Skip to main content

Chiara Melloni

Adjunct Associate Professor in the Department of Medicine
Medicine, Cardiology
Duke Box 3850, Durham, NC 27710
2400 Pratt St, Durham, NC 27710

Current Duke Appointments & Affiliations


Adjunct Associate Professor in the Department of Medicine · 2020 - Present Medicine, Cardiology, Medicine

Recent Scholarly Works


Aficamten in symptomatic obstructive hypertrophic cardiomyopathy: the FOREST-HCM long-term study.

Journal article Eur Heart J · June 23, 2026 BACKGROUND AND AIMS: Aficamten is a next-in-class, oral selective cardiac myosin inhibitor that ameliorates hypercontractility in hypertrophic cardiomyopathy (HCM). This study assessed the safety and efficacy of extended aficamten treatment in symptomatic ... Full text Link to item Cite

Concomitant Aficamten and Disopyramide in Symptomatic Obstructive Hypertrophic Cardiomyopathy.

Journal article JACC Heart Fail · February 2026 BACKGROUND: Disopyramide, used in obstructive hypertrophic cardiomyopathy (oHCM) for its negative inotropic properties mediated by its reduction in cytosolic calcium, has been recommended for decades as an option to relieve resistant obstruction. Aficamten ... Full text Link to item Cite
View All Scholarly Works

Recent Grants


PTN2- TO# BPCA Pharmacology Studies

ResearchPanel Member · Awarded by National Institute for Child Health & Human Develo · 2018 - 2023

PTN_TO#50 POPS LAB

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2022

Heart Failure Network: Year 12 Non-Compete Renewal

Clinical TrialMedical Monitor · Awarded by National Institutes of Health · 2006 - 2021

View All Grants

Education


University of Bologna (Italy) · 1999 M.D.