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Charlie Pyle

Research Associate, Senior
Molecular Genetics and Microbiology

Research Interests


Innate immunity, Host-directed therapy, Microbial pathogenesis

I graduated from the Ohio State University with a PharmD, where I then went on to earn a PhD in the lab of Larry Schlesinger investigating the impact of human zinc metabolism on macrophage inflammation and host-resistance to Mycobacterium tuberculosis. In the Tobin lab my work focuses on investigation of tuberculosis pathogenesis. I use a number of unique model systems to evaluate host genetic factors that govern the immune response within mycobacterial granulomas in an effort to discover novel immunomodulatory mechanisms for host-directed therapy.

Selected Grants


Innate Immune Determinants of Granuloma Formation in the Zebrafish

ResearchPostdoctoral Associate · Awarded by National Institute of Allergy and Infectious Diseases · 2017 - 2027

Genetic Dissection of Angiogenesis in the Tuberculous Granuloma

ResearchPostdoc Scholar · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027

Linking human TB genetic susceptibility loci to granuloma biology

ResearchPostdoc Scholar · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2026