Cynthia Dianne Guy | Scholars@Duke

Cynthia Dianne Guy
Professor of Pathology

My research interests include:
Fine Needle Aspiration of Liver, Gastrointestinal Tract, and Pancreatic Lesions
Biliary Duct Brushings
Nonalcoholic Fatty Liver Disease/NASH
Liver Fibrogenesis

Current Appointments & Affiliations

Professor of Pathology, Pathology, Clinical Science Departments 2017

Contact Information

206 A Davison Bldg, Durham, NC 27710
Duke Box 3712, Durham, NC 27710
cynthia.guy@duke.edu (919) 668-0794

Background
Education, Training, & Certifications
- M.D., Medical University of South Carolina School of Medicine 1993
- B.A., University of North Carolina at Chapel Hill 1985
Duke Appointment History
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2008 - 2017
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2006 - 2008
- Assistant Clinical Professor of Pathology, Pathology, Clinical Science Departments 2003 - 2006
- Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2003
- Clinical Associate in the Department of Pathology, Pathology, Clinical Science Departments 1999 - 2001
- Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 1999
Research
Selected Grants
- NASH Clinical Research Network awarded by National Institutes of Health 2004 - 2019
- TAIWANJ JKB 121-001 awarded by TaiwanJ Pharmaceuticals Co. Ltd 2015 - 2019
- Role of the Stroma in Fibrolamellar Hepatocellular Carcinoma awarded by Fibrolamellar Cancer Foundation 2016 - 2018
- Targeting Calreticulin in Colorectal Cancer Liver Metastasis awarded by National Institutes of Health 2015 - 2017
- Impact of Fructose on Metabolism, Energy Homeostasis and MR biomarkers in NAFLD awarded by National Institutes of Health 2012 - 2016
- HBV Clinical Research Network Site Application_Subcontract to UNC awarded by University of North Carolina - Chapel Hill 2008 - 2015
- Coherence Imaging for Assessing Colorectal Neoplasia awarded by National Institutes of Health 2009 - 2012
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Yang, JD, Abdelmalek, MF, Guy, CD, Diehl, AM, and Suzuki, A. "Reply." Clinical Gastroenterology and Hepatology 16, no. 10 (October 1, 2018): 1684-null. (Letter) Full Text Open Access Copy
  - Naggie, S, Swiderska-Syn, M, Choi, S, Lusk, S, Lan, A, Ferrari, G, Syn, W-K, Guy, CD, and Diehl, AM. "Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection." Open Forum Infectious Diseases 5, no. 7 (July 2018): ofy138-null. Full Text
  - Schild, MH, and Guy, CD. "Nonalcoholic Steatohepatitis: Histopathology Basics Within a Broader Context." Surgical Pathology Clinics 11, no. 2 (June 2018): 267-285. (Review) Full Text
  - Hameed, B, Terrault, NA, Gill, RM, Loomba, R, Chalasani, N, Hoofnagle, JH, Van Natta, ML, and NASH CRN, . "Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis." Alimentary Pharmacology & Therapeutics 47, no. 5 (March 2018): 645-656. Full Text
  - Harrison, G, Hemmerich, A, Guy, C, Perkinson, K, Fleming, D, McCall, S, Cardona, D, and Zhang, X. "Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas." American Journal of Clinical Pathology 149, no. 1 (December 2017): 67-75. Full Text
  - Newton, KP, Feldman, HS, Chambers, CD, Wilson, L, Behling, C, Clark, JM, Molleston, JP, Chalasani, N, Sanyal, AJ, Fishbein, MH, Lavine, JE, Schwimmer, JB, and Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), . "Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children." The Journal of Pediatrics 187 (August 2017): 141-146.e1. Full Text
  - Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Reply to Kim et al." The American Journal of Gastroenterology 112, no. 5 (May 2017): 807-808. Full Text
  - Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Lavine, JE, Yates, K, Klair, J, Terrault, NA, Clark, JM, Unalp-Arida, A, Diehl, AM, Suzuki, A, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 15, no. 1 (January 2017): 127-131.e2. Full Text
  - Nelson, JE, Handa, P, Aouizerat, B, Wilson, L, Vemulakonda, LA, Yeh, MM, Kowdley, KV, and NASH Clinical Research Network, . "Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms." Alimentary Pharmacology & Therapeutics 44, no. 11-12 (December 2016): 1253-1264. Full Text
  - Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis." The American Journal of Gastroenterology 111, no. 11 (November 2016): 1591-1598. Full Text
  - Klair, JS, Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Yates, K, Unalp-Arida, A, Lavine, JE, Clark, JM, Diehl, AM, Suzuki, A, and Nonalcoholic Steatohepatitis Clinical Research Network, . "A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 64, no. 1 (July 2016): 85-91. Full Text
  - Ludmir, EB, McCall, SJ, Cardona, DM, Perkinson, KR, Guy, CD, and Zhang, X. "Mixed Adenoneuroendocrine Carcinoma, Amphicrine Type, of the Small Bowel." American Journal of Clinical Pathology 145, no. 5 (May 2016): 703-709. Full Text
  - Michelotti, GA, Tucker, A, Swiderska-Syn, M, Machado, MV, Choi, SS, Kruger, L, Soderblom, E, Thompson, JW, Mayer-Salman, M, Himburg, HA, Moylan, CA, Guy, CD, Garman, KS, Premont, RT, Chute, JP, and Diehl, AM. "Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches." Gut 65, no. 4 (April 2016): 683-692. Full Text Open Access Copy
  - Boursier, J, Mueller, O, Barret, M, Machado, M, Fizanne, L, Araujo-Perez, F, Guy, CD, Seed, PC, Rawls, JF, David, LA, Hunault, G, Oberti, F, Calès, P, and Diehl, AM. "The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota." Hepatology (Baltimore, Md.) 63, no. 3 (March 2016): 764-775. Full Text
  - Guy, CD, and Diehl, AM. "Reply." Hepatology (Baltimore, Md.) 63, no. 3 (March 2016): 1057-1058. (Letter) Full Text
  - Zhu, R, Baker, SS, Moylan, CA, Abdelmalek, MF, Guy, CD, Zamboni, F, Wu, D, Lin, W, Liu, W, Baker, RD, Govindarajan, S, Cao, Z, Farci, P, Diehl, AM, and Zhu, L. "Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers." The Journal of Pathology 238, no. 4 (March 2016): 531-542. Full Text
  - Kim, J, Wang, S, Hyun, J, Guy, CD, and Jung, Y. "Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice." Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 40, no. 1-2 (January 2016): 263-276. Full Text
  - Cheriyan, D, Guy, C, and Burbridge, R. "Giant esophageal lipoma: endoscopic resection." Gastrointestinal endoscopy 82, no. 4 (October 2015): 742-. Full Text
  - Machado, MV, Michelotti, GA, Pereira, TDA, Boursier, J, Kruger, L, Swiderska-Syn, M, Karaca, G, Xie, G, Guy, CD, Bohinc, B, Lindblom, KR, Johnson, E, Kornbluth, S, and Diehl, AM. "Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis." Gut 64, no. 7 (July 2015): 1148-1157. Full Text Link to Item
  - Guy, C, Suzuki, A, Abdelmalek, M, Burchette, J, and Diehl, AM. "Reply." Hepatology 61, no. 5 (May 2015): 1770-1771. Full Text
  - Karaca, G, Xie, G, Moylan, C, Swiderska-Syn, M, Guy, CD, Krüger, L, Machado, MV, Choi, SS, Michelotti, GA, Burkly, LC, and Diehl, AM. "Role of Fn14 in acute alcoholic steatohepatitis in mice." American Journal of Physiology. Gastrointestinal and Liver Physiology 308, no. 4 (February 2015): G325-G334. Full Text
