Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Medical University of South Carolina, College of Medicine 1993
  • B.A., University of North Carolina - Chapel Hill 1985
• 

  Previous Appointments & Affiliations

  • Professor of Pathology, Pathology, Clinical Science Departments 2017 - 2020
  • Associate Professor of Pathology, Pathology, Clinical Science Departments 2008 - 2017
  • Assistant Professor of Pathology, Pathology, Clinical Science Departments 2006 - 2008
  • Assistant Clinical Professor of Pathology, Pathology, Clinical Science Departments 2003 - 2006
  • Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2003
  • Clinical Associate in the Department of Pathology, Pathology, Clinical Science Departments 1999 - 2001
  • Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 1999
• Research
• 

  Selected Grants

  • Prediction and Prevention of Hepatic Decompensation in Patients with Cirrhosis awarded by National Institutes of Health 2021 - 2026
  • A multidisciplinary study of biological disparities in NASH progression and response to statins to inform personalized liver cancer chemoprevention in NAFLD awarded by Department of Defense 2020 - 2024
  • Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) awarded by National Institutes of Health 2004 - 2024
  • TAIWANJ JKB 121-001 awarded by TaiwanJ Pharmaceuticals Co. Ltd 2015 - 2020
  • Role of the Stroma in Fibrolamellar Hepatocellular Carcinoma awarded by Fibrolamellar Cancer Foundation 2016 - 2019
  • Targeting Calreticulin in Colorectal Cancer Liver Metastasis awarded by National Institutes of Health 2015 - 2017
  • Impact of Fructose on Metabolism, Energy Homeostasis and MR biomarkers in NAFLD awarded by National Institutes of Health 2012 - 2016
  • HBV Clinical Research Network Site Application_Subcontract to UNC awarded by University of North Carolina - Chapel Hill 2008 - 2015
  • Coherence Imaging for Assessing Colorectal Neoplasia awarded by National Institutes of Health 2009 - 2012
• 

  External Relationships

  • 89Bio Pharmaceuticals
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Harrison, Stephen A., Manal F. Abdelmalek, Guy Neff, Nadege Gunn, Cynthia D. Guy, Naim Alkhouri, Mustafa R. Bashir, et al. “Aldafermin in patients with non-alcoholic steatohepatitis (ALPINE 2/3): a randomised, double-blind, placebo-controlled, phase 2b trial.” Lancet Gastroenterol Hepatol 7, no. 7 (July 2022): 603–16. https://doi.org/10.1016/S2468-1253(22)00017-6.
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    • Brunt, Elizabeth M., Andrew D. Clouston, Zachary Goodman, Cynthia Guy, David E. Kleiner, Carolin Lackner, Dina G. Tiniakos, et al. “Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD.” J Hepatol 76, no. 5 (May 2022): 1030–41. https://doi.org/10.1016/j.jhep.2022.01.011.
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    • Glass, Oliver, Daniel Liu, Elizabeth Bechard, Cynthia D. Guy, Jane Pendergast, Anna Mae Diehl, and Manal F. Abdelmalek. “Perceptions of Exercise and Its Challenges in Patients With Nonalcoholic Fatty Liver Disease: A Survey-Based Study.” Hepatol Commun 6, no. 2 (February 2022): 334–44. https://doi.org/10.1002/hep4.1808.
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    • Shi, Chanjuan, Rachel Jug, Sarah M. Bean, William R. Jeck, and Cynthia D. Guy. “Primary hepatic neoplasms arising in cirrhotic livers can have a variable spectrum of neuroendocrine differentiation.” Hum Pathol 116 (October 2021): 63–72. https://doi.org/10.1016/j.humpath.2021.07.007.
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    • Alexopoulos, Anastasia-Stefania, Matthew J. Crowley, Ying Wang, Cynthia A. Moylan, Cynthia D. Guy, Ricardo Henao, Dawn L. Piercy, et al. “Glycemic Control Predicts Severity of Hepatocyte Ballooning and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease.” Hepatology 74, no. 3 (September 2021): 1220–33. https://doi.org/10.1002/hep.31806.
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    • Kesseli, Samuel J., Jared N. Gloria, Nader Abraham, Samantha E. Halpern, Greta N. Cywinska, Min Zhang, Dimitrios Moris, et al. “Point-of-Care Assessment of DCD Livers During Normothermic Machine Perfusion in a Nonhuman Primate Model.” Hepatol Commun 5, no. 9 (September 2021): 1527–42. https://doi.org/10.1002/hep4.1734.
