Research Interests
snoRNAs, RNA modifications, RNA therapeutics, PGD (primary graft dysfunction), AMR (antibody-mediated rejection)
Selected Grants
iPediHeart: Interdisciplinary Research Training Program for Pediatric Heart Disease
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2025 - 2030IND-enabling studies for an RNA therapeutic to treat atherosclerosis
ResearchPrincipal Investigator · Awarded by Department of Defense · 2024 - 2029Targeting snoRNAs to Treat Atherosclerosis
ResearchPrincipal Investigator · Awarded by UH Harrington Discovery Institute · 2024 - 2027Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027Mechanisms of the small nucleolar RNA Snord67 in breast cancer lymphatic metastasis
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2027A High-Throughput Screening Platform to Discover RNA Methylation Inhibitors
ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2023 - 2026Mechanisms by which Small Nucleolar RNAs Exacerbate Atherosclerosis
ResearchCo-Principal Investigator · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2026Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2021 - 2026Hematology & Transfusion Medicine (T32)
Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 1975 - 2026Clinical and Therapeutic Implications of the Small Nucleolar RNA Snord67 in Breast Cancer Lymphatic Metastasis
ResearchMentor · Awarded by American Society of Clinical Oncology · 2024 - 2025Defining Novel Roles of Ubiquitin Accumulation During the Mammalian Oxidative Stress Response
FellowshipCo-Sponsor · Awarded by National Institute of Environmental Health Sciences · 2022 - 2025SnoRNA-guided modifications of mRNA
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2024Role of RNA modifications in heart failure
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2024Mechanistic Insights into m6A-Mediated Regulation of Brain Development
ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2018 - 2024Silencing small nucleolar RNAs with antisense oligonucleotides for treatment of atherosclerosis
ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2022 - 2024Multidisciplinary Heart and Vascular Diseases
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2023Epitranscriptomic modification of HIV-1 transcripts: Effects of drugs of abuse
ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2023Medical Scientist Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022Structural studies of post-transcriptionally modified snRNAs and their role in congenital heart disease
FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2020 - 2022Increasing the Diagnostic Accuracy of Antibody Mediated
Clinical TrialPrincipal Investigator · Awarded by CareDx, Inc. · 2020 - 2021Mass Spectrometric Screening of the Effect of Chemical Toxicants on the Human Epitranscriptome during Stem Cell Differentiation
ResearchPrincipal Investigator · Awarded by Athghin Biotechnology, Inc · 2017 - 2018Role of snoRNAs in regulation of cardiac hypertrophy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2018Regulation of oxidative stress and reactive oxygen species (ROS) in heart failure.
ResearchPrincipal Investigator · Awarded by American Heart Association · 2016 - 2017SNORNAS ARE ESSENTIAL MEDIATORS OF ROS SIGNALING IN CARDIOVASCULAR CELLS
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2017Bioactive sphingolipid signaling in cardiomyocyte mitophagy
FellowshipPrincipal Investigator · Awarded by American Heart Association · 2016 - 2016External Relationships
- NATA (Nucleic Acid Therapy Accelerator)
- Novo Nordisk
- OneFul Health
- snoPanTher
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.