Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow, Cardiology, Duke University School of Medicine 2005 - 2007
  • Fellow, Cardiology, University of Bologna (Italy) 2000 - 2004
  • M.D., University of Bologna (Italy) 1999
• 

  Duke Appointment History

  • Assistant Professor in Medicine, Medicine, Clinical Pharmacology, Medicine 2010 - 2018
  • Instructor, Temporary in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2009
• Research
• 

  Selected Grants

  • PTN2- TO# BPCA Pharmacology Studies awarded by National Institute for Child Health & Human Develo 2018 - 2022
  • Trial to Assess Chelation Therapy 2 (TACT2) DCC awarded by National Institutes of Health 2015 - 2021
  • Heart Failure Network: Year 12 Non-Compete Renewal awarded by National Institutes of Health 2006 - 2019
  • PTN_TO#50 POPS LAB awarded by National Institutes of Health 2017 - 2019
  • PTN TO#37 Timolol - Modification #1 awarded by National Institute for Child Health & Human Develo 2016 - 2019
  • PTN TO#38 Timolol awarded by National Institute for Child Health & Human Develo 2015 - 2019
  • PTN POPS III awarded by National Institutes of Health 2014 - 2018
  • BRIDGE CCC awarded by National Institutes of Health 2008 - 2017
  • PTN Task Order #6: Opportunistic Studies awarded by National Institutes of Health 2011 - 2016
  • PTN Task Order #20: POPS II awarded by National Institutes of Health 2012 - 2016
  • PTN Task Order #4: Hydroxyurea PK awarded by National Institutes of Health 2011 - 2014
  • REVEAL (Reduction of Infarct Expansion and Ventricular remodeling with Epo Administration after Large MI) awarded by National Institutes of Health 2005 - 2011
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Krone, RJ, Singh, PP, and Melloni, C. "Management of patients with coronary disease and cancer: Interactions between cancer, cancer treatment, and ischemia." In Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease, 175-214. April 11, 2017.  Full Text

  • Conference Papers

    • Slovin, SF, Melloni, C, Mansor-Lefebvre, S, Neijber, A, and Roe, M. "A multicenter, randomized, controlled trial comparing the occurrence of major adverse cardiovascular events (MACEs) in patients (pts) with prostate cancer (pc) and cardiovascular disease (CVD) receiving degarelix (GnRH receptor antagonist) or leuprolide (GnRH receptor agonist)." : AMER SOC CLINICAL ONCOLOGY, May 20, 2018.  Full Text  Link to Item
    • Fanaroff, AC, Clare, R, Pieper, K, Mahaffey, K, Melloni, C, Green, J, Alexander, J, Jones, W, Harrison, R, Mehta, R, Povsic, T, Moreira, H, Al-Khatib, S, Roe, M, Kong, D, Mathews, R, Tricoci, P, Holman, R, Wallentin, L, Held, C, Alexander, K, and Lopes, R. "UNDETERMINED CAUSE OF DEATH: A POOLED ANALYSIS OF 9,307 DEATHS ACROSS 9 CARDIOVASCULAR TRIALS." March 2018.  Full Text
    • Hanlon, A, Fleming, S, Hamilton, AS, Dinan, MA, Melloni, C, Harrison, MR, Khouri, M, Wu, X-C, Wilson, JF, Lipscomb, J, Cress, RD, Anderson, RT, and Kimmick, GG. "Androgen deprivation therapy (ADT) and cardiovascular mortality (CVD) in men with early-stage prostate cancer (PC) receiving curative radiation therapy (RT)." March 2018.  Full Text
    • Slovin, SF, Melloni, C, Mansor-Lefebvre, S, Neijber, A, and Roe, M. "A multicenter, randomized, controlled trial comparing the occurrence of major adverse cardiovascular events (MACEs) in patients (pts) with prostate cancer (pc) and cardiovascular disease (CVD) receiving degarelix (GnRH receptor antagonist) or leuprolide (GnRH receptor agonist)." February 20, 2018.  Full Text
    • Melloni, C, Dunning, A, Granger, CB, Thomas, L, Khouri, MG, Garcia, DA, Hylek, EM, Hanna, M, Wallentin, L, Gersh, BJ, Douglas, PS, Alexander, JH, and Lopes, RD. "Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial." December 2017.  Full Text
    • Melloni, C, Cornel, JH, Hafley, G, Neely, ML, Clemmensen, P, Zamoryakhin, D, Prabhakaran, D, White, HD, Fox, KA, Ohman, EM, Armstrong, PW, and Roe, MT. "Impact of chronic kidney disease on long-term ischemic and bleeding outcomes in medically managed patients with acute coronary syndromes: Insights from the TRILOGY ACS Trial." October 2016.  Full Text
    • Guptill, J, Greenberg, R, Melloni, C, Wu, H, Gonzalez, D, Ku, L, Hill, K, Hornik, C, Zheng, N, Jiang, W, and Cohen-Wolkowiez, M. "Narrow Therapeutic Index Classification of Antiepileptic Drugs Using a Comprehensive Literature Search." 68th Annual Meeting of the American-Academy-of-Neurology (AAN). Vancouver, CANADA. April 15, 2016 - April 21, 2016.: LIPPINCOTT WILLIAMS & WILKINS, April 5, 2016.  Link to Item
    • Melloni, C, Shrader, P, Carver, J, Piccini, J, Fonarow, G, Ansell, J, Gersh, B, Go, A, Hylek, E, Herling, I, Mahaffey, K, Peterson, E, and Kowey, P. "MANAGEMENT AND OUTCOMES OF PATIENTS WITH ATRIAL FIBRILLATION AND CANCER: THE ORBIT-AF REGISTRY." April 2016.  Full Text
