Rebeccah Catherine Rehder

Rebeccah Catherine Rehder
Associate Professor of Pathology

Current Appointments & Affiliations

Associate Professor of Pathology, Pathology, Clinical Science Departments 2019

Contact Information

2351 Erwin Rd., Rm 213 Wadsworth Bldg., Durham, NC 27710
Duke Box 3673, Durham, NC 27710
catherine.rehder@duke.edu (919) 613-8434

Background
Education, Training, & Certifications
- Ph.D., Virginia Commonwealth University 2004
- B.A., North Carolina State University 1999
- Resident Advisor, Ncsu University Housing, North Carolina State University 1996 - 1998
- Laboratory Assistant, Plant Pathology, North Carolina State University 1996
Duke Appointment History
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2007 - 2019
Research
Selected Grants
- Collaborative Innovation Award, CTSA Program awarded by Research Triangle Institute International 2016 - 2019
- RTI-TO2-Newborn Screening Pilot Study for Adrenoleukodystrophy (ALD) awarded by Research Triangle Institute International 2016 - 2018
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Mori, M, Haskell, G, Kazi, Z, Zhu, X, DeArmey, SM, Goldstein, JL, Bali, D, Rehder, C, Cirulli, ET, and Kishnani, PS. "Sensitivity of whole exome sequencing in detecting infantile- and late-onset Pompe disease." Molecular Genetics and Metabolism 122, no. 4 (December 2017): 189-197. Full Text
  - Griffin, NG, Cronin, KD, Walley, NM, Hulette, CM, Grant, GA, Mikati, MA, LaBreche, HG, Rehder, CW, Allen, AS, Crino, PB, and Heinzen, EL. "Somatic uniparental disomy of Chromosome 16p in hemimegalencephaly." Cold Spring Harbor Molecular Case Studies 3, no. 5 (September 2017). Full Text
  - Wu, B, Jug, R, Luedke, C, Su, P, Rehder, C, McCall, C, Lagoo, AS, and Wang, E. "Lineage Switch Between B-Lymphoblastic Leukemia and Acute Myeloid Leukemia Intermediated by "Occult" Myelodysplastic Neoplasm: Two Cases of Adult Patients With Evidence of Genomic Instability and Clonal Selection by Chemotherapy." American Journal of Clinical Pathology 148, no. 2 (August 2017): 136-147. Full Text
  - Wu, B, Ingersoll, K, Rehder, C, and Wang, E. "B-lymphoblastic leukemia in a patient with chronic lymphocytic leukemia: Sequential development of biclonal B-cell neoplasms over a 23-year period in a single individual." Pathology, research and practice 212, no. 11 (November 2016): 1089-1093. Full Text
  - Wu, B, Vallangeon, B, Galeotti, J, Sebastian, S, Rehder, C, and Wang, E. "Epstein-Barr virus-negative diffuse large B cell lymphoma with aberrant expression of CD3 and other T cell-associated antigens: report of three cases with a review of the literature." Annals of hematology 95, no. 10 (October 2016): 1671-1683. (Review) Full Text
  - Xu, Q, Goldstein, J, Wang, P, Gadi, IK, Labreche, H, Rehder, C, Wang, W-P, McConkie, A, Xu, X, and Jiang, Y-H. "Chromosomal microarray analysis in clinical evaluation of neurodevelopmental disorders-reporting a novel deletion of SETDB1 and illustration of counseling challenge." Pediatric research 80, no. 3 (September 2016): 371-381. Full Text
  - Wu, B, Ingersoll, K, Rehder, C, Sebastian, S, and Wang, E. "Sequential development of chronic myelogenous leukemia and primary myelofibrosis in a patient with history of large B-cell lymphoma treated with radiotherapy and chemotherapy: two myeloid neoplasms with distinct genotypic profiles suggestive of biclonality in a single individual." Annals of hematology 95, no. 8 (August 2016): 1383-1386. (Letter) Full Text
