Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of Alabama School of Medicine 2005
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Neurology, Neurology, MS & Neuroimmunology, Neurology 2021
  • Assistant Professor of Neurology, Neurology, MS & Neuroimmunology, Neurology 2015 - 2020
• Recognition
• 

  In the News

  • DEC 6, 2016

    Clinical Practice Today

    Tumefactive MS Evades Early Therapeutic Interventions
• Research
• 

  Selected Grants

  • A prospective, multicenter, observational, post-authorization safety study to evaluate the long term safety profile of LEMTRADA® (alemtuzumab) treatment in patients with relapsing forms of multiple sclerosis (PASS) awarded by Genzyme Corporation 2016 - 2028
  • A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with primary progressive multiple sclerosis (PERSEUS) awarded by Sanofi US 2020 - 2026
  • Deciphering the role of noncoding variation in the pathogenesis of multiple sclerosis awarded by National Institutes of Health 2021 - 2026
  • MS Clinical Trial: DUOC awarded by The Marcus Foundation 2020 - 2023
  • A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study in Subjects With Relapsing Multiple Sclerosis to Evaluate the Efficacy and Safety of BIIB033 as an Add-On Therapy to Anti-Inflammatory Disease-Modifying Therapies awarded by Biogen, Inc. 2018 - 2021
  • PA Fellowship in Clinical Neuroimmunology awarded by Biogen, Inc. 2017 - 2019
  • A PHASE III, OPEN-LABEL, EXTENSION TRIAL OF ECU-NMO-301 TO EVALUATE THE SAFETY AND EFFICACY OF ECULIZUMAB IN PATIENTS WITH RELAPSING NEUROMYELITIS OPTICA (NMO) awarded by Alexion Pharmaceuticals, Inc. 2015 - 2017
  • A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Trial to Evaluate the Safety and Efficacy of Eculizumab in Patients with Relapsing Neuromyelitis Optica awarded by Alexion Pharmaceuticals, Inc. 2015 - 2017
• 