    • Halim, S, Yang, Q, Schulte, P, Hochman, J, Melloni, C, Mahaffey, KW, Moliterno, DJ, Harrington, RA, White, HD, Armstrong, PW, Ohman, EM, Van de Werf, F, Giugliano, RP, and Newby, LK. "Evolution of Differences in Women and Men With Non-ST-Segment Elevation Acute Coronary Syndromes: Insights From Clinical Trials Over 15 Years." November 26, 2013.  Link to Item
    • Melloni, C, Washam, J, Jones, W, Halim, S, Mayer, SB, Heidenfelder, B, and Dolor, R. "CONFLICTING RESULTS BETWEEN RANDOMIZED TRIALS AND OBSERVATIONAL STUDIES ON THE IMPACT OF PROTON PUMP INHIBITORS ON CARDIOVASCULAR EVENTS." March 2013.  Full Text
    • Newby, LK, Sarov-Blat, L, Melloni, C, Patel, MR, Heitner, JF, Hamm, CW, Aylward, P, Tanguay, J-F, De Winter, RJ, Marber, MS, Lepore, JJ, Lerman, A, Hasselblad, V, Al-Khalidi, H, Sprecher, DL, and Granger, CB. "Safety and Efficacy of Losmapimod in Non-ST-Segment Elevation Acute Myocardial Infarction: Results of the SOLSTICE Phase 2 Randomized Trial." December 4, 2012.  Link to Item
    • Rao, SV, Kilaru, R, Povsic, TJ, Melloni, C, Melton, L, Kim, RJ, Heitner, J, Raman, S, Barsness, G, Ferrucci, L, Lakatta, EG, Harrington, RA, and Najjar, SS. "A Randomized Placebo Controlled Trial of Intravenous Erythropoietin to Reduce Infarct Size After ST-Segment Elevation Myocardial Infarction: Primary Results of the REVEAL Trial." November 23, 2010.  Link to Item
    • Alexander, KP, Melloni, C, Pappas, A, Newby, LK, LaPointe, NMA, Ohman, EM, Gibler, WB, Roe, MT, and Peterson, ED. "Potency of statins track with intensity of overall secondary prevention." 9th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke. Baltimore, MD. April 30, 2008 - May 2, 2008.: LIPPINCOTT WILLIAMS & WILKINS, May 27, 2008.  Link to Item
    • Melloni, C, Alexander, KP, Ou, F-S, LaPointe, NMA, Roe, MT, and Peterson, ED. "Factors associated with patient reported self-discontinuation of prescribed medicine after non-ST-segment elevation acute coronary syndromes." 9th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke. Baltimore, MD. April 30, 2008 - May 2, 2008.: LIPPINCOTT WILLIAMS & WILKINS, May 27, 2008.  Link to Item
    • Melloni, C, Wang, TY, Pieper, KS, Berger, JS, Dolor, RJ, Mark, DB, and Newby, KL. "Representation of women in randomized clinical trials of cardiovascular disease prevention." March 11, 2008.  Link to Item
    • Dyke, C, Steinhubl, S, Rusconi, C, Aberle, L, Myles, S, Melloni, C, Harrington, R, Becker, R, Alexander, J, and Kleiman, N. "First-in-man experience of an antidote-controlled anticoagulant using RNA aptamer technology: Results of the phase IA evaluation of the REG1 anticoagulation system, a product for the controlled regulation of factor IXa." November 28, 2006.  Link to Item
    • Dunlay, SM, Liang, L, Melloni, C, Kraschnewski, JL, Alexander, KP, Gibler, WB, Roe, MT, Ohman, EM, and Peterson, ED. "Quality of medical record documentation in an acute coronary syndrome population: Results from CRUSADE." 7th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke. Washington, DC. May 7, 2006 - May 9, 2006.: LIPPINCOTT WILLIAMS & WILKINS, May 30, 2006.  Link to Item
    • Melloni, C, Roe, MT, Milford-Boland, S, Alexander, KP, Newby, LK, Szczech, LA, Pollack, CV, Kirk, JD, Christenson, RH, Harrington, RA, Gibler, WB, Ohman, EM, Fesmire, FM, and Peterson, ED. "Renal insufficiency, troponin, and risk of death among patients with non-ST-segment elevation acute coronary syndromes." October 25, 2005.  Link to Item

  • Journal Articles

    • Chen, ST, and Melloni, C. "Atrial Fibrillation in Cancer Patients: Recognizing Gaps in Care." Journal of the American College of Cardiology 72, no. 16 (October 2018): 1923-1925.  Full Text
    • Chen, ST, Hellkamp, AS, Becker, RC, Berkowitz, SD, Breithardt, G, Fox, KAA, Hacke, W, Halperin, JL, Hankey, GJ, Mahaffey, KW, Nessel, CC, Piccini, JP, Singer, DE, Patel, MR, and Melloni, C. "Efficacy and Safety of Rivaroxaban versus Warfarin in Patients with Nonvalvular Atrial Fibrillation and a History of Cancer: Observations from ROCKET AF." European Heart Journal. Quality of Care & Clinical Outcomes (September 14, 2018).  Full Text
    • Hornik, CP, Gonzalez, D, van den Anker, J, Atz, AM, Yogev, R, Poindexter, BB, Ng, KC, Delmore, P, Harper, BL, Melloni, C, Lewandowski, A, Gelber, C, Cohen-Wolkowiez, M, Lee, JH, and Pediatric Trial Network Steering Committee, . "Population Pharmacokinetics of Intramuscular and Intravenous Ketamine in Children." Journal of Clinical Pharmacology (April 20, 2018).  Full Text