  - Shashi, V, McConkie-Rosell, A, Schoch, K, Kasturi, V, Rehder, C, Jiang, YH, Goldstein, DB, and McDonald, MT. "Practical considerations in the clinical application of whole-exome sequencing." Clinical Genetics 89, no. 2 (February 2016): 173-181. Full Text
  - Bali, DS, Goldstein, JL, Rehder, C, Kazi, ZB, Berrier, KL, Dai, J, and Kishnani, PS. "Clinical Laboratory Experience of Blood CRIM Testing in Infantile Pompe Disease." Molecular genetics and metabolism reports 5 (December 2015): 76-79. Full Text
  - Berrier, KL, Kazi, ZB, Prater, SN, Bali, DS, Goldstein, J, Stefanescu, MC, Rehder, CW, Botha, EG, Ellaway, C, Bhattacharya, K, Tylki-Szymanska, A, Karabul, N, Rosenberg, AS, and Kishnani, PS. "CRIM-negative infantile Pompe disease: characterization of immune responses in patients treated with ERT monotherapy." Genetics in Medicine : Official Journal of the American College of Medical Genetics 17, no. 11 (November 2015): 912-918. Full Text
  - Berrier, KL, Kazi, ZB, Prater, SN, Bali, DS, Goldstein, J, Stefanescu, MC, Rehder, CW, Botha, EG, Ellaway, C, Bhattacharya, K, Tylki-Szymanska, A, Karabul, N, Rosenberg, AS, and Kishnani, PS. "CORRIGENDUM: CRIM-negative infantile Pompe disease: characterization of immune responses in patients treated with ERT monotherapy." Genetics in Medicine : Official Journal of the American College of Medical Genetics 17, no. 7 (July 2015): 596-null. Full Text
  - Puranam, RS, He, XP, Yao, L, Le, T, Jang, W, Rehder, CW, Lewis, DV, and McNamara, JO. "Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, no. 23 (June 2015): 8866-8881. Full Text
  - Wei, Q, Papavassiliou, P, Rehder, C, Sebastian, S, and Wang, E. "T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities." Pathology, research and practice 210, no. 12 (December 2014): 1100-1105. Full Text
  - Wei, Q, Sebastian, S, Papavassiliou, P, Rehder, C, and Wang, E. "Metachronous/concomitant B-cell neoplasms with discordant light-chain or heavy-chain isotype restrictions: evidence of distinct B-cell neoplasms rather than clonal evolutions." Human pathology 45, no. 10 (October 2014): 2063-2076. Full Text
  - Wei, Q, Sebastian, S, Papavassiliou, P, Rehder, C, and Wang, E. "Metachronous/concomitant B-cell neoplasms with discordant light-chain or heavy-chain isotype restrictions: Evidence of distinct B-cell neoplasms rather than clonal evolutions." Human Pathology 45, no. 10 (October 1, 2014): 2063-2076. Full Text
  - Cooper, GM, Coe, BP, Girirajan, S, Rosenfeld, JA, Vu, TH, Baker, C, Williams, C, Stalker, H, Hamid, R, Hannig, V, Abdel-Hamid, H, Bader, P, McCracken, E, Niyazov, D, Leppig, K, Thiese, H, Hummel, M, Alexander, N, Gorski, J, Kussmann, J, Shashi, V, Johnson, K, Rehder, C, Ballif, BC, Shaffer, LG, and Eichler, EE. "Corrigendum: A copy number variation morbidity map of developmental delay." Nature Genetics 46, no. 9 (August 2014): 1040-null. Full Text
  - Holder, JL, Agadi, S, Reese, W, Rehder, C, and Quach, MM. "Infantile spasms and hyperekplexia associated with isolated sulfite oxidase deficiency." Jama Neurology 71, no. 6 (June 2014): 782-784. Full Text
  - Goldstein, JL, Dickerson, G, Kishnani, PS, Rehder, C, and Bali, DS. "Blood-based diagnostic testing for Pompe disease: consistency between GAA enzyme activity in dried blood spots and GAA gene sequencing results." Muscle Nerve 49, no. 5 (May 2014): 775-776. (Letter) Full Text Link to Item
  - Wang, E, Papavassiliou, P, Wang, AR, Louissaint, A, Wang, J, Hutchinson, CB, Huang, Q, Reddi, D, Wei, Q, Sebastian, S, Rehder, C, Brynes, R, and Siddiqi, I. "Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases." Human Pathology 45, no. 4 (April 2014): 768-784. Full Text
