 6, 2017 Medpage Today
  
  Antibiotics for Sinusitis
- JAN 1, 2017 Clinical Practice Today
  
  Inhaled CO as a Therapy for ARDS
- DEC 8, 2016 Clinical Practice Today
  
  Hyperbaric Oxygen for Airway Necrosis after Lung Transplantation
- DEC 1, 2015
  
  Bryan Kraft Journal Article Cited by the American Journal of Physiology-Lung
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER) awarded by National Institutes of Health 2022 - 2026
- METABOLIC SYSTEM FOR IN VIVO RODENT TESTING awarded by Office of Naval Research 2021 - 2022
- ICU COVID-19 Biorepository Plasma Samples 2021 - 2022
- Role of S-nitrosothiols on Akt1 signaling and pneumonia resolution awarded by National Institutes of Health 2017 - 2021
- IMPALA MOL-PAP-002 A randomised double blind placebo controlled multicentre clinical trial of inhaled molgramostim in autoimmune pulmonary alveolar proteinosis patients 2018 - 2019
- Novel Dialysis-Like Therapeutics in Sepsis-induced Shock and Organ Failure awarded by Defense Advanced Research Projects Agency 2015 - 2018
- Project 2: Regulation of Mitochondrial Quality Control by Heme Oxygenase-1 System in Sepsis awarded by Brigham and Women's Hospital 2011 - 2017
External Relationships
- Atheneum
- CryoCell International
- Eli Lilly & Co.
- Paratek Pharmaceuticals
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Mohan AA, Olson LB, Naqvi IA, Morrison SA, Kraft BD, Chen L, et al. Age and Comorbidities Predict COVID-19 Outcome, Regardless of Innate Immune Response Severity: A Single Institutional Cohort Study. Critical Care Explorations. 2022 Dec;4(12):e0799.
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  - Amin AN, Dellinger EP, Harnett G, Kraft BD, LaPlante KL, LoVecchio F, et al. It’s about the patients: Practical antibiotic stewardship in outpatient settings in the United States. Frontiers in Medicine. 2022 Jul 27;9.
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  - Giroux NS, Ding S, McClain MT, Burke TW, Petzold E, Chung HA, et al. Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion. Sci Rep. 2022 Jul 9;12(1):11714.
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  - Corey KM, Olson LB, Naqvi IA, Morrison SA, Davis C, Nimjee SM, et al. Suppression of Fibrinolysis and Hypercoagulability, Severity of Hypoxemia, and Mortality in COVID-19 Patients: A Retrospective Cohort Study. Anesthesiology. 2022 Jul 1;137(1):67–78.
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  - Stalls V, Lindenberger J, Gobeil SM-C, Henderson R, Parks R, Barr M, et al. Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike. Cell Rep. 2022 Jun 28;39(13):111009.
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  - Chabata CV, Frederiksen JW, Olson LB, Naqvi IA, Hall SE, Gunaratne R, et al. Combining Heparin and a FX/Xa Aptamer to Reduce Thrombin Generation in Cardiopulmonary Bypass and COVID-19. Nucleic Acid Ther. 2022 Jun;32(3):139–50.
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  - Giroux NS, Ding S, McClain MT, Burke TW, Petzold E, Chung HA, et al. Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion. Res Sq. 2022 Apr 7;
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  - Naqvi I, Giroux N, Olson L, Morrison SA, Llanga T, Akinade TO, et al. DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonists. Biomaterials. 2022 Apr;283:121393.
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  - Suliman HB, Healy Z, Zobi F, Kraft BD, Welty-Wolf K, Smith J, et al. Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis. Iscience. 2022 Jan 21;25(1):103535.
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  - Alvarez Villela M, Dunworth SA, Kraft BD, Harlan NP, Natoli MJ, Suliman HB, et al. Effects of high-intensity interval training with hyperbaric oxygen. Front Physiol. 2022;13:963799.
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  - Wolf MA, Thielman NM, Kraft BD. Treatment of Acanthamoeba Encephalitis. Am J Med. 2022 Jan;135(1):e20–1.
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  - Heggestad JT, Britton RJ, Kinnamon DS, Wall SA, Joh DY, Hucknall AM, et al. Rapid test to assess the escape of SARS-CoV-2 variants of concern. Sci Adv. 2021 Dec 3;7(49):eabl7682.