    • Dallefeld, SH, Atz, AM, Yogev, R, Sullivan, JE, Al-Uzri, A, Mendley, SR, Laughon, M, Hornik, CP, Melloni, C, Harper, B, Lewandowski, A, Mitchell, J, Wu, H, Green, TP, and Cohen-Wolkowiez, M. "A pharmacokinetic model for amiodarone in infants developed from an opportunistic sampling trial and published literature data." Journal of pharmacokinetics and pharmacodynamics (February 12, 2018).  Full Text
    • Le, J, Poindexter, B, Sullivan, JE, Laughon, M, Delmore, P, Blackford, M, Yogev, R, James, LP, Melloni, C, Harper, B, Mitchell, J, Benjamin, DK, Boakye-Agyeman, F, and Cohen-Wolkowiez, M. "Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates." Therapeutic Drug Monitoring 40, no. 1 (February 2018): 103-108.  Full Text
    • Autmizguine, J, Melloni, C, Hornik, CP, Dallefeld, S, Harper, B, Yogev, R, Sullivan, JE, Atz, AM, Al-Uzri, A, Mendley, S, Poindexter, B, Mitchell, J, Lewandowski, A, Delmore, P, Cohen-Wolkowiez, M, Gonzalez, D, and the Pediatric Trials Network Steering Committee, . "Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children." Antimicrobial Agents and Chemotherapy 62, no. 1 (January 2018).  Full Text
    • Mandurino-Mirizzi, A, Leonardi, S, and Melloni, C. "Concomitant use of proton pump inhibitors and dual antiplatelet therapy for cardiovascular outcomes." Minerva endocrinologica 42, no. 3 (September 2017): 228-237. (Review)  Full Text
    • Melloni, C, Shrader, P, Carver, J, Piccini, JP, Thomas, L, Fonarow, GC, Ansell, J, Gersh, B, Go, AS, Hylek, E, Herling, IM, Mahaffey, KW, Yu, AF, Peterson, ED, Kowey, PR, and ORBIT-AF Steering Committee, . "Management and outcomes of patients with atrial fibrillation and a history of cancer: the ORBIT-AF registry." European Heart Journal. Quality of Care & Clinical Outcomes 3, no. 3 (July 2017): 192-197.  Full Text  Open Access Copy
    • Ericson, JE, Zimmerman, KO, Gonzalez, D, Melloni, C, Guptill, JT, Hill, KD, Wu, H, and Cohen-Wolkowiez, M. "A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation." Therapeutic Drug Monitoring 39, no. 1 (February 2017): 13-20. (Review)  Full Text
    • Ku, LC, Wu, H, Greenberg, RG, Hill, KD, Gonzalez, D, Hornik, CP, Berezny, A, Guptill, JT, Jiang, W, Zheng, N, Cohen-Wolkowiez, M, and Melloni, C. "Use of Therapeutic Drug Monitoring, Electronic Health Record Data, and Pharmacokinetic Modeling to Determine the Therapeutic Index of Phenytoin and Lamotrigine." Therapeutic Drug Monitoring 38, no. 6 (December 2016): 728-737.  Full Text
    • Zimmerman, KO, Wu, H, Greenberg, R, Guptill, JT, Hill, K, Patel, UD, Ku, L, Gonzalez, D, Hornik, C, Jiang, W, Zheng, N, Melloni, C, and Cohen-Wolkowiez, M. "Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients." Therapeutic Drug Monitoring 38, no. 5 (October 2016): 600-606.  Full Text
    • Greenberg, RG, Melloni, C, Wu, H, Gonzalez, D, Ku, L, Hill, KD, Hornik, CP, Cohen-Wolkowiez, M, and Guptill, JT. "Therapeutic Index Estimation of Antiepileptic Drugs: A Systematic Literature Review Approach." Clinical neuropharmacology 39, no. 5 (September 2016): 232-240. (Review)  Full Text
    • Washam, JB, Dolor, RJ, Jones, WS, Halim, SA, Hasselblad, V, Mayer, SB, Heidenfelder, BL, and Melloni, C. "Erratum to: Dual antiplatelet therapy with or without oral anticoagulation in the postdischarge management of acute coronary syndrome patients with an indication for long term anticoagulation: a systematic review." Journal of thrombosis and thrombolysis 42, no. 2 (August 2016): 312-.  Full Text
    • Melloni, C, and Alexander, KP. "Exploring the Nexus Between Chronic Kidney Disease and Cardiovascular Disease." European Heart Journal. Quality of Care & Clinical Outcomes 2, no. 2 (April 2016): 62-63.  Full Text
    • Zimerman, A, Lopes, RD, Stebbins, AL, Guimarães, PO, Haque, G, Melloni, C, Trollinger, K, James, SK, Alexander, JH, Tricoci, P, Roe, MT, Ohman, EM, Mahaffey, KW, Held, C, Tinga, B, Pieper, KS, and Alexander, KP. "Pooled analysis of adverse event collection from 4 acute coronary syndrome trials." American Heart Journal 174 (April 2016): 60-67.  Full Text
    • Estepp, JH, Melloni, C, Thornburg, CD, Wiczling, P, Rogers, Z, Rothman, JA, Green, NS, Liem, R, Brandow, AM, Crary, SE, Howard, TH, Morris, MH, Lewandowski, A, Garg, U, Jusko, WJ, Neville, KA, and Best Pharmaceuticals for Children Act-Pediatric Trials Network Administrative Core Committee, . "Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia." Journal of clinical pharmacology 56, no. 3 (March 2016): 298-306.  Full Text
    • Melloni, C, Cornel, JH, Hafley, G, Neely, ML, Clemmensen, P, Zamoryakhin, D, Prabhakaran, D, White, HD, Fox, KAA, Ohman, EM, Armstrong, PW, and Roe, MT. "Impact of chronic kidney disease on long-term ischemic and bleeding outcomes in medically managed patients with acute coronary syndromes: Insights from the TRILOGY ACS trial." European Heart Journal: Acute Cardiovascular Care 5, no. 6 (January 1, 2016): 443-454.  Full Text
