Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Virginia Commonwealth University 2000
• 

  Duke Appointment History

  • Assistant Clinical Professor of Surgery, Orthopaedics, Orthopaedics 2006 - 2007
• Research
• 

  Selected Grants

  • Fresh Tissue Lab Agreement awarded by Si-Bone Inc. 2019
  • Fresh Tissue Lab Agreement awarded by Novus Technologies Inc 2015
  • Fresh tissue lab agreement awarded by Novus Technologies Inc 2014
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Wang, Timothy Y., Gautam Nayar, Christopher R. Brown, Luiz Pimenta, Isaac O. Karikari, and Robert E. Isaacs. “Bony Lateral Recess Stenosis and Other Radiographic Predictors of Failed Indirect Decompression via Extreme Lateral Interbody Fusion: Multi-Institutional Analysis of 101 Consecutive Spinal Levels..” World Neurosurgery 106 (October 2017): 819–26. https://doi.org/10.1016/j.wneu.2017.07.045.
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    • Blizzard, Daniel J., Colin T. Penrose, Charles Z. Sheets, Thorsten M. Seyler, Michael P. Bolognesi, and Christopher R. Brown. “Ankylosing Spondylitis Increases Perioperative and Postoperative Complications After Total Hip Arthroplasty..” The Journal of Arthroplasty 32, no. 8 (August 2017): 2474–79. https://doi.org/10.1016/j.arth.2017.03.041.
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    • Blizzard, Daniel J., Charles Z. Sheets, Thorsten M. Seyler, Colin T. Penrose, Mitchell R. Klement, Michael A. Gallizzi, and Christopher R. Brown. “The Impact of Lumbar Spine Disease and Deformity on Total Hip Arthroplasty Outcomes..” Orthopedics 40, no. 3 (May 2017): e520–25. https://doi.org/10.3928/01477447-20170327-03.
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    • Wilhelm, Mark, Michael Reiman, Adam Goode, William Richardson, Christopher Brown, Daniel Vaughn, and Chad Cook. “Psychological Predictors of Outcomes with Lumbar Spinal Fusion: A Systematic Literature Review..” Physiotherapy Research International : The Journal for Researchers and Clinicians in Physical Therapy 22, no. 2 (April 2017). https://doi.org/10.1002/pri.1648.
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    • Blizzard, DJ, Caputo, AM, Sheets, CZ, Klement, MR, Michael, KW, Isaacs, RE, and Brown, CR. "Laminoplasty versus laminectomy with fusion for the treatment of spondylotic cervical myelopathy: short-term follow-up." European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 26, no. 1 (January 2017): 85-93.  Full Text
    • Dunphy, Louise, Shabnam Iyer, and Christopher Brown. “Rare cause of back pain: Staphylococcus aureus vertebral osteomyelitis complicated by recurrent epidural abscess and severe sepsis..” Bmj Case Reports 2016 (December 13, 2016). https://doi.org/10.1136/bcr-2016-217111.
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    • Blizzard, Daniel J., Michael A. Gallizzi, Robert E. Isaacs, and Christopher R. Brown. “Renal artery injury during lateral transpsoas interbody fusion: case report..” Journal of Neurosurgery. Spine 25, no. 4 (October 2016): 464–66. https://doi.org/10.3171/2016.2.spine15785.
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    • Karikari, Isaac O., Chris Brown, D Gregg Anderson, and Debbie Chi. “167 Reducing Radiation an Order of Magnitude During Fluoroscopic-Guided Kyphoplasty..” Neurosurgery 63 Suppl 1 (August 2016). https://doi.org/10.1227/01.neu.0000489736.23975.83.
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    • Tang, Xinyan, Liufang Jing, William J. Richardson, Robert E. Isaacs, Robert D. Fitch, Christopher R. Brown, Melissa M. Erickson, Lori A. Setton, and Jun Chen. “Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration..” Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society 34, no. 8 (August 2016): 1316–26. https://doi.org/10.1002/jor.23244.
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    • Brown, CR, Criscione-Schreiber, L, O'Rourke, KS, Fuchs, HA, Putterman, C, Tan, IJ, Valeriano-Marcet, J, Hsieh, E, Zirkle, S, and Bolster, MB. "What Is a Rheumatologist and How Do We Make One?." Arthritis Care & Research 68, no. 8 (August 2016): 1166-1172.  Full Text
    • Chapman, Todd M., Daniel J. Blizzard, and Christopher R. Brown. “CT accuracy of percutaneous versus open pedicle screw techniques: a series of 1609 screws..” European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 25, no. 6 (June 2016): 1781–86. https://doi.org/10.1007/s00586-015-4163-z.