  - Guy, CD, Suzuki, A, Abdelmalek, MF, Burchette, JL, Diehl, AM, and NASH CRN, . "Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity." Hepatology (Baltimore, Md.) 61, no. 1 (January 2015): 98-107. Full Text
  - Guy, CD, Suzuki, A, Abdelmalek, MF, Burchette, JL, and Diehl, AM. "Treatment response in the PIVENS trial is associated with decreased hedgehog pathway activity." Hepatology 61, no. 1 (January 1, 2015): 98-107. Full Text
  - Machado, MV, Michelotti, GA, Pereira, TDA, Boursier, J, Kruger, L, Swiderska-Syn, M, Karaca, G, Xie, G, Guy, CD, Bohinc, B, Lindblom, KR, Johnson, E, Kornbluth, S, and Diehl, AM. "Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis." Gut 64, no. 7 (2015): 1148-1157. Full Text
  - Machado, MV, Michelotti, GA, Xie, G, Almeida Pereira, T, Boursier, J, Bohnic, B, Guy, CD, and Diehl, AM. "Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease." Plos One 10, no. 5 (January 2015): e0127991-null. Full Text
  - Machado, MV, Michelotti, GA, Xie, G, de Almeida, TP, Boursier, J, Bohnic, B, Guy, CD, and Diehl, AM. "Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease." PloS one 10, no. 6 (January 2015): e0132315-. Full Text
  - Nightingale, KR, Rouze, NC, Rosenzweig, SJ, Wang, MH, Abdelmalek, MF, Guy, CD, and Palmeri, ML. "Derivation and analysis of viscoelastic properties in human liver: impact of frequency on fibrosis and steatosis staging." Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 62, no. 1 (January 2015): 165-175. Full Text
  - Yang, JD, Guy, CD, and Suzuki, A. "Reply." Hepatology 61, no. 3 (January 1, 2015): 1094-1094. (Letter) Full Text
  - Bohinc, BN, Michelotti, G, Xie, G, Pang, H, Suzuki, A, Guy, CD, Piercy, D, Kruger, L, Swiderska-Syn, M, Machado, M, Pereira, T, Zavacki, AM, Abdelmalek, M, and Diehl, AM. "Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism." Endocrinology 155, no. 11 (November 2014): 4591-4601. Full Text
  - Siddique, A, Nelson, JE, Aouizerat, B, Yeh, MM, Kowdley, KV, and NASH Clinical Research Network, . "Iron deficiency in patients with nonalcoholic Fatty liver disease is associated with obesity, female gender, and low serum hepcidin." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 12, no. 7 (July 2014): 1170-1178. Full Text
  - Choi, SS, Claridge, LC, Jhaveri, R, Swiderska-Syn, M, Clark, P, Suzuki, A, Pereira, TA, Mi, Z, Kuo, PC, Guy, CD, Pereira, FEL, Diehl, AM, Patel, K, and Syn, W-K. "Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication." Clinical Science (London, England : 1979) 126, no. 12 (June 2014): 845-855. Full Text
  - Chan, IS, Guy, CD, Machado, MV, Wank, A, Kadiyala, V, Michelotti, G, Choi, S, Swiderska-Syn, M, Karaca, G, Pereira, TA, Yip-Schneider, MT, Max Schmidt, C, and Diehl, AM. "Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis." Alcohol Clin Exp Res 38, no. 3 (March 2014): 787-800. Full Text Link to Item
  - Moylan, CA, Pang, H, Dellinger, A, Suzuki, A, Garrett, ME, Guy, CD, Murphy, SK, Ashley-Koch, AE, Choi, SS, Michelotti, GA, Hampton, DD, Chen, Y, Tillmann, HL, Hauser, MA, Abdelmalek, MF, and Diehl, AM. "Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease." Hepatology 59, no. 2 (February 2014): 471-482. Full Text Link to Item