    • Sherwood, MW, Melloni, C, Jones, WS, Washam, JB, Hasselblad, V, and Dolor, RJ. "Individual Proton Pump Inhibitors and Outcomes in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy: A Systematic Review." Journal of the American Heart Association 4, no. 11 (October 29, 2015). (Review)  Full Text  Open Access Copy
    • Melloni, C, and Roe, MT. "Cardiac Troponin and Risk Stratification in Ischemic Heart Disease." The New England journal of medicine 373, no. 7 (August 2015): 672-674.  Full Text
    • Kragholm, K, Halim, SA, Yang, Q, Schulte, PJ, Hochman, JS, Melloni, C, Mahaffey, KW, Moliterno, DJ, Harrington, RA, White, HD, Armstrong, PW, Ohman, EM, Van de Werf, F, Tricoci, P, Alexander, JH, Giugliano, RP, and Newby, LK. "Sex-Stratified Trends in Enrollment, Patient Characteristics, Treatment, and Outcomes Among Non-ST-Segment Elevation Acute Coronary Syndrome Patients: Insights From Clinical Trials Over 17 Years." Circulation. Cardiovascular Quality and Outcomes 8, no. 4 (July 7, 2015): 357-367.  Full Text
    • Sabol, ME, Finkle, J, Krucoff, M, Stockbridge, N, Parkhill, N, Shinagawa, K, Mahaffey, K, Tcheng, J, Lenihan, D, Melloni, C, Todaro, T, Michelson, E, Munley, J, Zander, J, and Oh, R. "Cardiac Safety Research Consortium (CSRC): Cardiovascular Safety and Adverse Event Case Report Forms." Therapeutic Innovation & Regulatory Science 49, no. 4 (July 2015): 511-513.  Full Text
    • Melloni, C, Washam, JB, Jones, WS, Halim, SA, Hasselblad, V, Mayer, SB, Heidenfelder, BL, and Dolor, RJ. "Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review." Circulation. Cardiovascular Quality and Outcomes 8, no. 1 (January 13, 2015): 47-55. (Review)  Full Text
    • Gonzalez, D, Melloni, C, Poindexter, BB, Yogev, R, Atz, AM, Sullivan, JE, Mendley, SR, Delmore, P, Delinsky, A, Zimmerman, K, Lewandowski, A, Harper, B, Lewis, KC, Benjamin, DK, Cohen-Wolkowiez, M, and Best Pharmaceuticals for Children Act--Pediatric Trials Network Administrative Core Committee, . "Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots." Bioanalysis 7, no. 9 (January 2015): 1137-1149.  Full Text
    • Kragholm, K, Newby, LK, and Melloni, C. "Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod." Drug Design, Development and Therapy 9 (January 2015): 4279-4286. (Review)  Full Text  Open Access Copy
    • Gonzalez, D, Melloni, C, Yogev, R, Poindexter, BB, Mendley, SR, Delmore, P, Sullivan, JE, Autmizguine, J, Lewandowski, A, Harper, B, Watt, KM, Lewis, KC, Capparelli, EV, Benjamin, DK, Cohen-Wolkowiez, M, and Best Pharmaceuticals for Children Act – Pediatric Trials Network Administrative Core Committee, . "Use of opportunistic clinical data and a population pharmacokinetic model to support dosing of clindamycin for premature infants to adolescents." Clinical Pharmacology and Therapeutics 96, no. 4 (October 2014): 429-437.  Full Text
    • Gonzalez, D, Melloni, C, Yogev, R, Poindexter, BB, Mendley, SR, Delmore, P, Sullivan, JE, Autmizguine, J, Lewandowski, A, Harper, B, Watt, KM, Lewis, KC, Capparelli, EV, Benjamin, DK, and Cohen-Wolkowiez, M. "Use of opportunistic clinical data and a population pharmacokinetic model to support dosing of clindamycin for premature infants to adolescents." Clinical Pharmacology and Therapeutics 96, no. 4 (October 1, 2014): 429-437.  Full Text
    • Washam, JB, Dolor, RJ, Jones, WS, Halim, SA, Hasselblad, V, Mayer, SB, Heidenfelder, BL, and Melloni, C. "Dual antiplatelet therapy with or without oral anticoagulation in the postdischarge management of acute coronary syndrome patients with an indication for long term anticoagulation: a systematic review." Journal of thrombosis and thrombolysis 38, no. 3 (October 2014): 285-298. (Review)  Full Text
    • "Department of Error." The Lancet 384, no. 9949 (September 2014): 1186-1186.  Full Text
    • Melloni, C, and Lenihan, DJ. "Balancing cancer treatment efficacy with the risk of cardiotoxicity and strategies for cardioprotection in adults." Progress in Pediatric Cardiology 36, no. 1-2 (September 2014): 61-63.  Full Text
    • Newby, LK, Marber, MS, Melloni, C, Sarov-Blat, L, Aberle, LH, Aylward, PE, Cai, G, de Winter, RJ, Hamm, CW, Heitner, JF, Kim, R, Lerman, A, Patel, MR, Tanguay, J-F, Lepore, JJ, Al-Khalidi, HR, Sprecher, DL, Granger, CB, and SOLSTICE Investigators, . "Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial." Lancet (London, England) 384, no. 9949 (September 2014): 1187-1195.  Full Text
    • Shen, L, and Melloni, C. "Representation of Women in Randomized Clinical Trials of Cardiovascular Disease Prevention." Current Cardiovascular Risk Reports 8, no. 7 (July 2014).  Full Text
