Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow, Cardiology, Duke University School of Medicine 2005 - 2007
  • Fellow, Cardiology, University of Bologna (Italy) 2000 - 2004
  • M.D., University of Bologna (Italy) 1999
• 

  Duke Appointment History

  • Assistant Professor in Medicine, Medicine, Clinical Pharmacology, Medicine 2010 - 2018
  • Instructor, Temporary in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2009
• Research
• 

  Selected Grants

  • PTN2- TO# BPCA Pharmacology Studies 2018 - 2022
  • Trial to Assess Chelation Therapy 2 (TACT2) DCC awarded by National Institutes of Health 2015 - 2021
  • Trial to Assess Chelation Therapy 2 (TACT2) DCC awarded by National Institutes of Health 2015 - 2021
  • Safety and Effectiveness of Direct Oral Anticoagulants in Patients with Atrial Fibrillation and Cancer 2019 - 2021
  • Heart Failure Network: Year 12 Non-Compete Renewal awarded by National Institutes of Health 2006 - 2019
  • PTN TO#37 Timolol - Modification #1 2016 - 2019
  • PTN TO#38 Timolol 2015 - 2019
  • PTN_TO#50 POPS LAB awarded by National Institutes of Health 2017 - 2019
  • PTN POPS III awarded by National Institutes of Health 2014 - 2018
  • BRIDGE CCC awarded by National Institutes of Health 2008 - 2017
  • PTN Task Order #6: Opportunistic Studies awarded by National Institutes of Health 2011 - 2016
  • PTN Task Order #20: POPS II awarded by National Institutes of Health 2012 - 2016
  • PTN Task Order #4: Hydroxyurea PK awarded by National Institutes of Health 2011 - 2014
  • REVEAL (Reduction of Infarct Expansion and Ventricular remodeling with Epo Administration after Large MI) awarded by National Institutes of Health 2005 - 2011
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Dent, Susan, Chiara Melloni, Josee Ivars, Sarah Sammons, and Gretchen Kimmick. “Cardiotoxicities of Modern Treatments in Breast Cancer..” Curr Treat Options Cardiovasc Med 21, no. 7 (June 15, 2019). https://doi.org/10.1007/s11936-019-0738-z.
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    • Chen, Sean T., Anne S. Hellkamp, Richard C. Becker, Scott D. Berkowitz, Günter Breithardt, Keith A. A. Fox, Werner Hacke, et al. “Efficacy and safety of rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation and a history of cancer: observations from ROCKET AF..” Eur Heart J Qual Care Clin Outcomes 5, no. 2 (April 1, 2019): 145–52. https://doi.org/10.1093/ehjqcco/qcy040.
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    • Melloni, Chiara, and Matthew T. Roe. “Androgen deprivation therapy and cardiovascular disease..” Urol Oncol, March 14, 2019. https://doi.org/10.1016/j.urolonc.2019.02.010.
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    • Drolet, Beth A., Felix Boakye-Agyeman, Barrie Harper, Kristen Holland, Andrew Lewandowski, Nicole Stefanko, Chiara Melloni, and Chiara Pediatric Trials Network Steering Committee. “Systemic Timolol Exposure Following Topical Application to Infantile Hemangiomas..” J Am Acad Dermatol, February 18, 2019. https://doi.org/10.1016/j.jaad.2019.02.029.
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    • Fanaroff, Alexander C., Robert Clare, Karen S. Pieper, Kenneth W. Mahaffey, Chiara Melloni, Jennifer B. Green, John H. Alexander, et al. “Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials..” Circulation 139, no. 7 (February 12, 2019): 863–73. https://doi.org/10.1161/CIRCULATIONAHA.118.037202.
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    • Inohara, Taku, Ayaka Endo, and Chiara Melloni. “Unmet Needs in Managing Myocardial Infarction in Patients With Malignancy..” Front Cardiovasc Med 6 (2019). https://doi.org/10.3389/fcvm.2019.00057.
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    • Ungar, Leo, Robert M. Clare, Fatima Rodriguez, Bradley J. Kolls, Paul W. Armstrong, Philip Aylward, Claes Held, et al. “Stroke Outcomes With Vorapaxar Versus Placebo in Patients With Acute Coronary Syndromes: Insights From the TRACER Trial..” J Am Heart Assoc 7, no. 24 (December 18, 2018). https://doi.org/10.1161/JAHA.118.009609.
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    • Hernandez, Adrian F., Jennifer B. Green, Salim Janmohamed, Ralph B. D’Agostino, Christopher B. Granger, Nigel P. Jones, Lawrence A. Leiter, et al. “Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial..” Lancet 392, no. 10157 (October 27, 2018): 1519–29. https://doi.org/10.1016/S0140-6736(18)32261-X.
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    • Chen, Sean T., and Chiara Melloni. “Atrial Fibrillation in Cancer Patients: Recognizing Gaps in Care..” J Am Coll Cardiol 72, no. 16 (October 16, 2018): 1923–25. https://doi.org/10.1016/j.jacc.2018.07.078.
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    • Dallefeld, Samantha H., Andrew M. Atz, Ram Yogev, Janice E. Sullivan, Amira Al-Uzri, Susan R. Mendley, Matthew Laughon, et al. “A pharmacokinetic model for amiodarone in infants developed from an opportunistic sampling trial and published literature data..” J Pharmacokinet Pharmacodyn 45, no. 3 (June 2018): 419–30. https://doi.org/10.1007/s10928-018-9576-y.
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    • Hornik, Christoph P., Daniel Gonzalez, John van den Anker, Andrew M. Atz, Ram Yogev, Brenda B. Poindexter, Kee Chong Ng, et al. “Population Pharmacokinetics of Intramuscular and Intravenous Ketamine in Children..” J Clin Pharmacol, April 20, 2018. https://doi.org/10.1002/jcph.1116.