  - Chan, IS, Guy, CD, Machado, MV, Wank, A, Kadiyala, V, Michelotti, G, Choi, S, Swiderska-Syn, M, Karaca, G, Pereira, TA, Yip-Schneider, MT, Max Schmidt, C, and Diehl, AM. "Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis." Alcoholism: Clinical and Experimental Research 38, no. 3 (January 1, 2014): 787-800. Full Text
  - Yang, JD, Abdelmalek, MF, Pang, H, Guy, CD, Smith, AD, Diehl, AM, and Suzuki, A. "Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis." Hepatology 59, no. 4 (January 1, 2014): 1406-1414. Full Text
  - Black, T, Guy, CD, and Burbridge, RA. "Retroperitoneal cystic lymphangioma diagnosed by endoscopic ultrasound-guided fine needle aspiration." Clin Endosc 46, no. 5 (September 2013): 595-597. Full Text Link to Item
  - Youssef, NA, Abdelmalek, MF, Binks, M, Guy, CD, Omenetti, A, Smith, AD, Diehl, AME, and Suzuki, A. "Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease." Liver Int 33, no. 7 (August 2013): 1062-1070. Full Text Link to Item
  - Swiderska-Syn, M, Suzuki, A, Guy, CD, Schwimmer, JB, Abdelmalek, MF, Lavine, JE, and Diehl, AM. "Hedgehog pathway and pediatric nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 57, no. 5 (May 2013): 1814-1825. Full Text
  - Corbin, KD, Abdelmalek, MF, Spencer, MD, da Costa, K-A, Galanko, JA, Sha, W, Suzuki, A, Guy, CD, Cardona, DM, Torquati, A, Diehl, AM, and Zeisel, SH. "Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 27, no. 4 (April 2013): 1674-1689. Full Text
  - Swiderska-Syn, M, Suzuki, A, Guy, CD, Schwimmer, JB, Abdelmalek, MF, Lavine, JE, and Diehl, AM. "Hedgehog pathway and pediatric nonalcoholic fatty liver disease." Hepatology 57, no. 5 (2013): 1814-1825. Full Text
  - Youssef, NA, Abdelmalek, MF, Binks, M, Guy, CD, Omenetti, A, Smith, AD, Diehl, AME, and Suzuki, A. "Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease." Liver International 33, no. 7 (2013): 1062-1070. Full Text
  - Chan, IS, Guy, CD, Chen, Y, Lu, J, Swiderska-Syn, M, Michelotti, GA, Karaca, G, Xie, G, Krüger, L, Syn, W-K, Anderson, BR, Pereira, TA, Choi, SS, Baldwin, AS, and Diehl, AM. "Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma." Cancer Research 72, no. 24 (December 2012): 6344-6350. Full Text
  - Syn, W-K, Agboola, KM, Swiderska, M, Michelotti, GA, Liaskou, E, Pang, H, Xie, G, Philips, G, Chan, IS, Karaca, GF, Pereira, TDA, Chen, Y, Mi, Z, Kuo, PC, Choi, SS, Guy, CD, Abdelmalek, MF, and Diehl, AM. "NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease." Gut 61, no. 9 (September 2012): 1323-1329. Full Text
  - Syn, W-K, Agboola, KM, Swiderska, M, Michelotti, GA, Liaskou, E, Pang, H, Xie, G, Philips, G, Chan, IS, Karaca, GF, Pereira, TDA, Chen, Y, Mi, Z, Kuo, PC, Choi, SS, Guy, CD, Abdelmalek, MF, and Diehl, AM. "NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease." Gut 61, no. 9 (September 2012): 1323-1329. Full Text
  - Zagar, TM, White, RR, Willett, CG, Tyler, DS, Papavassiliou, P, Papalezova, KT, Guy, CD, Broadwater, G, Clough, RW, and Czito, BG. "Resected pancreatic neuroendocrine tumors: patterns of failure and disease-related outcomes with or without radiotherapy." Int J Radiat Oncol Biol Phys 83, no. 4 (July 15, 2012): 1126-1131. Full Text Link to Item
  - Suzuki, A, Abdelmalek, MF, Schwimmer, JB, Lavine, JE, Scheimann, AO, Unalp-Arida, A, Yates, KP, Sanyal, AJ, Guy, CD, Diehl, AM, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Association between puberty and features of nonalcoholic fatty liver disease." Clin Gastroenterol Hepatol 10, no. 7 (July 2012): 786-794. Full Text Link to Item
