Overview
Dr. Kraft has a wide variety of clinical and research interests, including sepsis, pneumonia, and acute respiratory distress syndrome (ARDS), and has special expertise in rare lung diseases such as pulmonary fibrosis and pulmonary alveolar proteinosis (PAP). PAP can be congenital, hereditary, autoimmune, or due to occupational exposures (e.g. dusts, fibers, silica).
Dr. Kraft performs whole lung lavage (WLL) at Duke in a state-of-the art hyperbaric chamber within the Duke Center for Hyperbaric Medicine and Environmental Physiology. Performing WLL with hyperbaric oxygen (when necessary) augments oxygen delivery during the procedure, meaning both lungs can be lavaged on the same day, during a single episode of anesthesia.
Dr. Kraft’s research laboratory is devoted to understanding mechanisms of acute lung injury resolution, and uses translational models and clinical patient samples to identify novel pathways of recovery. Dr. Kraft is also an active investigator in clinical trials to develop new therapies for patients with lung diseases.
Current Appointments & Affiliations
Recent Publications
SARS-CoV-2 viremia but not respiratory viral load is associated with respiratory complications in patients with severe COVID-19.
Journal Article BMC Pulm Med · July 29, 2024 BACKGROUND: Severe COVID-19 carries a high morbidity and mortality. Previous studies have shown an association between COVID-19 severity and SARS-CoV-2 viral load (VL). We sought to measure VL in multiple compartments (urine, plasma, lower respiratory trac ... Full text Link to item CiteAcute chest syndrome from sickle cell disease successfully supported with veno-venous extracorporeal membrane oxygenation.
Journal Article Artif Organs · July 2024 Full text Link to item CiteExtracorporeal Membrane Oxygenation for Respiratory Failure: A Narrative Review
Journal Article Journal of Clinical Medicine · July 1, 2024 Extracorporeal membrane oxygenation support for respiratory failure in the intensive care unit continues to have an expanded role in select patients. While acute respiratory distress syndrome remains the most common indication, extracorporeal membrane oxyg ... Full text CiteRecent Grants
Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER)
Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2026METABOLIC SYSTEM FOR IN VIVO RODENT TESTING
EquipmentMentor · Awarded by Office of Naval Research · 2021 - 2022Role of S-nitrosothiols on Akt1 signaling and pneumonia resolution
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2021View All Grants