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    • Le, Jennifer, Brenda Poindexter, Janice E. Sullivan, Matthew Laughon, Paula Delmore, Martha Blackford, Ram Yogev, et al. “Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates..” Ther Drug Monit 40, no. 1 (February 2018): 103–8. https://doi.org/10.1097/FTD.0000000000000466.
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    • Autmizguine, Julie, Chiara Melloni, Christoph P. Hornik, Samantha Dallefeld, Barrie Harper, Ram Yogev, Janice E. Sullivan, et al. “Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children..” Antimicrob Agents Chemother 62, no. 1 (January 2018). https://doi.org/10.1128/AAC.01813-17.
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    • Mandurino-Mirizzi, Alessandro, Sergio Leonardi, and Chiara Melloni. “Concomitant use of proton pump inhibitors and dual antiplatelet therapy for cardiovascular outcomes..” Minerva Endocrinol 42, no. 3 (September 2017): 228–37. https://doi.org/10.23736/S0391-1977.16.02571-2.
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    • Melloni, Chiara, Peter Shrader, Joseph Carver, Jonathan P. Piccini, Laine Thomas, Gregg C. Fonarow, Jack Ansell, et al. “Management and outcomes of patients with atrial fibrillation and a history of cancer: the ORBIT-AF registry..” Eur Heart J Qual Care Clin Outcomes 3, no. 3 (July 1, 2017): 192–97. https://doi.org/10.1093/ehjqcco/qcx004.
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    • Ericson, Jessica E., Kanecia O. Zimmerman, Daniel Gonzalez, Chiara Melloni, Jeffrey T. Guptill, Kevin D. Hill, Huali Wu, and Michael Cohen-Wolkowiez. “A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation..” Ther Drug Monit 39, no. 1 (February 2017): 13–20. https://doi.org/10.1097/FTD.0000000000000364.
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    • Ku, Lawrence C., Huali Wu, Rachel G. Greenberg, Kevin D. Hill, Daniel Gonzalez, Christoph P. Hornik, Alysha Berezny, et al. “Use of Therapeutic Drug Monitoring, Electronic Health Record Data, and Pharmacokinetic Modeling to Determine the Therapeutic Index of Phenytoin and Lamotrigine..” Ther Drug Monit 38, no. 6 (December 2016): 728–37. https://doi.org/10.1097/FTD.0000000000000354.
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    • Zimmerman, Kanecia O., Huali Wu, Rachel Greenberg, Jeffrey T. Guptill, Kevin Hill, Uptal D. Patel, Lawrence Ku, et al. “Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients..” Ther Drug Monit 38, no. 5 (October 2016): 600–606. https://doi.org/10.1097/FTD.0000000000000313.
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    • Greenberg, Rachel G., Chiara Melloni, Huali Wu, Daniel Gonzalez, Lawrence Ku, Kevin D. Hill, Christoph P. Hornik, Michael Cohen-Wolkowiez, and Jeffrey T. Guptill. “Therapeutic Index Estimation of Antiepileptic Drugs: A Systematic Literature Review Approach..” Clin Neuropharmacol 39, no. 5 (September 2016): 232–40. https://doi.org/10.1097/WNF.0000000000000172.
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    • Washam, Jeffrey B., Rowena J. Dolor, W Schuyler Jones, Sharif A. Halim, Victor Hasselblad, Stephanie B. Mayer, Brooke L. Heidenfelder, and Chiara Melloni. “Erratum to: Dual antiplatelet therapy with or without oral anticoagulation in the postdischarge management of acute coronary syndrome patients with an indication for long term anticoagulation: a systematic review..” J Thromb Thrombolysis 42, no. 2 (August 2016). https://doi.org/10.1007/s11239-016-1379-7.
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    • Melloni, Chiara, and Karen P. Alexander. “Exploring the Nexus Between Chronic Kidney Disease and Cardiovascular Disease..” Eur Heart J Qual Care Clin Outcomes 2, no. 2 (April 1, 2016): 62–63. https://doi.org/10.1093/ehjqcco/qcw009.
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    • Zimerman, André, Renato D. Lopes, Amanda L. Stebbins, Patrícia O. Guimarães, Ghazala Haque, Chiara Melloni, Kathleen Trollinger, et al. “Pooled analysis of adverse event collection from 4 acute coronary syndrome trials..” Am Heart J 174 (April 2016): 60–67. https://doi.org/10.1016/j.ahj.2016.01.003.
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    • Estepp, Jeremie H., Chiara Melloni, Courtney D. Thornburg, Paweł Wiczling, Zora Rogers, Jennifer A. Rothman, Nancy S. Green, et al. “Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia..” J Clin Pharmacol 56, no. 3 (March 2016): 298–306. https://doi.org/10.1002/jcph.598.
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    • Sherwood, Matthew W., Chiara Melloni, W Schuyler Jones, Jeffrey B. Washam, Vic Hasselblad, and Rowena J. Dolor. “Individual Proton Pump Inhibitors and Outcomes in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy: A Systematic Review..” J Am Heart Assoc 4, no. 11 (October 29, 2015). https://doi.org/10.1161/JAHA.115.002245.
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    • Melloni, Chiara, and Matthew T. Roe. “Cardiac Troponin and Risk Stratification in Ischemic Heart Disease..” N Engl J Med 373, no. 7 (August 13, 2015): 672–74. https://doi.org/10.1056/NEJMe1506298.
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    • Kragholm, Kristian, Sharif A. Halim, Qinghong Yang, Phillip J. Schulte, Judith S. Hochman, Chiara Melloni, Kenneth W. Mahaffey, et al. “Sex-Stratified Trends in Enrollment, Patient Characteristics, Treatment, and Outcomes Among Non-ST-Segment Elevation Acute Coronary Syndrome Patients: Insights From Clinical Trials Over 17 Years..” Circ Cardiovasc Qual Outcomes 8, no. 4 (July 2015): 357–67. https://doi.org/10.1161/CIRCOUTCOMES.114.001615.