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    • Klement, Mitchell R., Lindsay T. Kleeman, Daniel J. Blizzard, Michael A. Gallizzi, Megan Eure, and Christopher R. Brown. “C5 palsy after cervical laminectomy and fusion: does width of laminectomy matter?.” The Spine Journal : Official Journal of the North American Spine Society 16, no. 4 (April 2016): 462–67. https://doi.org/10.1016/j.spinee.2015.07.437.
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    • Chapman, Todd M., Daniel J. Blizzard, Charles Sheets, and Christopher R. Brown. “Erratum to: CT accuracy of percutaneous versus open pedicle screw techniques: a series of 1609 screws..” European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 25, no. 3 (March 2016). https://doi.org/10.1007/s00586-015-4288-0.
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    • Blizzard, Daniel J., Michael A. Gallizzi, Charles Sheets, Benjamin T. Smith, Robert E. Isaacs, Megan Eure, and Christopher R. Brown. “Sagittal Balance Correction in Lateral Interbody Fusion for Degenerative Scoliosis..” International Journal of Spine Surgery 10 (January 2016). https://doi.org/10.14444/3029.
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    • Blizzard, DJ, Gallizzi, MA, Sheets, C, Klement, MR, Kleeman, LT, Caputo, AM, Eure, M, and Brown, CR. "The role of iatrogenic foraminal stenosis from lordotic correction in the development of C5 palsy after posterior laminectomy and fusion." Journal of Orthopaedic Surgery and Research 10, no. 1 (December 2015).  Full Text
    • Blizzard, Daniel J., Christopher P. Hills, Robert E. Isaacs, and Christopher R. Brown. “Extreme lateral interbody fusion with posterior instrumentation for spondylodiscitis..” Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 22, no. 11 (November 2015): 1758–61. https://doi.org/10.1016/j.jocn.2015.05.021.
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    • Nimjee, Shahid M., Isaac O. Karikari, A. B. Carolyn A Hardin, Jonathan Choi, Ciaran J. Powers, Christopher R. Brown, and Robert E. Isaacs. “Safe and accurate placement of thoracic and thoracolumbar percutaneous pedicle screws without image-navigation..” Asian Journal of Neurosurgery 10, no. 4 (October 2015): 272–75. https://doi.org/10.4103/1793-5482.162700.
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    • Blizzard, D. J., C. P. Hills, R. E. Isaacs, and C. R. Brown. “Extreme lateral interbody fusion with posterior instrumentation for spondylodiscitis.” Journal of Clinical Neuroscience 22, no. 11 (2015): 1758–61. https://doi.org/10.1016/j.jocn.2015.05.021.
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    • Blizzard, Daniel J., Michael A. Gallizzi, Charles Sheets, Mitchell R. Klement, Lindsay T. Kleeman, Adam M. Caputo, Megan Eure, and Christopher R. Brown. “The role of iatrogenic foraminal stenosis from lordotic correction in the development of C5 palsy after posterior laminectomy and fusion..” Journal of Orthopaedic Surgery and Research 10 (January 2015). https://doi.org/10.1186/s13018-015-0297-2.
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    • Godin, J, Brown, C, Mardam-Bey, S, Deshpande, C, Manson, M, Boling, J, Olson, S, and Zura, R. "Two admission pathways for elderly patients with hip fracture: Clinical outcomes at a single institution." Current Orthopaedic Practice 26, no. 4 (January 1, 2015): 387-394.  Full Text
    • Martin, JR, Adogwa, O, Brown, CR, Kuchibhatla, M, Bagley, CA, Lad, SP, and Gottfried, ON. "Experience with intrawound vancomycin powder for posterior cervical fusion surgery." Journal of Neurosurgery. Spine 22, no. 1 (January 2015): 26-33.  Full Text
    • Tang, X, Richardson, WJ, Fitch, RD, Brown, CR, Isaacs, RE, and Chen, J. "A new non-enzymatic method for isolating human intervertebral disc cells preserves the phenotype of nucleus pulposus cells." Cytotechnology 66, no. 6 (December 2014): 979-986.  Full Text
    • Eastlack, Robert K., Steven R. Garfin, Christopher R. Brown, and S Craig Meyer. “Osteocel Plus cellular allograft in anterior cervical discectomy and fusion: evaluation of clinical and radiographic outcomes from a prospective multicenter study..” Spine 39, no. 22 (October 2014): E1331–37. https://doi.org/10.1097/brs.0000000000000557.
