Scholars@Duke
Carrie Rebecca Muh

Carrie Rebecca Muh

Adjunct Assistant Professor in the Department of Neurosurgery
Neurosurgery
carrie.muh@duke.edu
4544 Hospital South, Box 3272, Durham, NC 27710

Selected Publications

Epilepsy surgery education and practice around the globe: An ILAE taskforce report.

Journal Article Epilepsia · February 2025 Up to 80% of the world's population with epilepsy lives in low and middle-income countries. Around one-third of these patients will have drug-resistant epilepsy, for which epilepsy surgery is an option. Unfortunately, many of these regions, as well as some ... Full text Link to item Cite

Does new research address persistent questions since the publication of the CDC's 2018 pediatric mTBI guideline.

Other Childs Nerv Syst · December 16, 2024 BACKGROUND AND OBJECTIVE: Due to the potential debilitating sequelae following pediatric mTBI, the CDC published the Guideline on the Diagnosis and Management of mTBI Among Children in 2018. However, the guideline identified several key gaps in our clinica ... Full text Link to item Cite

Bilateral pulvinar responsive neurostimulation for bilateral multifocal posteriorly dominant drug resistant epilepsy.

Journal Article Epilepsia Open · December 2024 OBJECTIVE: To describe four cases of Responsive Neurostimulation (RNS) in the bilateral pulvinar nuclei (PUL) in individuals with drug resistant epilepsy (DRE). This will show that due to widespread PUL connectivity, bilateral PUL RNS may be an option for ... Full text Link to item Cite

Responsive neurostimulation in pediatric epilepsy: a systematic review and individual patient meta-analysis supplemented by a single institution case series in 105 aggregated patients.

Journal Article Childs Nerv Syst · November 2024 PURPOSE: To assess responsive neurostimulation (RNS) efficacy in pediatric patients with drug-resistant epilepsy, comparing response (≥ 50% reduction in seizure frequency) rates between patients with two or fewer seizure foci and those with multifocal or g ... Full text Link to item Cite

Overcoming Graft Rejection in Induced Pluripotent Stem Cell-Derived Inhibitory Interneurons for Drug-Resistant Epilepsy.

Journal Article Brain Sci · October 16, 2024 BACKGROUND: Cell-based therapies for drug-resistant epilepsy using induced pluripotent stem cell-derived inhibitory interneurons are now in early-phase clinical trials, building on findings from trials in Parkinson's disease (PD) and Huntington's disease ( ... Full text Link to item Cite

Responsive neurostimulation of the frontal lobe for the detection and treatment of seizures in intractable epilepsy due to tuberous sclerosis complex: illustrative case.

Journal Article J Neurosurg Case Lessons · October 7, 2024 BACKGROUND: Responsive neurostimulation (RNS) is often considered to be a palliative therapy for drug-resistant epilepsy (DRE) and is generally not considered to be a treatment for patients with tuberous sclerosis complex (TSC). Here, the authors present t ... Full text Link to item Cite

Association of reductions in rescue medication requirements with vagus nerve stimulation: Results of long-term community collected data from a seizure diary app.

Journal Article Epilepsy Behav · October 2024 OBJECTIVE: To assess the impact of vagus nerve stimulation (VNS) on quality of life contributors such as rescue medications. METHODS: Using the seizure diary application SeizureTracker™ database, we examined trends in rescue administration frequency before ... Full text Link to item Cite

Safety and Preliminary Efficacy of Cervical Paraspinal Interfascial Plane Block for Postoperative Pain after Pediatric Chiari Decompression.

Journal Article Healthcare (Basel) · July 17, 2024 BACKGROUND: Surgery for lesions of the posterior fossa is associated with significant postoperative pain in pediatric patients related to extensive manipulation of the suboccipital musculature and bone. In this study, we assess the preliminary safety, effe ... Full text Link to item Cite

Low serum albumin as a risk factor for delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage: eICU collaborative research database analysis.