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    • Sabol, Mary Elizabeth, John Finkle, Mitch Krucoff, Norman Stockbridge, Nancy Parkhill, Kaori Shinagawa, Kenneth Mahaffey, et al. “Cardiac Safety Research Consortium (CSRC): Cardiovascular Safety and Adverse Event Case Report Forms..” Ther Innov Regul Sci 49, no. 4 (July 2015): 511–13. https://doi.org/10.1177/2168479014567319.
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    • Gonzalez, Daniel, Chiara Melloni, Brenda B. Poindexter, Ram Yogev, Andrew M. Atz, Janice E. Sullivan, Susan R. Mendley, et al. “Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots..” Bioanalysis 7, no. 9 (2015): 1137–49. https://doi.org/10.4155/bio.15.38.
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    • Kragholm, Kristian, Laura Kristin Newby, and Chiara Melloni. “Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod..” Drug Des Devel Ther 9 (2015): 4279–86. https://doi.org/10.2147/DDDT.S69546.
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    • Melloni, Chiara, Jeffrey B. Washam, W Schuyler Jones, Sharif A. Halim, Victor Hasselblad, Stephanie B. Mayer, Brooke L. Heidenfelder, and Rowena J. Dolor. “Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review..” Circ Cardiovasc Qual Outcomes 8, no. 1 (January 2015): 47–55. https://doi.org/10.1161/CIRCOUTCOMES.114.001177.
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    • Gonzalez, D., C. Melloni, R. Yogev, B. B. Poindexter, S. R. Mendley, P. Delmore, J. E. Sullivan, et al. “Use of opportunistic clinical data and a population pharmacokinetic model to support dosing of clindamycin for premature infants to adolescents..” Clin Pharmacol Ther 96, no. 4 (October 2014): 429–37. https://doi.org/10.1038/clpt.2014.134.
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    • Washam, Jeffrey B., Rowena J. Dolor, W Schuyler Jones, Sharif A. Halim, Victor Hasselblad, Stephanie B. Mayer, Brooke L. Heidenfelder, and Chiara Melloni. “Dual antiplatelet therapy with or without oral anticoagulation in the postdischarge management of acute coronary syndrome patients with an indication for long term anticoagulation: a systematic review..” J Thromb Thrombolysis 38, no. 3 (October 2014): 285–98. https://doi.org/10.1007/s11239-014-1094-1.
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    • Newby, L Kristin, Michael S. Marber, Chiara Melloni, Lea Sarov-Blat, Laura H. Aberle, Philip E. Aylward, Gengqian Cai, et al. “Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial..” Lancet 384, no. 9949 (September 27, 2014): 1187–95. https://doi.org/10.1016/S0140-6736(14)60417-7.
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    • Tremoulet, Adriana, Jennifer Le, Brenda Poindexter, Janice E. Sullivan, Matthew Laughon, Paula Delmore, Andrea Salgado, et al. “Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design..” Antimicrob Agents Chemother 58, no. 6 (June 2014): 3013–20. https://doi.org/10.1128/AAC.02374-13.
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    • Sherwood, Matthew W., Chiara Melloni, Schuyler Jones, Jeffrey Washam, Victor Hasselblad, and Rowena Dolor. “INDIVIDUAL PROTON PUMP INHIBITORS AND OUTCOMES IN PATIENTS WITH CORONARY ARTERY DISEASE ON DUAL ANTIPLATELET THERAPY.” Journal of the American College of Cardiology 63, no. 12 (April 2014): A203–A203. https://doi.org/10.1016/s0735-1097(14)60203-5.
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    • Melloni, C., and D. J. Lenihan. “Balancing cancer treatment efficacy with the risk of cardiotoxicity and strategies for cardioprotection in adults.” Progress in Pediatric Cardiology 36, no. 1–2 (January 1, 2014): 61–63. https://doi.org/10.1016/j.ppedcard.2014.09.010.
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    • Newby, L. K., M. S. Marber, and C. Melloni. “Erratum: On behalf of the SOLSTICE Investigators. Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: A randomised phase 2 trial (The Lancet (2014) 384 (1187-1195)).” The Lancet 384, no. 9949 (January 1, 2014). https://doi.org/10.1016/S0140-6736(14)61726-8.
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    • Shen, L., and C. Melloni. “Representation of Women in Randomized Clinical Trials of Cardiovascular Disease Prevention.” Current Cardiovascular Risk Reports 8, no. 7 (January 1, 2014): 1–5. https://doi.org/10.1007/s12170-014-0390-9.
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    • Melloni, Chiara, Dennis L. Sprecher, Lea Sarov-Blat, Manesh R. Patel, John F. Heitner, Christian W. Hamm, Philip Aylward, et al. “The study of LoSmapimod treatment on inflammation and InfarCtSizE (SOLSTICE): design and rationale..” Am Heart J 164, no. 5 (November 2012): 646-653.e3. https://doi.org/10.1016/j.ahj.2012.07.030.
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    • Roe, Matthew T., Paul W. Armstrong, Keith A. A. Fox, Harvey D. White, Dorairaj Prabhakaran, Shaun G. Goodman, Jan H. Cornel, et al. “Prasugrel versus clopidogrel for acute coronary syndromes without revascularization..” N Engl J Med 367, no. 14 (October 4, 2012): 1297–1309. https://doi.org/10.1056/NEJMoa1205512.