  - Guy, CD, Suzuki, A, Burchette, JL, Brunt, EM, Abdelmalek, MF, Cardona, D, McCall, SJ, Ünalp, A, Belt, P, Ferrell, LD, Diehl, AM, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease." Hum Pathol 43, no. 6 (June 2012): 790-800. Full Text Link to Item
  - Guy, CD, Suzuki, A, Zdanowicz, M, Abdelmalek, MF, Burchette, J, Unalp, A, Diehl, AM, and NASH CRN, . "Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 55, no. 6 (June 2012): 1711-1721. Full Text
  - Levine, EA, Blazer, DG, Kim, MK, Shen, P, Stewart, JH, Guy, C, and Hsu, DS. "Gene expression profiling of peritoneal metastases from appendiceal and colon cancer demonstrates unique biologic signatures and predicts patient outcomes." Journal of the American College of Surgeons 214, no. 4 (April 2012): 599-606. Full Text
  - Nelson, JE, Brunt, EM, Kowdley, KV, Abrams, SH, Fairly, LA, McCullough, AJ, Brandt, P, Bringman, D, Dasarathy, S, Dasarathy, J, Hawkins, C, Liu, Y-C, Rogers, N, Stager, M, Whitwell, J, McCullough, AJ, Dasarathy, S, Pagadala, M, Sargent, R, Yerian, L, Zein, C, Merriman, R, Nguyen, A, Mohan, P, Nair, K, DeVore, S, Kohli, R, Lake, K, Xanthakos, S, Cosme, Y, Lavine, JE, Mencin, A, Ovchinsky, N, Abdelmalek, MF, Buie, S, Diehl, AM, Gottfried, M, Guy, C, Hanna, M, Kigongo, C, Killenberg, P, and Kwan, S et al. "Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations." Hepatology 56, no. 5 (2012): 1730-1740. Full Text
  - Vos, MB, Colvin, R, Belt, P, Molleston, JP, Murray, KF, Rosenthal, P, Schwimmer, JB, Tonascia, J, Unalp, A, and Lavine, JE. "Correlation of Vitamin E, Uric Acid, and Diet Composition With Histologic Features of Pediatric NAFLD." Journal of Pediatric Gastroenterology and Nutrition 54, no. 1 (January 2012): 90-96. Full Text
  - Tillmann, HL, Patel, K, Muir, AJ, Guy, CD, Li, JH, Lao, XQ, Thompson, A, Clark, PJ, Gardner, SD, McHutchison, JG, and McCarthy, JJ. "Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C." J Hepatol 55, no. 6 (December 2011): 1195-1200. Full Text Link to Item
  - Terry, N, Zhu, Y, Thacker, JKM, Migaly, J, Guy, C, Mantyh, CR, and Wax, A. "Detection of intestinal dysplasia using angle-resolved low coherence interferometry." Journal of Biomedical Optics 16, no. 10 (October 2011): 106002-null. Full Text
  - Palmeri, ML, Wang, MH, Rouze, NC, Abdelmalek, MF, Guy, CD, Moser, B, Diehl, AM, and Nightingale, KR. "Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease." Journal of Hepatology 55, no. 3 (September 2011): 666-672. Full Text
  - Rangwala, F, Guy, CD, Lu, J, Suzuki, A, Burchette, JL, Abdelmalek, MF, Chen, W, and Diehl, AM. "Increased production of sonic hedgehog by ballooned hepatocytes." J Pathol 224, no. 3 (July 2011): 401-410. Full Text Link to Item
  - Omenetti, A, Bass, LM, Anders, RA, Clemente, MG, Francis, H, Guy, CD, McCall, S, Choi, SS, Alpini, G, Schwarz, KB, Diehl, AM, and Whitington, PF. "Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia." Hepatology (Baltimore, Md.) 53, no. 4 (April 2011): 1246-1258. Full Text
  - Speliotes, EK, Yerges-Armstrong, LM, Wu, J, Hernaez, R, Kim, LJ, Palmer, CD, Gudnason, V, Eiriksdottir, G, Garcia, ME, Launer, LJ, Nalls, MA, Clark, JM, Mitchell, BD, Shuldiner, AR, Butler, JL, Tomas, M, Hoffmann, U, Hwang, S-J, Massaro, JM, O'Donnell, CJ, Sahani, DV, Salomaa, V, Schadt, EE, Schwartz, SM, Siscovick, DS, NASH CRN, , GIANT Consortium, , MAGIC Investigators, , Voight, BF, Carr, JJ, Feitosa, MF, Harris, TB, Fox, CS, Smith, AV, Kao, WHL, Hirschhorn, JN, Borecki, IB, and GOLD Consortium, . "Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits." Plos Genetics 7, no. 3 (March 10, 2011): e1001324-null. Full Text