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  - Chen L, Kraft BD, Roggli VL, Healy ZR, Woods CW, Tsalik EL, et al. Heparin-based blood purification attenuates organ injury in baboons with Streptococcus pneumoniae pneumonia. Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1;321(2):L321–35.
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  - Chun HJ, Coutavas E, Pine AB, Lee AI, Yu VL, Shallow MK, et al. Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection. Jci Insight. 2021 Jul 22;6(14).
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  - Heggestad JT, Kinnamon DS, Olson LB, Liu J, Kelly G, Wall SA, et al. Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test. Sci Adv. 2021 Jun;7(26).
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  - Chun HJ, Coutavas E, Pine A, Lee AI, Yu V, Shallow M, et al. Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2 infection (PASC). Medrxiv. 2021 Apr 21;
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  - Kraft BD, Mahmood K, Harlan NP, Hartwig MG, Snyder LD, Suliman HB, et al. Hyperbaric oxygen therapy to prevent central airway stenosis after lung transplantation. J Heart Lung Transplant. 2021 Apr;40(4):269–78.
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  - Olson LB, Naqvi IA, Turner DJ, Morrison SA, Kraft BD, Chen L, et al. Key Pathogenic Factors in Coronavirus Disease 2019-Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report. A a Pract. 2021 Mar 30;15(4):e01432.
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  - McClain MT, Constantine FJ, Henao R, Liu Y, Tsalik EL, Burke TW, et al. Dysregulated transcriptional responses to SARS-CoV-2 in the periphery. Nat Commun. 2021 Feb 17;12(1):1079.
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  - Grimberg DC, Tejwani R, Allkanjari A, Forrester MT, Kraft BD, Kaye DR. Ischemic priapism due to coagulopathy of severe COVID-19 infection. Journal of Clinical Urology. 2021 Jan 1;
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  - Giroux NS, Ding S, McClain MT, Burke TW, Petzold E, Chung HA, et al. Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity. Biorxiv. 2020 Dec 9;
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  - Heggestad JT, Kinnamon DS, Olson LB, Liu J, Kelly G, Wall SA, et al. Multiplexed, quantitative serological profiling of COVID-19 from a drop of blood by a point-of-care test. Medrxiv. 2020 Nov 7;
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  - McClain MT, Constantine FJ, Henao R, Liu Y, Tsalik EL, Burke TW, et al. Dysregulated transcriptional responses to SARS-CoV-2 in the periphery support novel diagnostic approaches. Medrxiv. 2020 Jul 26;
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  - Kraft BD, Chen L, Suliman HB, Piantadosi CA, Welty-Wolf KE. Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis. Crit Care Med. 2019 May;47(5):651–8.
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  - Chen L, Welty-Wolf KE, Kraft BD. Nonhuman primate species as models of human bacterial sepsis. Lab Anim (Ny). 2019 Feb;48(2):57–65.
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  - Khatri A, Kraft BD, Tata PR, Randell SH, Piantadosi CA, Pendergast AM. ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1603–12.
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  - Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, et al. A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. Jci Insight. 2018 Dec 6;3(23).
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  - Suliman HB, Kraft B, Bartz R, Chen L, Welty-Wolf KE, Piantadosi CA. Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2017 Oct 1;313(4):L699–709.
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  - Mahmood K, Kraft BD, Glisinski K, Hartwig MG, Harlan NP, Piantadosi CA, et al. Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant. Clin Transplant. 2016 Sep;30(9):1134–9.