    • Tremoulet, A, Le, J, Poindexter, B, Sullivan, JE, Laughon, M, Delmore, P, Salgado, A, Ian-U Chong, S, Melloni, C, Gao, J, Benjamin, DK, Capparelli, EV, Cohen-Wolkowiez, M, and Administrative Core Committee of the Best Pharmaceuticals for Children Act-Pediatric Trials Network, . "Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design." Antimicrobial Agents and Chemotherapy 58, no. 6 (June 2014): 3013-3020.  Full Text
    • Sherwood, MW, Melloni, C, Jones, S, Washam, J, Hasselblad, V, and Dolor, R. "INDIVIDUAL PROTON PUMP INHIBITORS AND OUTCOMES IN PATIENTS WITH CORONARY ARTERY DISEASE ON DUAL ANTIPLATELET THERAPY." Journal of the American College of Cardiology 63, no. 12 (April 2014): A203-A203.  Full Text
    • Newby, LK, Marber, MS, Melloni, C, Sarov-Blat, L, Aberle, LH, Aylward, PE, Cai, G, De Winter, RJ, Hamm, CW, Heitner, JF, Kim, R, Lerman, A, Patel, MR, Tanguay, JF, Lepore, JJ, Al-Khalidi, HR, Sprecher, DL, and Granger, CBI. "Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: A randomised phase 2 trial." The Lancet 384, no. 9949 (January 1, 2014): 1187-1195.  Full Text
    • Washam, JB, Dolor, RJ, Jones, WS, Halim, SA, Hasselblad, V, Mayer, SB, Heidenfelder, BL, and Melloni, C. "Dual antiplatelet therapy with or without oral anticoagulation in the postdischarge management of acute coronary syndrome patients with an indication for long term anticoagulation: A systematic review." Journal of Thrombosis and Thrombolysis 38, no. 3 (January 1, 2014): 285-298.  Full Text
    • Melloni, C, Sprecher, DL, Sarov-Blat, L, Patel, MR, Heitner, JF, Hamm, CW, Aylward, P, Tanguay, J-F, DeWinter, RJ, Marber, MS, Lerman, A, Hasselblad, V, Granger, CB, and Newby, LK. "The study of LoSmapimod treatment on inflammation and InfarCtSizE (SOLSTICE): design and rationale." Am Heart J 164, no. 5 (November 2012): 646-653.e3.  Full Text  Link to Item
    • Roe, MT, Armstrong, PW, Fox, KAA, White, HD, Prabhakaran, D, Goodman, SG, Cornel, JH, Bhatt, DL, Clemmensen, P, Martinez, F, Ardissino, D, Nicolau, JC, Boden, WE, Gurbel, PA, Ruzyllo, W, Dalby, AJ, McGuire, DK, Leiva-Pons, JL, Parkhomenko, A, Gottlieb, S, Topacio, GO, Hamm, C, Pavlides, G, Goudev, AR, Oto, A, Tseng, C-D, Merkely, B, Gasparovic, V, Corbalan, R, Cinteză, M, McLendon, RC, Winters, KJ, Brown, EB, Lokhnygina, Y, Aylward, PE, Huber, K, Hochman, JS, Ohman, EM, and TRILOGY ACS Investigators, . "Prasugrel versus clopidogrel for acute coronary syndromes without revascularization." The New England Journal of Medicine 367, no. 14 (October 2012): 1297-1309.  Full Text
    • Melloni, C, James, SK, White, JA, Giugliano, RP, Harrington, RA, Huber, K, Tricoci, P, Armstrong, PW, Van de Werf, F, Montalescot, G, Califf, RM, and Newby, LK. "Safety and efficacy of adjusted-dose eptifibatide in patients with acute coronary syndromes and reduced renal function." American Heart Journal 162, no. 5 (November 2011): 884-892.e1.  Full Text
    • Melloni, C, Roe, MT, Chen, AY, Wang, TY, Wiviott, SD, Ho, PM, Peterson, ED, and Alexander, KP. "Use of early clopidogrel by reperfusion strategy among patients presenting with ST-segment elevation myocardial infarction." Circulation. Cardiovascular Quality and Outcomes 4, no. 6 (November 2011): 603-609.  Full Text
    • Najjar, SS, Rao, SV, Melloni, C, Raman, SV, Povsic, TJ, Melton, L, Barsness, GW, Prather, K, Heitner, JF, Kilaru, R, Gruberg, L, Hasselblad, V, Greenbaum, AB, Patel, M, Kim, RJ, Talan, M, Ferrucci, L, Longo, DL, Lakatta, EG, Harrington, RA, and REVEAL Investigators, . "Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial." JAMA 305, no. 18 (May 11, 2011): 1863-1872.  Full Text  Link to Item
    • Allen LaPointe, NM, Ou, F-S, Calvert, SB, Melloni, C, Stafford, JA, Harding, T, Peterson, ED, and Alexander, KP. "Association between patient beliefs and medication adherence following hospitalization for acute coronary syndrome." American Heart Journal 161, no. 5 (May 2011): 855-863.  Full Text
    • Truffa, AA, Newby, LK, and Melloni, C. "Extended-release ranolazine: critical evaluation of its use in stable angina." Vascular Health and Risk Management 7 (January 2011): 535-539. (Review)  Full Text  Open Access Copy
    • Melloni, C, Shah, BR, Ou, F-S, Roe, MT, Smith, SC, Pollack, CV, Ohman, M, Gibler, WB, Peterson, ED, and Alexander, KP. "Lipid-lowering intensification and low-density lipoprotein cholesterol achievement from hospital admission to 1-year follow-up after an acute coronary syndrome event: results from the Medications ApplIed aNd SusTAINed Over Time (MAINTAIN) registry." American Heart Journal 160, no. 6 (December 2010): 1121-1129.e1.  Full Text
