Overview
Our laboratory explores the contribution of the immune system and inflammatory mediators to the progression of target organ damage in the setting of cardiovascular disease. We are pursuing several related projects in this field:
(1) The actions of type 1 angiotensin receptors on specific immune cell populations in hypertension, target organ damage, and tissue fibrosis.
(2) Cell-specific actions of inflammatory cytokines in regulating blood pressure and end-organ injury.
(3) Mechanism through which dendritic cells regulate renal sodium reabsorption.
(4) The contributions of Wnt O-acylation to kidney scar formation.
(1) The actions of type 1 angiotensin receptors on specific immune cell populations in hypertension, target organ damage, and tissue fibrosis.
(2) Cell-specific actions of inflammatory cytokines in regulating blood pressure and end-organ injury.
(3) Mechanism through which dendritic cells regulate renal sodium reabsorption.
(4) The contributions of Wnt O-acylation to kidney scar formation.
Current Appointments & Affiliations
Professor of Medicine
·
2020 - Present
Medicine, Nephrology,
Medicine
Member of the Duke Cancer Institute
·
1996 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Psychological Resilience and Physical Function in Veterans With Chronic Kidney Disease: A Brief Report.
Journal Article J Am Geriatr Soc · March 13, 2025 BACKGROUND: Psychological resilience has been characterized as the ability to recover from stressful life events. Not well studied is whether self-reported measures of psychological resilience are associated with physical function recovery. Therefore, we e ... Full text Link to item CiteTranscription factor Twist1 drives fibroblast activation to promote kidney fibrosis via signaling proteins Prrx1/TNC.
Journal Article Kidney Int · November 2024 The transcription factor Twist1 plays a vital role in normal development in many tissue systems and continues to be important throughout life. However, inappropriate Twist1 activity has been associated with kidney injury and fibrosis, though the underlying ... Full text Link to item CiteSalt and CHIP: Tet2-CH Aggravates Salt-Sensitive Hypertension in Mice.
Journal Article Circ Res · October 11, 2024 Full text Link to item CiteRecent Grants
TRIO NRSA Training Core-Post Doc Trainee
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2024 - 2028TRIO NRSA Training Core-Pre Doc Trainee
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2023 - 2028U2C/TL1 NC KUH TRIO Administrative Core
ResearchCo-Core Leader · Awarded by University of North Carolina - Chapel Hill · 2023 - 2028View All Grants
Education, Training & Certifications
Duke University ·
1996
M.D.