Rebeccah Catherine Rehder

Rebeccah Catherine Rehder
Assistant Professor of Pathology

Current Appointments & Affiliations

Assistant Professor of Pathology, Pathology, Clinical Science Departments 2007
Associate Professor of Pathology, Pathology, Clinical Science Departments 2019

Contact Information

2351 Erwin Rd., Rm 213 Wadsworth Bldg., Durham, NC 27710
Duke Box 3673, Durham, NC 27710
catherine.rehder@duke.edu (919) 613-8434

Background
Education, Training, & Certifications
- Ph.D., Virginia Commonwealth University 2004
- B.A., North Carolina State University 1999
- Resident Advisor, Ncsu University Housing, North Carolina State University 1996 - 1998
- Laboratory Assistant, Plant Pathology, North Carolina State University 1996
Research
Selected Grants
- Collaborative Innovation Award, CTSA Program awarded by Research Triangle Institute International 2016 - 2019
- RTI-TO2-Newborn Screening Pilot Study for Adrenoleukodystrophy (ALD) awarded by Research Triangle Institute International 2016 - 2018
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Mori, M, Haskell, G, Kazi, Z, Zhu, X, DeArmey, SM, Goldstein, JL, Bali, D, Rehder, C, Cirulli, ET, and Kishnani, PS. "Sensitivity of whole exome sequencing in detecting infantile- and late-onset Pompe disease." Molecular Genetics and Metabolism 122, no. 4 (December 2017): 189-197. Full Text
  - Griffin, NG, Cronin, KD, Walley, NM, Hulette, CM, Grant, GA, Mikati, MA, LaBreche, HG, Rehder, CW, Allen, AS, Crino, PB, and Heinzen, EL. "Somatic uniparental disomy of Chromosome 16p in hemimegalencephaly." Cold Spring Harbor Molecular Case Studies 3, no. 5 (September 2017). Full Text
  - Wu, B, Jug, R, Luedke, C, Su, P, Rehder, C, McCall, C, Lagoo, AS, and Wang, E. "Lineage Switch Between B-Lymphoblastic Leukemia and Acute Myeloid Leukemia Intermediated by "Occult" Myelodysplastic Neoplasm: Two Cases of Adult Patients With Evidence of Genomic Instability and Clonal Selection by Chemotherapy." American Journal of Clinical Pathology 148, no. 2 (August 2017): 136-147. Full Text
  - Wu, B, Ingersoll, K, Rehder, C, and Wang, E. "B-lymphoblastic leukemia in a patient with chronic lymphocytic leukemia: Sequential development of biclonal B-cell neoplasms over a 23-year period in a single individual." Pathology, research and practice 212, no. 11 (November 2016): 1089-1093. Full Text
  - Wu, B, Vallangeon, B, Galeotti, J, Sebastian, S, Rehder, C, and Wang, E. "Epstein-Barr virus-negative diffuse large B cell lymphoma with aberrant expression of CD3 and other T cell-associated antigens: report of three cases with a review of the literature." Annals of hematology 95, no. 10 (October 2016): 1671-1683. (Review) Full Text
  - Xu, Q, Goldstein, J, Wang, P, Gadi, IK, Labreche, H, Rehder, C, Wang, W-P, McConkie, A, Xu, X, and Jiang, Y-H. "Chromosomal microarray analysis in clinical evaluation of neurodevelopmental disorders-reporting a novel deletion of SETDB1 and illustration of counseling challenge." Pediatric research 80, no. 3 (September 2016): 371-381. Full Text
  - Wu, B, Ingersoll, K, Rehder, C, Sebastian, S, and Wang, E. "Sequential development of chronic myelogenous leukemia and primary myelofibrosis in a patient with history of large B-cell lymphoma treated with radiotherapy and chemotherapy: two myeloid neoplasms with distinct genotypic profiles suggestive of biclonality in a single individual." Annals of hematology 95, no. 8 (August 2016): 1383-1386. (Letter) Full Text
