Scholars@Duke
Christopher Leo

Christopher Leo

Assistant Professor of Medicine
Medicine, Hospital Medicine

Selected Publications

Effects of B Vitamins on Homocysteine Lowering and Thrombotic Risk Reduction-A Review of Randomized Controlled Trials Published Since January 1996.

Journal Article Nutrients · March 24, 2025 Homocysteine is an amino acid derived from methionine which is metabolized via vitamin B6 (pyridoxine)- and vitamin B12 (cobalamin)-dependent pathways. Supplementation of B vitamins has been shown to effectively reduce plasma homocysteine levels. Previous ... Full text Open Access Link to item Cite

Evaluation of Vitamin D Supplementation in Critically Ill Patients-A Narrative Review of Randomized Controlled Trials Published in the Last 5 Years.

Journal Article Nutrients · February 27, 2025 The prevalence of vitamin D deficiency among intensive care unit (ICU) patients is potentially associated with an increased risk of mechanical ventilation, sepsis, prolonged hospital stays, and mortality. Although ICU patient care has significantly improve ... Full text Open Access Link to item Cite

Machine learning functional impairment classification with electronic health record data.

Journal Article J Am Geriatr Soc · September 2023 BACKGROUND: Poor functional status is a key marker of morbidity, yet is not routinely captured in clinical encounters. We developed and evaluated the accuracy of a machine learning algorithm that leveraged electronic health record (EHR) data to provide a s ... Full text Open Access Link to item Cite

Successful percutaneous coronary intervention in a patient with combined deficiency of FV and FVIII due to novel compound heterozygous mutations in LMAN1

Journal Article Haemophilia · July 2013 SummaryPercutaneous coronary intervention (PCI) in patients with congenital coagulation factor deficiencies presents a unique challenge. They are not only at inc ... Full text Open Access Cite

Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII

Journal Article Blood · December 16, 2010 AbstractThe LMAN1-MCFD2 (lectin, mannose binding 1/multiple coagulation factor deficiency protein 2) cargo receptor complex transports coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum (ER) to the E ... Full text Open Access Cite

EF-hand domains of MCFD2 mediate interactions with both LMAN1 and coagulation factor V or VIII

Journal Article Blood · February 4, 2010 AbstractCombined deficiency of factor V and factor VIII (F5F8D) is a bleeding disorder caused by mutations in either LMAN1 or MCFD2. LMAN1 (ERGIC-53) and MCFD2 form a Ca2+-dependent cargo receptor that cycles between the en ... Full text Cite

Living Yeast Cells as a Controllable Biosynthesizer for Fluorescent Quantum Dots

Journal Article Advanced Functional Materials · August 10, 2009 AbstractThere are currently some problems in the field of chemical synthesis, such as environmental impact, energy loss, and safety, that need to be tackled urgently. An interdisciplinary approach, based on different backgr ... Full text Cite