    • Melloni, C, Rao, SV, Povsic, TJ, Melton, L, Kim, RJ, Kilaru, R, Patel, MR, Talan, M, Ferrucci, L, Longo, DL, Lakatta, EG, Najjar, SS, and Harrington, RA. "Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial." Am Heart J 160, no. 5 (November 2010): 795-803.e2.  Full Text  Link to Item
    • Gharacholou, SM, Alexander, KP, Chen, AY, Wang, TY, Melloni, C, Gibler, WB, Pollack, CV, Ohman, EM, Peterson, ED, and Roe, MT. "Implications and reasons for the lack of use of reperfusion therapy in patients with ST-segment elevation myocardial infarction: findings from the CRUSADE initiative." American Heart Journal 159, no. 5 (May 2010): 757-763.  Full Text
    • Rao, SV, Melloni, C, Myles-Dimauro, S, Broderick, S, Kosinski, AS, Kleiman, NS, Dzavík, V, Tanguay, JF, Chandna, H, Gammon, R, Rivera, E, Alexander, JH, Fier, I, Roach, J, Becker, RC, and EMINENCE Investigators, . "Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial." Circulation 121, no. 15 (April 5, 2010): 1713-1721.  Full Text
    • Allen LaPointe, NM, Ou, F-S, Calvert, SB, Melloni, C, Stafford, JA, Harding, T, Alexander, KP, and Peterson, ED. "Changes in beliefs about medications during long-term care for ischemic heart disease." American Heart Journal 159, no. 4 (April 2010): 561-569.  Full Text
    • Melloni, C, Berger, JS, Wang, TY, Gunes, F, Stebbins, A, Pieper, KS, Dolor, RJ, Douglas, PS, Mark, DB, and Newby, LK. "Representation of women in randomized clinical trials of cardiovascular disease prevention." Circulation. Cardiovascular Quality and Outcomes 3, no. 2 (March 2010): 135-142. (Review)  Full Text
    • Ali, RC, Melloni, C, Ou, F-S, Schmader, K, Ohman, EM, Roe, MT, Peterson, ED, and Alexander, KP. "Age and persistent use of cardiovascular medication after acute coronary syndrome: results from medication applied and sustained over time." Journal of the American Geriatrics Society 57, no. 11 (November 2009): 1990-1996.  Full Text
    • Berger, JS, Melloni, C, Wang, TY, Dolor, RJ, Frazier, CG, Samad, Z, Peterson, ED, Mark, DB, and Newby, LK. "Reporting and representation of race/ethnicity in published randomized trials." American Heart Journal 158, no. 5 (November 2009): 742-747.  Full Text
    • Melloni, C, Fier, I, Roach, J, Kosinski, AS, Broderick, S, Sigmon, K, Myles, S, Becker, RC, Rao, SV, and EMINENCE Investigators, . "Design and rationale of the Evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) trial." Am Heart J 158, no. 5 (November 2009): 726-733.  Full Text  Link to Item
    • Melloni, C, and Newby, LK. "Risk factor management after acute coronary syndromes." Heart 95, no. 17 (September 2009): 1382-1384.  Full Text  Link to Item
    • Melloni, C, Alexander, KP, Ou, F-S, LaPointe, NMA, Roe, MT, Newby, LK, Baloch, K, Ho, PM, Rumsfeld, JS, and Peterson, ED. "Predictors of early discontinuation of evidence-based medicine after acute coronary syndrome." The American Journal of Cardiology 104, no. 2 (July 2009): 175-181.  Full Text
    • Melloni, C, and Newby, LK. "Sex differences in medical care after acute myocardial infarction: what can be done to address the problem?." Womens Health (Lond) 5, no. 4 (July 2009): 339-341.  Full Text  Link to Item
    • Melloni, C, Peterson, ED, Chen, AY, Szczech, LA, Newby, LK, Harrington, RA, Gibler, WB, Ohman, EM, Spinler, SA, Roe, MT, and Alexander, KP. "Cockcroft-Gault Versus Modification of Diet in Renal Disease: Importance of Glomerular Filtration Rate Formula for Classification of Chronic Kidney Disease in Patients With Non-ST-Segment Elevation Acute Coronary Syndromes Editorial Comment." JOURNAL OF UROLOGY 181, no. 4 (April 2009): 1813-1814.  Link to Item
    • Berger, JS, Melloni, C, Wang, TY, Dolor, RJ, Frazier, CG, Samad, Z, Peterson, ED, Douglas, PS, Mark, DB, and Newby, LK. "Reporting and Representation of Race in Published Randomized Trials." Journal of the American College of Cardiology 53, no. 10 (March 10, 2009): A372-A372.  Link to Item
    • Chan, M, Rusconi, C, Cohen, M, Melloni, C, Tonkens, R, Myles, S, Dyke, C, Alexander, J, Harrington, R, Becker, R, and Investigators, R. "An RNA aptamer inhibiting factor IXa and its complementary oligonucleotide antidote." EUROPEAN HEART JOURNAL 29 (September 2008): 328-328.  Link to Item
    • Dunlay, SM, Alexander, KP, Melloni, C, Kraschnewski, JL, Liang, L, Gibler, WB, Roe, MT, Ohman, EM, and Peterson, ED. "Medical records and quality of care in acute coronary syndromes: results from CRUSADE." Archives of Internal Medicine 168, no. 15 (August 2008): 1692-1698.  Full Text
    • Melloni, C, Alexander, KP, Chen, AY, Newby, LK, Roe, MT, Allen LaPointe, NM, Pollack, CV, Gibler, WB, Ohman, EM, Peterson, ED, and CRUSADE Investigators, . "Unfractionated heparin dosing and risk of major bleeding in non-ST-segment elevation acute coronary syndromes." American Heart Journal 156, no. 2 (August 2008): 209-215.  Full Text