  - Omenetti, A, Yang, L, Gainetdinov, RR, Guy, CD, Choi, SS, Chen, W, Caron, MG, and Diehl, AM. "Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults." American Journal of Physiology. Gastrointestinal and Liver Physiology 300, no. 2 (February 2011): G303-G315. Full Text
  - Philips, GM, Chan, IS, Swiderska, M, Schroder, VT, Guy, C, Karaca, GF, Moylan, C, Venkatraman, T, Feuerlein, S, Syn, W-K, Jung, Y, Witek, RP, Choi, S, Michelotti, GA, Rangwala, F, Merkle, E, Lascola, C, and Diehl, AM. "Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer." Plos One 6, no. 9 (January 2011): e23943-null. Full Text Open Access Copy
  - Syn, W-K, Choi, SS, Liaskou, E, Karaca, GF, Agboola, KM, Oo, YH, Mi, Z, Pereira, TA, Zdanowicz, M, Malladi, P, Chen, Y, Moylan, C, Jung, Y, Bhattacharya, SD, Teaberry, V, Omenetti, A, Abdelmalek, MF, Guy, CD, Adams, DH, Kuo, PC, Michelotti, GA, Whitington, PF, and Diehl, AM. "Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis." Hepatology (Baltimore, Md.) 53, no. 1 (January 2011): 106-115. Full Text
  - Suzuki, A, Abdelmalek, MF, Unalp-Arida, A, Yates, K, Sanyal, A, Guy, C, and Diehl, AM. "Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 8, no. 12 (December 2010): 1062-1069. Full Text
  - Abdelmalek, MF, Suzuki, A, Guy, C, Unalp-Arida, A, Colvin, R, Johnson, RJ, Diehl, AM, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 51, no. 6 (June 2010): 1961-1971. Full Text
  - Syn, W-K, Oo, YH, Pereira, TA, Karaca, GF, Jung, Y, Omenetti, A, Witek, RP, Choi, SS, Guy, CD, Fearing, CM, Teaberry, V, Pereira, FEL, Adams, DH, and Diehl, AM. "Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 51, no. 6 (June 2010): 1998-2007. Full Text
  - Jung, Y, Witek, RP, Syn, W-K, Choi, SS, Omenetti, A, Premont, R, Guy, CD, and Diehl, AM. "Signals from dying hepatocytes trigger growth of liver progenitors." Gut 59, no. 5 (May 2010): 655-665. Full Text Link to Item
  - Lavine, JE, Schwimmer, JB, Molleston, JP, Scheimann, AO, Murray, KF, Abrams, SH, Rosenthal, P, Sanyal, AJ, Robuck, PR, Brunt, EM, Unalp, A, Tonascia, J, and Nonalcoholic Steatohepatitis Clinical Research Network Research Group, . "Treatment of nonalcoholic fatty liver disease in children: TONIC trial design." Contemporary Clinical Trials 31, no. 1 (January 2010): 62-70. Full Text
  - Witek, RP, Stone, WC, Karaca, FG, Syn, W-K, Pereira, TA, Agboola, KM, Omenetti, A, Jung, Y, Teaberry, V, Choi, SS, Guy, CD, Pollard, J, Charlton, P, and Diehl, AM. "Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis." Hepatology (Baltimore, Md.) 50, no. 5 (November 2009): 1421-1430. Full Text
  - Shah, AG, Lydecker, A, Murray, K, Tetri, BN, Contos, MJ, Sanyal, AJ, and Nash Clinical Research Network, . "Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 7, no. 10 (October 2009): 1104-1112. Full Text
  - Syn, W-K, Jung, Y, Omenetti, A, Abdelmalek, M, Guy, CD, Yang, L, Wang, J, Witek, RP, Fearing, CM, Pereira, TA, Teaberry, V, Choi, SS, Conde-Vancells, J, Karaca, GF, and Diehl, AM. "Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease." Gastroenterology 137, no. 4 (October 2009): 1478-1488.e8. Full Text Link to Item
  - Wang, MH, Palmeri, ML, Guy, CD, Yang, L, Hedlund, LW, Diehl, AM, and Nightingale, KR. "In vivo quantification of liver stiffness in a rat model of hepatic fibrosis with acoustic radiation force." Ultrasound Med Biol 35, no. 10 (October 2009): 1709-1721. Full Text Link to Item
