Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Virginia Commonwealth University 2000
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2007 - 2020
  • Assistant Professor – Track IV in Neurosurgery, Neurosurgery, Neurosurgery 2017 - 2020
  • Assistant Clinical Professor of Surgery, Orthopaedic Surgery, Clinical Science Departments 2006 - 2007
• Research
• 

  Selected Grants

  • Fresh Tissue Lab Agreement awarded by Alphatec Spine, Inc. 2020
  • Fresh Tissue Lab Agreement awarded by Si-Bone Inc. 2019
  • Fresh Tissue Lab Agreement awarded by Novus Technologies Inc 2015
  • Fresh tissue lab agreement awarded by Novus Technologies Inc 2014
• 

  External Relationships

  • Alphatech Inc
  • NuVasive, Inc.
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Crutcher, C., H. Zhang, and C. Brown. “Relevant anatomy for lateral access surgery.” Seminars in Spine Surgery 34, no. 2 (June 1, 2022). https://doi.org/10.1016/j.semss.2022.100940.
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    • Zhang, H., B. Dial, and C. Brown. “Early fusion rates after direct lateral lumbar interbody fusion with bone-morphogenetic protein.” International Journal of Spine Surgery 15, no. 3 (June 1, 2021): 423–28. https://doi.org/10.14444/8063.
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    • Wang, Timothy Y., Gautam Nayar, Christopher R. Brown, Luiz Pimenta, Isaac O. Karikari, and Robert E. Isaacs. “Bony Lateral Recess Stenosis and Other Radiographic Predictors of Failed Indirect Decompression via Extreme Lateral Interbody Fusion: Multi-Institutional Analysis of 101 Consecutive Spinal Levels.” World Neurosurg 106 (October 2017): 819–26. https://doi.org/10.1016/j.wneu.2017.07.045.
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    • Blizzard, Daniel J., Colin T. Penrose, Charles Z. Sheets, Thorsten M. Seyler, Michael P. Bolognesi, and Christopher R. Brown. “Ankylosing Spondylitis Increases Perioperative and Postoperative Complications After Total Hip Arthroplasty.” J Arthroplasty 32, no. 8 (August 2017): 2474–79. https://doi.org/10.1016/j.arth.2017.03.041.
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    • Blizzard, Daniel J., Charles Z. Sheets, Thorsten M. Seyler, Colin T. Penrose, Mitchell R. Klement, Michael A. Gallizzi, and Christopher R. Brown. “The Impact of Lumbar Spine Disease and Deformity on Total Hip Arthroplasty Outcomes.” Orthopedics 40, no. 3 (May 1, 2017): e520–25. https://doi.org/10.3928/01477447-20170327-03.
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    • Wilhelm, Mark, Michael Reiman, Adam Goode, William Richardson, Christopher Brown, Daniel Vaughn, and Chad Cook. “Psychological Predictors of Outcomes with Lumbar Spinal Fusion: A Systematic Literature Review.” Physiother Res Int 22, no. 2 (April 2017). https://doi.org/10.1002/pri.1648.
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    • Blizzard, Daniel J., Adam M. Caputo, Charles Z. Sheets, Mitchell R. Klement, Keith W. Michael, Robert E. Isaacs, and Christopher R. Brown. “Laminoplasty versus laminectomy with fusion for the treatment of spondylotic cervical myelopathy: short-term follow-up.” Eur Spine J 26, no. 1 (January 2017): 85–93. https://doi.org/10.1007/s00586-016-4746-3.
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    • Dunphy, Louise, Shabnam Iyer, and Christopher Brown. “Rare cause of back pain: Staphylococcus aureus vertebral osteomyelitis complicated by recurrent epidural abscess and severe sepsis.” Bmj Case Rep 2016 (December 13, 2016). https://doi.org/10.1136/bcr-2016-217111.
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    • Blizzard, Daniel J., Michael A. Gallizzi, Robert E. Isaacs, and Christopher R. Brown. “Renal artery injury during lateral transpsoas interbody fusion: case report.” J Neurosurg Spine 25, no. 4 (October 2016): 464–66. https://doi.org/10.3171/2016.2.SPINE15785.