Journal Article J Neurosurg Sci · June 2024 BACKGROUND: Delayed cerebral ischemia (DCI) represents a devastating complication of aneurysmal subarachnoid hemorrhage (aSAH) and is a significant predictor of morbidity and mortality. Recent studies have implicated inflammatory processes in the pathogene ... Full text Link to item Cite

Feasibility and safety of stereoelectroencephalography in young children.

Journal Article Childs Nerv Syst · May 2024 PURPOSE: Stereoelectroencephalography (SEEG) is a diagnostic surgery that implants electrodes to identify areas of epileptic onset in patients with drug-resistant epilepsy (DRE). SEEG is effective in identifying the epileptic zone; however, placement of el ... Full text Link to item Cite

Pediatric neuromodulation for drug-resistant epilepsy: Survey of current practices, techniques, and outcomes across US epilepsy centers.

Journal Article Epilepsia Open · April 2024 Neuromodulation via Responsive Neurostimulation (RNS) or Deep Brain Stimulation (DBS) is an emerging treatment strategy for pediatric drug-resistant epilepsy (DRE). Knowledge gaps exist in patient selection, surgical technique, and perioperative care. Here ... Full text Link to item Cite

Guidelines for Specialized Epilepsy Centers: Executive Summary of the Report of the National Association of Epilepsy Centers Guideline Panel.

Journal Article Neurology · February 2024 The National Association of Epilepsy Centers first published the guidelines for epilepsy centers in 1990, which were last updated in 2010. Since that update, epilepsy care and the science of guideline development have advanced significantly, including the ... Full text Cite

Middle Meningeal Artery Embolization in Pediatric Patients.

Journal Article Pediatr Neurosurg · 2024 BACKGROUND: Middle meningeal artery (MMA) embolization has been increasingly applied in adult populations for the treatment of chronic subdural hematomas (cSDH). There is a paucity of literature on the indications, safety, and outcomes of MMA embolization ... Full text Link to item Cite

Myasthenia gravis in a pediatric patient with Lennox-Gastaut syndrome following responsive neurostimulation device implantation: illustrative case.

Journal Article J Neurosurg Case Lessons · November 27, 2023 BACKGROUND: Myasthenia gravis (MG) is an autoimmune disorder in which the postsynaptic acetylcholine receptor of the neuromuscular junction is destroyed by autoantibodies. The authors report a case of MG in a pediatric patient who also suffered from Lennox ... Full text Link to item Cite

Acute ischemic strokes in patients with developmental disabilities: A cross-sectional analysis.

Journal Article Interv Neuroradiol · October 2023 OBJECTIVE: Patients with developmental disabilities (DD) are frequently excluded from acute ischemic stroke (AIS) randomized control trials. We sought to evaluate the impact of having DD on this patient cohort. METHODS: The National Inpatient Sample was an ... Full text Link to item Cite

An institutional report of heparin induced thrombocytopenia type II in aneurysmal subarachnoid hemorrhage patients.

Journal Article Interv Neuroradiol · August 2023 BACKGROUND: Heparin induced thrombocytopenia Type II (HIT-II) is a dangerous thromboembolic complication of heparin therapy. The current literature on incidence and outcomes of HIT-II in aneurysmal subarachnoid hemorrhage (aSAH) patients remains sparse. OB ... Full text Link to item Cite

Significant Mortality Associated With COVID-19 and Comorbid Cerebrovascular Disease: A Quantitative Systematic Review.

Journal Article Cardiol Rev · July 2023 We report the first quantitative systematic review of cerebrovascular disease in coronavirus disease 2019 (COVID-19) to provide occurrence rates and associated mortality. Through a comprehensive search of PubMed we identified 8 cohort studies, 5 case serie ... Full text Link to item Cite

Safety of vagus nerve stimulation and responsive neurostimulation used in combination for multifocal and generalized onset epilepsy in pediatric patients.