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    • Foster, Norah A., Dawn M. Elfenbein, Wayne Kelley, Christopher R. Brown, Carolyn Foley, John E. Scarborough, Steven N. Vaslef, and Mark L. Shapiro. “Comparison of helicopter versus ground transport for the interfacility transport of isolated spinal injury..” The Spine Journal : Official Journal of the North American Spine Society 14, no. 7 (July 2014): 1147–54. https://doi.org/10.1016/j.spinee.2013.07.478.
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    • Foster, NA, Elfenbein, DM, Kelley, W, Brown, CR, Foley, C, Scarborough, JE, Vaslef, SN, and Shapiro, ML. "Comparison of helicopter versus ground transport for the interfacility transport of isolated spinal injury." Spine Journal 14, no. 7 (July 1, 2014): 1147-1154.  Full Text
    • Martin, JR, Adogwa, O, Brown, CR, Bagley, CA, Richardson, WJ, Lad, SP, Kuchibhatla, M, and Gottfried, ON. "Experience with intrawound vancomycin powder for spinal deformity surgery." Spine 39, no. 2 (January 15, 2014): 177-184.  Full Text
    • Martin, Joel R., Owoicho Adogwa, Christopher R. Brown, Carlos A. Bagley, William J. Richardson, Shivanand P. Lad, Maragatha Kuchibhatla, and Oren N. Gottfried. “Experience with intrawound vancomycin powder for spinal deformity surgery..” Spine 39, no. 2 (January 2014): 177–84. https://doi.org/10.1097/brs.0000000000000071.
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    • Massey, G. M., A. M. Caputo, K. W. Michael, R. E. Isaacs, and C. R. Brown. “Lumbar facet cyst resolution following anterior interbody fusion..” Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 20, no. 12 (December 1, 2013): 1771–73.
    • Massey, Gene M., Adam M. Caputo, Keith W. Michael, Robert E. Isaacs, and Christopher R. Brown. “Lumbar facet cyst resolution following anterior interbody fusion..” Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 20, no. 12 (December 2013): 1771–73. https://doi.org/10.1016/j.jocn.2012.12.021.
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    • Massey, GM, Caputo, AM, Michael, KW, Isaacs, RE, and Brown, CR. "Lumbar facet cyst resolution following anterior interbody fusion." Journal of Clinical Neuroscience 20, no. 12 (December 1, 2013): 1771-1773.  Full Text
    • Caputo, Adam M., Keith W. Michael, Todd M. Chapman, Jason M. Jennings, Elizabeth W. Hubbard, Robert E. Isaacs, and Christopher R. Brown. “Extreme lateral interbody fusion for the treatment of adult degenerative scoliosis..” Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 20, no. 11 (November 2013): 1558–63. https://doi.org/10.1016/j.jocn.2012.12.024.
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    • Bridgen, D. T., C. L. Gilchrist, W. J. Richardson, R. E. Isaacs, C. R. Brown, K. L. Yang, J. Chen, and L. A. Setton. “Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc..” Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society 31, no. 10 (October 2013): 1661–67. https://doi.org/10.1002/jor.22395.
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    • Lark, Robert K., Adam M. Caputo, Christopher R. Brown, Keith W. Michael, Julie K. Thacker, and William J. Richardson. “Distant Harrington rod migration 35 years after implantation..” Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 20, no. 10 (October 2013): 1452–53. https://doi.org/10.1016/j.jocn.2012.08.019.
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    • Brown, CA, McAdams, TR, Harris, AHS, Maffulli, N, and Safran, MR. "ACL Reconstruction in Patients Aged 40 Years and Older." The American Journal of Sports Medicine 41, no. 9 (September 2013): 2181-2190.  Full Text
    • Bridgen, D. T., C. L. Gilchrist, W. J. Richardson, R. E. Isaacs, C. R. Brown, K. L. Yang, J. Chen, and L. A. Setton. “Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc.” Journal of Orthopaedic Research 31, no. 10 (2013): 1661–67. https://doi.org/10.1002/jor.22395.
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    • Brown, Christopher A., Steven Olson, and Robert Zura. “Predictors of length of hospital stay in elderly hip fracture patients..” Journal of Surgical Orthopaedic Advances 22, no. 2 (January 2013): 160–63. https://doi.org/10.3113/jsoa.2013.0160.