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    • Karikari, Isaac O., Chris Brown, D Gregg Anderson, and Debbie Chi. “167 Reducing Radiation an Order of Magnitude During Fluoroscopic-Guided Kyphoplasty.” Neurosurgery 63 Suppl 1 (August 2016): 167. https://doi.org/10.1227/01.neu.0000489736.23975.83.
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    • Brown, Calvin R., Lisa Criscione-Schreiber, Kenneth S. O’Rourke, Howard A. Fuchs, Chaim Putterman, Irene J. Tan, Joanne Valeriano-Marcet, Evelyn Hsieh, Sarah Zirkle, and Marcy B. Bolster. “What Is a Rheumatologist and How Do We Make One?” Arthritis Care Res (Hoboken) 68, no. 8 (August 2016): 1166–72. https://doi.org/10.1002/acr.22817.
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    • Tang, Xinyan, Liufang Jing, William J. Richardson, Robert E. Isaacs, Robert D. Fitch, Christopher R. Brown, Melissa M. Erickson, Lori A. Setton, and Jun Chen. “Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration.” J Orthop Res 34, no. 8 (August 2016): 1316–26. https://doi.org/10.1002/jor.23244.
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    • Chapman, Todd M., Daniel J. Blizzard, and Christopher R. Brown. “CT accuracy of percutaneous versus open pedicle screw techniques: a series of 1609 screws.” Eur Spine J 25, no. 6 (June 2016): 1781–86. https://doi.org/10.1007/s00586-015-4163-z.
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    • Klement, Mitchell R., Lindsay T. Kleeman, Daniel J. Blizzard, Michael A. Gallizzi, Megan Eure, and Christopher R. Brown. “C5 palsy after cervical laminectomy and fusion: does width of laminectomy matter?” Spine J 16, no. 4 (April 2016): 462–67. https://doi.org/10.1016/j.spinee.2015.07.437.
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    • Chapman, Todd M., Daniel J. Blizzard, Charles Sheets, and Christopher R. Brown. “Erratum to: CT accuracy of percutaneous versus open pedicle screw techniques: a series of 1609 screws.” Eur Spine J 25, no. 3 (March 2016): 970. https://doi.org/10.1007/s00586-015-4288-0.
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    • Blizzard, Daniel J., Michael A. Gallizzi, Charles Sheets, Benjamin T. Smith, Robert E. Isaacs, Megan Eure, and Christopher R. Brown. “Sagittal Balance Correction in Lateral Interbody Fusion for Degenerative Scoliosis.” Int J Spine Surg 10 (2016): 29. https://doi.org/10.14444/3029.
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    • Blizzard, Daniel J., Christopher P. Hills, Robert E. Isaacs, and Christopher R. Brown. “Extreme lateral interbody fusion with posterior instrumentation for spondylodiscitis.” J Clin Neurosci 22, no. 11 (November 2015): 1758–61. https://doi.org/10.1016/j.jocn.2015.05.021.
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    • Blizzard, Daniel J., Michael A. Gallizzi, Charles Sheets, Mitchell R. Klement, Lindsay T. Kleeman, Adam M. Caputo, Megan Eure, and Christopher R. Brown. “The role of iatrogenic foraminal stenosis from lordotic correction in the development of C5 palsy after posterior laminectomy and fusion.” J Orthop Surg Res 10 (October 6, 2015): 160. https://doi.org/10.1186/s13018-015-0297-2.
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    • Godin, J., C. Brown, S. Mardam-Bey, C. Deshpande, M. Manson, J. Boling, S. Olson, and R. Zura. “Two admission pathways for elderly patients with hip fracture: Clinical outcomes at a single institution.” Current Orthopaedic Practice 26, no. 4 (July 9, 2015): 387–94. https://doi.org/10.1097/BCO.0000000000000255.
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    • Blizzard, D. J., M. A. Gallizzi, C. Sheets, M. R. Klement, L. T. Kleeman, A. M. Caputo, M. Eure, and C. R. Brown. “The role of iatrogenic foraminal stenosis from lordotic correction in the development of C5 palsy after posterior laminectomy and fusion.” Journal of Orthopaedic Surgery and Research 10, no. 1 (2015). https://doi.org/10.1186/s13018-015-0297-2.
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    • Martin, Joel R., Owoicho Adogwa, Christopher R. Brown, Maragatha Kuchibhatla, Carlos A. Bagley, Shivanand P. Lad, and Oren N. Gottfried. “Experience with intrawound vancomycin powder for posterior cervical fusion surgery.” J Neurosurg Spine 22, no. 1 (January 2015): 26–33. https://doi.org/10.3171/2014.9.SPINE13826.