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  - Abril MK, Barnett AS, Wegermann K, Fountain E, Strand A, Heyman BM, et al. Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing. Open Forum Infect Dis. 2016 Sep;3(3):ofw144.
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  - Kraft BD, Suliman HB, Colman EC, Mahmood K, Hartwig MG, Piantadosi CA, et al. Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation. Am J Respir Crit Care Med. 2016 Mar 1;193(5):552–60.
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  - Babi M-A, Kraft BD, Sengupta S, Peterson H, Orgel R, Wegermann Z, et al. Related or not? Development of spontaneous Creutzfeldt-Jakob disease in a patient with chronic, well-controlled HIV: A case report and review of the literature. Sage Open Med Case Rep. 2016;4:2050313X16672153.
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  - Fredenburgh LE, Kraft BD, Hess DR, Harris RS, Wolf MA, Suliman HB, et al. Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L834–46.
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  - Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, et al. The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. Am J Respir Cell Mol Biol. 2015 Sep;53(3):314–25.
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  - Shinohara M, Kibi M, Riley IR, Chiang N, Dalli J, Kraft BD, et al. Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L746–57.
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  - Kraft BD, Piantadosi CA, Benjamin AM, Lucas JE, Zaas AK, Betancourt-Quiroz M, et al. Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates. Am J Respir Cell Mol Biol. 2014 May;50(5):995–1004.
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  - Coeytaux RR, Schmit KM, Kraft BD, Kosinski AS, Mingo AM, Vann LM, et al. Comparative effectiveness and safety of drug therapy for pulmonary arterial hypertension: a systematic review and meta-analysis. Chest. 2014 May;145(5):1055–63.
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  - McCrory DC, Coeytaux RR, Schmit KM, Kraft B, Kosinski AS, Mingo AM, et al. Pulmonary Arterial Hypertension: Screening, Management, and Treatment. Comparative Effectiveness Review No. 117. (Prepared by the Duke Evidence based Practice Center under Contract No. 290-2007-10066-I.) AHRQ Publication No. 13-EHC087-EF. Ahrq Comparative Effectiveness Reviews. 2013 Apr;
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  - Kraft BD, Westman EC. Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature. Nutr Metab (Lond). 2009 Feb 26;6:10.
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  - Liu Z, Yelverton RW, Kraft B, Tanner SB, Olsen NJ, Aune TM. Highly conserved gene expression profiles in humans with allergic rhinitis altered by immunotherapy. Clin Exp Allergy. 2005 Dec;35(12):1581–90.
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  - Olsen N, Sokka T, Seehorn CL, Kraft B, Maas K, Moore J, et al. A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. Ann Rheum Dis. 2004 Nov;63(11):1387–92.
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- Book Sections
  - Wysham N, Mullaney M, Kraft BD. Pneumonia. In: Hess DR, MacIntyre NR, Galvin WF, Mishoe SC, editors. Respiratory Care: Principles and Practice. Jones & Bartlett Publishers; 2015. p. 858–89.
- Conference Papers
  - Kraft B, Brown L, Scott M, Vrionis F, Palumbo R, Troy J, et al. Abstract 12 Phase I Study of Cord Tissue Derived Mesenchymal Stromal Cells in COVID-19–Related Acute Respiratory Distress Syndrome. In: Stem Cells Translational Medicine. Oxford University Press (OUP); 2022. p. S14–S14.
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  - Mohan A, Olson L, Naqvi I, Morrison S, Kraft B, Chen L, et al. AGE AND COMORBIDITIES PREDICT COVID-19 OUTCOME REGARDLESS OF SEVERITY OF INNATE IMMUNE RESPONSE. In: Critical Care Medicine. 2022. p. 51–51.
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  - Shaz B, Kraft B, Troy J, Poehlein E, Chen L, Cheatham L, et al. SAFETY OF CORD TISSUE DERIVED MESENCHYMAL STROMAL CELLS IN COVID-19 RELATED ACUTE RESPIRATORY DISTRESS SYNDROME. In: Cytotherapy. 2022. p. S53–S53.