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    • Melloni, Chiara, Matthew T. Roe, Anita Y. Chen, Tracy Y. Wang, Stephen D. Wiviott, P Michael Ho, Eric D. Peterson, and Karen P. Alexander. “Use of early clopidogrel by reperfusion strategy among patients presenting with ST-segment elevation myocardial infarction..” Circ Cardiovasc Qual Outcomes 4, no. 6 (November 1, 2011): 603–9. https://doi.org/10.1161/CIRCOUTCOMES.111.961045.
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    • Melloni, Chiara, Stefan K. James, Jennifer A. White, Robert P. Giugliano, Robert A. Harrington, Kurt Huber, Pierluigi Tricoci, et al. “Safety and efficacy of adjusted-dose eptifibatide in patients with acute coronary syndromes and reduced renal function..” Am Heart J 162, no. 5 (November 2011): 884-892.e1. https://doi.org/10.1016/j.ahj.2011.08.020.
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    • Najjar, Samer S., Sunil V. Rao, Chiara Melloni, Subha V. Raman, Thomas J. Povsic, Laura Melton, Gregory W. Barsness, et al. “Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial..” Jama 305, no. 18 (May 11, 2011): 1863–72. https://doi.org/10.1001/jama.2011.592.
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    • Allen LaPointe, Nancy M., Fang-Shu Ou, Sara B. Calvert, Chiara Melloni, Judith A. Stafford, Tina Harding, Eric D. Peterson, and Karen P. Alexander. “Association between patient beliefs and medication adherence following hospitalization for acute coronary syndrome..” Am Heart J 161, no. 5 (May 2011): 855–63. https://doi.org/10.1016/j.ahj.2011.02.009.
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    • Truffa, Adriano Am, L Kristin Newby, and Chiara Melloni. “Extended-release ranolazine: critical evaluation of its use in stable angina..” Vasc Health Risk Manag 7 (2011): 535–39. https://doi.org/10.2147/VHRM.S15560.
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    • Melloni, Chiara, Bimal R. Shah, Fang-Shu Ou, Matthew T. Roe, Sidney C. Smith, Charles V. Pollack, Magnus Ohman, W Brian Gibler, Eric D. Peterson, and Karen P. Alexander. “Lipid-lowering intensification and low-density lipoprotein cholesterol achievement from hospital admission to 1-year follow-up after an acute coronary syndrome event: results from the Medications ApplIed aNd SusTAINed Over Time (MAINTAIN) registry..” Am Heart J 160, no. 6 (December 2010): 1121-1129.e1. https://doi.org/10.1016/j.ahj.2010.09.008.
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    • Melloni, Chiara, Sunil V. Rao, Thomas J. Povsic, Laura Melton, Raymond J. Kim, Rakhi Kilaru, Manesh R. Patel, et al. “Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial..” Am Heart J 160, no. 5 (November 2010): 795-803.e2. https://doi.org/10.1016/j.ahj.2010.09.007.
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    • Gharacholou, Shahyar Michael, Karen P. Alexander, Anita Y. Chen, Tracy Y. Wang, Chiara Melloni, W Brian Gibler, Charles V. Pollack, E Magnus Ohman, Eric D. Peterson, and Matthew T. Roe. “Implications and reasons for the lack of use of reperfusion therapy in patients with ST-segment elevation myocardial infarction: findings from the CRUSADE initiative..” Am Heart J 159, no. 5 (May 2010): 757–63. https://doi.org/10.1016/j.ahj.2010.02.009.
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    • Rao, Sunil V., Chiara Melloni, Shelley Myles-Dimauro, Samuel Broderick, Andrzej S. Kosinski, Neal S. Kleiman, Vladimír Dzavík, et al. “Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial..” Circulation 121, no. 15 (April 20, 2010): 1713–21. https://doi.org/10.1161/CIRCULATIONAHA.109.913277.
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    • Allen LaPointe, Nancy M., Fang-Shu Ou, Sara B. Calvert, Chiara Melloni, Judith A. Stafford, Tina Harding, Karen P. Alexander, and Eric D. Peterson. “Changes in beliefs about medications during long-term care for ischemic heart disease..” Am Heart J 159, no. 4 (April 2010): 561–69. https://doi.org/10.1016/j.ahj.2009.12.025.
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    • Melloni, Chiara, Jeffrey S. Berger, Tracy Y. Wang, Funda Gunes, Amanda Stebbins, Karen S. Pieper, Rowena J. Dolor, Pamela S. Douglas, Daniel B. Mark, and L Kristin Newby. “Representation of women in randomized clinical trials of cardiovascular disease prevention..” Circ Cardiovasc Qual Outcomes 3, no. 2 (March 2010): 135–42. https://doi.org/10.1161/CIRCOUTCOMES.110.868307.
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    • Ali, Robin C., Chiara Melloni, Fang-Shu Ou, Kenneth Schmader, E Magnus Ohman, Matthew T. Roe, Eric D. Peterson, and Karen P. Alexander. “Age and persistent use of cardiovascular medication after acute coronary syndrome: results from medication applied and sustained over time..” J Am Geriatr Soc 57, no. 11 (November 2009): 1990–96. https://doi.org/10.1111/j.1532-5415.2009.02483.x.
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    • Berger, Jeffrey S., Chiara Melloni, Tracy Y. Wang, Rowena J. Dolor, Camille G. Frazier, Zainab Samad, Eric D. Peterson, Daniel B. Mark, and L Kristin Newby. “Reporting and representation of race/ethnicity in published randomized trials..” Am Heart J 158, no. 5 (November 2009): 742–47. https://doi.org/10.1016/j.ahj.2009.08.018.
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    • Melloni, Chiara, Ian Fier, James Roach, Andrzej S. Kosinski, Samuel Broderick, Kristina Sigmon, Shelley Myles, Richard C. Becker, Sunil V. Rao, and Sunil V. EMINENCE Investigators. “Design and rationale of the Evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) trial..” American Heart Journal 158, no. 5 (November 2009): 726–33. https://doi.org/10.1016/j.ahj.2009.08.020.