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    • Caputo, A. M., K. W. Michael, T. M. Chapman, J. M. Jennings, E. W. Hubbard, R. E. Isaacs, and C. R. Brown. “Extreme lateral interbody fusion for the treatment of adult degenerative scoliosis.” Journal of Clinical Neuroscience 20, no. 11 (2013): 1558–63. https://doi.org/10.1016/j.jocn.2012.12.024.
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    • Caputo, Adam M., Ryan P. Dobbertien, Jeffrey M. Ferranti, Christopher R. Brown, Keith W. Michael, and William J. Richardson. “Risk factors for infection after orthopaedic spine surgery at a high-volume institution..” Journal of Surgical Orthopaedic Advances 22, no. 4 (January 2013): 295–98. https://doi.org/10.3113/jsoa.2013.0295.
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    • Lark, R. K., A. M. Caputo, C. R. Brown, K. W. Michael, J. K. Thacker, and W. J. Richardson. “Distant Harrington rod migration 35 years after implantation.” Journal of Clinical Neuroscience 20, no. 10 (2013): 1452–53. https://doi.org/10.1016/j.jocn.2012.08.019.
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    • Babu, R, Park, JG, Mehta, AI, Shan, T, Grossi, PM, Brown, CR, Richardson, WJ, Isaacs, RE, Bagley, CA, Kuchibhatla, M, and Gottfried, ON. "Comparison of superior-level facet joint violations during open and percutaneous pedicle screw placement." Neurosurgery 71, no. 5 (November 2012): 962-970.  Full Text
    • Brown, CA, Boling, J, Manson, M, Owens, T, and Zura, R. "Relation between prefracture characteristics and perioperative complications in the elderly adult patient with hip fracture." Southern Medical Journal 105, no. 6 (June 2012): 306-310.  Full Text
    • Brown, Christopher A., Aijing Z. Starr, and James A. Nunley. “Analysis of past secular trends of hip fractures and predicted number in the future 2010-2050..” Journal of Orthopaedic Trauma 26, no. 2 (February 2012): 117–22. https://doi.org/10.1097/bot.0b013e318219c61a.
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    • Caputo, Adam M., Keith W. Michael, Todd M. Chapman, Gene M. Massey, Cameron R. Howes, Robert E. Isaacs, and Christopher R. Brown. “Clinical outcomes of extreme lateral interbody fusion in the treatment of adult degenerative scoliosis..” Thescientificworldjournal 2012 (January 2012). https://doi.org/10.1100/2012/680643.
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    • Cook, Chad, Christopher Brown, Keith Michael, Robert Isaacs, Cameron Howes, William Richardson, Matthew Roman, and Eric Hegedus. “The clinical value of a cluster of patient history and observational findings as a diagnostic support tool for lumbar spine stenosis..” Physiotherapy Research International : The Journal for Researchers and Clinicians in Physical Therapy 16, no. 3 (September 2011): 170–78. https://doi.org/10.1002/pri.500.
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    • Karikari, Isaac O., Shahid M. Nimjee, Carolyn A. Hardin, Betsy D. Hughes, Tiffany R. Hodges, Ankit I. Mehta, Jonathan Choi, Christopher R. Brown, and Robert E. Isaacs. “Extreme lateral interbody fusion approach for isolated thoracic and thoracolumbar spine diseases: initial clinical experience and early outcomes..” Journal of Spinal Disorders & Techniques 24, no. 6 (August 2011): 368–75. https://doi.org/10.1097/bsd.0b013e3181ffefd2.
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    • Sinclair, S Michael, Mohammed F. Shamji, Jun Chen, Liufang Jing, William J. Richardson, Christopher R. Brown, Robert D. Fitch, and Lori A. Setton. “Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist..” Spine 36, no. 15 (July 2011): 1190–96. https://doi.org/10.1097/BRS.0b013e3181ebdb43.
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    • Goode, Adam P., Chad Cook, J Brian Gill, Sean Tackett, Christopher Brown, and William Richardson. “The risk of risk-adjustment measures for perioperative spine infection after spinal surgery..” Spine 36, no. 9 (April 2011): 752–58. https://doi.org/10.1097/BRS.0b013e3181e030b3.