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    • Allende, Daniela S., Samer Gawrieh, Oscar W. Cummings, Patricia Belt, Laura Wilson, Mark Van Natta, Cynthia A. Behling, et al. “Glycogenosis is common in nonalcoholic fatty liver disease and is independently associated with ballooning, but lower steatosis and lower fibrosis.” Liver Int 41, no. 5 (May 2021): 996–1011. https://doi.org/10.1111/liv.14773.
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    • Wegermann, Kara, Catherine Howe, Ricardo Henao, Ying Wang, Cynthia D. Guy, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia A. Moylan. “Serum Bile Acid, Vitamin E, and Serotonin Metabolites Are Associated With Future Liver-Related Events in Nonalcoholic Fatty Liver Disease.” Hepatol Commun 5, no. 4 (April 2021): 608–17. https://doi.org/10.1002/hep4.1665.
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    • Wegermann, Kara, Melanie E. Garrett, Jiayin Zheng, Andrea Coviello, Cynthia A. Moylan, Manal F. Abdelmalek, Shein-Chung Chow, et al. “Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD.” Hepatol Commun 5, no. 4 (April 2021): 598–607. https://doi.org/10.1002/hep4.1668.
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    • Canivet, Clemence M., Norma David, Helene Pailhoriès, Martial Briand, Cynthia D. Guy, Olivier Bouchez, Gilles Hunault, et al. “Cross-linkage between bacterial taxonomy and gene functions: a study of metagenome-assembled genomes of gut microbiota in adult non-alcoholic fatty liver disease.” Aliment Pharmacol Ther 53, no. 6 (March 2021): 722–32. https://doi.org/10.1111/apt.16262.
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    • Zhao, Lei, Liyan Xu, Amanda Hemmerich, N Lynn Ferguson, Cynthia D. Guy, Shannon J. McCall, Diana M. Cardona, et al. “Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.” Virchows Arch 478, no. 3 (March 2021): 427–34. https://doi.org/10.1007/s00428-020-02925-2.
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    • Vernuccio, Federica, Stephanie Austin, Mathias Meyer, Cynthia D. Guy, Priya S. Kishnani, and Daniele Marin. “"Bull's eye" appearance of hepatocellular adenomas in patients with glycogen storage disease type I - atypical magnetic resonance imaging findings: Two case reports.” World J Clin Cases 9, no. 4 (February 6, 2021): 871–77. https://doi.org/10.12998/wjcc.v9.i4.871.
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    • Harrison, Stephen A., Guy Neff, Cynthia D. Guy, Mustafa R. Bashir, Angelo H. Paredes, Juan P. Frias, Ziad Younes, et al. “Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis.” Gastroenterology 160, no. 1 (January 2021): 219-231.e1. https://doi.org/10.1053/j.gastro.2020.08.004.
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    • Loomba, Rohit, Brent A. Neuschwander-Tetri, Arun Sanyal, Naga Chalasani, Anna Mae Diehl, Norah Terrault, Kris Kowdley, et al. “Multicenter Validation of Association Between Decline in MRI-PDFF and Histologic Response in NASH.” Hepatology 72, no. 4 (October 2020): 1219–29. https://doi.org/10.1002/hep.31121.
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    • Torbenson, Michael, Saba Yasir, Robert Anders, Cynthia D. Guy, Hee Eun Lee, Sudhakar K. Venkatesh, Tsung-Teh Wu, and Zongming Eric Chen. “Regenerative hepatic pseudotumor: a new pseudotumor of the liver.” Hum Pathol 99 (May 2020): 43–52. https://doi.org/10.1016/j.humpath.2020.03.010.
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    • Harrison, Stephen A., Stephen J. Rossi, Angelo H. Paredes, James F. Trotter, Mustafa R. Bashir, Cynthia D. Guy, Rajarshi Banerjee, et al. “NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis.” Hepatology 71, no. 4 (April 2020): 1198–1212. https://doi.org/10.1002/hep.30590.
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    • Jewell, Mark L., Jason R. Gibson, Cynthia D. Guy, Jeongeun Hyun, Kuo Du, Seh-Hoon Oh, Richard T. Premont, et al. “Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma.” Am J Pathol 190, no. 1 (January 2020): 93–107. https://doi.org/10.1016/j.ajpath.2019.09.018.
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    • Siddiqui, Mohammad Shadab, Mark L. Van Natta, Margery A. Connelly, Raj Vuppalanchi, Brent A. Neuschwander-Tetri, James Tonascia, Cynthia Guy, et al. “Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis.” J Hepatol 72, no. 1 (January 2020): 25–33. https://doi.org/10.1016/j.jhep.2019.10.006.