  - David, K, Kowdley, KV, Unalp, A, Kanwal, F, Brunt, EM, Schwimmer, JB, and NASH CRN Research Group, . "Quality of life in adults with nonalcoholic fatty liver disease: baseline data from the nonalcoholic steatohepatitis clinical research network." Hepatology (Baltimore, Md.) 49, no. 6 (June 2009): 1904-1912. Full Text
  - Brunt, EM, Kleiner, DE, Wilson, LA, Unalp, A, Behling, CE, Lavine, JE, Neuschwander-Tetri, BA, and NASH Clinical Research NetworkA list of members of the Nonalcoholic Steatohepatitis Clinical Research Network can be found in the Appendix, . "Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network." Hepatology (Baltimore, Md.) 49, no. 3 (March 2009): 809-820. Full Text
  - Waugh, MS, Guy, CD, Maygarden, SJ, Livasy, CA, Jones, CK, and Volmar, KE. "Use of the ThinPrep method in bile duct brushings: analysis of morphologic parameters associated with malignancy and determination of interobserver reliability." Diagn Cytopathol 36, no. 9 (September 2008): 651-656. Full Text Link to Item
  - "Image of the month. Syphilitic proctitis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 6, no. 4 (April 1, 2008).
  - Teitelman, M, Wilson, JAP, and Guy, CD. "Image of the month. Syphilitic proctitis." Clin Gastroenterol Hepatol 6, no. 4 (April 2008): xxvi-. Full Text Link to Item
  - Teitelman, M, Wilson, JAP, and Guy, CD. "Syphilitic Proctitis." Clinical Gastroenterology and Hepatology 6, no. 4 (2008): A26-. Full Text
  - Wang, MH, Hedlund, LW, Palmeri, ML, Guy, CD, Yang, L, Diehl, AM, and Nightingale, KR. "In-vivo staging of liver fibrosis in a rat model using acoustic radiation force." Proceedings Ieee Ultrasonics Symposium (December 1, 2007): 562-565. Full Text
  - Guy, CD, Yuan, S, and Ballo, MS. "Spindle-cell lesions of the liver: diagnosis by fine-needle aspiration biopsy." Diagn Cytopathol 25, no. 2 (August 2001): 94-100. Link to Item
  - Cokgor, I, Akabani, G, Friedman, HS, Friedman, AH, Zalutsky, MR, Zehngebot, LM, Provenzale, JM, Guy, CD, Wikstrand, CJ, and Bigner, DD. "Long term response in a patient with neoplastic meningitis secondary to melanoma treated with (131)I-radiolabeled antichondroitin proteoglycan sulfate Mel-14 F(ab')(2): a case study." Cancer 91, no. 9 (May 2001): 1809-1813. Full Text
  - Guy, CD, and Jones, CK. "Abdominal fat pad aspiration biopsy for tissue confirmation of systemic amyloidosis: specificity, positive predictive value, and diagnostic pitfalls." Diagn Cytopathol 24, no. 3 (March 2001): 181-185. Link to Item
  - Ballo, MS, and Guy, CD. "Percutaneous fine-needle aspiration of gastrointestinal wall lesions with image guidance." Diagnostic Cytopathology 24, no. 1 (January 2001): 16-20. Full Text
  - Guy, CD, and Ballo, MS. "Fine needle aspiration biopsy of the liver." Adv Anat Pathol 6, no. 6 (November 1999): 303-316. (Review) Link to Item
  - Chung, CJ, Lorenzo, R, Rayder, S, Schemankewitz, E, Guy, CD, Cutting, J, and Munden, M. "Rhabdoid tumors of the kidney in children: CT findings." AJR Am J Roentgenol 164, no. 3 (March 1995): 697-700. Full Text Link to Item
- Conference Papers
  - Yang, JD, Abdelmalek, MF, Pang, H, Guy, CD, Smith, AD, Diehl, AM, and Suzuki, A. "Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis." April 2014. Full Text

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Education, Training, & Certifications

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Conference Papers