Scholars@Duke
Casey Yesol Lee

Casey Yesol Lee

Assistant Professor of Radiation Oncology
Radiation Oncology
casey.y.lee@duke.edu
Dept of Radiation Oncology, Box 3295, Durham, NC 27710
40 Duke Medicine Circle, Durham, NC 27710

Selected Publications

Age-associated change in pyruvate metabolism investigated with hyperpolarized 13 C-MRI of the human brain.

Journal Article Hum Brain Mapp · July 2023 In this study, hyperpolarized 13 C MRI (HP-13 C MRI) was used to investigate changes in the uptake and metabolism of pyruvate with age. Hyperpolarized 13 C-pyruvate was administered to healthy aging individuals (N = 35, ages 21-77) and whole-brain spatial ... Full text Link to item Cite

Catheter reconstruction and dosimetric verification of MRI-only treatment planning (MRTP) for interstitial HDR brachytherapy using PETRA sequence.

Journal Article Phys Med Biol · January 17, 2023 Objective. The feasibility of MRI-only treatment planning (MRTP) for interstitial high-dose rate (HDR) brachytherapy (BT) was investigated for patients diagnosed with gynecologic cancer.Approach. A clinical MRTP workflow utilizing a 'pointwise encoding tim ... Full text Link to item Cite

A Novel Approach to Utilization of Magnetic Resonance Imaging (MRI) in High-Dose-Rate (HDR) Brachytherapy

Conference Lecture Notes in Networks and Systems · January 1, 2023 High-dose-rate (HDR) brachytherapy is a commonly used radiotherapy technique for treating gynecological and skin cancers. Localized delivery of the radiation is regulated by moving the radioactive isotope through catheters on various types of applicators. ... Full text Cite

First pointwise encoding time reduction with radial acquisition (PETRA) implementation for catheter detection in interstitial high-dose-rate (HDR) brachytherapy.

Journal Article Brachytherapy · 2022 PURPOSE: A pointwise encoding time reduction with radial acquisition (PETRA) sequence was optimized to detect empty catheters in interstitial (HDR) brachytherapy with clinically acceptable spatial accuracy for the first time. Image quality and catheter det ... Full text Link to item Cite

Feasibility of magnetic resonance-only high-dose-rate surface brachytherapy for clinical application.

Journal Article Med Phys · November 2021 PURPOSE: In this article, we investigate the feasibility of magnetic resonance (MR)-only imaging for high-dose-rate (HDR) surface brachytherapy (SABT). We examined whether a standard CT-based planning can be replaced with an MR-only planning. For this purp ... Full text Link to item Cite

Predicting response to radiotherapy of intracranial metastases with hyperpolarized [Formula: see text]C MRI.

Journal Article J Neurooncol · May 2021 BACKGROUND: Stereotactic radiosurgery (SRS) is used to manage intracranial metastases in a significant fraction of patients. Local progression after SRS can often only be detected with increased volume of enhancement on serial MRI scans which may lag true ... Full text Link to item Cite

Partial Fourier reconstruction for improved resolution in 3D hyperpolarized 13 C EPI.

Journal Article Magn Reson Med · June 2020 PURPOSE: Asymmetric in-plane k-space sampling of EPI can reduce the minimum achievable TE in hyperpolarized 13C with spectral-spatial radio frequency pulses, thereby reducing T2* weighting and signal-losses. Partial Fourier image reconstruction exploits th ... Full text Link to item Cite

Correlation of hyperpolarized 13 C-MRI data with tissue extract measurements.

Journal Article NMR Biomed · May 2020 Hyperpolarized (HP) 13C MRI provides the means to monitor lactate metabolism noninvasively in tumours. Since 13C -lactate signal levels obtained from HP 13C imaging depend on multiple factors, such as the rate of 13C substrate delivery via the vasculature, ... Full text Link to item Cite

Lactate topography of the human brain using hyperpolarized 13C-MRI.

Journal Article Neuroimage · January 1, 2020 Lactate is now recognized as an important intermediate in brain metabolism, but its role is still under investigation. In this work we mapped the distribution of lactate and bicarbonate produced from intravenously injected 13C-pyruvate over the whole brain ... Full text Link to item Cite

Investigating the Relationship between Transverse Relaxation Rate (R2) and Interecho Time in MagA-Expressing, Iron-Labeled Cells.

Journal Article Mol Imaging · 2015 Reporter gene-based labeling of cells with iron is an emerging method of providing magnetic resonance imaging contrast for long-term cell tracking and monitoring cellular activities. This report investigates 9.4 T nuclear magnetic resonance properties of m ... Full text Link to item Cite