    • Melloni, C, and Mahaffey, KW. "Management of acute coronary syndromes in patients with renal dysfunction." Current Opinion in Cardiology 23, no. 4 (July 2008): 320-326. (Review)  Full Text
    • Chan, MY, Cohen, MG, Dyke, CK, Myles, SK, Aberle, LG, Lin, M, Walder, J, Steinhubl, SR, Gilchrist, IC, Kleiman, NS, Vorchheimer, DA, Chronos, N, Melloni, C, Alexander, JH, Harrington, RA, Tonkens, RM, Becker, RC, and Rusconi, CP. "Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease." Circulation 117, no. 22 (June 2008): 2865-2874.  Full Text
    • Allen, LA, Jolicoeur, EM, Melloni, C, Lopes, RD, Chan, MY, Majidi, M, Piccini, JP, Berger, JS, Katz, JN, and Shah, BR. "Highlights from American Heart Association, November 4-7, 2007, Orlando, Florida, USA. Late-breaking trials summary." American heart journal 155, no. 4 (April 2008): 615-623. (Academic Article)  Full Text
    • Melloni, C, Alexander, KP, Milford-Beland, S, Newby, LK, Szczech, LA, Pollack, CV, Kirk, JD, Christenson, RH, Harrington, RA, Gibler, WB, Ohman, EM, Peterson, ED, Roe, MT, and Crusade Investigators, . "Prognostic value of troponins in patients with non-ST-segment elevation acute coronary syndromes and chronic kidney disease." Clinical Cardiology 31, no. 3 (March 2008): 125-129.  Full Text
    • Melloni, C, Peterson, ED, Chen, AY, Szczech, LA, Newby, LK, Harrington, RA, Gibler, WB, Ohman, EM, Spinler, SA, Roe, MT, and Alexander, KP. "Cockcroft-Gault versus modification of diet in renal disease: importance of glomerular filtration rate formula for classification of chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes." Journal of the American College of Cardiology 51, no. 10 (March 2008): 991-996.  Full Text
    • Lopes, RD, Chan, M, Melloni, C, Jolicoeur, EM, Allen, LA, Shah, BR, Katz, JN, Berger, JS, and Piccini, JP. "Late-breaking trials summary from the 2008 American College of Cardiology Scientific Sessions, March 29 to April 1, Chicago, IL." American Heart Journal 156, no. 1 (2008): 7-12.  Full Text
    • Melloni, C, and Newby, LK. "Metabolic efficiency with ranolazine for less ischemia in non-ST elevation acute coronary syndromes (MERLIN TIMI-36) study." Expert Review of Cardiovascular Therapy 6, no. 1 (January 2008): 9-16.  Full Text
    • Chan, MY, Cohen, MG, Rusconi, CP, Alexander, JH, Myles, SK, Aberle, LG, Lin, M, Melloni, C, Tonkens, RM, Harrington, RA, and Becker, RC. "A first-in-class oligonucleotide drug-antidote pair efficiently modulates factor IXa activity in human subjects - A nascent platform for antidote-controlled periprocedural anticoagulation." CIRCULATION 116, no. 16 (October 16, 2007): 617-617.  Link to Item
    • Melloni, C, Alexander, KP, Chen, AY, Roe, MT, Newby, LK, Ohman, M, Gibler, WB, Smith, SC, Pollak, CV, and Peterson, ED. "Unfractionated heparin dosing and major bleeding in non-ST-segment elevation acute coronary syndromes." Circulation 116, no. 16 (October 16, 2007): 383-383.  Link to Item
    • Adams, GL, Mills, JS, Melloni, C, Allen, LA, Jolicoeur, EM, Wang, T, Chan, M, Majidi, M, and Lopes, RD. "Highlights from the 56th annual scientific sessions of the American College of Cardiology: March 25 to 27, 2007, Atlanta, Georgia." Am Heart J 154, no. 2 (August 2007): 247-259.  Full Text  Link to Item
    • Kraschnewski, JL, Liang, L, Dunlay, SM, Melloni, C, Diercks, DB, Gibler, WB, Roe, MT, Ohman, EM, Peterson, ED, and Alexander, KP. "Age, presentation, and emergency department diagnosis of acute coronary syndromes: Results from CRUSADE." Circulation 115, no. 21 (May 29, 2007): E584-E584.  Link to Item
    • Mills, JS, Adams, GL, Tricoci, P, Melloni, C, Joliceur, EM, Wang, TW, and Thomas, KL. "Highlights from the 20th Scientific Sessions of the American Heart Association: November 12 to 15, 2006, Chicago, Illinois." American Heart Journal 153, no. 2 (2007): 213-223.  Full Text
    • Dyke, CK, Steinhubl, SR, Kleiman, NS, Cannon, RO, Aberle, LG, Lin, M, Myles, SK, Melloni, C, Harrington, RA, Alexander, JH, Becker, RC, and Rusconi, CP. "First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity." Circulation 114, no. 23 (December 2006): 2490-2497.  Full Text
    • Goyal, A, Mills, JS, Tricoci, P, Thomas, KL, Baeza, R, Adams, GL, and Melloni, C. "Highlights from the 55th Annual Scientific Sessions of the American College of Cardiology: March 11 to 14, 2006, Atlanta, Georgia." American Heart Journal 151, no. 6 (2006): 1156-1172.  Full Text
    • Goyal, A, Tricoci, P, Melloni, C, Mills, JS, Thomas, KL, Adams, GL, Mitchell, RG, and Turer, AT. "Highlights from the American Heart Association Scientific Sessions, November 13 to 16, 2005, Dallas, TX." American Heart Journal 151, no. 2 (2006): 295-307.  Full Text
