Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of Alabama School of Medicine 2005
• Recognition
• 

  In the News

  • DEC 6, 2016

    Clinical Practice Today

    Tumefactive MS Evades Early Therapeutic Interventions
• Research
• 

  Selected Grants

  • Lemtrada in MS -PASS awarded by Genzyme Corporation 2016 - 2028
  • Biogen AFFINITY awarded by Biogen, Inc. 2018 - 2020
  • PA Fellowship in Clinical Neuroimmunology awarded by Biogen, Inc. 2017 - 2019
  • Alexion NMO awarded by Alexion Pharmaceuticals, Inc. 2015 - 2017
  • Alexion NMO_ OL Ext. awarded by Alexion Pharmaceuticals, Inc. 2015 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Cardinale, Kathleen M., Alexandra Bocharnikov, Sarah J. Hart, Jane Ann Baker, Christopher Eckstein, Joan M. Jasien, William Gallentine, Gordon Worley, Priya S. Kishnani, and Heather Van Mater. “Immunotherapy in selected patients with Down syndrome disintegrative disorder..” Developmental Medicine and Child Neurology, December 12, 2018. https://doi.org/10.1111/dmcn.14127.
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    • Dunn-Pirio, Anastasie M., and Christopher Eckstein. “Recurrent schilder's disease..” Multiple Sclerosis and Related Disorders 26 (November 2018): 8–10. https://doi.org/10.1016/j.msard.2018.09.001.
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    • Dunn-Pirio, Anastasie M., Suma Shah, and Christopher Eckstein. “Neurosarcoidosis following Immune Checkpoint Inhibition..” Case Reports in Oncology 11, no. 2 (May 2018): 521–26. https://doi.org/10.1159/000491599.
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    • Eckstein, Christopher, and M Tariq Bhatti. “Currently approved and emerging oral therapies in multiple sclerosis: An update for the ophthalmologist..” Survey of Ophthalmology 61, no. 3 (May 2016): 318–32. https://doi.org/10.1016/j.survophthal.2015.12.001.
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    • Sotirchos, Elias S., Pavan Bhargava, Christopher Eckstein, Keith Van Haren, Moira Baynes, Achilles Ntranos, Anne Gocke, Lawrence Steinman, Ellen M. Mowry, and Peter A. Calabresi. “Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis..” Neurology 86, no. 4 (January 2016): 382–90. https://doi.org/10.1212/WNL.0000000000002316.
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    • Ratchford, John N., Shiv Saidha, Elias S. Sotirchos, Jiwon A. Oh, Michaela A. Seigo, Christopher Eckstein, Mary K. Durbin, et al. “Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning..” Neurology 80, no. 1 (January 2013): 47–54. https://doi.org/10.1212/WNL.0b013e31827b1a1c.
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    • Saidha, Shiv, Elias S. Sotirchos, Jiwon Oh, Stephanie B. Syc, Michaela A. Seigo, Navid Shiee, Chistopher Eckstein, et al. “Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis..” Jama Neurology 70, no. 1 (January 2013): 34–43. https://doi.org/10.1001/jamaneurol.2013.573.
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    • Seigo, Michaela A., Elias S. Sotirchos, Scott Newsome, Aleksandra Babiarz, Christopher Eckstein, E’tona Ford, Jonathan D. Oakley, et al. “In vivo assessment of retinal neuronal layers in multiple sclerosis with manual and automated optical coherence tomography segmentation techniques..” Journal of Neurology 259, no. 10 (October 2012): 2119–30. https://doi.org/10.1007/s00415-012-6466-x.
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    • Eckstein, Christopher, Shiv Saidha, Elias S. Sotirchos, Gita Byraiah, Michaela Seigo, Aleksandra Stankiewicz, Stephanie B. Syc, et al. “Detection of clinical and subclinical retinal abnormalities in neurosarcoidosis with optical coherence tomography..” Journal of Neurology 259, no. 7 (July 2012): 1390–98. https://doi.org/10.1007/s00415-011-6363-8.
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    • Eckstein, Christopher, Shiv Saidha, and Michael Levy. “A differential diagnosis of central nervous system demyelination: beyond multiple sclerosis..” Journal of Neurology 259, no. 5 (May 2012): 801–16. https://doi.org/10.1007/s00415-011-6240-5.
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    • Saidha, Shiv, Elias S. Sotirchos, and Christopher Eckstein. “Etiology of sarcoidosis: does infection play a role?.” The Yale Journal of Biology and Medicine 85, no. 1 (March 29, 2012): 133–41.
    • Saidha, Shiv, Christopher Eckstein, and Peter A. Calabresi. “New and emerging disease modifying therapies for multiple sclerosis..” Annals of the New York Academy of Sciences 1247 (January 6, 2012): 117–37. https://doi.org/10.1111/j.1749-6632.2011.06272.x.
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    • Eckstein, C., S. Syc, and S. Saidha. “Differential diagnosis of longitudinally extensive transverse myelitis in adults.” European Neurological Journal 3, no. 1 (November 11, 2011): 27–39.
    • Skarica, Mario, Christopher Eckstein, Katharine A. Whartenby, and Peter A. Calabresi. “Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients..” Journal of Neuroimmunology 235, no. 1–2 (June 2011): 70–76. https://doi.org/10.1016/j.jneuroim.2011.02.010.