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  - Olson LB, Naqvi IA, CHEN L, Que LG, KRAFT BD, Nair SK, et al. Abstract P102: Elevated Von Willebrand Factor in Patients Presenting With Large-Vessel Occlusion Stroke as First Symptom of COVID-19 Mirrors Levels in Patients With COVID-19 Requiring ICU-Level Care. In: Stroke. Ovid Technologies (Wolters Kluwer Health); 2021.
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  - Kraft BD, Suliman HB, Pavlisko EN, Roggli VL, Piantadosi CA. Alveolar Mitochondria! Quality Control During Acute Respiratory Distress Syndrome. In: American Journal of Respiratory and Critical Care Medicine. 2020.
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  - Chen L, Kraft BD, Roggli VL, Suliman H, Piantadosi CA, Welty-Wolf KE. Blood Filtration Using Dialysis-Like Therapy Attenuates Organ Injury in Nonhuman Primates with Severe Streptococcus Pneumoniae Sepsis. In: American Journal of Respiratory and Critical Care Medicine. AMER THORACIC SOC; 2019.
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  - Chen L, Kraft BD, Roggli VL, Suliman HB, Piantadosi CA, Welty-Wolf KE. Severe Pneumococcal Pneumonia Causes Cardiac and Skeletal Muscle Injuries in Baboons. In: American Journal of Respiratory and Critical Care Medicine. AMER THORACIC SOC; 2018.
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  - Chen L, Kraft BD, Welty-Wolf K, Suhman HB, Piantadosi C. Peripheral Blood Mononuclear Cells Demonstrate Reversible Mitochondrial Distress In Patients With Sepsis. In: American Journal of Respiratory and Critical Care Medicine. AMER THORACIC SOC; 2017.
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  - Bartz R, Suliman H, Kraft B, Cherry A, Welty-Wolf K, Keenan J, et al. Heme Oxygenase-1 Is Cardioprotective Against Hyperoxia. In: American Journal of Respiratory and Critical Care Medicine. AMER THORACIC SOC; 2016.
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  - Shofer S, Kraft B, Hartwig M, Piantadosi C. Large Airway Oximetry and Hypoxia Related Gene Expression in Bronchial Epithelium in Early Post-Lung Transplantation. In: The Journal of Heart and Lung Transplantation. Elsevier BV; 2015. p. S253–4.
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  - Chang A, Kraft B, Suliman H, Piantadosi C. Redox Regulated Mitophagy in the Lung during Murine Sepsis. In: Free Radical Biology and Medicine. Elsevier BV; 2013. p. S140–1.
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  - Bartz RR, Kraft B, Piantadosi CA, Fu P, Suliman H, Zaas A, et al. Elevated Lung Anti-Oxidant/cytoprotective Enzymes In The Resolution Phase Of Streptococcal Pneumonia In Non-Human Primates. In: American Journal of Respiratory and Critical Care Medicine. AMER THORACIC SOC; 2013.
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  - Kraft B, Piantadosi CA, Suliman HB, Ginsburg GS, Bartz RR, Zaas A, et al. Pneumococcal Pneumonia And Sepsis In Baboons Mirrors The Human Disease. In: American Journal of Respiratory and Critical Care Medicine. AMER THORACIC SOC; 2013.
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  - Olsen NJ, Sokka TM, Seehorn CL, Kraft B, Maas K, Moore JH, et al. A gene expression signature for recent onset rheumatoid arthritis. In: Faseb Journal. FEDERATION AMER SOC EXP BIOL; 2003. p. C35–C35.
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  - Gasier H, Demchenko I, Kraft B, Suliman H, Piantadosi C. The toxic effects of hyperbaric oxygen in S-nitrosoglutathione reductase null mice. In Undersea and Hyperbaric Medical Society;
Scholarly, Clinical, & Service Activities
Academic & Administrative Activities
- Duke Institutional Review Board Member, Department of Medicine, 2015-2017
  Chest Infections NetWork Steering Committee, American College of Chest Physicians, 2014-2018

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Education, Training, & Certifications

Previous Appointments & Affiliations

Academic Positions Outside Duke

In the News

Awards & Honors

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers

Academic & Administrative Activities