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Chakib Ayoub

Professor of Anesthesiology
Anesthesiology, General, Vascular, High Risk Transplant & Critical Care
Duke University School of Medi, 2301 Erwin Road, 5673 Hapf, Durham, NC 27710

Current Duke Appointments & Affiliations


Recent Scholarly Works


Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial.

Journal article JAMA Netw Open · April 1, 2026 IMPORTANCE: The apolipoprotein E (APOE) gene ε4 allele leads to increased Alzheimer disease risk and neuroinflammation and is also believed to play a role in postoperative delirium. However, the safety and feasibility of modulating apoE protein signaling t ... Full text Link to item Cite

Post-Operative Delirium and Awake Spine Surgery

Book section · November 20, 2025 The book is organized into three parts and 22 chapters covering preoperative, intraoperative, and postoperative considerations. ... Cite

The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Prospective Cohort Study.

Journal article Anesth Analg · January 1, 2025 BACKGROUND: Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of ... Full text Open Access Link to item Cite
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Education


Ecole Superieure De Commerce De Reims (France) · 2004 M.B.A.
St. Joseph University of Beirut (Lebanon) · 1991 M.D.