    • Patel, MR, Baeza, RG, Goyal, A, Halabi, AR, Melloni, C, Oliveira, GBF, Tricoci, P, and Valente, AM. "Highlights from the American College of Cardiology Annual Scientific Session 2005: March 6 to 9, 2005, Orlando, Florida." Am Heart J 149, no. 6 (June 2005): 1009-1019.  Full Text  Link to Item
    • Montebugnoli, L, Servidio, D, Miaton, RA, Prati, C, Tricoci, P, Melloni, C, and Melandri, G. "Periodontal health improves systemic inflammatory and haemostatic status in subjects with coronary heart disease." J Clin Periodontol 32, no. 2 (February 2005): 188-192.  Full Text  Link to Item
    • Melandri, G, Melloni, C, Tricoci, P, Marrozzini, C, Ortolani, P, Marzocchi, A, Serantoni, C, Taglioni, M, and Branzi, A. "Significant decrease of door-to-balloon time by direct transport from ambulance to cath lab." CIRCULATION 110, no. 17 (October 26, 2004): 537-537.  Link to Item
    • Ferioli, V, Manes, A, Melloni, C, Nanni, S, and Boncompagni, G. "Atypical neuroleptic malignant syndrome caused by clozapine and venlafaxine: early brief treatment with dantrolene." Can J Psychiatry 49, no. 7 (July 2004): 497-498. (Letter)  Full Text  Link to Item
    • Montebugnoli, L, Servidio, D, Miaton, RA, Prati, C, Tricoci, P, and Melloni, C. "Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors." J Clin Periodontol 31, no. 1 (January 2004): 25-29.  Link to Item
    • Nanni, S, Melandri, G, Hanemaaijer, R, Cervi, V, Tomasi, L, Altimari, A, Tricoci, P, Melloni, C, and Branzi, A. "Matrix metalloproteinase genetic polymorphisms in premature coronary artery disease." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 41, no. 6 (March 19, 2003): 234A-234A.  Link to Item
    • Nanni, S, Melandri, G, Hanemaaijer, R, Cervi, V, Tomasi, L, Melloni, C, Tricoci, P, and Branzi, A. "Matrix metalloproteinases and their inhibitors in premature coronary atherosclerosis: Relation with inflammation and metabolic markers." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 41, no. 6 (March 19, 2003): 282A-283A.  Link to Item
    • Melandri, G, Fallani, F, Semprini, F, Nanni, S, Melloni, C, Tricoci, P, and Branzi, A. "Acute coronary syndromes: New trends in blood anticoagulation." Haematologica 88, no. SUPPL. 4 (2003): 36-39.
    • Tricoci, P, Melloni, C, Melandri, G, and Branzi, A. "Plasma homocysteine levels independently correlate with angiographic extension of coronary artery disease." EUROPEAN HEART JOURNAL 24 (2003): 436-436.  Full Text  Link to Item
    • Melandri, G, Tricoci, P, Melloni, C, Nanni, S, Semprini, F, Fallani, F, and Branzi, A. "Clinical use of novel antithrombotic agents in the management of acute coronary syndromes." Pathophysiol Haemost Thromb 32, no. 5-6 (September 2002): 282-288. (Review)  Full Text  Link to Item
    • Nanni, S, Melandri, G, Hanemaaijer, R, Cervi, V, Tomasi, L, Melloni, C, Tricoci, P, and Branzi, A. "Determinants of matrix metalloproteinases plasma concentration and activity in premature coronary atherosclerosis." EUROPEAN HEART JOURNAL 23 (2002): 135-135.  Link to Item
    • Tricoci, P, Melloni, C, Melandri, G, Cervi, V, Tomasi, L, and Branzi, A. "Effect of simvastatin on endothelial damage markers and clinical outcomes in acute coronary syndromes." EUROPEAN HEART JOURNAL 23 (2002): 419-419.  Link to Item
    • Melandri, G, Nanni, S, Tricoci, P, Melloni, C, Semprini, F, Fallani, F, Bracchetti, G, and Branzi, A. "Heparins: their established role in acute coronary syndromes and perspectives in atrial fibrillation." Haematologica 86, no. 11 Suppl 2 (November 2001): 54-57. (Review)  Link to Item
    • Melandri, G, Nanni, S, Tricoci, P, Melloni, C, Semprini, F, Fallani, F, Bracchetti, G, and Branzi, A. "Heparins: their established role in acute coronary syndromes and perspectives in atrial fibrillation." HAEMATOLOGICA 86, no. 11 (November 2001): 54-57.  Link to Item
    • Nanni, S, Melandri, G, Cervi, V, Altimari, A, Tomasi, L, Conti, R, Branzi, A, and Melloni, C. "Genetic variation in human Stromelysin-1 and Gelatinase B genes and acute coronary syndromes in young males." EUROPEAN HEART JOURNAL 22 (September 2001): 164-164.  Link to Item
    • Melandri, G, Nanni, S, Tricoci, P, Melloni, C, Semprini, F, Fallani, F, Bracchetti, G, and Branzi, A. "Heparins: Their established role in acute coronary syndromes and perspectives in atrial fibrillation." Haematologica 86, no. 11 SUPPL. 2 (2001): 54-57.

  • Reports

    • DOLOR, RJ, Melloni, C, Chatterjee, R, Allen Lapointe, N, williams, JB, Coeytaux, RR, McBroom, AJ, Musty, MD, Wing, L, Samsa, GP, and Patel, MR. Treatment Strategies for Women With Coronary Artery Disease. August 1, 2012.

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