  - Bali, DS, Goldstein, JL, Fredrickson, K, Rehder, C, Boney, A, Austin, S, Weinstein, DA, Lutz, R, Boneh, A, and Kishnani, PS. "Variability of disease spectrum in children with liver phosphorylase kinase deficiency caused by mutations in the PHKG2 gene." Mol Genet Metab 111, no. 3 (March 2014): 309-313. Full Text Link to Item
  - Kishnani, PS. "Variability of disease spectrum in children with liver phosphorylase kinase deficiency caused by mutations in the PHKG2 gene." Molecular Genetics and Metabolism 111, no. 3 (March 1, 2014): 309-313. Full Text
  - Haga, SB, Mills, R, Pollak, KI, Rehder, C, Buchanan, AH, Lipkus, IM, Crow, JH, and Datto, M. "Developing patient-friendly genetic and genomic test reports: formats to promote patient engagement and understanding." Genome medicine 6, no. 7 (January 2014): 58-. Full Text
  - Sund, KL, and Rehder, CW. "Detection and reporting of homozygosity associated with consanguinity in the clinical laboratory." Human heredity 77, no. 1-4 (January 2014): 217-224. (Review) Full Text
  - Wang, E, Papavassiliou, P, Wang, AR, Louissaint, A, Wang, J, Hutchinson, CB, Huang, Q, Reddi, D, Wei, Q, Sebastian, S, Rehder, C, Brynes, R, and Siddiqi, I. "Composite lymphoid neoplasm of B-cell and T-cell origins: A pathologic study of 14 cases." Human Pathology 45, no. 4 (January 1, 2014): 768-784. Full Text
  - Wei, Q, Papavassiliou, P, Rehder, C, Sebastian, S, and Wang, E. "T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities." Pathology Research and Practice 210, no. 12 (2014): 1100-1105. Full Text
  - Rehder, CW, David, KL, Hirsch, B, Toriello, HV, Wilson, CM, and Kearney, HM. "Response to Rosenberg et al." Genetics in Medicine : Official Journal of the American College of Medical Genetics 15, no. 9 (September 2013): 754-null. (Letter) Full Text
  - Rehder, CW, David, KL, Hirsch, B, Toriello, HV, Wilson, CM, and Kearney, HM. "American College of Medical Genetics and Genomics: standards and guidelines for documenting suspected consanguinity as an incidental finding of genomic testing." Genet Med 15, no. 2 (February 2013): 150-152. Full Text Link to Item
  - Banugaria, SG, Prater, SN, Patel, TT, Dearmey, SM, Milleson, C, Sheets, KB, Bali, DS, Rehder, CW, Raiman, JAJ, Wang, RA, Labarthe, F, Charrow, J, Harmatz, P, Chakraborty, P, Rosenberg, AS, and Kishnani, PS. "Algorithm for the early diagnosis and treatment of patients with cross reactive immunologic material-negative classic infantile pompe disease: a step towards improving the efficacy of ERT. (Published online)" PLoS One 8, no. 6 (2013): e67052-. Full Text Open Access Copy Link to Item
  - Wang, E, Stoecker, M, Burchette, J, and Rehder, C. "Follicular lymphoma with prominent Dutcher body formation: a pathologic study of 3 cases in comparison with nodal or splenic lymphoplasmacytic lymphoma and marginal zone lymphoma." Hum Pathol 43, no. 11 (November 2012): 2001-2011. Full Text Link to Item
  - Landi, D, Lockhart, E, Miller, SE, Datto, M, Rehder, C, Kanaly, A, and Thornburg, CD. "Report of a young girl with MYH9 mutation and review of the literature." J Pediatr Hematol Oncol 34, no. 7 (October 2012): 538-540. (Review) Full Text Link to Item
  - Young, SP, Piraud, M, Goldstein, JL, Zhang, H, Rehder, C, Laforet, P, Kishnani, PS, Millington, DS, Bashir, MR, and Bali, DS. "Assessing disease severity in Pompe disease: the roles of a urinary glucose tetrasaccharide biomarker and imaging techniques." Am J Med Genet C Semin Med Genet 160C, no. 1 (February 15, 2012): 50-58. Full Text Link to Item
