Selected Presentations & Appearances
Presented scientific findings from studies on novel human immune system-humanized rodents. Specifically, detailed the development of two humanized rodent models. The first is an NSG-platform mouse model that contains co-engrafted hematopoietic stem cells and fetal lymphoid tissues, namely 1 mm^3 human spleen and human thymus organoids. This mouse model was used to study wild type and delta-Nef HIV replication and associated disease pathogenesis in-vivo. The second model involved co-engrafting human hematopoitic stem cells, human fetal thymus organoid, and full thickness skin into a Hera Labs SRG rat platform. This model is being developed to provide a platform to evaluate in-vivo human skin-human immune system interactions and modeling of skin disease pathogenesis.