Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Medical Physics Resident, Radiation Oncology Physics Division, Duke University 2018 - 2019
  • Medical Physics Resident, Radiation Oncology Physics Division, Duke University 2016 - 2018
  • Ph.D., Duke University 2016
• 

  Duke Appointment History

  • Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2020
• Recognition
• 

  Awards & Honors

  • AAPM Science Council Associates Mentorship Fellowship. AAPM. July 2018
  • BEST/AAPM Fellowship . AAPM. June 2017
  • Annual Meeting Outstanding Abstract Travel Award. American Society of Radiation Oncology (ASTRO). June 2015
  • Douglas Wagenaar Memorial Research Fellowship. Duke University. October 2014
• Research
• 

  Selected Grants

  • Clinical Experience Guided Reinforcement Learning for Pancreas SBRT awarded by Varian Medical Systems, Inc. 2019 - 2022
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Wang, Chunhao, Kyle R. Padgett, Min-Ying Su, Eric A. Mellon, Danilo Maziero, and Zheng Chang. “Multi-parametric MRI (mpMRI) for treatment response assessment of radiation therapy.” Med Phys, August 10, 2021. https://doi.org/10.1002/mp.15130.
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    • Lafata, Kyle J., Yushi Chang, Chunhao Wang, Yvonne M. Mowery, Irina Vergalasova, Donna Niedzwiecki, David S. Yoo, Jian-Guo Liu, David M. Brizel, and Fang-Fang Yin. “Intrinsic radiomic expression patterns after 20 Gy demonstrate early metabolic response of oropharyngeal cancers.” Med Phys 48, no. 7 (July 2021): 3767–77. https://doi.org/10.1002/mp.14926.
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    • Li, Xinyi, Chunhao Wang, Yang Sheng, Jiahan Zhang, Wentao Wang, Fang-Fang Yin, Qiuwen Wu, Q Jackie Wu, and Yaorong Ge. “An artificial intelligence-driven agent for real-time head-and-neck IMRT plan generation using conditional generative adversarial network (cGAN).” Med Phys 48, no. 6 (June 2021): 2714–23. https://doi.org/10.1002/mp.14770.
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    • Zhang, Jiahan, Chunhao Wang, Yang Sheng, Manisha Palta, Brian Czito, Christopher Willett, Jiang Zhang, et al. “An Interpretable Planning Bot for Pancreas Stereotactic Body Radiation Therapy.” Int J Radiat Oncol Biol Phys 109, no. 4 (March 15, 2021): 1076–85. https://doi.org/10.1016/j.ijrobp.2020.10.019.
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    • Liu, Chenyang, Shen-Chiang Hu, Chunhao Wang, Kyle Lafata, and Fang-Fang Yin. “Automatic detection of pulmonary nodules on CT images with YOLOv3: development and evaluation using simulated and patient data.” Quant Imaging Med Surg 10, no. 10 (October 2020): 1917–29. https://doi.org/10.21037/qims-19-883.
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    • Li, Xinyi, Jiahan Zhang, Yang Sheng, Yushi Chang, Fang-Fang Yin, Yaorong Ge, Q Jackie Wu, and Chunhao Wang. “Automatic IMRT planning via static field fluence prediction (AIP-SFFP): a deep learning algorithm for real-time prostate treatment planning.” Phys Med Biol 65, no. 17 (September 8, 2020): 175014. https://doi.org/10.1088/1361-6560/aba5eb.
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    • Zhang, Jiahan, Yaorong Ge, Yang Sheng, Chunhao Wang, Jiang Zhang, Yuan Wu, Qiuwen Wu, Fang-Fang Yin, and Q Jackie Wu. “Knowledge-Based Tradeoff Hyperplanes for Head and Neck Treatment Planning.” Int J Radiat Oncol Biol Phys 106, no. 5 (April 1, 2020): 1095–1103. https://doi.org/10.1016/j.ijrobp.2019.12.034.
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    • Chang, Yushi, Kyle Lafata, Chunhao Wang, Xiaoyu Duan, Ruiqi Geng, Zhenyu Yang, and Fang-Fang Yin. “Digital phantoms for characterizing inconsistencies among radiomics extraction toolboxes.” Biomed Phys Eng Express 6, no. 2 (March 2, 2020): 025016. https://doi.org/10.1088/2057-1976/ab779c.
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    • Wang, Chunhao, Chenyang Liu, Yushi Chang, Kyle Lafata, Yunfeng Cui, Jiahan Zhang, Yang Sheng, Yvonne Mowery, David Brizel, and Fang-Fang Yin. “Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application.” Front Oncol 10 (2020): 1592. https://doi.org/10.3389/fonc.2020.01592.
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    • Liang, Xiao, Fang-Fang Yin, Chunhao Wang, and Jing Cai. “A robust deformable image registration enhancement method based on radial basis function.” Quant Imaging Med Surg 9, no. 7 (July 2019): 1315–25. https://doi.org/10.21037/qims.2019.07.05.
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    • Wang, Chunhao, Ergys Subashi, Fang-Fang Yin, Zheng Chang, and Jing Cai. “A Spatiotemporal-Constrained Sorting Method for Motion-Robust 4D-MRI: A Feasibility Study.” Int J Radiat Oncol Biol Phys 103, no. 3 (March 1, 2019): 758–66. https://doi.org/10.1016/j.ijrobp.2018.10.004.
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    • Chang, Yushi, Kyle Lafata, Wenzheng Sun, Chunhao Wang, Zheng Chang, John P. Kirkpatrick, and Fang-Fang Yin. “An investigation of machine learning methods in delta-radiomics feature analysis.” Plos One 14, no. 12 (2019): e0226348. https://doi.org/10.1371/journal.pone.0226348.
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    • Li, Xinyi, Jackie Wu, Manisha Palta, You Zhang, Yang Sheng, Jiahan Zhang, and Chunhao Wang. “A Collimator Setting Optimization Algorithm for Dual-Arc Volumetric Modulated Arc Therapy in Pancreas Stereotactic Body Radiation Therapy.” Technol Cancer Res Treat 18 (January 1, 2019): 1533033819870767. https://doi.org/10.1177/1533033819870767.