  - Shashi, V, McConkie-Rosell, A, Schoch, K, Kasturi, V, Rehder, C, Jiang, YH, Goldstein, DB, and McDonald, MT. "Practical considerations in the clinical application of whole-exome sequencing." Clinical Genetics 89, no. 2 (February 2016): 173-181. Full Text
  - Bali, DS, Goldstein, JL, Rehder, C, Kazi, ZB, Berrier, KL, Dai, J, and Kishnani, PS. "Clinical Laboratory Experience of Blood CRIM Testing in Infantile Pompe Disease." Molecular genetics and metabolism reports 5 (December 2015): 76-79. Full Text
  - Berrier, KL, Kazi, ZB, Prater, SN, Bali, DS, Goldstein, J, Stefanescu, MC, Rehder, CW, Botha, EG, Ellaway, C, Bhattacharya, K, Tylki-Szymanska, A, Karabul, N, Rosenberg, AS, and Kishnani, PS. "CRIM-negative infantile Pompe disease: characterization of immune responses in patients treated with ERT monotherapy." Genetics in Medicine : Official Journal of the American College of Medical Genetics 17, no. 11 (November 2015): 912-918. Full Text
  - Berrier, KL, Kazi, ZB, Prater, SN, Bali, DS, Goldstein, J, Stefanescu, MC, Rehder, CW, Botha, EG, Ellaway, C, Bhattacharya, K, Tylki-Szymanska, A, Karabul, N, Rosenberg, AS, and Kishnani, PS. "CORRIGENDUM: CRIM-negative infantile Pompe disease: characterization of immune responses in patients treated with ERT monotherapy." Genetics in Medicine : Official Journal of the American College of Medical Genetics 17, no. 7 (July 2015): 596-null. Full Text
  - Puranam, RS, He, XP, Yao, L, Le, T, Jang, W, Rehder, CW, Lewis, DV, and McNamara, JO. "Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, no. 23 (June 2015): 8866-8881. Full Text
  - Wei, Q, Papavassiliou, P, Rehder, C, Sebastian, S, and Wang, E. "T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities." Pathology, research and practice 210, no. 12 (December 2014): 1100-1105. Full Text
  - "Metachronous/concomitant B-cell neoplasms with discordant light-chain or heavy-chain isotype restrictions: Evidence of distinct B-cell neoplasms rather than clonal evolutions." Human Pathology 45, no. 10 (October 1, 2014): 2063-2076. Full Text
  - Wei, Q, Sebastian, S, Papavassiliou, P, Rehder, C, and Wang, E. "Metachronous/concomitant B-cell neoplasms with discordant light-chain or heavy-chain isotype restrictions: evidence of distinct B-cell neoplasms rather than clonal evolutions." Human pathology 45, no. 10 (October 2014): 2063-2076. Full Text
  - Cooper, GM, Coe, BP, Girirajan, S, Rosenfeld, JA, Vu, TH, Baker, C, Williams, C, Stalker, H, Hamid, R, Hannig, V, Abdel-Hamid, H, Bader, P, McCracken, E, Niyazov, D, Leppig, K, Thiese, H, Hummel, M, Alexander, N, Gorski, J, Kussmann, J, Shashi, V, Johnson, K, Rehder, C, Ballif, BC, Shaffer, LG, and Eichler, EE. "Corrigendum: A copy number variation morbidity map of developmental delay." Nature Genetics 46, no. 9 (August 2014): 1040-null. Full Text
  - Holder, JL, Agadi, S, Reese, W, Rehder, C, and Quach, MM. "Infantile spasms and hyperekplexia associated with isolated sulfite oxidase deficiency." Jama Neurology 71, no. 6 (June 2014): 782-784. Full Text
  - Goldstein, JL, Dickerson, G, Kishnani, PS, Rehder, C, and Bali, DS. "Blood-based diagnostic testing for Pompe disease: consistency between GAA enzyme activity in dried blood spots and GAA gene sequencing results." Muscle Nerve 49, no. 5 (May 2014): 775-776. (Letter) Full Text Link to Item
  - Wang, E, Papavassiliou, P, Wang, AR, Louissaint, A, Wang, J, Hutchinson, CB, Huang, Q, Reddi, D, Wei, Q, Sebastian, S, Rehder, C, Brynes, R, and Siddiqi, I. "Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases." Human Pathology 45, no. 4 (April 2014): 768-784. Full Text