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    • Gawrieh, Samer, Xiuqing Guo, Jingyi Tan, Marie Lauzon, Kent D. Taylor, Rohit Loomba, Oscar W. Cummings, et al. “A Pilot Genome-Wide Analysis Study Identifies Loci Associated With Response to Obeticholic Acid in Patients With NASH.” Hepatol Commun 3, no. 12 (December 2019): 1571–84. https://doi.org/10.1002/hep4.1439.
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    • Harrison, Stephen A., Mustafa R. Bashir, Cynthia D. Guy, Rong Zhou, Cynthia A. Moylan, Juan P. Frias, Naim Alkhouri, et al. “Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.” Lancet 394, no. 10213 (November 30, 2019): 2012–24. https://doi.org/10.1016/S0140-6736(19)32517-6.
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    • Kleiner, David E., Elizabeth M. Brunt, Laura A. Wilson, Cynthia Behling, Cynthia Guy, Melissa Contos, Oscar Cummings, et al. “Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease.” Jama Netw Open 2, no. 10 (October 2, 2019): e1912565. https://doi.org/10.1001/jamanetworkopen.2019.12565.
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    • Loomba, Rohit, Anjali Jain, Anna Mae Diehl, Cynthia D. Guy, Dana Portenier, Ranjan Sudan, Seema Singh, et al. “Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis.” Clin Gastroenterol Hepatol 17, no. 9 (August 2019): 1867-1876.e3. https://doi.org/10.1016/j.cgh.2018.11.004.
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    • Siddiqui, Mohammad Shadab, Goro Yamada, Raj Vuppalanchi, Mark Van Natta, Rohit Loomba, Cynthia Guy, Danielle Brandman, et al. “Diagnostic Accuracy of Noninvasive Fibrosis Models to Detect Change in Fibrosis Stage.” Clin Gastroenterol Hepatol 17, no. 9 (August 2019): 1877-1885.e5. https://doi.org/10.1016/j.cgh.2018.12.031.
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    • Hyun, Jeongeun, Seh-Hoon Oh, Richard T. Premont, Cynthia D. Guy, Carl L. Berg, and Anna Mae Diehl. “Dysregulated activation of fetal liver programme in acute liver failure.” Gut 68, no. 6 (June 2019): 1076–87. https://doi.org/10.1136/gutjnl-2018-317603.
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    • Corey, Kathleen E., Laura A. Wilson, Akif Altinbas, Katherine P. Yates, David E. Kleiner, Raymond T. Chung, Ronald M. Krauss, Naga Chalasani, and Naga NASH Clinical Research Network. “Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial.” Aliment Pharmacol Ther 49, no. 9 (May 2019): 1205–13. https://doi.org/10.1111/apt.15216.
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    • Dinh, Timothy A., Mark L. Jewell, Matt Kanke, Adam Francisco, Ramja Sritharan, Rigney E. Turnham, Seona Lee, et al. “MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma.” Cell Mol Gastroenterol Hepatol 7, no. 4 (2019): 803–17. https://doi.org/10.1016/j.jcmgh.2019.01.008.
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    • Xi, Rui, Preetish Kadur Lakshminarasimha Murthy, Kuei-Ling Tung, Cynthia D. Guy, Ji Wan, Feng Li, Zhuo Wang, et al. “SENP3-mediated host defense response contains HBV replication and restores protein synthesis.” Plos One 14, no. 1 (2019): e0209179. https://doi.org/10.1371/journal.pone.0209179.
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    • Glass, Oliver, Ricardo Henao, Keyur Patel, Cynthia D. Guy, Hans J. Gruss, Wing-Kin Syn, Cynthia A. Moylan, et al. “Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.” Hepatol Commun 2, no. 11 (November 2018): 1344–55. https://doi.org/10.1002/hep4.1237.
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    • Yang, Ju Dong, Manal F. Abdelmalek, Cynthia D. Guy, Anna Mae Diehl, and Ayako Suzuki. “Reply.” Clin Gastroenterol Hepatol 16, no. 10 (October 2018): 1684. https://doi.org/10.1016/j.cgh.2017.05.003.
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    • Kleinstein, Sarah E., Matthew Rein, Manal F. Abdelmalek, Cynthia D. Guy, David B. Goldstein, Anna Mae Diehl, and Cynthia A. Moylan. “Whole-Exome Sequencing Study of Extreme Phenotypes of NAFLD.” Hepatol Commun 2, no. 9 (September 2018): 1021–29. https://doi.org/10.1002/hep4.1227.
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    • Naggie, Susanna, Marzena Swiderska-Syn, Steve Choi, Sam Lusk, Audrey Lan, Guido Ferrari, Wing-Kin Syn, Cynthia D. Guy, and Anna Mae Diehl. “Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.” Open Forum Infect Dis 5, no. 7 (July 2018): ofy138. https://doi.org/10.1093/ofid/ofy138.