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    • Petroccia, Heather M., Irina Malajovich, Andrew R. Barsky, Alireza Fotouhi Ghiam, Joshua Jones, Chunhao Wang, Wei Zou, et al. “Spine SBRT With Halcyon™: Plan Quality, Modulation Complexity, Delivery Accuracy, and Speed.” Front Oncol 9 (2019): 319. https://doi.org/10.3389/fonc.2019.00319.
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    • Sheng, Yang, Jiahan Zhang, Chunhao Wang, Fang-Fang Yin, Q Jackie Wu, and Yaorong Ge. “Incorporating Case-Based Reasoning for Radiation Therapy Knowledge Modeling: A Pelvic Case Study.” Technol Cancer Res Treat 18 (January 1, 2019): 1533033819874788. https://doi.org/10.1177/1533033819874788.
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    • Wang, Chunhao, Xiaofeng Zhu, Julian C. Hong, and Dandan Zheng. “Artificial Intelligence in Radiotherapy Treatment Planning: Present and Future.” Technol Cancer Res Treat 18 (January 1, 2019): 1533033819873922. https://doi.org/10.1177/1533033819873922.
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    • Zhang, Jiang, Q Jackie Wu, Yaorong Ge, Chunhao Wang, Yang Sheng, Jatinder Palta, Joseph K. Salama, Fang-Fang Yin, and Jiahan Zhang. “Knowledge-Based Statistical Inference Method for Plan Quality Quantification.” Technol Cancer Res Treat 18 (January 1, 2019): 1533033819857758. https://doi.org/10.1177/1533033819857758.
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    • Zheng, Dandan, Julian C. Hong, Chunhao Wang, and Xiaofeng Zhu. “Radiotherapy Treatment Planning in the Age of AI: Are We Ready Yet?” Technol Cancer Res Treat 18 (January 2019): 1533033819894577. https://doi.org/10.1177/1533033819894577.
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    • Lafata, Kyle, Jing Cai, Chunhao Wang, Julian Hong, Chris R. Kelsey, and Fang-Fang Yin. “Spatial-temporal variability of radiomic features and its effect on the classification of lung cancer histology.” Phys Med Biol 63, no. 22 (November 8, 2018): 225003. https://doi.org/10.1088/1361-6560/aae56a.
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    • Harris, Wendy, Chunhao Wang, Fang-Fang Yin, Jing Cai, and Lei Ren. “A Novel method to generate on-board 4D MRI using prior 4D MRI and on-board kV projections from a conventional LINAC for target localization in liver SBRT.” Med Phys 45, no. 7 (July 2018): 3238–45. https://doi.org/10.1002/mp.12998.
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    • Wang, Chunhao, Wenzheng Sun, John Kirkpatrick, Zheng Chang, and Fang-Fang Yin. “Assessment of concurrent stereotactic radiosurgery and bevacizumab treatment of recurrent malignant gliomas using multi-modality MRI imaging and radiomics analysis.” J Radiosurg Sbrt 5, no. 3 (2018): 171–81.
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    • Harris, Wendy, Fang-Fang Yin, Chunhao Wang, You Zhang, Jing Cai, and Lei Ren. “Accelerating volumetric cine MRI (VC-MRI) using undersampling for real-time 3D target localization/tracking in radiation therapy: a feasibility study.” Phys Med Biol 63, no. 1 (December 14, 2017): 01NT01. https://doi.org/10.1088/1361-6560/aa9746.
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    • Wang, Chunhao, Fang-Fang Yin, W. P. Segars, Zheng Chang, and Lei Ren. “Development of a Computerized 4-D MRI Phantom for Liver Motion Study.” Technol Cancer Res Treat 16, no. 6 (December 2017): 1051–59. https://doi.org/10.1177/1533034617723753.
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    • Wang, Chunhao, Fang-Fang Yin, John P. Kirkpatrick, and Zheng Chang. “Accelerated Brain DCE-MRI Using Iterative Reconstruction With Total Generalized Variation Penalty for Quantitative Pharmacokinetic Analysis: A Feasibility Study.” Technol Cancer Res Treat 16, no. 4 (August 2017): 446–60. https://doi.org/10.1177/1533034616649294.
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    • Wang, Chunhao, Janet K. Horton, Fang-Fang Yin, and Zheng Chang. “Assessment of Treatment Response With Diffusion-Weighted MRI and Dynamic Contrast-Enhanced MRI in Patients With Early-Stage Breast Cancer Treated With Single-Dose Preoperative Radiotherapy: Initial Results.” Technol Cancer Res Treat 15, no. 5 (October 2016): 651–60. https://doi.org/10.1177/1533034615593191.
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    • Wang, Chunhao, Ergys Subashi, Xiao Liang, Fang-Fang Yin, and Zheng Chang. “Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study.” Phys Med Biol 61, no. 13 (July 7, 2016): 4763–80. https://doi.org/10.1088/0031-9155/61/13/4763.
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    • Wang, Chunhao, Ergys Subashi, Fang-Fang Yin, and Zheng Chang. “Dynamic fractal signature dissimilarity analysis for therapeutic response assessment using dynamic contrast-enhanced MRI.” Med Phys 43, no. 3 (March 2016): 1335–47. https://doi.org/10.1118/1.4941739.
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    • Wang, Chunhao, Fang-Fang Yin, and Zheng Chang. “An efficient calculation method for pharmacokinetic parameters in brain permeability study using dynamic contrast-enhanced MRI.” Magn Reson Med 75, no. 2 (February 2016): 739–49. https://doi.org/10.1002/mrm.25659.
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    • Horton, Janet K., Rachel C. Blitzblau, Sua Yoo, Joseph Geradts, Zheng Chang, Jay A. Baker, Gregory S. Georgiade, et al. “Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers.” Int J Radiat Oncol Biol Phys 92, no. 4 (July 15, 2015): 846–55. https://doi.org/10.1016/j.ijrobp.2015.03.007.
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  • Conference Papers