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    • Nimjee, Shahid M., Isaac O. Karikari, A. B. Carolyn A Hardin, Jonathan Choi, Ciaran J. Powers, Christopher R. Brown, and Robert E. Isaacs. “Safe and accurate placement of thoracic and thoracolumbar percutaneous pedicle screws without image-navigation.” Asian J Neurosurg 10, no. 4 (2015): 272–75. https://doi.org/10.4103/1793-5482.162700.
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    • Tang, Xinyan, William J. Richardson, Robert D. Fitch, Christopher R. Brown, Robert E. Isaacs, and Jun Chen. “A new non-enzymatic method for isolating human intervertebral disc cells preserves the phenotype of nucleus pulposus cells.” Cytotechnology 66, no. 6 (December 2014): 979–86. https://doi.org/10.1007/s10616-013-9650-7.
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    • Eastlack, Robert K., Steven R. Garfin, Christopher R. Brown, and S Craig Meyer. “Osteocel Plus cellular allograft in anterior cervical discectomy and fusion: evaluation of clinical and radiographic outcomes from a prospective multicenter study.” Spine (Phila Pa 1976) 39, no. 22 (October 15, 2014): E1331–37. https://doi.org/10.1097/BRS.0000000000000557.
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    • Foster, Norah A., Dawn M. Elfenbein, Wayne Kelley, Christopher R. Brown, Carolyn Foley, John E. Scarborough, Steven N. Vaslef, and Mark L. Shapiro. “Comparison of helicopter versus ground transport for the interfacility transport of isolated spinal injury.” Spine J 14, no. 7 (July 1, 2014): 1147–54. https://doi.org/10.1016/j.spinee.2013.07.478.
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    • Martin, Joel R., Owoicho Adogwa, Christopher R. Brown, Carlos A. Bagley, William J. Richardson, Shivanand P. Lad, Maragatha Kuchibhatla, and Oren N. Gottfried. “Experience with intrawound vancomycin powder for spinal deformity surgery.” Spine (Phila Pa 1976) 39, no. 2 (January 15, 2014): 177–84. https://doi.org/10.1097/BRS.0000000000000071.
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    • Massey, G. M., A. M. Caputo, K. W. Michael, R. E. Isaacs, and C. R. Brown. “Lumbar facet cyst resolution following anterior interbody fusion.” Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 20, no. 12 (December 1, 2013): 1771–73.
    • Massey, Gene M., Adam M. Caputo, Keith W. Michael, Robert E. Isaacs, and Christopher R. Brown. “Lumbar facet cyst resolution following anterior interbody fusion.” J Clin Neurosci 20, no. 12 (December 2013): 1771–73. https://doi.org/10.1016/j.jocn.2012.12.021.
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    • Caputo, Adam M., Keith W. Michael, Todd M. Chapman, Jason M. Jennings, Elizabeth W. Hubbard, Robert E. Isaacs, and Christopher R. Brown. “Extreme lateral interbody fusion for the treatment of adult degenerative scoliosis.” J Clin Neurosci 20, no. 11 (November 2013): 1558–63. https://doi.org/10.1016/j.jocn.2012.12.024.
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    • Bridgen, D. T., C. L. Gilchrist, W. J. Richardson, R. E. Isaacs, C. R. Brown, K. L. Yang, J. Chen, and L. A. Setton. “Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc.” J Orthop Res 31, no. 10 (October 2013): 1661–67. https://doi.org/10.1002/jor.22395.
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    • Lark, Robert K., Adam M. Caputo, Christopher R. Brown, Keith W. Michael, Julie K. Thacker, and William J. Richardson. “Distant Harrington rod migration 35 years after implantation.” J Clin Neurosci 20, no. 10 (October 2013): 1452–53. https://doi.org/10.1016/j.jocn.2012.08.019.
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    • Brown, C. A., T. R. McAdams, A. H. S. Harris, N. Maffulli, and M. R. Safran. “ACL reconstruction in patients aged 40 years and older: A systematic review and introduction of a new methodology score for ACL studies.” American Journal of Sports Medicine 41, no. 9 (2013): 2181–90. https://doi.org/10.1177/0363546513481947.