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    • Melloni, Chiara, and L Kristin Newby. “Risk factor management after acute coronary syndromes..” Heart 95, no. 17 (September 2009): 1382–84. https://doi.org/10.1136/hrt.2009.166595.
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    • Melloni, Chiara, Karen P. Alexander, Fang-Shu Ou, Nancy M Allen LaPointe, Matthew T. Roe, L Kristin Newby, Khaula Baloch, P Michael Ho, John S. Rumsfeld, and Eric D. Peterson. “Predictors of early discontinuation of evidence-based medicine after acute coronary syndrome..” Am J Cardiol 104, no. 2 (July 15, 2009): 175–81. https://doi.org/10.1016/j.amjcard.2009.03.013.
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    • Melloni, Chiara, and L Kristin Newby. “Sex differences in medical care after acute myocardial infarction: what can be done to address the problem?.” Womens Health (Lond) 5, no. 4 (July 2009): 339–41. https://doi.org/10.2217/whe.09.25.
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    • Melloni, C., E. D. Peterson, A. Y. Chen, L. A. Szczech, L. K. Newby, R. A. Harrington, W. B. Gibler, et al. “Cockcroft-Gault Versus Modification of Diet in Renal Disease: Importance of Glomerular Filtration Rate Formula for Classification of Chronic Kidney Disease in Patients With Non-ST-Segment Elevation Acute Coronary Syndromes Editorial Comment.” Journal of Urology 181, no. 4 (April 1, 2009): 1813–14.
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    • Berger, Jeffrey S., Chiara Melloni, Tracy Y. Wang, Rowena J. Dolor, Camille G. Frazier, Zainab Samad, Eric D. Peterson, Pamela S. Douglas, Daniel B. Mark, and L Kristin Newby. “Reporting and Representation of Race in Published Randomized Trials.” Journal of the American College of Cardiology 53, no. 10 (March 10, 2009): A372–A372.
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    • Chan, M., C. Rusconi, M. Cohen, C. Melloni, R. Tonkens, S. Myles, C. Dyke, J. Alexander, R. Harrington, and R. Becker. “An RNA aptamer inhibiting factor IXa and its complementary oligonucleotide antidote.” European Heart Journal 29 (September 1, 2008): 328–328.
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    • Dunlay, Shannon M., Karen P. Alexander, Chiara Melloni, Jennifer L. Kraschnewski, Li Liang, W Brian Gibler, Matthew T. Roe, E Magnus Ohman, and Eric D. Peterson. “Medical records and quality of care in acute coronary syndromes: results from CRUSADE..” Arch Intern Med 168, no. 15 (August 11, 2008): 1692–98. https://doi.org/10.1001/archinte.168.15.1692.
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    • Melloni, Chiara, Karen P. Alexander, Anita Y. Chen, L Kristin Newby, Matthew T. Roe, Nancy M. Allen LaPointe, Charles V. Pollack, et al. “Unfractionated heparin dosing and risk of major bleeding in non-ST-segment elevation acute coronary syndromes..” Am Heart J 156, no. 2 (August 2008): 209–15. https://doi.org/10.1016/j.ahj.2008.03.023.
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    • Lopes, R. D., M. Chan, C. Melloni, E. M. Jolicoeur, L. A. Allen, B. R. Shah, J. N. Katz, J. S. Berger, and J. P. Piccini. “Late-breaking trials summary from the 2008 American College of Cardiology Scientific Sessions, March 29 to April 1, Chicago, IL.” American Heart Journal 156, no. 1 (July 1, 2008): 7–12. https://doi.org/10.1016/j.ahj.2008.04.008.
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    • Melloni, Chiara, and Kenneth W. Mahaffey. “Management of acute coronary syndromes in patients with renal dysfunction..” Curr Opin Cardiol 23, no. 4 (July 2008): 320–26. https://doi.org/10.1097/HCO.0b013e3283021b08.
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    • Chan, Mark Y., Mauricio G. Cohen, Christopher K. Dyke, Shelley K. Myles, Laura G. Aberle, Min Lin, James Walder, et al. “Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease..” Circulation 117, no. 22 (June 3, 2008): 2865–74. https://doi.org/10.1161/CIRCULATIONAHA.107.745687.
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    • Allen, Larry A., E Marc Jolicoeur, Chiara Melloni, Renato D. Lopes, Mark Y. Chan, Mohamed Majidi, Jonathan P. Piccini, Jeffrey S. Berger, Jason N. Katz, and Bimal R. Shah. “Highlights from American Heart Association, November 4-7, 2007, Orlando, Florida, USA. Late-breaking trials summary..” American Heart Journal 155, no. 4 (April 2008): 615–23. https://doi.org/10.1016/j.ahj.2007.12.001.
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    • Melloni, Chiara, Eric D. Peterson, Anita Y. Chen, Lynda A. Szczech, L Kristin Newby, Robert A. Harrington, W Brian Gibler, et al. “Cockcroft-Gault versus modification of diet in renal disease: importance of glomerular filtration rate formula for classification of chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes..” J Am Coll Cardiol 51, no. 10 (March 11, 2008): 991–96. https://doi.org/10.1016/j.jacc.2007.11.045.
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    • Melloni, Chiara, Karen P. Alexander, Sarah Milford-Beland, L Kristin Newby, Lynda A. Szczech, Charles V. Pollack, J Douglas Kirk, et al. “Prognostic value of troponins in patients with non-ST-segment elevation acute coronary syndromes and chronic kidney disease..” Clin Cardiol 31, no. 3 (March 2008): 125–29. https://doi.org/10.1002/clc.20210.
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    • Melloni, Chiara, and L Kristin Newby. “Metabolic efficiency with ranolazine for less ischemia in non-ST elevation acute coronary syndromes (MERLIN TIMI-36) study..” Expert Rev Cardiovasc Ther 6, no. 1 (January 2008): 9–16. https://doi.org/10.1586/14779072.6.1.9.