  - Wang, E, Papavassiliou, P, Wang, AR, Louissaint, A, Wang, J, Hutchinson, CB, Huang, Q, Reddi, D, Wei, Q, Sebastian, S, Rehder, C, Brynes, R, and Siddiqi, I. "Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases." Human Pathology 45, no. 4 (April 2014): 768-784. Full Text
  - Bali, DS, Goldstein, JL, Fredrickson, K, Rehder, C, Boney, A, Austin, S, Weinstein, DA, Lutz, R, Boneh, A, and Kishnani, PS. "Variability of disease spectrum in children with liver phosphorylase kinase deficiency caused by mutations in the PHKG2 gene." Mol Genet Metab 111, no. 3 (March 2014): 309-313. Full Text Link to Item
  - Kishnani, PS. "Variability of disease spectrum in children with liver phosphorylase kinase deficiency caused by mutations in the PHKG2 gene." Molecular Genetics and Metabolism 111, no. 3 (March 1, 2014): 309-313. Full Text
  - Haga, SB, Mills, R, Pollak, KI, Rehder, C, Buchanan, AH, Lipkus, IM, Crow, JH, and Datto, M. "Developing patient-friendly genetic and genomic test reports: formats to promote patient engagement and understanding." Genome medicine 6, no. 7 (January 2014): 58-. Full Text
  - Sund, KL, and Rehder, CW. "Detection and reporting of homozygosity associated with consanguinity in the clinical laboratory." Human heredity 77, no. 1-4 (January 2014): 217-224. (Review) Full Text
  - Wei, Q, Papavassiliou, P, Rehder, C, Sebastian, S, and Wang, E. "T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities." Pathology Research and Practice 210, no. 12 (2014): 1100-1105. Full Text
  - Rehder, CW, David, KL, Hirsch, B, Toriello, HV, Wilson, CM, and Kearney, HM. "Response to Rosenberg et al." Genetics in Medicine : Official Journal of the American College of Medical Genetics 15, no. 9 (September 2013): 754-null. (Letter) Full Text
  - Rehder, CW, David, KL, Hirsch, B, Toriello, HV, Wilson, CM, and Kearney, HM. "American College of Medical Genetics and Genomics: standards and guidelines for documenting suspected consanguinity as an incidental finding of genomic testing." Genet Med 15, no. 2 (February 2013): 150-152. Full Text Link to Item
  - Banugaria, SG, Prater, SN, Patel, TT, Dearmey, SM, Milleson, C, Sheets, KB, Bali, DS, Rehder, CW, Raiman, JAJ, Wang, RA, Labarthe, F, Charrow, J, Harmatz, P, Chakraborty, P, Rosenberg, AS, and Kishnani, PS. "Algorithm for the early diagnosis and treatment of patients with cross reactive immunologic material-negative classic infantile pompe disease: a step towards improving the efficacy of ERT. (Published online)" PLoS One 8, no. 6 (2013): e67052-. Full Text Open Access Copy Link to Item
  - Wang, E, Stoecker, M, Burchette, J, and Rehder, C. "Follicular lymphoma with prominent Dutcher body formation: a pathologic study of 3 cases in comparison with nodal or splenic lymphoplasmacytic lymphoma and marginal zone lymphoma." Hum Pathol 43, no. 11 (November 2012): 2001-2011. Full Text Link to Item
  - Landi, D, Lockhart, E, Miller, SE, Datto, M, Rehder, C, Kanaly, A, and Thornburg, CD. "Report of a young girl with MYH9 mutation and review of the literature." J Pediatr Hematol Oncol 34, no. 7 (October 2012): 538-540. (Review) Full Text Link to Item
  - Young, SP, Piraud, M, Goldstein, JL, Zhang, H, Rehder, C, Laforet, P, Kishnani, PS, Millington, DS, Bashir, MR, and Bali, DS. "Assessing disease severity in Pompe disease: the roles of a urinary glucose tetrasaccharide biomarker and imaging techniques." Am J Med Genet C Semin Med Genet 160C, no. 1 (February 15, 2012): 50-58. Full Text Link to Item