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    • Brown, Christopher A., Steven Olson, and Robert Zura. “Predictors of length of hospital stay in elderly hip fracture patients.” J Surg Orthop Adv 22, no. 2 (2013): 160–63. https://doi.org/10.3113/jsoa.2013.0160.
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    • Caputo, Adam M., Ryan P. Dobbertien, Jeffrey M. Ferranti, Christopher R. Brown, Keith W. Michael, and William J. Richardson. “Risk factors for infection after orthopaedic spine surgery at a high-volume institution.” J Surg Orthop Adv 22, no. 4 (2013): 295–98. https://doi.org/10.3113/jsoa.2013.0295.
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    • Babu, Ranjith, Jong G. Park, Ankit I. Mehta, Tony Shan, Peter M. Grossi, Christopher R. Brown, William J. Richardson, et al. “Comparison of superior-level facet joint violations during open and percutaneous pedicle screw placement.” Neurosurgery 71, no. 5 (November 2012): 962–70. https://doi.org/10.1227/NEU.0b013e31826a88c8.
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    • Brown, Christopher A., John Boling, Maria Manson, Thomas Owens, and Robert Zura. “Relation between prefracture characteristics and perioperative complications in the elderly adult patient with hip fracture.” South Med J 105, no. 6 (June 2012): 306–10. https://doi.org/10.1097/SMJ.0b013e3182574bfd.
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    • Brown, Christopher A., Aijing Z. Starr, and James A. Nunley. “Analysis of past secular trends of hip fractures and predicted number in the future 2010-2050.” J Orthop Trauma 26, no. 2 (February 2012): 117–22. https://doi.org/10.1097/BOT.0b013e318219c61a.
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    • Caputo, Adam M., Keith W. Michael, Todd M. Chapman, Gene M. Massey, Cameron R. Howes, Robert E. Isaacs, and Christopher R. Brown. “Clinical outcomes of extreme lateral interbody fusion in the treatment of adult degenerative scoliosis.” Scientificworldjournal 2012 (2012): 680643. https://doi.org/10.1100/2012/680643.
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    • Cook, Chad, Christopher Brown, Keith Michael, Robert Isaacs, Cameron Howes, William Richardson, Matthew Roman, and Eric Hegedus. “The clinical value of a cluster of patient history and observational findings as a diagnostic support tool for lumbar spine stenosis.” Physiother Res Int 16, no. 3 (September 2011): 170–78. https://doi.org/10.1002/pri.500.
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    • Karikari, Isaac O., Shahid M. Nimjee, Carolyn A. Hardin, Betsy D. Hughes, Tiffany R. Hodges, Ankit I. Mehta, Jonathan Choi, Christopher R. Brown, and Robert E. Isaacs. “Extreme lateral interbody fusion approach for isolated thoracic and thoracolumbar spine diseases: initial clinical experience and early outcomes.” J Spinal Disord Tech 24, no. 6 (August 2011): 368–75. https://doi.org/10.1097/BSD.0b013e3181ffefd2.
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    • Sinclair, S Michael, Mohammed F. Shamji, Jun Chen, Liufang Jing, William J. Richardson, Christopher R. Brown, Robert D. Fitch, and Lori A. Setton. “Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist.” Spine (Phila Pa 1976) 36, no. 15 (July 1, 2011): 1190–96. https://doi.org/10.1097/BRS.0b013e3181ebdb43.
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    • Goode, Adam P., Chad Cook, J Brian Gill, Sean Tackett, Christopher Brown, and William Richardson. “The risk of risk-adjustment measures for perioperative spine infection after spinal surgery.” Spine (Phila Pa 1976) 36, no. 9 (April 20, 2011): 752–58. https://doi.org/10.1097/BRS.0b013e3181e030b3.
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    • Karikari, Isaac O., Peter M. Grossi, Shahid M. Nimjee, Carolyn Hardin, Tiffany R. Hodges, Betsy D. Hughes, Christopher R. Brown, and Robert E. Isaacs. “Minimally invasive lumbar interbody fusion in patients older than 70 years of age: analysis of peri- and postoperative complications.” Neurosurgery 68, no. 4 (April 2011): 897–902. https://doi.org/10.1227/NEU.0b013e3182098bfa.
