Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 2014
• Research
• 

  Selected Grants

  • Area A: Development of genetically tractable, driver gene-syngeneic brain tumor models for pre-clinical adoptive TCR-T therapy awarded by National Institutes of Health 2017 - 2020
  • Poliovirus Vector-Delivered Tumor-Associated Antigens for Glioma Immunotherapy awarded by The Hope Funds For Cancer Research 2017 - 2020
  • The Role of IDH1 Mutations in Gliomagenesis and Metabolism awarded by National Institutes of Health 2009 - 2020
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Pirozzi, CJ, and Yan, H. "Improved grading of IDH-mutated astrocytic gliomas." Nature Reviews. Neurology 14, no. 7 (July 2018): 383-384.  Full Text
    • Waitkus, MS, Pirozzi, CJ, Moure, CJ, Diplas, BH, Hansen, LJ, Carpenter, AB, Yang, R, Wang, Z, Ingram, BO, Karoly, ED, Mohney, RP, Spasojevic, I, McLendon, RE, Friedman, HS, He, Y, Bigner, DD, and Yan, H. "Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities." Cancer Research 78, no. 1 (January 2018): 36-50.  Full Text
    • Yang, R, Chen, LH, Hansen, LJ, Carpenter, AB, Moure, CJ, Liu, H, Pirozzi, CJ, Diplas, BH, Waitkus, MS, Greer, PK, Zhu, H, McLendon, RE, Bigner, DD, He, Y, and Yan, H. "Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation." Cancer Research 77, no. 22 (November 2017): 6097-6108.  Full Text
    • Pirozzi, CJ, Carpenter, AB, Waitkus, MS, Wang, CY, Zhu, H, Hansen, LJ, Chen, LH, Greer, PK, Feng, J, Wang, Y, Bock, CB, Fan, P, Spasojevic, I, McLendon, RE, Bigner, DD, He, Y, and Yan, H. "Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression." Molecular Cancer Research : Mcr 15, no. 5 (May 2017): 507-520.  Full Text
    • Killela, PJ, Pirozzi, CJ, Healy, P, Reitman, ZJ, Lipp, E, Rasheed, BA, Yang, R, Diplas, BH, Wang, Z, Greer, PK, Zhu, H, Wang, CY, Carpenter, AB, Friedman, H, Friedman, AH, Keir, ST, He, J, He, Y, McLendon, RE, Herndon, JE, Yan, H, and Bigner, DD. "Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas." Oncotarget 5, no. 6 (March 2014): 1515-1525.  Full Text  Open Access Copy
    • Killela, PJ, Pirozzi, CJ, Reitman, ZJ, Jones, S, Rasheed, BA, Lipp, E, Friedman, H, Friedman, AH, He, Y, McLendon, RE, Bigner, DD, and Yan, H. "The genetic landscape of anaplastic astrocytoma." Oncotarget 5, no. 6 (March 2014): 1452-1457.  Full Text
    • Reitman, ZJ, Pirozzi, CJ, and Yan, H. "Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors." Acta Neuropathologica 126, no. 6 (December 2013): 789-792.  Full Text
    • Reitman, ZJ, Pirozzi, CJ, and Yan, H. "Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors." Acta Neuropathologica 126, no. 6 (November 12, 2013): 789-792. (Review)  Full Text
    • Guo, C, Chen, LH, Huang, Y, Chang, C-C, Wang, P, Pirozzi, CJ, Qin, X, Bao, X, Greer, PK, McLendon, RE, Yan, H, Keir, ST, Bigner, DD, and He, Y. "KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation." Oncotarget 4, no. 11 (November 2013): 2144-2153.  Full Text
    • Pirozzi, CJ, Reitman, ZJ, and Yan, H. "Releasing the block: setting differentiation free with mutant IDH inhibitors." Cancer Cell 23, no. 5 (May 2013): 570-572.  Full Text
    • Jin, G, Pirozzi, CJ, Chen, LH, Lopez, GY, Duncan, CG, Feng, J, Spasojevic, I, Bigner, DD, He, Y, and Yan, H. "Mutant IDH1 is required for IDH1 mutated tumor cell growth." Oncotarget 3, no. 8 (August 2012): 774-782.  Full Text  Open Access Copy
    • Jiao, Y, Killela, PJ, Reitman, ZJ, Rasheed, AB, Heaphy, CM, de Wilde, RF, Rodriguez, FJ, Rosemberg, S, Oba-Shinjo, SM, Nagahashi Marie, SK, Bettegowda, C, Agrawal, N, Lipp, E, Pirozzi, C, Lopez, G, He, Y, Friedman, H, Friedman, AH, Riggins, GJ, Holdhoff, M, Burger, P, McLendon, R, Bigner, DD, Vogelstein, B, Meeker, AK, Kinzler, KW, Papadopoulos, N, Diaz, LA, and Yan, H. "Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas." Oncotarget 3, no. 7 (July 2012): 709-722.  Full Text  Open Access Copy
    • Guo, C, Pirozzi, CJ, Lopez, GY, and Yan, H. "Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target." Current Opinion in Neurology 24, no. 6 (December 2011): 648-652. (Review)  Full Text  Open Access Copy

  • Book Sections

    • Chandramohan, V, Sanchez-Perez, L, He, Y, Pirozzi, CJ, Congdon, KL, and Bigner, DD. "Preclinical Immunotherapeutic Animal Models for Brain Tumors." In Translational Immunotherapy of Brain Tumors, 111-147. March 2, 2017.  Full Text
    • Pirozzi, CJ, Carpenter, AB, Hennika, T, Becher, OJ, and Yan, H. "Tumor-Specific Mutations in Gliomas and their Implications for Immunotherapy." In Translational Immunotherapy of Brain Tumors, 83-107. March 2, 2017.  Full Text

  • Conference Papers

    • Pirozzi, CJ, Wang, CY, Carpenter, AB, Zhu, H, Greer, PK, McLendon, RE, Bigner, DD, He, Y, and Yan, H. "Abstract 63: Driving brain tumorigenesis: Generation of a mutant IDH1 mouse model of progressive glioma." : American Association for Cancer Research (AACR), October 1, 2014.  Full Text

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