  - Bali, DS, Goldstein, JL, Banugaria, S, Dai, J, Mackey, J, Rehder, C, and Kishnani, PS. "Predicting cross-reactive immunological material (CRIM) status in Pompe disease using GAA mutations: lessons learned from 10 years of clinical laboratory testing experience." American Journal of Medical Genetics. Part C, Seminars in Medical Genetics 160C, no. 1 (February 2012): 40-49. Full Text
  - Lanasa, MC, Davis, PH, Datto, M, Li, Z, Gockerman, JP, Moore, JO, DeCastro, CM, Friedman, DR, Diehl, LF, Rehder, C, Cook, H, Daugherty, FJ, Matta, KMB, Weinberg, JB, and Rizzieri, D. "Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia." Leuk Lymphoma 53, no. 2 (February 2012): 218-224. Full Text Link to Item
  - Achouitar, S, Goldstein, JL, Mohamed, M, Austin, S, Boyette, K, Blanpain, FM, Rehder, CW, Kishnani, PS, Wortmann, SB, den Heijer, M, Lefeber, DJ, Wevers, RA, Bali, DS, and Morava, E. "Common mutation in the PHKA2 gene with variable phenotype in patients with liver phosphorylase b kinase deficiency." Mol Genet Metab 104, no. 4 (December 2011): 691-694. Full Text Link to Item
  - Deak, KL, Horn, SR, and Rehder, CW. "The evolving picture of microdeletion/microduplication syndromes in the age of microarray analysis: variable expressivity and genomic complexity." Clin Lab Med 31, no. 4 (December 2011): 543-viii. (Review) Full Text Link to Item
  - Prajnya, R, Rehder, C, Phadke, SR, and Bali, D. "Prenatal diagnosis of Pompe disease: enzyme assay or molecular testing?." Indian Pediatr 48, no. 11 (November 11, 2011): 901-902. Link to Item
  - Cooper, GM, Coe, BP, Girirajan, S, Rosenfeld, JA, Vu, TH, Baker, C, Williams, C, Stalker, H, Hamid, R, Hannig, V, Abdel-Hamid, H, Bader, P, McCracken, E, Niyazov, D, Leppig, K, Thiese, H, Hummel, M, Alexander, N, Gorski, J, Kussmann, J, Shashi, V, Johnson, K, Rehder, C, Ballif, BC, Shaffer, LG, and Eichler, EE. "A copy number variation morbidity map of developmental delay." Nature Genetics 43, no. 9 (August 14, 2011): 838-846. Full Text
  - Wang, E, Papalas, J, Siddiqi, I, Stoecker, M, Rehder, C, Sebastain, S, Burchette, J, and Huang, Q. "A small cell variant of ALK-positive, CD8-positive anaplastic large cell lymphoma with primary subcutaneous presentation mimicking subcutaneous panniculitis-like T-cell lymphoma." Pathology, Research and Practice 207, no. 8 (August 2011): 522-526. Full Text
  - Wang, E, Hutchinson, CB, Huang, Q, Lu, CM, Crow, J, Wang, FF, Sebastian, S, Rehder, C, Lagoo, A, Horwitz, M, Rizzieri, D, Yu, J, Goodman, B, Datto, M, and Buckley, P. "Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature." American Journal of Clinical Pathology 135, no. 4 (April 2011): 525-540. (Review) Full Text
  - Wang, E, Papalas, J, Hutchinson, CB, Kulbacki, E, Huang, Q, Sebastian, S, Rehder, C, Silbermins, D, Moore, J, and Datto, M. "Sequential development of histiocytic sarcoma and diffuse large b-cell lymphoma in a patient with a remote history of follicular lymphoma with genotypic evidence of a clonal relationship: a divergent (bilineal) neoplastic transformation of an indolent B-cell lymphoma in a single individual." Am J Surg Pathol 35, no. 3 (March 2011): 457-463. Full Text Link to Item
  - Wang, E, Boswell, E, Siddiqi, I, Lu, CM, Sebastian, S, Rehder, C, and Huang, Q. "Pseudo-Pelger-Huët anomaly induced by medications: a clinicopathologic study in comparison with myelodysplastic syndrome-related pseudo-Pelger-Huët anomaly." American Journal of Clinical Pathology 135, no. 2 (February 2011): 291-303. Full Text
