Overview
Investigator on the following Studies/Protocols:
Study Title: "A multicenter Phase II Study of TP-38 in those patients with glioblastoma multiforme who have recurred or progressed after previous resection and radiation therapy and are scheduled for gross total resection"
Study Title: "A Phase II Trial of Gliodal PWS06-Benzylquanine for patients with recurrent glioblastoma multiforme"
Study Title: "T-regs in blood underlying tumor escape"
Study Title: "Specimen collection in patients treated up front for malignant astrocytoma"
Study Title: A Complementary Trial of an Immunotherapy Vaccine Against Tumor-Specific EGFRvIII
Study Title: Specimen Collection on Patients Treated Up Front for Malignant Astrocytomas
Study Title: Phase III Randomized Evaluation of Convection Enhanced Delivery of IL13-PE38QQR Compared to Gliadel Wafer with Survival Endpoint in Glioblastoma Multiforme Patients At First Recurrence
Study Title: Phase II Study of 131I-Labeled Anti-tenascin Murine Monoclonal Antibody 81C6 (mu81C6) Administered to Deliver a Targeted Radiation Boost Dose of 44Gy to the Surgically Created Cystic Resection Cavity Perimeter Followed by Conventional External Beam Radiotherapy and Temozolomide for Patients with Newly Diagnosed Glioblastoma Multiforme
Study Title: "A multicenter Phase II Study of TP-38 in those patients with glioblastoma multiforme who have recurred or progressed after previous resection and radiation therapy and are scheduled for gross total resection"
Study Title: "A Phase II Trial of Gliodal PWS06-Benzylquanine for patients with recurrent glioblastoma multiforme"
Study Title: "T-regs in blood underlying tumor escape"
Study Title: "Specimen collection in patients treated up front for malignant astrocytoma"
Study Title: A Complementary Trial of an Immunotherapy Vaccine Against Tumor-Specific EGFRvIII
Study Title: Specimen Collection on Patients Treated Up Front for Malignant Astrocytomas
Study Title: Phase III Randomized Evaluation of Convection Enhanced Delivery of IL13-PE38QQR Compared to Gliadel Wafer with Survival Endpoint in Glioblastoma Multiforme Patients At First Recurrence
Study Title: Phase II Study of 131I-Labeled Anti-tenascin Murine Monoclonal Antibody 81C6 (mu81C6) Administered to Deliver a Targeted Radiation Boost Dose of 44Gy to the Surgically Created Cystic Resection Cavity Perimeter Followed by Conventional External Beam Radiotherapy and Temozolomide for Patients with Newly Diagnosed Glioblastoma Multiforme
Current Appointments & Affiliations
Assistant Professor Emeritus in Neurosurgery
·
2025 - Present
Neurosurgery,
Neurosurgery
Recent Publications
Retrolabyrinthine transsigmoid approach to complex parabrainstem tumors in the posterior fossa.
Journal Article J Neurosurg · April 1, 2022 OBJECTIVE: The surgical management of large and complex tumors of the posterior fossa poses a formidable challenge in neurosurgery. The standard retrosigmoid craniotomy approach has been performed at most neurosurgical centers; however, the retrosigmoid ap ... Full text Link to item CiteThe Effect of Propofol vs. Isoflurane Anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine Levels: Results from a Randomized Trial.
Journal Article Front Immunol · 2017 INTRODUCTION: Aside from direct effects on neurotransmission, inhaled and intravenous anesthetics have immunomodulatory properties. In vitro and mouse model studies suggest that propofol inhibits, while isoflurane increases, neuroinflammation. If these fin ... Full text Link to item CiteThe Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.
Journal Article J Alzheimers Dis · April 15, 2016 BACKGROUND: Preclinical studies have found differential effects of isoflurane and propofol on the Alzheimer's disease (AD)-associated markers tau, phosphorylated tau (p-tau) and amyloid-β (Aβ). OBJECTIVE: We asked whether isoflurane and propofol have diffe ... Full text Open Access Link to item CiteEducation, Training & Certifications
Duke University ·
1994
M.H.S.
Duke University ·
1986
P.A.- C.