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    • Brown, Christopher, Alison Toth, and Robert Magnussen. “Clinical benefits of intra-articular anakinra for persistent knee effusion.” J Knee Surg 24, no. 1 (March 2011): 61–65. https://doi.org/10.1055/s-0031-1275398.
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    • Donaldson, Megan B., Ken Learman, Alexis Wright, Christopher Brown, Cameron Howes, and Chad E. Cook. “Factor structure and concurrent/convergent validity of the modified somatic perception questionnaire and pain beliefs instrument.” J Manipulative Physiol Ther 34, no. 1 (January 2011): 30–36. https://doi.org/10.1016/j.jmpt.2010.11.002.
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    • Goode, Adam, Chad Cook, Christopher Brown, Robert Isaacs, Matthew Roman, and William Richardson. “Differences in comorbidities on low back pain and low back related leg pain.” Pain Pract 11, no. 1 (2011): 42–47. https://doi.org/10.1111/j.1533-2500.2010.00391.x.
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    • Brown, Christopher A., Alison P. Toth, and Bob Magnussen. “Clinical benefits of intra-articular anakinra for arthrofibrosis.” Orthopedics 33, no. 12 (December 1, 2010): 877. https://doi.org/10.3928/01477447-20101021-09.
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    • Cook, Chad, Christopher Brown, Robert Isaacs, Matthew Roman, Samuel Davis, and William Richardson. “Clustered clinical findings for diagnosis of cervical spine myelopathy.” J Man Manip Ther 18, no. 4 (December 2010): 175–80. https://doi.org/10.1179/106698110X12804993427045.
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    • Shamji, Mohammed F., Lori A. Setton, Wingrove Jarvis, Stephen So, Jun Chen, Liufang Jing, Robert Bullock, Robert E. Isaacs, Christopher Brown, and William J. Richardson. “Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues.” Arthritis Rheum 62, no. 7 (July 2010): 1974–82. https://doi.org/10.1002/art.27444.
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    • Roman, Matthew, Christopher Brown, William Richardson, Robert Isaacs, Cameron Howes, and Chad Cook. “The development of a clinical decision making algorithm for detection of osteoporotic vertebral compression fracture or wedge deformity.” J Man Manip Ther 18, no. 1 (March 2010): 44–49. https://doi.org/10.1179/106698110X12595770849641.
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    • Shamji, Mohammed F., Stephen Parker, Chad Cook, Ricardo Pietrobon, Christopher Brown, and Robert E. Isaacs. “Impact of body habitus on perioperative morbidity associated with fusion of the thoracolumbar and lumbar spine.” Neurosurgery 65, no. 3 (September 2009): 490–98. https://doi.org/10.1227/01.NEU.0000350863.69524.8E.
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    • Shamji, Mohammed F., Chad Cook, Ricardo Pietrobon, Sean Tackett, Christopher Brown, and Robert E. Isaacs. “Impact of surgical approach on complications and resource utilization of cervical spine fusion: a nationwide perspective to the surgical treatment of diffuse cervical spondylosis.” Spine J 9, no. 1 (2009): 31–38. https://doi.org/10.1016/j.spinee.2008.07.005.
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    • Hollinger, J. O., J. P. Schmitz, G. E. Friedlaender, C. R. Brown, S. D. Boden, and S. Lynch. “Therapeutic Opportunities for Bone Grafting,” December 1, 2008, 1164–75. https://doi.org/10.1016/B978-012369410-2.50070-X.
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    • Heck, Christopher A., Christopher R. Brown, and William J. Richardson. “Venous thromboembolism in spine surgery.” J Am Acad Orthop Surg 16, no. 11 (November 2008): 656–64. https://doi.org/10.5435/00124635-200811000-00006.
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    • Shamji, Mohammed F., Chad Cook, Sean Tackett, Christopher Brown, and Robert E. Isaacs. “Impact of preoperative neurological status on perioperative morbidity associated with anterior and posterior cervical fusion.” J Neurosurg Spine 9, no. 1 (July 2008): 10–16. https://doi.org/10.3171/SPI/2008/9/7/010.
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    • Brown, C. R., and J. G. Heller. “Patient Selection for Cervical Disc Arthroplasty.” Seminars in Spine Surgery 18, no. 2 (June 1, 2006): 47–52. https://doi.org/10.1053/j.semss.2006.03.005.
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