    • Wang, C., X. Li, Y. Chang, Y. Sheng, J. Zhang, F. F. Yin, and Q. J. J. Wu. “Rapid Auto IMRT Planning Using Cascade Dense Convolutional Neural Network (CDCNN): A Feasibility Study for Fluence Map Prediction Using Deep Learning on Prostate IMRT Patients.” In International Journal of Radiation Oncology*Biology*Physics, 105:E789–90. Elsevier BV, 2019. https://doi.org/10.1016/j.ijrobp.2019.06.760.
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    • Li, X., J. Wu, M. Palta, Y. Zhang, Y. Sheng, J. Zhang, and C. Wang. “A Collimator Setting Optimization Algorithm for Dual-Arc Volumetric Modulated Arc Therapy in Pancreas Stereotactic Body Radiation Therapy.” In Technology in Cancer Research &Amp; Treatment, Vol. 18, 2019. https://doi.org/10.1177/1533033819870767.
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    • Sheng, Y., J. Zhang, C. Wang, F. F. Yin, Q. J. Wu, and Y. Ge. “Incorporating Case-Based Reasoning for Radiation Therapy Knowledge Modeling: A Pelvic Case Study.” In Technology in Cancer Research &Amp; Treatment, Vol. 18, 2019. https://doi.org/10.1177/1533033819874788.
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• Teaching & Mentoring
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  Recent Courses

  • MEDPHY 791K: Independent Study in Medical Physics 2021
• Scholarly, Clinical, & Service Activities
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  Clinical Activities

  • • Gastrointestinal radiotherapy planning
    • Liver/pancreas stereotactic body radiation therapy (SBRT)
    • SRS planning
    • GYN HDR and eye plaque LDR brachytherapy

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