  External Relationships

  • Viela Bio
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Giarraputo, James, Stephanie Giamberardino, Stephanie Arvai, Sarah Maichle, Christopher Eckstein, L Kristin Newby, and Simon Gregory. “Profiling serum neurofilament light chain and glial fibrillary acidic protein in primary progressive multiple sclerosis.” J Neuroimmunol 354 (May 15, 2021): 577541. https://doi.org/10.1016/j.jneuroim.2021.577541.
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    • Shah, Suma, Abigail Berezoski, Shareena Rahman, Christopher Eckstein, and Matthew Luedke. “Genetic or Autoimmune: POLG-Related Epilepsy Initially Treated as an Autoimmune Encephalitis, a Case Report.” Neurohospitalist 11, no. 1 (January 2021): 80–83. https://doi.org/10.1177/1941874420952263.
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    • Brayo, Petra, F Lee Hartsell, Mark Skeen, Joel Morgenlander, Christopher Eckstein, and Suma Shah. “The clinical presentation and treatment of MOG antibody disease at a single academic center: A case series.” J Neuroimmunol 337 (December 15, 2019): 577078. https://doi.org/10.1016/j.jneuroim.2019.577078.
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    • Sengupta, Sweta, Christopher Eckstein, and Timothy Collins. “The Dilemma of Diagnosing Idiopathic Intracranial Hypertension Without Papilledema in Patients With Chronic Migraine.” Jama Neurol 76, no. 9 (September 1, 2019): 1001–2. https://doi.org/10.1001/jamaneurol.2019.1696.
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    • Shah, Suma, and Christopher Eckstein. “B cell depletion and pregnancy: Review and applications for MS treatment.” Mult Scler Relat Disord 33 (August 2019): 153–57. https://doi.org/10.1016/j.msard.2019.06.003.
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    • Cardinale, Kathleen M., Alexandra Bocharnikov, Sarah J. Hart, Jane Ann Baker, Christopher Eckstein, Joan M. Jasien, William Gallentine, Gordon Worley, Priya S. Kishnani, and Heather Van Mater. “Immunotherapy in selected patients with Down syndrome disintegrative disorder.” Dev Med Child Neurol 61, no. 7 (July 2019): 847–51. https://doi.org/10.1111/dmcn.14127.
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    • Dunn-Pirio, Anastasie M., and Christopher Eckstein. “Recurrent schilder's disease.” Mult Scler Relat Disord 26 (November 2018): 8–10. https://doi.org/10.1016/j.msard.2018.09.001.
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    • Dunn-Pirio, Anastasie M., Suma Shah, and Christopher Eckstein. “Neurosarcoidosis following Immune Checkpoint Inhibition.” Case Rep Oncol 11, no. 2 (May 2018): 521–26. https://doi.org/10.1159/000491599.
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    • Eckstein, Christopher, and M Tariq Bhatti. “Currently approved and emerging oral therapies in multiple sclerosis: An update for the ophthalmologist.” Surv Ophthalmol 61, no. 3 (May 2016): 318–32. https://doi.org/10.1016/j.survophthal.2015.12.001.
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    • Sotirchos, Elias S., Pavan Bhargava, Christopher Eckstein, Keith Van Haren, Moira Baynes, Achilles Ntranos, Anne Gocke, Lawrence Steinman, Ellen M. Mowry, and Peter A. Calabresi. “Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis.” Neurology 86, no. 4 (January 26, 2016): 382–90. https://doi.org/10.1212/WNL.0000000000002316.
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    • Ratchford, John N., Shiv Saidha, Elias S. Sotirchos, Jiwon A. Oh, Michaela A. Seigo, Christopher Eckstein, Mary K. Durbin, et al. “Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning.” Neurology 80, no. 1 (January 1, 2013): 47–54. https://doi.org/10.1212/WNL.0b013e31827b1a1c.
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    • Saidha, Shiv, Elias S. Sotirchos, Jiwon Oh, Stephanie B. Syc, Michaela A. Seigo, Navid Shiee, Chistopher Eckstein, et al. “Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis.” Jama Neurol 70, no. 1 (January 2013): 34–43. https://doi.org/10.1001/jamaneurol.2013.573.
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    • Seigo, Michaela A., Elias S. Sotirchos, Scott Newsome, Aleksandra Babiarz, Christopher Eckstein, E’tona Ford, Jonathan D. Oakley, et al. “In vivo assessment of retinal neuronal layers in multiple sclerosis with manual and automated optical coherence tomography segmentation techniques.” J Neurol 259, no. 10 (October 2012): 2119–30. https://doi.org/10.1007/s00415-012-6466-x.
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    • Eckstein, Christopher, Shiv Saidha, Elias S. Sotirchos, Gita Byraiah, Michaela Seigo, Aleksandra Stankiewicz, Stephanie B. Syc, et al. “Detection of clinical and subclinical retinal abnormalities in neurosarcoidosis with optical coherence tomography.” J Neurol 259, no. 7 (July 2012): 1390–98. https://doi.org/10.1007/s00415-011-6363-8.
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    • Eckstein, Christopher, Shiv Saidha, and Michael Levy. “A differential diagnosis of central nervous system demyelination: beyond multiple sclerosis.” J Neurol 259, no. 5 (May 2012): 801–16. https://doi.org/10.1007/s00415-011-6240-5.
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    • Saidha, Shiv, Elias S. Sotirchos, and Christopher Eckstein. “Etiology of sarcoidosis: does infection play a role?” Yale J Biol Med 85, no. 1 (March 2012): 133–41.
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    • Saidha, Shiv, Christopher Eckstein, and Peter A. Calabresi. “New and emerging disease modifying therapies for multiple sclerosis.” Ann N Y Acad Sci 1247 (January 2012): 117–37. https://doi.org/10.1111/j.1749-6632.2011.06272.x.
