Skip to main content

Chiara Melloni

Adjunct Associate Professor in the Department of Medicine
Medicine, Cardiology
Duke Box 3850, Durham, NC 27710
2400 Pratt St, Durham, NC 27710

Current Appointments & Affiliations


Adjunct Associate Professor in the Department of Medicine · 2020 - Present Medicine, Cardiology, Medicine

Recent Publications


Aficamten Treatment for Symptomatic Obstructive Hypertrophic Cardiomyopathy: 48-Week Results From FOREST-HCM.

Journal Article JACC Heart Fail · June 19, 2025 BACKGROUND: Long-term safety and efficacy data for aficamten in symptomatic obstructive hypertrophic cardiomyopathy are needed. OBJECTIVES: This study aims to evaluate 48-week experience from the ongoing FOREST-HCM (A Follow-Up, Open-Label, Research Evalua ... Full text Link to item Cite

Concomitant Aficamten and Disopyramide in Symptomatic Obstructive Hypertrophic Cardiomyopathy.

Journal Article JACC Heart Fail · April 2, 2025 BACKGROUND: Disopyramide, used in obstructive hypertrophic cardiomyopathy (oHCM) for its negative inotropic properties mediated by its reduction in cytosolic calcium, has been recommended for decades as an option to relieve resistant obstruction. Aficamten ... Full text Link to item Cite

Standard-of-Care Medication Withdrawal in Patients With Obstructive Hypertrophic Cardiomyopathy Receiving Aficamten in FOREST-HCM.

Journal Article J Am Coll Cardiol · November 5, 2024 BACKGROUND: Standard-of-care (SoC) medications for the treatment of obstructive hypertrophic cardiomyopathy (oHCM) are recommended as first-line therapy despite the lack of evidence from controlled clinical trials and well known off-target side effects. OB ... Full text Link to item Cite
View All Publications

Recent Grants


PTN2- TO# BPCA Pharmacology Studies

ResearchPanel Member · Awarded by National Institute for Child Health & Human Develo · 2018 - 2023

PTN_TO#50 POPS LAB

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2022

Heart Failure Network: Year 12 Non-Compete Renewal

Clinical TrialMedical Monitor · Awarded by National Institutes of Health · 2006 - 2021

View All Grants

Education, Training & Certifications


University of Bologna (Italy) · 1999 M.D.