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    • Chan, Mark Y., Mauricio G. Cohen, Christopher P. Rusconi, John H. Alexander, Shelley K. Myles, Laura G. Aberle, Min Lin, et al. “A first-in-class oligonucleotide drug-antidote pair efficiently modulates factor IXa activity in human subjects - A nascent platform for antidote-controlled periprocedural anticoagulation.” Circulation 116, no. 16 (October 16, 2007): 617–617.
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    • Melloni, Chiara, Karen P. Alexander, Anita Y. Chen, Matthew T. Roe, L Kristin Newby, Magnus Ohman, W Brian Gibler, Sidney C. Smith, Charles V. Pollak, and Eric D. Peterson. “Unfractionated heparin dosing and major bleeding in non-ST-segment elevation acute coronary syndromes.” Circulation 116, no. 16 (October 16, 2007): 383–383.
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    • Adams, George L., James S. Mills, Chiara Melloni, Larry A. Allen, E Marc Jolicoeur, Tracy Wang, Mark Chan, Mohamed Majidi, and Renato D. Lopes. “Highlights from the 56th annual scientific sessions of the American College of Cardiology: March 25 to 27, 2007, Atlanta, Georgia..” Am Heart J 154, no. 2 (August 2007): 247–59. https://doi.org/10.1016/j.ahj.2007.05.005.
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    • Kraschnewski, Jennifer L., Li Liang, Shannon M. Dunlay, Chiara Melloni, Deborah B. Diercks, W Brian Gibler, Matthew T. Roe, E Magnus Ohman, Eric D. Peterson, and Karen P. Alexander. “Age, presentation, and emergency department diagnosis of acute coronary syndromes: Results from CRUSADE.” Circulation 115, no. 21 (May 29, 2007): E584–E584.
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    • Mills, J. S., G. L. Adams, P. Tricoci, C. Melloni, E. M. Joliceur, T. W. Wang, and K. L. Thomas. “Highlights from the 20th Scientific Sessions of the American Heart Association: November 12 to 15, 2006, Chicago, Illinois.” American Heart Journal 153, no. 2 (February 1, 2007): 213–23. https://doi.org/10.1016/j.ahj.2006.12.001.
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    • Dyke, Christopher K., Steven R. Steinhubl, Neal S. Kleiman, Richard O. Cannon, Laura G. Aberle, Min Lin, Shelley K. Myles, et al. “First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity..” Circulation 114, no. 23 (December 5, 2006): 2490–97. https://doi.org/10.1161/CIRCULATIONAHA.106.668434.
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    • Goyal, A., J. S. Mills, P. Tricoci, K. L. Thomas, R. Baeza, G. L. Adams, and C. Melloni. “Highlights from the 55th Annual Scientific Sessions of the American College of Cardiology: March 11 to 14, 2006, Atlanta, Georgia.” American Heart Journal 151, no. 6 (June 1, 2006): 1156–72. https://doi.org/10.1016/j.ahj.2006.03.021.
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    • Goyal, A., P. Tricoci, C. Melloni, J. S. Mills, K. L. Thomas, G. L. Adams, R. G. Mitchell, and A. T. Turer. “Highlights from the American Heart Association Scientific Sessions, November 13 to 16, 2005, Dallas, TX.” American Heart Journal 151, no. 2 (February 1, 2006): 295–307. https://doi.org/10.1016/j.ahj.2005.12.011.
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    • Patel, Manesh R., Ricardo G. Baeza, Abhinav Goyal, Abdul R. Halabi, Chiara Melloni, Gustavo B. F. Oliveira, Pierluigi Tricoci, and Anne Marie Valente. “Highlights from the American College of Cardiology Annual Scientific Session 2005: March 6 to 9, 2005, Orlando, Florida..” Am Heart J 149, no. 6 (June 2005): 1009–19. https://doi.org/10.1016/j.ahj.2005.04.001.
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    • Montebugnoli, L., D. Servidio, R. A. Miaton, C. Prati, P. Tricoci, C. Melloni, and G. Melandri. “Periodontal health improves systemic inflammatory and haemostatic status in subjects with coronary heart disease..” J Clin Periodontol 32, no. 2 (February 2005): 188–92. https://doi.org/10.1111/j.1600-051X.2005.00641.x.
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    • Melandri, G., C. Melloni, P. Tricoci, C. Marrozzini, P. Ortolani, A. Marzocchi, C. Serantoni, M. Taglioni, and A. Branzi. “Significant decrease of door-to-balloon time by direct transport from ambulance to cath lab.” Circulation 110, no. 17 (October 26, 2004): 537–537.
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    • Ferioli, Vittorio, Allesandra Manes, Chiara Melloni, Samuele Nanni, and Giancarlo Boncompagni. “Atypical neuroleptic malignant syndrome caused by clozapine and venlafaxine: early brief treatment with dantrolene..” Can J Psychiatry 49, no. 7 (July 2004): 497–98. https://doi.org/10.1177/070674370404900719.
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    • Montebugnoli, L., D. Servidio, R. A. Miaton, C. Prati, P. Tricoci, and C. Melloni. “Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors..” J Clin Periodontol 31, no. 1 (January 2004): 25–29.
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    • Melandri, G., F. Fallani, F. Semprini, S. Nanni, C. Melloni, P. Tricoci, and A. Branzi. “Acute coronary syndromes: New trends in blood anticoagulation.” Haematologica 88, no. SUPPL. 4 (December 1, 2003): 36–39.
    • Nanni, S., G. Melandri, R. Hanemaaijer, V. Cervi, L. Tomasi, A. Altimari, P. Tricoci, C. Melloni, and A. Branzi. “Matrix metalloproteinase genetic polymorphisms in premature coronary artery disease.” Journal of the American College of Cardiology 41, no. 6 (March 19, 2003): 234A-234A.