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    • Eckstein, C., S. Syc, and S. Saidha. “Differential diagnosis of longitudinally extensive transverse myelitis in adults.” European Neurological Journal 3, no. 1 (November 11, 2011): 27–39.
    • Skarica, Mario, Christopher Eckstein, Katharine A. Whartenby, and Peter A. Calabresi. “Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients.” J Neuroimmunol 235, no. 1–2 (June 2011): 70–76. https://doi.org/10.1016/j.jneuroim.2011.02.010.
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    • Saidha, Shiv, Stephanie B. Syc, Mohamed A. Ibrahim, Christopher Eckstein, Christina V. Warner, Sheena K. Farrell, Jonathan D. Oakley, et al. “Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography.” Brain 134, no. Pt 2 (February 2011): 518–33. https://doi.org/10.1093/brain/awq346.
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    • Saidha, S., S. B. Syc, M. K. Durbin, C. Eckstein, J. D. Oakley, S. A. Meyer, A. Conger, et al. “Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fiber layer thickness.” Multiple Sclerosis Journal 17, no. 12 (January 1, 2011): 1449–63. https://doi.org/10.1177/1352458511418630.
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    • Pineda, Tiffany, Christopher Eckstein, Gill Diethelm, and Joel Cure. “Neurocysticercosis.” Headache 47, no. 5 (May 2007): 717–18. https://doi.org/10.1111/j.1526-4610.2007.00793.x.
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    • Vilatoba, Mario, Christopher Eckstein, Guadalupe Bilbao, Cheryl A. Smyth, Stacie Jenkins, J Anthony Thompson, Devin E. Eckhoff, and Juan L. Contreras. “Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis.” Surgery 138, no. 2 (August 2005): 342–51. https://doi.org/10.1016/j.surg.2005.04.019.
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    • Xie, Dong, Cheryl A. Smyth, Christopher Eckstein, Guadalupe Bilbao, Jimmy Mays, Devin E. Eckhoff, and Juan L. Contreras. “Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation.” Biomaterials 26, no. 4 (February 2005): 403–12. https://doi.org/10.1016/j.biomaterials.2004.02.048.
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    • Vilatoba, M., C. Eckstein, G. Bilbao, L. Frennete, D. E. Eckhoff, and J. L. Contreras. “17beta-estradiol differentially activates mitogen-activated protein-kinases and improves survival following reperfusion injury of reduced-size liver in mice.” Transplant Proc 37, no. 1 (January 2005): 399–403. https://doi.org/10.1016/j.transproceed.2004.12.053.
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    • Contreras, Juan L., Christopher Eckstein, Cheryl A. Smyth, Guadalupe Bilbao, Mario Vilatoba, Sharman E. Ringland, Carlton Young, et al. “Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death.” Diabetes 53, no. 11 (November 2004): 2804–14. https://doi.org/10.2337/diabetes.53.11.2804.
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    • Contreras, Juan L., Dong Xie, Jimmy Mays, Cheryl A. Smyth, Christopher Eckstein, Firoz G. Rahemtulla, Carlton J. Young, et al. “A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets.” Surgery 136, no. 3 (September 2004): 537–47. https://doi.org/10.1016/j.surg.2004.05.031.
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    • Contreras, Juan L., Mario Vilatoba, Christopher Eckstein, Guadalupe Bilbao, J. Anthony Thompson, and Devin E. Eckhoff. “Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice.” Surgery 136, no. 2 (August 2004): 390–400. https://doi.org/10.1016/j.surg.2004.05.015.
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    • Eckhoff, Devin E., Christopher Eckstein, Cheryl A. Smyth, Mario Vilatoba, Guadalupe Bilbao, Firoz G. Rahemtulla, Carlton J. Young, J. Anthony Thompson, Irshad H. Chaudry, and Juan L. Contreras. “Enhanced isolated pancreatic islet recovery and functionality in rats by 17beta-estradiol treatment of brain death donors.” Surgery 136, no. 2 (August 2004): 336–45. https://doi.org/10.1016/j.surg.2004.05.009.
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    • Contreras, Juan L., Christopher Eckstein, Cheryl A. Smyth, Marty T. Sellers, Mario Vilatoba, Guadalupe Bilbao, Firoz G. Rahemtulla, et al. “Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats.” Diabetes 52, no. 12 (December 2003): 2935–42. https://doi.org/10.2337/diabetes.52.12.2935.
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    • Contreras, Juan L., Cheryl A. Smyth, Christopher Eckstein, Guadalupe Bilbao, J Anthony Thompson, Carlton J. Young, and Devin E. Eckhoff. “Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation.” Surgery 134, no. 2 (August 2003): 390–98. https://doi.org/10.1067/msy.2003.250.
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    • Eckhoff, Devin E., Cheryl A. Smyth, Christopher Eckstein, Guadalupe Bilbao, Carlton J. Young, J Anthony Thompson, and Juan L. Contreras. “Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction.” Surgery 134, no. 2 (August 2003): 169–79. https://doi.org/10.1067/msy.2003.219.
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    • Contreras, Juan L., Hongju Wu, Cheryl A. Smyth, Christopher P. Eckstein, Carlton J. Young, Toshiro Seki, Guadalupe Bilbao, David T. Curiel, and Devin E. Eckhoff. “Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets.” Transplantation 76, no. 1 (July 15, 2003): 252–61. https://doi.org/10.1097/01.TP.0000066361.02042.CA.
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    • Contreras, Juan L., Cheryl A. Smyth, Guadalupe Bilbao, Christopher Eckstein, Carlton J. Young, J Anthony Thompson, David T. Curiel, and Devin E. Eckhoff. “Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bcl-2.” Transpl Int 16, no. 7 (July 2003): 537–42. https://doi.org/10.1007/s00147-003-0619-x.
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