Journal Article J Neurosurg Pediatr · June 1, 2023 OBJECTIVE: The aim of this study was to assess the safety and efficacy of combined active responsive neurostimulation (RNS) and vagus nerve stimulation (VNS) therapies in pediatric patients with drug-resistant epilepsy. METHODS: A single-center retrospecti ... Full text Link to item Cite

Ruptured arteriovenous malformation mortality: Incidence, risk factors, and inpatient outcome score.

Journal Article Interv Neuroradiol · May 8, 2023 BACKGROUND: Limited literature exists on the morbidity and mortality of AVM associated intracerebral hemorrhage (ICH) compared with non-AVM ICH. OBJECTIVE: We examine morbidity and mortality in cAVM in a large nationwide inpatient sample to create a progno ... Full text Link to item Cite

Use of Neuronavigation in Suturectomy for Craniosynostosis.

Journal Article J Craniofac Surg · May 1, 2023 Smaller operative exposures associated with suturectomy for craniosynostosis may result in difficulties visualizing the prematurely fused suture during surgery. The authors report cases of suturectomy for lambdoid and metopic craniosynostosis in which neur ... Full text Link to item Cite

Magnetic resonance imaging-guided stereotactic laser ablation therapy for the treatment of pediatric epilepsy: a retrospective multiinstitutional study.

Journal Article J Neurosurg Pediatr · March 3, 2023 OBJECTIVE: The authors of this study evaluated the safety and efficacy of stereotactic laser ablation (SLA) for the treatment of drug-resistant epilepsy (DRE) in children. METHODS: Seventeen North American centers were enrolled in the study. Data for pedia ... Full text Link to item Cite

Use of Intraoperative Neuromonitoring in Surgical Treatment of Acute Presentation of Chiari I Malformation: A Case Report.

Journal Article J Neurol Surg Rep · January 2023 Intraoperative neuromonitoring (IONM) has been used in neurosurgical procedures to assess patient safety and minimize risk of neurological deficit. However, its use in decompressive surgeries of Chiari malformation type I (CM-I) remains a topic of debate. ... Full text Link to item Cite

Socioeconomic characteristics of pediatric traumatic brain injury patients.

Journal Article Clin Neurol Neurosurg · October 2022 BACKGROUND: Traumatic brain injuries (TBIs) play a significant role in pediatric mortality and morbidity. Environment may play a role in the type, severity, and outcome of pediatric TBI (pTBI). Our objective was to characterize the impact of poor socioecon ... Full text Link to item Cite

Tranexamic Acid Dosing in Craniosynostosis Surgery: A Systematic Review with Meta-analysis.

Journal Article Plast Reconstr Surg Glob Open · October 2022 UNLABELLED: This study aimed to compare operative time, blood loss, and transfusion requirement in patients receiving a high tranexamic acid (TXA) dose of greater than 10 mg/kg versus those receiving a low dose of 10 mg/kg or less. METHODS: PubMed, Cochran ... Full text Link to item Cite

Book Review: Tumors of the Spinal Canal.

Journal Article Neurosurgery · June 1, 2022 Full text Link to item Cite

Book Review: Tumors of the Spinal Canal.

Journal Article Neurosurgery · June 1, 2022 Full text Link to item Cite

Book Review: Tumors of the Spinal Canal.

Journal Article Neurosurgery · June 1, 2022 Full text Link to item Cite

Endovascular Thrombectomy for Pediatric Acute Ischemic Stroke.

Journal Article Stroke · May 2022 BACKGROUND: Evidence regarding the utilization and outcomes of endovascular thrombectomy (EVT) for pediatric ischemic stroke is limited, and justification for its use is largely based on extrapolation from clinical benefits observed in adults. METHODS: Wei ... Full text Link to item Cite

Responsive Neurostimulation Targeting the Anterior, Centromedian and Pulvinar Thalamic Nuclei and the Detection of Electrographic Seizures in Pediatric and Young Adult Patients.