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    • Saidha, Shiv, Stephanie B. Syc, Mohamed A. Ibrahim, Christopher Eckstein, Christina V. Warner, Sheena K. Farrell, Jonathan D. Oakley, et al. “Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography..” Brain : A Journal of Neurology 134, no. Pt 2 (February 2011): 518–33. https://doi.org/10.1093/brain/awq346.
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    • Saidha, S., S. B. Syc, M. K. Durbin, C. Eckstein, J. D. Oakley, S. A. Meyer, A. Conger, et al. “Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fiber layer thickness.” Multiple Sclerosis Journal 17, no. 12 (January 1, 2011): 1449–63. https://doi.org/10.1177/1352458511418630.
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    • Pineda, Tiffany, Christopher Eckstein, Gill Diethelm, and Joel Cure. “Neurocysticercosis..” Headache 47, no. 5 (May 2007): 717–18. https://doi.org/10.1111/j.1526-4610.2007.00793.x.
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    • Vilatoba, Mario, Christopher Eckstein, Guadalupe Bilbao, Cheryl A. Smyth, Stacie Jenkins, J Anthony Thompson, Devin E. Eckhoff, and Juan L. Contreras. “Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis..” Surgery 138, no. 2 (August 2005): 342–51. https://doi.org/10.1016/j.surg.2005.04.019.
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    • Xie, Dong, Cheryl A. Smyth, Christopher Eckstein, Guadalupe Bilbao, Jimmy Mays, Devin E. Eckhoff, and Juan L. Contreras. “Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation..” Biomaterials 26, no. 4 (February 2005): 403–12. https://doi.org/10.1016/j.biomaterials.2004.02.048.
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    • Vilatoba, M., C. Eckstein, G. Bilbao, L. Frennete, D. E. Eckhoff, and J. L. Contreras. “17beta-estradiol differentially activates mitogen-activated protein-kinases and improves survival following reperfusion injury of reduced-size liver in mice..” Transplantation Proceedings 37, no. 1 (January 2005): 399–403. https://doi.org/10.1016/j.transproceed.2004.12.053.
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    • Contreras, Juan L., Christopher Eckstein, Cheryl A. Smyth, Guadalupe Bilbao, Mario Vilatoba, Sharman E. Ringland, Carlton Young, et al. “Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death..” Diabetes 53, no. 11 (November 2004): 2804–14. https://doi.org/10.2337/diabetes.53.11.2804.
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    • Contreras, Juan L., Dong Xie, Jimmy Mays, Cheryl A. Smyth, Christopher Eckstein, Firoz G. Rahemtulla, Carlton J. Young, et al. “A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets..” Surgery 136, no. 3 (September 2004): 537–47. https://doi.org/10.1016/j.surg.2004.05.031.
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    • Contreras, Juan L., Mario Vilatoba, Christopher Eckstein, Guadalupe Bilbao, J. Anthony Thompson, and Devin E. Eckhoff. “Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice..” Surgery 136, no. 2 (August 2004): 390–400. https://doi.org/10.1016/j.surg.2004.05.015.
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    • Eckhoff, Devin E., Christopher Eckstein, Cheryl A. Smyth, Mario Vilatoba, Guadalupe Bilbao, Firoz G. Rahemtulla, Carlton J. Young, J. Anthony Thompson, Irshad H. Chaudry, and Juan L. Contreras. “Enhanced isolated pancreatic islet recovery and functionality in rats by 17beta-estradiol treatment of brain death donors..” Surgery 136, no. 2 (August 2004): 336–45. https://doi.org/10.1016/j.surg.2004.05.009.
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    • Contreras, Juan L., Christopher Eckstein, Cheryl A. Smyth, Marty T. Sellers, Mario Vilatoba, Guadalupe Bilbao, Firoz G. Rahemtulla, et al. “Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats..” Diabetes 52, no. 12 (December 2003): 2935–42. https://doi.org/10.2337/diabetes.52.12.2935.
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    • Contreras, Juan L., Cheryl A. Smyth, Christopher Eckstein, Guadalupe Bilbao, J Anthony Thompson, Carlton J. Young, and Devin E. Eckhoff. “Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation..” Surgery 134, no. 2 (August 2003): 390–98. https://doi.org/10.1067/msy.2003.250.
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    • Eckhoff, Devin E., Cheryl A. Smyth, Christopher Eckstein, Guadalupe Bilbao, Carlton J. Young, J Anthony Thompson, and Juan L. Contreras. “Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction..” Surgery 134, no. 2 (August 2003): 169–79. https://doi.org/10.1067/msy.2003.219.
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    • Contreras, Juan L., Cheryl A. Smyth, Guadalupe Bilbao, Christopher Eckstein, Carlton J. Young, J Anthony Thompson, David T. Curiel, and Devin E. Eckhoff. “Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bcl-2..” Transplant International : Official Journal of the European Society for Organ Transplantation 16, no. 7 (July 2003): 537–42. https://doi.org/10.1007/s00147-003-0619-x.
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    • Contreras, Juan L., Hongju Wu, Cheryl A. Smyth, Christopher P. Eckstein, Carlton J. Young, Toshiro Seki, Guadalupe Bilbao, David T. Curiel, and Devin E. Eckhoff. “Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets..” Transplantation 76, no. 1 (July 2003): 252–61. https://doi.org/10.1097/01.tp.0000066361.02042.ca.
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