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    • Nanni, S., G. Melandri, R. Hanemaaijer, V. Cervi, L. Tomasi, C. Melloni, P. Tricoci, and A. Branzi. “Matrix metalloproteinases and their inhibitors in premature coronary atherosclerosis: Relation with inflammation and metabolic markers.” Journal of the American College of Cardiology 41, no. 6 (March 19, 2003): 282A-283A.
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    • TRICOCI, P. “P2275 Plasma homocystein levels independently correlate with angiographic extension of coronary artery disease.” European Heart Journal 24, no. 5 (March 2003): 436–436. https://doi.org/10.1016/s0195-668x(03)95269-9.
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    • Melandri, Giovanni, Pierluigi Tricoci, Chiara Melloni, Samuele Nanni, Franco Semprini, Francesco Fallani, and Angelo Branzi. “Clinical use of novel antithrombotic agents in the management of acute coronary syndromes..” Pathophysiol Haemost Thromb 32, no. 5–6 (September 2002): 282–88. https://doi.org/10.1159/000073582.
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    • Nanni, S., G. Melandri, R. Hanemaaijer, V. Cervi, L. Tomasi, C. Melloni, P. Tricoci, and A. Branzi. “Determinants of matrix metalloproteinases plasma concentration and activity in premature coronary atherosclerosis.” European Heart Journal 23 (August 1, 2002): 135–135.
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    • Tricoci, P., C. Melloni, G. Melandri, V. Cervi, L. Tomasi, and A. Branzi. “Effect of simvastatin on endothelial damage markers and clinical outcomes in acute coronary syndromes.” European Heart Journal 23 (August 1, 2002): 419–419.
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    • Melandri, G., S. Nanni, P. Tricoci, C. Melloni, F. Semprini, F. Fallani, G. Bracchetti, and A. Branzi. “Heparins: Their established role in acute coronary syndromes and perspectives in atrial fibrillation.” Haematologica 86, no. 11 SUPPL. 2 (December 1, 2001): 54–57.
    • Melandri, G., S. Nanni, P. Tricoci, C. Melloni, F. Semprini, F. Fallani, G. Bracchetti, and A. Branzi. “Heparins: their established role in acute coronary syndromes and perspectives in atrial fibrillation..” Haematologica 86, no. 11 Suppl 2 (November 2001): 54–57.
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    • Melandri, G., S. Nanni, P. Tricoci, C. Melloni, F. Semprini, F. Fallani, G. Bracchetti, and A. Branzi. “Heparins: their established role in acute coronary syndromes and perspectives in atrial fibrillation.” Haematologica 86, no. 11 (November 1, 2001): 54–57.
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    • Nanni, S., G. Melandri, V. Cervi, A. Altimari, L. Tomasi, R. Conti, A. Branzi, and C. Melloni. “Genetic variation in human Stromelysin-1 and Gelatinase B genes and acute coronary syndromes in young males.” European Heart Journal 22 (September 1, 2001): 164–164.
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  • Book Sections

    • Krone, R. J., P. P. Singh, and C. Melloni. “Management of patients with coronary disease and cancer: Interactions between cancer, cancer treatment, and ischemia.” In Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease, 175–214, 2017. https://doi.org/10.1007/978-3-319-43096-6_8.
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  • Reports

    • DOLOR, R. J., C. Melloni, R. Chatterjee, N. Allen Lapointe, J. B. williams, R. R. Coeytaux, A. J. McBroom, et al. “Treatment Strategies for Women With Coronary Artery Disease.” Comparative Effectiveness Reviews, No. 66, August 1, 2012.

  • Conference Papers

    • Slovin, Susan F., Chiara Melloni, Samreen Mansor-Lefebvre, Anders Neijber, and Matthew Roe. “A multicenter, randomized, controlled trial comparing the occurrence of major adverse cardiovascular events (MACEs) in patients (pts) with prostate cancer (pc) and cardiovascular disease (CVD) receiving degarelix (GnRH receptor antagonist) or leuprolide (GnRH receptor agonist)..” In Journal of Clinical Oncology, 36:TPS5101–TPS5101. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.tps5101.
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    • Fanaroff, Alexander C., Robert Clare, Karen Pieper, Kenneth Mahaffey, Chiara Melloni, Jennifer Green, John Alexander, et al. “UNDETERMINED CAUSE OF DEATH: A POOLED ANALYSIS OF 9,307 DEATHS ACROSS 9 CARDIOVASCULAR TRIALS.” In Journal of the American College of Cardiology, 71:A90–A90. Elsevier BV, 2018. https://doi.org/10.1016/s0735-1097(18)30631-4.
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    • Hanlon, Ashley, Steven Fleming, Ann S. Hamilton, Michaela Ann Dinan, Chiara Melloni, Michael Roger Harrison, Michel Khouri, et al. “Androgen deprivation therapy (ADT) and cardiovascular mortality (CVD) in men with early-stage prostate cancer (PC) receiving curative radiation therapy (RT)..” In Journal of Clinical Oncology, 36:127–127. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.7_suppl.127.
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    • Slovin, Susan F., Chiara Melloni, Samreen Mansor-Lefebvre, Anders Neijber, and Matthew Roe. “A multicenter, randomized, controlled trial comparing the occurrence of major adverse cardiovascular events (MACEs) in patients (pts) with prostate cancer (pc) and cardiovascular disease (CVD) receiving degarelix (GnRH receptor antagonist) or leuprolide (GnRH receptor agonist)..” In Journal of Clinical Oncology, 36:TPS395–TPS395. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.6_suppl.tps395.