Journal Article Front Hum Neurosci · 2022 Featured Publication BACKGROUND: Responsive neurostimulation (RNS System) has been utilized as a treatment for intractable epilepsy. The RNS System delivers stimulation in response to detected abnormal activity, via leads covering the seizure foci, in response to detections of ... Full text Link to item Cite

Hemispherectomy

Chapter · January 1, 2022 Hemispherectomy, or its variant hemispherotomy, is an effective surgical technique to treat patients with hemispheric epilepsy. This surgery removes or disconnects the affected hemisphere from the more appropriately functioning portions of the brain. Thoug ... Full text Cite

Non-Operative Management of a Pediatric Patient With Bilateral Subdural Hematomas in the Setting of Ruptured Arachnoid Cyst.

Journal Article Cureus · December 2021 Pediatric subdural hematomas (SDH) are associated with arachnoid cysts (AC), particularly in the middle cranial fossa (MCF). Operative management of these hemorrhages is a mainstay of treatment. Conservative management may be an option if there is minimal ... Full text Link to item Cite

Ventriculomegaly and postoperative lateral/third ventricular blood as predictors of cerebrospinal fluid diversion following posterior fossa tumor resection.

Journal Article J Neurosurg Pediatr · November 1, 2021 OBJECTIVE: Postoperative hydrocephalus occurs in one-third of children after posterior fossa tumor resection. Although models to predict the need for CSF diversion after resection exist for preoperative variables, it is unknown which postoperative variable ... Full text Link to item Cite

Book Review: I Want to be a Neurosurgeon

Journal Article Neurosurgery · June 2021 Full text Cite

Acute subdural hematomas secondary to aneurysmal subarachnoid hemorrhage confer poor prognosis: a national perspective.

Journal Article J Neurointerv Surg · May 2021 BACKGROUND: Aneurysmal ruptures typically cause subarachnoid bleeding with intraparenchymal and intraventricular extension. However, rare instances of acute aneurysmal ruptures present with concomitant, non-traumatic subdural hemorrhage (SDH). We explored ... Full text Link to item Cite

Middle Meningeal Artery Embolization Using Combined Particle Embolization and n-BCA with the Dextrose 5% in Water Push Technique for Chronic Subdural Hematomas: A Prospective Safety and Feasibility Study.

Journal Article AJNR Am J Neuroradiol · May 2021 BACKGROUND AND PURPOSE: Embolization of the middle meningeal artery for treatment of refractory or recurrent chronic subdural hematomas has gained momentum during the past few years. Little has been reported on the use of the n-BCA liquid embolic system fo ... Full text Link to item Cite

Image quality of EOS low-dose radiography in comparison with conventional radiography for assessment of ventriculoperitoneal shunt integrity.

Journal Article J Neurosurg Pediatr · April 1, 2021 OBJECTIVE: Patients with shunted hydrocephalus often accumulate high levels of radiation over their lifetimes during evaluation of hardware integrity. Current practice involves the use of a series of conventional radiographs for this purpose. Newer low-dos ... Full text Link to item Cite

Fatal Cerebral Edema in a Child With COVID-19.

Journal Article Pediatr Neurol · January 2021 Full text Link to item Cite

Magnetic resonance-guided stereotactic laser ablation therapy for the treatment of pediatric brain tumors: a multiinstitutional retrospective study.

Journal Article J Neurosurg Pediatr · July 1, 2020 Featured Publication OBJECTIVE: This study aimed to assess the safety and efficacy of MR-guided stereotactic laser ablation (SLA) therapy in the treatment of pediatric brain tumors. METHODS: Data from 17 North American centers were retrospectively reviewed. Clinical, technical ... Full text Link to item Cite

Global Perspectives on Task Shifting and Task Sharing in Neurosurgery.

Conference World Neurosurg X · April 2020 BACKGROUND: Neurosurgical task shifting and task sharing (TS/S), delegating clinical care to non-neurosurgeons, is ongoing in many hospital systems in which neurosurgeons are scarce. Although TS/S can increase access to treatment, it remains highly controv ... Full text Link to item Cite

Cortical stimulation mapping for localization of visual and auditory language in pediatric epilepsy patients.