  - Crow, J, Youens, K, Michalowski, S, Perrine, G, Emhart, C, Johnson, F, Gerling, A, Kurtzberg, J, Goodman, BK, Sebastian, S, Rehder, CW, and Datto, MB. "Donor cell leukemia in umbilical cord blood transplant patients: a case study and literature review highlighting the importance of molecular engraftment analysis." J Mol Diagn 12, no. 4 (July 2010): 530-537. (Review) Full Text Link to Item
  - Goldstein, JL, Austin, SL, Boyette, K, Kanaly, A, Veerapandiyan, A, Rehder, C, Kishnani, PS, and Bali, DS. "Molecular analysis of the AGL gene: identification of 25 novel mutations and evidence of genetic heterogeneity in patients with Glycogen Storage Disease Type III." Genetics in Medicine : Official Journal of the American College of Medical Genetics 12, no. 7 (July 2010): 424-430. Full Text
  - Wang, E, and Kulbacki, E. "Pseudo-Pelger-Huët anomaly induced by transplant medications." International journal of hematology 92, no. 1 (July 2010): 1-2. Full Text
  - Wang, E, Hutchinson, CB, Huang, Q, Sebastian, S, Rehder, C, Kanaly, A, Moore, J, and Datto, M. "Histiocytic sarcoma arising in indolent small B-cell lymphoma: report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution." Leuk Lymphoma 51, no. 5 (May 2010): 802-812. Full Text Link to Item
  - Kulbacki, E, Rehder, C, and Wang, E. "Prominent Dutcher body formation in a case of follicular lymphoma with BCL6 gene rearrangement and intact BCL2 gene." Am J Hematol 85, no. 3 (March 2010): 218-219. (Letter) Full Text Link to Item
  - Weinberg, JB, Volkheimer, AD, Chen, Y, Beasley, BE, Jiang, N, Lanasa, MC, Friedman, D, Vaccaro, G, Rehder, CW, Decastro, CM, Rizzieri, DA, Diehl, LF, Gockerman, JP, Moore, JO, Goodman, BK, and Levesque, MC. "Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia." American Journal of Hematology 82, no. 12 (December 2007): 1063-1070. Full Text
  - Poss, AF, Goldenberg, PC, Rehder, CW, Kearney, HM, Melvin, EC, Koeberl, DD, and McDonald, MT. "Clinical experience with array CGH: case presentations from nine months of practice." Am J Med Genet A 140, no. 19 (October 1, 2006): 2050-2056. Full Text Link to Item
  - Gong, JZ, Bayerl, MG, Sandhaus, LM, Sebastian, S, Rehder, CW, Routbort, M, Lagoo, AS, Szabolcs, P, Chiu, J, Comito, M, and Buckley, PJ. "Posttransplant lymphoproliferative disorder after umbilical cord blood transplantation in children." The American Journal of Surgical Pathology 30, no. 3 (March 2006): 328-336. Full Text
  - Gong, JZ, Bayerl, MG, Sandhaus, LM, Sebastian, S, Rehder, CW, Routbort, M, Lagoo, AS, Szabolcs, P, Chiu, J, Comito, M, and Buckley, PJ. "Posttransplant lymphoproliferative disorder after umbilical cord blood transplantation in children." American Journal of Surgical Pathology 30, no. 3 (2006): 328-336. Full Text
  - Leach, NT, Rehder, C, Jensen, K, Holt, S, and Jackson-Cook, C. "Human chromosomes with shorter telomeres and large heterochromatin regions have a higher frequency of acquired somatic cell aneuploidy." Mechanisms of Ageing and Development 125, no. 8 (2004): 563-573. Full Text
  - Elmore, LW, Rehder, CW, Di, X, McChesney, PA, Jackson-Cook, CK, Gewirtz, DA, and Holt, SE. "Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction." The Journal of Biological Chemistry 277, no. 38 (September 2002): 35509-35515. Full Text
- Conference Papers
  - Wu, B, Ingersoll, K, Jug, R, Yang, L-H, Luedke, C, Lo, A, Su, P, Liu, X, Rehder, C, Gong, J, Lu, CM, and Wang, E. "Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases." December 2017. Full Text

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Education, Training, & Certifications

Selected Grants

Selected Publications

Academic Articles

Conference Papers