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    • Melloni, Chiara, Allison Dunning, Christopher B. Granger, Laine Thomas, Michel G. Khouri, David A. Garcia, Elaine M. Hylek, et al. “Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial..” In Am J Med, 130:1440-1448.e1, 2017. https://doi.org/10.1016/j.amjmed.2017.06.026.
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    • Melloni, Chiara, Jan H. Cornel, Gail Hafley, Megan L. Neely, Peter Clemmensen, Dmitry Zamoryakhin, Dorairaj Prabhakaran, et al. “Impact of chronic kidney disease on long-term ischemic and bleeding outcomes in medically managed patients with acute coronary syndromes: Insights from the TRILOGY ACS Trial..” In Eur Heart J Acute Cardiovasc Care, 5:443–54, 2016. https://doi.org/10.1177/2048872615598631.
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    • Guptill, Jeff, Rachel Greenberg, Chiara Melloni, Huali Wu, Daniel Gonzalez, Lawrence Ku, Kevin Hill, et al. “Narrow Therapeutic Index Classification of Antiepileptic Drugs Using a Comprehensive Literature Search.” In Neurology, Vol. 86. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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    • Melloni, Chiara, Peter Shrader, Joseph Carver, Jonathan Piccini, Gregg Fonarow, Jack Ansell, Bernard Gersh, et al. “MANAGEMENT AND OUTCOMES OF PATIENTS WITH ATRIAL FIBRILLATION AND CANCER: THE ORBIT-AF REGISTRY.” In Journal of the American College of Cardiology, 67:727–727. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)30728-8.
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    • Halim, Sharif, Qinghong Yang, Phillip Schulte, Judith Hochman, Chiara Melloni, Kenneth W. Mahaffey, David J. Moliterno, et al. “Evolution of Differences in Women and Men With Non-ST-Segment Elevation Acute Coronary Syndromes: Insights From Clinical Trials Over 15 Years.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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    • Melloni, Chiara, Jeffrey Washam, William Jones, Sharif Halim, Stephanie B. Mayer, Brooke Heidenfelder, and Rowena Dolor. “CONFLICTING RESULTS BETWEEN RANDOMIZED TRIALS AND OBSERVATIONAL STUDIES ON THE IMPACT OF PROTON PUMP INHIBITORS ON CARDIOVASCULAR EVENTS.” In Journal of the American College of Cardiology, 61:E137–E137. Elsevier BV, 2013. https://doi.org/10.1016/s0735-1097(13)60138-2.
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    • Newby, L Kristin, Lea Sarov-Blat, Chiara Melloni, Manesh R. Patel, John F. Heitner, Christian W. Hamm, Philip Aylward, et al. “Safety and Efficacy of Losmapimod in Non-ST-Segment Elevation Acute Myocardial Infarction: Results of the SOLSTICE Phase 2 Randomized Trial.” In Circulation, 126:2787–88. LIPPINCOTT WILLIAMS & WILKINS, 2012.
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    • Rao, Sunil V., Rakhi Kilaru, Thomas J. Povsic, Chiara Melloni, Laura Melton, Raymond J. Kim, John Heitner, et al. “A Randomized Placebo Controlled Trial of Intravenous Erythropoietin to Reduce Infarct Size After ST-Segment Elevation Myocardial Infarction: Primary Results of the REVEAL Trial.” In Circulation, 122:2222–2222. LIPPINCOTT WILLIAMS & WILKINS, 2010.
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    • Alexander, Karen P., Chiara Melloni, A. Pappas, L Kristin Newby, Nancy M Allen LaPointe, E Magnus Ohman, W Brian Gibler, Matthew T. Roe, and Eric D. Peterson. “Potency of statins track with intensity of overall secondary prevention.” In Circulation, 117:E453–E453. LIPPINCOTT WILLIAMS & WILKINS, 2008.
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    • Melloni, Chiara, Karen P. Alexander, Fang-Shu Ou, Nancy M Allen LaPointe, Matthew T. Roe, and Eric D. Peterson. “Factors associated with patient reported self-discontinuation of prescribed medicine after non-ST-segment elevation acute coronary syndromes.” In Circulation, 117:E418–E418. LIPPINCOTT WILLIAMS & WILKINS, 2008.
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    • Melloni, Chiara, Tracy Y. Wang, Karen S. Pieper, Jeffreys S. Berger, Rowena J. Dolor, Daniel B. Mark, and Kristin L. Newby. “Representation of women in randomized clinical trials of cardiovascular disease prevention.” In Journal of the American College of Cardiology, 51:A249–50. ELSEVIER SCIENCE INC, 2008.
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    • Dyke, Christopher, Steven Steinhubl, Christopher Rusconi, Laura Aberle, Shelley Myles, Chiara Melloni, Robert Harrington, Robert Becker, John Alexander, and Neal Kleiman. “First-in-man experience of an antidote-controlled anticoagulant using RNA aptamer technology: Results of the phase IA evaluation of the REG1 anticoagulation system, a product for the controlled regulation of factor IXa.” In Circulation, 114:2427–2427. LIPPINCOTT WILLIAMS & WILKINS, 2006.
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    • Dunlay, Shannon M., Li Liang, Chiara Melloni, Jennifer L. Kraschnewski, Karen P. Alexander, W Brian Gibler, Matthew T. Roe, E Magnus Ohman, and Eric D. Peterson. “Quality of medical record documentation in an acute coronary syndrome population: Results from CRUSADE.” In Circulation, 113:E802–3. LIPPINCOTT WILLIAMS & WILKINS, 2006.
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    • Melloni, C., M. T. Roe, S. Milford-Boland, K. P. Alexander, L. K. Newby, L. A. Szczech, C. V. Pollack, et al. “Renal insufficiency, troponin, and risk of death among patients with non-ST-segment elevation acute coronary syndromes.” In Circulation, 112:U587–88. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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