Journal Article J Neurosurg Pediatr · February 1, 2020 Featured Publication OBJECTIVE: To determine resection margins near eloquent tissue, electrical cortical stimulation (ECS) mapping is often used with visual naming tasks. In recent years, auditory naming tasks have been found to provide a more comprehensive map. Differences in ... Full text Open Access Link to item Cite

Outcomes in children undergoing posterior fossa decompression and duraplasty with and without tonsillar reduction for Chiari malformation type I and syringomyelia: a pilot prospective multicenter cohort study.

Journal Article Journal of neurosurgery. Pediatrics · January 2020 ObjectiveDespite significant advances in diagnostic and surgical techniques, the surgical management of Chiari malformation type I (CM-I) with associated syringomyelia remains controversial, and the type of surgery performed is surgeon dependent. ... Full text Cite

COVID-19-Induced Neurovascular Injury: a Case Series with Emphasis on Pathophysiological Mechanisms.

Journal Article SN Compr Clin Med · 2020 Coronavirus disease 2019 (COVID-19) is associated with a high inflammatory burden that can induce severe respiratory disease among other complications; vascular and neurological damage has emerged as a key threat to COVID-19 patients. Risk of severe infect ... Full text Link to item Cite

Image Guidance for Ventricular Shunt Surgery: An Analysis of Ventricular Size and Proximal Revision Rates.

Journal Article Neurosurgery · March 1, 2019 BACKGROUND: Image guidance is a promising technology that could lead to lower rates of premature shunt failure by decreasing the rate of inaccurate proximal catheter placement. OBJECTIVE: To perform a detailed radiographic analysis of ventricular size usin ... Full text Link to item Cite

MRI-guided laser interstitial thermal therapy in an infant with tuberous sclerosis: technical case report.

Journal Article J Neurosurg Pediatr · January 1, 2019 Featured Publication Cortical tubers associated with tuberous sclerosis complex (TSC) are potential epileptic foci that are often amenable to resective or ablative surgeries, and controlling seizures at a younger age may lead to improved functional outcomes. MRI-guided laser i ... Full text Link to item Cite

Characterization of Perinatal Risk Factors and Complications Associated With Nonsyndromic Craniosynostosis.

Journal Article J Craniofac Surg · 2019 Featured Publication BACKGROUND: Certain intrauterine risk factors are known to increase the risk of premature cranial suture fusion and may cause complications during birth. Some of these risk factors may be modifiable. Therefore, the authors sought to characterize the instit ... Full text Link to item Cite

Socioeconomic Factors, Perioperative Complications, and 30-Day Readmission Rates Associated With Delayed Cranial Vault Reconstruction for Craniosynostosis.

Journal Article The Journal of craniofacial surgery · October 2018 BackgroundPremature fusion of the cranial sutures can lead to significant neurocognitive, developmental, and esthetic consequences, especially if not corrected within the first year of life. This study aimed to identify the drivers of delayed cran ... Full text Cite

Complications following pediatric cranioplasty after decompressive craniectomy: a multicenter retrospective study.

Journal Article J Neurosurg Pediatr · September 2018 OBJECTIVE In children, the repair of skull defects arising from decompressive craniectomy presents a unique set of challenges. Single-center studies have identified different risk factors for the common complications of cranioplasty resorption and infectio ... Full text Link to item Cite

Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy.

Journal Article Ann Neurol · June 2018 OBJECTIVE: Somatic variants are a recognized cause of epilepsy-associated focal malformations of cortical development (MCD). We hypothesized that somatic variants may underlie a wider range of focal epilepsy, including nonlesional focal epilepsy (NLFE). Th ... Full text Link to item Cite

Comment

Journal Article Operative Neurosurgery · March 1, 2018 Cite

Cortical Language Areas and Plasticity in Pediatric Patients With Epilepsy: A Review.

