Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 2014
• Research
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  Selected Grants

  • Modulating Th17 cells in IDH1-mutant glioma to promote anti-tumor immunity awarded by Department of Defense 2020 - 2022
  • Area A: Development of genetically tractable, driver gene-syngeneic brain tumor models for pre-clinical adoptive TCR-T therapy awarded by National Institutes of Health 2017 - 2021
  • Poliovirus Vector-Delivered Tumor-Associated Antigens for Glioma Immunotherapy awarded by The Hope Funds For Cancer Research 2017 - 2020
  • The Role of IDH1 Mutations in Gliomagenesis and Metabolism awarded by National Institutes of Health 2009 - 2020
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Pirozzi, Christopher J., and Hai Yan. “Hitting Gliomas When They Are Down: Exploiting IDH-Mutant Metabolic Vulnerabilities.” Cancer Discov 10, no. 11 (November 2020): 1629–31. https://doi.org/10.1158/2159-8290.CD-20-1215.
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    • Moure, Casey J., Bill H. Diplas, Lee H. Chen, Rui Yang, Christopher J. Pirozzi, Zhaohui Wang, Ivan Spasojevic, Matthew S. Waitkus, Yiping He, and Hai Yan. “CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.” Mol Cancer Res 17, no. 10 (October 2019): 2042–50. https://doi.org/10.1158/1541-7786.MCR-19-0309.
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    • Liu, Yang, Austin B. Carpenter, Christopher J. Pirozzi, Hsiangkuo Yuan, Matthew S. Waitkus, Zhengyuan Zhou, Landon Hansen, et al. “Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe.” Nanotechnology 30, no. 27 (July 5, 2019): 275101. https://doi.org/10.1088/1361-6528/ab0e9c.
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    • Hansen, Landon J., Ran Sun, Rui Yang, Simranjit X. Singh, Lee H. Chen, Christopher J. Pirozzi, Casey J. Moure, et al. “MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.” Cancer Res 79, no. 13 (July 1, 2019): 3383–94. https://doi.org/10.1158/0008-5472.CAN-18-1010.
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    • Pirozzi, Christopher J., and Hai Yan. “Improved grading of IDH-mutated astrocytic gliomas.” Nat Rev Neurol 14, no. 7 (July 2018): 383–84. https://doi.org/10.1038/s41582-018-0019-6.
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    • Waitkus, Matthew S., Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, et al. “Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.” Cancer Res 78, no. 1 (January 1, 2018): 36–50. https://doi.org/10.1158/0008-5472.CAN-17-1352.
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    • Yang, Rui, Lee H. Chen, Landon J. Hansen, Austin B. Carpenter, Casey J. Moure, Heng Liu, Christopher J. Pirozzi, et al. “Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.” Cancer Res 77, no. 22 (November 15, 2017): 6097–6108. https://doi.org/10.1158/0008-5472.CAN-17-1018.
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    • Pirozzi, Christopher J., Austin B. Carpenter, Matthew S. Waitkus, Catherine Y. Wang, Huishan Zhu, Landon J. Hansen, Lee H. Chen, et al. “Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.” Mol Cancer Res 15, no. 5 (May 2017): 507–20. https://doi.org/10.1158/1541-7786.MCR-16-0485.
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    • Killela, Patrick J., Christopher J. Pirozzi, Patrick Healy, Zachary J. Reitman, Eric Lipp, B Ahmed Rasheed, Rui Yang, et al. “Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.” Oncotarget 5, no. 6 (March 30, 2014): 1515–25. https://doi.org/10.18632/oncotarget.1765.
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    • Killela, Patrick J., Christopher J. Pirozzi, Zachary J. Reitman, Sian Jones, B Ahmed Rasheed, Eric Lipp, Henry Friedman, et al. “The genetic landscape of anaplastic astrocytoma.” Oncotarget 5, no. 6 (March 30, 2014): 1452–57. https://doi.org/10.18632/oncotarget.1505.
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    • Reitman, Zachary J., Christopher J. Pirozzi, and Hai Yan. “Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors.” Acta Neuropathol 126, no. 6 (December 2013): 789–92. https://doi.org/10.1007/s00401-013-1207-5.
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    • Guo, Changcun, Lee H. Chen, Yafen Huang, Chun-Chi Chang, Ping Wang, Christopher J. Pirozzi, Xiaoxia Qin, et al. “KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation.” Oncotarget 4, no. 11 (November 2013): 2144–53. https://doi.org/10.18632/oncotarget.1555.
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    • Pirozzi, Christopher J., Zachary J. Reitman, and Hai Yan. “Releasing the block: setting differentiation free with mutant IDH inhibitors.” Cancer Cell 23, no. 5 (May 13, 2013): 570–72. https://doi.org/10.1016/j.ccr.2013.04.024.
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    • Jin, Genglin, Christopher J. Pirozzi, Lee H. Chen, Giselle Y. Lopez, Christopher G. Duncan, Jie Feng, Ivan Spasojevic, Darell D. Bigner, Yiping He, and Hai Yan. “Mutant IDH1 is required for IDH1 mutated tumor cell growth.” Oncotarget 3, no. 8 (August 2012): 774–82. https://doi.org/10.18632/oncotarget.577.
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    • Jiao, Yuchen, Patrick J. Killela, Zachary J. Reitman, Ahmed B. Rasheed, Christopher M. Heaphy, Roeland F. de Wilde, Fausto J. Rodriguez, et al. “Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.” Oncotarget 3, no. 7 (July 2012): 709–22. https://doi.org/10.18632/oncotarget.588.
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    • Guo, Changcun, Christopher J. Pirozzi, Giselle Y. Lopez, and Hai Yan. “Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target.” Curr Opin Neurol 24, no. 6 (December 2011): 648–52. https://doi.org/10.1097/WCO.0b013e32834cd415.
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  • Book Sections

    • Chandramohan, V., L. Sanchez-Perez, Y. He, C. J. Pirozzi, K. L. Congdon, and D. D. Bigner. “Preclinical Immunotherapeutic Animal Models for Brain Tumors.” In Translational Immunotherapy of Brain Tumors, 111–47, 2017. https://doi.org/10.1016/B978-0-12-802420-1.00006-5.
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    • Pirozzi, C. J., A. B. Carpenter, T. Hennika, O. J. Becher, and H. Yan. “Tumor-Specific Mutations in Gliomas and their Implications for Immunotherapy.” In Translational Immunotherapy of Brain Tumors, 83–107, 2017. https://doi.org/10.1016/B978-0-12-802420-1.00005-3.
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  • Conference Papers

    • Pirozzi, Christopher J., Catherine Y. Wang, Austin B. Carpenter, Huishan Zhu, Paula K. Greer, Roger E. McLendon, Darell D. Bigner, Yiping He, and Hai Yan. “Abstract 63: Driving brain tumorigenesis: Generation of a mutant IDH1 mouse model of progressive glioma.” In Tumor Biology. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-63.
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