  - Bali, DS, Goldstein, JL, Banugaria, S, Dai, J, Mackey, J, Rehder, C, and Kishnani, PS. "Predicting cross-reactive immunological material (CRIM) status in Pompe disease using GAA mutations: lessons learned from 10 years of clinical laboratory testing experience." American Journal of Medical Genetics. Part C, Seminars in Medical Genetics 160C, no. 1 (February 2012): 40-49. Full Text
  - Lanasa, MC, Davis, PH, Datto, M, Li, Z, Gockerman, JP, Moore, JO, DeCastro, CM, Friedman, DR, Diehl, LF, Rehder, C, Cook, H, Daugherty, FJ, Matta, KMB, Weinberg, JB, and Rizzieri, D. "Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia." Leukemia & Lymphoma 53, no. 2 (February 2012): 218-224. Full Text
  - Achouitar, S, Goldstein, JL, Mohamed, M, Austin, S, Boyette, K, Blanpain, FM, Rehder, CW, Kishnani, PS, Wortmann, SB, den Heijer, M, Lefeber, DJ, Wevers, RA, Bali, DS, and Morava, E. "Common mutation in the PHKA2 gene with variable phenotype in patients with liver phosphorylase b kinase deficiency." Mol Genet Metab 104, no. 4 (December 2011): 691-694. Full Text Link to Item
  - Deak, KL, Horn, SR, and Rehder, CW. "The evolving picture of microdeletion/microduplication syndromes in the age of microarray analysis: variable expressivity and genomic complexity." Clin Lab Med 31, no. 4 (December 2011): 543-viii. (Review) Full Text Link to Item
  - Prajnya, R, Rehder, C, Phadke, SR, and Bali, D. "Prenatal diagnosis of Pompe disease: enzyme assay or molecular testing?." Indian Pediatr 48, no. 11 (November 11, 2011): 901-902. Link to Item
  - Cooper, GM, Coe, BP, Girirajan, S, Rosenfeld, JA, Vu, TH, Baker, C, Williams, C, Stalker, H, Hamid, R, Hannig, V, Abdel-Hamid, H, Bader, P, McCracken, E, Niyazov, D, Leppig, K, Thiese, H, Hummel, M, Alexander, N, Gorski, J, Kussmann, J, Shashi, V, Johnson, K, Rehder, C, Ballif, BC, Shaffer, LG, and Eichler, EE. "A copy number variation morbidity map of developmental delay." Nature Genetics 43, no. 9 (August 14, 2011): 838-846. Full Text
  - Wang, E, Papalas, J, Siddiqi, I, Stoecker, M, Rehder, C, Sebastain, S, Burchette, J, and Huang, Q. "A small cell variant of ALK-positive, CD8-positive anaplastic large cell lymphoma with primary subcutaneous presentation mimicking subcutaneous panniculitis-like T-cell lymphoma." Pathology, Research and Practice 207, no. 8 (August 2011): 522-526. Full Text
  - Wang, E, Hutchinson, CB, Huang, Q, Lu, CM, Crow, J, Wang, FF, Sebastian, S, Rehder, C, Lagoo, A, Horwitz, M, Rizzieri, D, Yu, J, Goodman, B, Datto, M, and Buckley, P. "Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature." American Journal of Clinical Pathology 135, no. 4 (April 2011): 525-540. (Review) Full Text
  - Wang, E, Papalas, J, Hutchinson, CB, Kulbacki, E, Huang, Q, Sebastian, S, Rehder, C, Silbermins, D, Moore, J, and Datto, M. "Sequential development of histiocytic sarcoma and diffuse large b-cell lymphoma in a patient with a remote history of follicular lymphoma with genotypic evidence of a clonal relationship: a divergent (bilineal) neoplastic transformation of an indolent B-cell lymphoma in a single individual." Am J Surg Pathol 35, no. 3 (March 2011): 457-463. Full Text Link to Item
  - Wang, E, Boswell, E, Siddiqi, I, Lu, CM, Sebastian, S, Rehder, C, and Huang, Q. "Pseudo-Pelger-Huët anomaly induced by medications: a clinicopathologic study in comparison with myelodysplastic syndrome-related pseudo-Pelger-Huët anomaly." American Journal of Clinical Pathology 135, no. 2 (February 2011): 291-303. Full Text