Journal Article Pediatr Neurol · January 2018 Featured Publication Chronic injury to the brain from seizure activity is associated with decreased language skills in pediatric patients, as measured on neuropsychological tests for language function and academic achievement. This makes the study of language in patients with ... Full text Link to item Cite

Shunt freedom and clinical resolution of idiopathic intracranial hypertension after bariatric surgery in the pediatric population: report of 3 cases.

Journal Article J Neurosurg Pediatr · December 2017 Idiopathic intracranial hypertension (IIH), formerly known as pseudotumor cerebri, is a disease of elevated intracranial pressure that is thought to develop due to impaired CSF absorption related to elevated venous sinus pressure in the setting of increase ... Full text Link to item Cite

Rates and predictors of success and failure in repeat epilepsy surgery: A meta-analysis and systematic review.

Journal Article Epilepsia · December 2017 Featured Publication OBJECTIVE: Medically refractory epilepsy is a debilitating disorder that is particularly challenging to treat in patients who have already failed a surgical resection. Evidence regarding outcomes of further epilepsy surgery is limited to small case series ... Full text Link to item Cite

Comparing Outcomes and Cost of 3 Surgical Treatments for Sagittal Synostosis: A Retrospective Study Including Procedure-Related Cost Analysis.

Journal Article Neurosurgery · October 1, 2017 BACKGROUND: Neurosurgical techniques for repair of sagittal synostosis include total cranial vault (TCV) reconstruction, open sagittal strip (OSS) craniectomy, and endoscopic strip (ES) craniectomy. OBJECTIVE: To evaluate outcomes and cost associated with ... Full text Link to item Cite

Risk Factors for Delayed Referral to a Craniofacial Specialist for Treatment of Craniosynostosis.

Journal Article J Pediatr · July 2017 Featured Publication OBJECTIVE: To assess the impact of age at referral on treatment options in craniosynostosis and to identify risk factors for referral delays in this population. STUDY DESIGN: A retrospective cohort study was performed on patients with an abnormal head shap ... Full text Link to item Cite

Temporary Lumbar Drain as Treatment for Pediatric Fulminant Idiopathic Intracranial Hypertension.

Journal Article J Neuroophthalmol · June 2017 Fulminant idiopathic intracranial hypertension (FIIH) is a subtype of idiopathic intracranial hypertension (IIH) characterized by rapid, severe, progressive vision loss. Surgical intervention is often performed either as a cerebrospinal fluid (CSF) shunt p ... Full text Link to item Cite

127 Multimodality Word-Finding Distinctions in Pediatric Cortical Stimulation Mapping.

Journal Article Neurosurgery · August 2016 Featured Publication INTRODUCTION: Recently, auditory naming has become a part of cortical stimulation mapping (CSM) to provide a comprehensive language map prior to resection in epilepsy patients. Modality-specific language sites have been found using CSM in adult epilepsy pa ... Full text Link to item Cite

Current and Emerging Surgical Therapies for Severe Pediatric Epilepsies.

Journal Article Semin Pediatr Neurol · May 2016 Featured Publication The use of epilepsy surgery in various medically resistant epilepsies is well established. For patients with intractable pediatric epilepsy, the role of intracranial electrodes, resective surgery, hemispherectomy, corpus callosotomy, neurostimulation, and ... Full text Link to item Cite

Morphometric Analysis of Predictors of Cervical Syrinx Formation in the Setting of Chiari I Malformation.

Journal Article Pediatr Neurosurg · 2016 BACKGROUND/AIMS: We performed a morphometric analysis of Chiari I malformations to look for predictors of cervical syrinx formation. METHODS: Eighteen patients with Chiari I malformation and associated cervical syrinx and 16 patients with Chiari I malforma ... Full text Link to item Cite

The Chiari Severity Index: a preoperative grading system for Chiari malformation type 1.

