Overview
Chris Chidley is an Assistant Professor in the Department of Pharmacology and Cancer Biology since September 2024.
The Chidley lab investigates the role of transporter proteins in nutrient and metabolite import/export and their impact on cell physiology and response to chemotherapeutics. The lab uses unbiased genetic screening in cell and animal models along with biochemistry, cell biology, and analytical chemistry tools to identify critical small molecule transporters across different environments, characterize their function, and explore how the tumor microenvironment impacts cancer metabolism. Our research aims to guide the development of metabolic strategies to suppress tumor growth, and aid precision medicine efforts by revealing determinants of drug sensitivity.
For more information, visit our lab website.
The Chidley lab investigates the role of transporter proteins in nutrient and metabolite import/export and their impact on cell physiology and response to chemotherapeutics. The lab uses unbiased genetic screening in cell and animal models along with biochemistry, cell biology, and analytical chemistry tools to identify critical small molecule transporters across different environments, characterize their function, and explore how the tumor microenvironment impacts cancer metabolism. Our research aims to guide the development of metabolic strategies to suppress tumor growth, and aid precision medicine efforts by revealing determinants of drug sensitivity.
For more information, visit our lab website.
Current Appointments & Affiliations
Assistant Professor of Pharmacology and Cancer Biology
·
2024 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2025 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress.
Journal Article Dev Cell · August 19, 2024 Control of cellular identity requires coordination of developmental programs with environmental factors such as nutrient availability, suggesting that perturbing metabolism can alter cell state. Here, we find that nucleotide depletion and DNA replication s ... Full text Link to item CiteASCT2 is a major contributor to serine uptake in cancer cells
Journal Article Cell Reports · August 2024 Full text CiteA CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments.
Journal Article Nat Cell Biol · May 2024 Blocking the import of nutrients essential for cancer cell proliferation represents a therapeutic opportunity, but it is unclear which transporters to target. Here we report a CRISPR interference/activation screening platform to systematically interrogate ... Full text Open Access Link to item CiteEducation, Training & Certifications
Swiss Federal Institute of Technology-EPFL Lausanne (Switzerland) ·
2010
Ph.D.