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    • Karikari, Isaac O., Peter M. Grossi, Shahid M. Nimjee, Carolyn Hardin, Tiffany R. Hodges, Betsy D. Hughes, Christopher R. Brown, and Robert E. Isaacs. “Minimally invasive lumbar interbody fusion in patients older than 70 years of age: analysis of peri- and postoperative complications..” Neurosurgery 68, no. 4 (April 2011): 897–902. https://doi.org/10.1227/neu.0b013e3182098bfa.
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    • Brown, Christopher, Alison Toth, and Robert Magnussen. “Clinical benefits of intra-articular anakinra for persistent knee effusion..” The Journal of Knee Surgery 24, no. 1 (March 2011): 61–65.
    • Donaldson, Megan B., Ken Learman, Alexis Wright, Christopher Brown, Cameron Howes, and Chad E. Cook. “Factor structure and concurrent/convergent validity of the modified somatic perception questionnaire and pain beliefs instrument..” Journal of Manipulative and Physiological Therapeutics 34, no. 1 (January 2011): 30–36. https://doi.org/10.1016/j.jmpt.2010.11.002.
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    • Goode, Adam, Chad Cook, Christopher Brown, Robert Isaacs, Matthew Roman, and William Richardson. “Differences in comorbidities on low back pain and low back related leg pain..” Pain Practice : The Official Journal of World Institute of Pain 11, no. 1 (January 2011): 42–47. https://doi.org/10.1111/j.1533-2500.2010.00391.x.
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    • Brown, Christopher A., Alison P. Toth, and Bob Magnussen. “Clinical benefits of intra-articular anakinra for arthrofibrosis..” Orthopedics 33, no. 12 (December 2010). https://doi.org/10.3928/01477447-20101021-09.
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    • Cook, C, Brown, C, Isaacs, R, Roman, M, Davis, S, and Richardson, W. "Clustered clinical findings for diagnosis of cervical spine myelopathy." Journal of Manual and Manipulative Therapy 18, no. 4 (December 1, 2010): 175-180.  Full Text
    • Roman, M, Brown, C, Richardson, W, Isaacs, R, Howes, C, and Cook, C. "The development of a clinical decision making algorithm for detection of osteoporotic vertebral compression fracture or wedge deformity." Journal of Manual and Manipulative Therapy 18, no. 1 (August 2, 2010): 44-49.  Full Text
    • Shamji, MF, Setton, LA, Jarvis, W, So, S, Chen, J, Jing, L, Bullock, R, Isaacs, RE, Brown, C, and Richardson, WJ. "Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues." Arthritis and Rheumatism 62, no. 7 (July 2010): 1974-1982.  Full Text
    • Shamji, Mohammed F., Stephen Parker, Chad Cook, Ricardo Pietrobon, Christopher Brown, and Robert E. Isaacs. “Impact of body habitus on perioperative morbidity associated with fusion of the thoracolumbar and lumbar spine..” Neurosurgery 65, no. 3 (September 2009): 490–98. https://doi.org/10.1227/01.neu.0000350863.69524.8e.
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    • Shamji, Mohammed F., Chad Cook, Ricardo Pietrobon, Sean Tackett, Christopher Brown, and Robert E. Isaacs. “Impact of surgical approach on complications and resource utilization of cervical spine fusion: a nationwide perspective to the surgical treatment of diffuse cervical spondylosis..” The Spine Journal : Official Journal of the North American Spine Society 9, no. 1 (January 2009): 31–38. https://doi.org/10.1016/j.spinee.2008.07.005.
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    • Heck, Christopher A., Christopher R. Brown, and William J. Richardson. “Venous thromboembolism in spine surgery..” The Journal of the American Academy of Orthopaedic Surgeons 16, no. 11 (November 2008): 656–64.
    • Shamji, Mohammed F., Chad Cook, Sean Tackett, Christopher Brown, and Robert E. Isaacs. “Impact of preoperative neurological status on perioperative morbidity associated with anterior and posterior cervical fusion..” Journal of Neurosurgery. Spine 9, no. 1 (July 2008): 10–16. https://doi.org/10.3171/spi/2008/9/7/010.
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    • Hollinger, JO, Schmitz, JP, Friedlaender, GE, Brown, CR, Boden, SD, and Lynch, S. "Therapeutic Opportunities for Bone Grafting." (2008): 1164-1175.  Full Text
    • Brown, CR, and Heller, JG. "Patient Selection for Cervical Disc Arthroplasty." Seminars in Spine Surgery 18, no. 2 (June 2006): 47-52.  Full Text

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