Journal Article Neurosurgery · March 2015 BACKGROUND: To develop evidence-based treatment guidelines for Chiari malformation type 1 (CM-1), preoperative prognostic indices capable of stratifying patients for comparative trials are needed. OBJECTIVE: To develop a preoperative Chiari Severity Index ... Full text Link to item Cite

Tethered Cord Surgery

Chapter · 2015 Cite

LOW GRADE GLIOMAS.

Journal Article Neuro-oncology · June 2014 Full text Cite

Preface

Journal Article Proceedings of the International Astronomical Union · January 1, 2014 Cite

PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.

Journal Article J Neurooncol · January 2014 Featured Publication Glioblastoma (GBM) is the most common brain cancer and is highly lethal in both adults and children. 2-methoxyestradiol (2ME2) is a microtubule inhibitor that potently inhibits HIF1α, GBM angiogenesis and tumor growth in preclinical models. In patients, 2M ... Full text Link to item Cite

Traumatic brain injury and hypothermia.

Journal Article J Neurosurg · May 2012 Full text Link to item Cite

Traumatic brain injury and hypothermia RESPONSE

Journal Article JOURNAL OF NEUROSURGERY · May 1, 2012 Link to item Cite

Growth Hormone-Secreting Tumors

Chapter · January 1, 2012 Featured Publication Full text Cite

Inflammatory pseudotumor of the lateral ventricle in a pediatric patient.

Journal Article Pediatr Neurosurg · 2012 Inflammatory pseudotumor (IP) is a benign process that most commonly occurs in the lung and orbit. Extension into the central nervous system is extremely rare, and primary intraventricular lesions of the lateral ventricles are even more infrequent with onl ... Full text Link to item Cite

Pituitary tumors: Diagnosis and management

Journal Article Principles of Neurological Surgery · 2012 Featured Publication Full text Cite

Clinical problem solving: monster on the hook--case problems in neurosurgery.

Journal Article Neurosurgery · March 2011 BACKGROUND AND OBJECTIVE: Nonfunctioning and functioning pituitary tumors can present in numerous ways. They may be difficult to diagnose correctly and, even with proper treatment, may lead to complications. METHODS: We present the case of a patient who pr ... Full text Link to item Cite

Headaches, rapidly progressive visual loss, and bilateral disc edema

Journal Article Reviews in Neurological Diseases · September 1, 2009 Full text Cite

Discrete cerebral hypothermia in the management of traumatic brain injury: a randomized controlled trial.

Journal Article J Neurosurg · June 2009 Featured Publication OBJECT: Hypothermia has been extensively evaluated in the management of traumatic brain injury (TBI), but no consensus as to its effectiveness has yet been reached. Explanatory hypotheses include a possible confounding effect of the neuroprotective benefit ... Full text Link to item Cite

PI-3 kinase-PTEN signaling node: an intercept point for the control of angiogenesis.

Journal Article Curr Pharm Des · 2009 Featured Publication Angiogenesis is tightly regulated by opposing mechanisms in mammalian cells and is controlled by the angiogenic switch. Other review articles have described a central role for the PTEN/PI-3 kinase/AKT signaling node in the coordinate control of cell divisi ... Full text Link to item Cite

Headaches, rapidly progressive visual loss, and bilateral disc edema.

Journal Article Rev Neurol Dis · 2009 The diagnosis and management of a 28-year-old obese woman who presented with neck pain, headache, and rapidly progressive visual loss is discussed here. Results of her initial general examination were normal. Thorough medical follow-up resulted in a rare d ... Link to item Cite

Preface

Journal Article Chiral Dynamics 2006 - Proceedings of the 5th International Workshop on Chiral Dynamics, Theory and Experiment, CD 2006 · December 1, 2007 Cite

Prolonged convection-enhanced delivery into the rat brainstem.

Journal Article Neurosurgery · February 2003 Featured Publication OBJECTIVE: Prolonged convection-enhanced delivery was used in an attempt to achieve large volumes of distribution (V(d)) in the rat brainstem. Clinical assessment and histological analysis were performed to establish the safety of this approach. METHODS: F ... Full text Link to item Cite