  - Crow, J, Youens, K, Michalowski, S, Perrine, G, Emhart, C, Johnson, F, Gerling, A, Kurtzberg, J, Goodman, BK, Sebastian, S, Rehder, CW, and Datto, MB. "Donor cell leukemia in umbilical cord blood transplant patients: a case study and literature review highlighting the importance of molecular engraftment analysis." J Mol Diagn 12, no. 4 (July 2010): 530-537. (Review) Full Text Link to Item
  - Goldstein, JL, Austin, SL, Boyette, K, Kanaly, A, Veerapandiyan, A, Rehder, C, Kishnani, PS, and Bali, DS. "Molecular analysis of the AGL gene: identification of 25 novel mutations and evidence of genetic heterogeneity in patients with Glycogen Storage Disease Type III." Genetics in Medicine : Official Journal of the American College of Medical Genetics 12, no. 7 (July 2010): 424-430. Full Text
  - Wang, E, and Kulbacki, E. "Pseudo-Pelger-Huët anomaly induced by transplant medications." International journal of hematology 92, no. 1 (July 2010): 1-2. Full Text
  - Wang, E, Hutchinson, CB, Huang, Q, Sebastian, S, Rehder, C, Kanaly, A, Moore, J, and Datto, M. "Histiocytic sarcoma arising in indolent small B-cell lymphoma: report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution." Leuk Lymphoma 51, no. 5 (May 2010): 802-812. Full Text Link to Item
  - Kulbacki, E, Rehder, C, and Wang, E. "Prominent Dutcher body formation in a case of follicular lymphoma with BCL6 gene rearrangement and intact BCL2 gene." Am J Hematol 85, no. 3 (March 2010): 218-219. (Letter) Full Text Link to Item
  - Weinberg, JB, Volkheimer, AD, Chen, Y, Beasley, BE, Jiang, N, Lanasa, MC, Friedman, D, Vaccaro, G, Rehder, CW, Decastro, CM, Rizzieri, DA, Diehl, LF, Gockerman, JP, Moore, JO, Goodman, BK, and Levesque, MC. "Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia." American Journal of Hematology 82, no. 12 (December 2007): 1063-1070. Full Text
  - Poss, AF, Goldenberg, PC, Rehder, CW, Kearney, HM, Melvin, EC, Koeberl, DD, and McDonald, MT. "Clinical experience with array CGH: case presentations from nine months of practice." Am J Med Genet A 140, no. 19 (October 1, 2006): 2050-2056. Full Text Link to Item
  - Gong, JZ, Bayerl, MG, Sandhaus, LM, Sebastian, S, Rehder, CW, Routbort, M, Lagoo, AS, Szabolcs, P, Chiu, J, Comito, M, and Buckley, PJ. "Posttransplant lymphoproliferative disorder after umbilical cord blood transplantation in children." The American Journal of Surgical Pathology 30, no. 3 (March 2006): 328-336. Full Text
  - Gong, JZ, Bayerl, MG, Sandhaus, LM, Sebastian, S, Rehder, CW, Routbort, M, Lagoo, AS, Szabolcs, P, Chiu, J, Comito, M, and Buckley, PJ. "Posttransplant lymphoproliferative disorder after umbilical cord blood transplantation in children." American Journal of Surgical Pathology 30, no. 3 (2006): 328-336. Full Text
  - Leach, NT, Rehder, C, Jensen, K, Holt, S, and Jackson-Cook, C. "Human chromosomes with shorter telomeres and large heterochromatin regions have a higher frequency of acquired somatic cell aneuploidy." Mechanisms of Ageing and Development 125, no. 8 (2004): 563-573. Full Text
  - Elmore, LW, Rehder, CW, Di, X, McChesney, PA, Jackson-Cook, CK, Gewirtz, DA, and Holt, SE. "Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction." The Journal of Biological Chemistry 277, no. 38 (September 2002): 35509-35515. Full Text
- Conference Papers
  - Wu, B, Ingersoll, K, Jug, R, Yang, L-H, Luedke, C, Lo, A, Su, P, Liu, X, Rehder, C, Gong, J, Lu, CM, and Wang, E. "Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases." December 2017. Full Text

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Conference Papers