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    • Schild, Michael H., and Cynthia D. Guy. “Nonalcoholic Steatohepatitis: Histopathology Basics Within a Broader Context.” Surg Pathol Clin 11, no. 2 (June 2018): 267–85. https://doi.org/10.1016/j.path.2018.02.013.
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    • Hameed, B., N. A. Terrault, R. M. Gill, R. Loomba, N. Chalasani, J. H. Hoofnagle, M. L. Van Natta, and M. L. NASH CRN. “Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis.” Aliment Pharmacol Ther 47, no. 5 (March 2018): 645–56. https://doi.org/10.1111/apt.14492.
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    • Harrison, Grant, Amanda Hemmerich, Cynthia Guy, Kathryn Perkinson, Debra Fleming, Shannon McCall, Diana Cardona, and Xuefeng Zhang. “Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas.” Am J Clin Pathol 149, no. 1 (December 20, 2017): 67–75. https://doi.org/10.1093/ajcp/aqx142.
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    • Newton, Kimberly P., Haruna S. Feldman, Christina D. Chambers, Laura Wilson, Cynthia Behling, Jeanne M. Clark, Jean P. Molleston, et al. “Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children.” J Pediatr 187 (August 2017): 141-146.e1. https://doi.org/10.1016/j.jpeds.2017.03.007.
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    • Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Reply to Kim et al.” Am J Gastroenterol 112, no. 5 (May 2017): 807–8. https://doi.org/10.1038/ajg.2017.45.
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    • Yang, Ju Dong, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Joel E. Lavine, Katherine Yates, Jagpal Klair, et al. “Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis.” Clin Gastroenterol Hepatol 15, no. 1 (January 2017): 127-131.e2. https://doi.org/10.1016/j.cgh.2016.07.034.
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    • Nelson, J. E., P. Handa, B. Aouizerat, L. Wilson, L. A. Vemulakonda, M. M. Yeh, K. V. Kowdley, and K. V. NASH Clinical Research Network. “Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms.” Aliment Pharmacol Ther 44, no. 11–12 (December 2016): 1253–64. https://doi.org/10.1111/apt.13824.
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    • Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis.” Am J Gastroenterol 111, no. 11 (November 2016): 1591–98. https://doi.org/10.1038/ajg.2016.406.
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    • Klair, Jagpal Singh, Ju Dong Yang, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Katherine Yates, Aynur Unalp-Arida, et al. “A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease.” Hepatology 64, no. 1 (July 2016): 85–91. https://doi.org/10.1002/hep.28514.
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    • Ludmir, Ethan B., Shannon J. McCall, Diana M. Cardona, Kathryn R. Perkinson, Cynthia D. Guy, and Xuefeng Zhang. “Mixed Adenoneuroendocrine Carcinoma, Amphicrine Type, of the Small Bowel.” Am J Clin Pathol 145, no. 5 (May 2016): 703–9. https://doi.org/10.1093/ajcp/aqw028.
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    • Michelotti, Gregory A., Anikia Tucker, Marzena Swiderska-Syn, Mariana Verdelho Machado, Steve S. Choi, Leandi Kruger, Erik Soderblom, et al. “Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.” Gut 65, no. 4 (April 2016): 683–92. https://doi.org/10.1136/gutjnl-2014-308176.
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    • Boursier, Jérôme, Olaf Mueller, Matthieu Barret, Mariana Machado, Lionel Fizanne, Felix Araujo-Perez, Cynthia D. Guy, et al. “The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota.” Hepatology 63, no. 3 (March 2016): 764–75. https://doi.org/10.1002/hep.28356.
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    • Guy, Cynthia D., and Anna Mae Diehl. “Reply.” Hepatology 63, no. 3 (March 2016): 1057–58. https://doi.org/10.1002/hep.28011.
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    • Zhu, Ruixin, Susan S. Baker, Cynthia A. Moylan, Manal F. Abdelmalek, Cynthia D. Guy, Fausto Zamboni, Dingfeng Wu, et al. “Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers.” J Pathol 238, no. 4 (March 2016): 531–42. https://doi.org/10.1002/path.4650.
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    • Kim, Jieun, Sihyung Wang, Jeongeun Hyun, Cynthia D. Guy, and Youngmi Jung. “Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice.” Cell Physiol Biochem 40, no. 1–2 (2016): 263–76. https://doi.org/10.1159/000452543.
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    • Cheriyan, Danny, Cynthia Guy, and Rebecca Burbridge. “Giant esophageal lipoma: endoscopic resection.” Gastrointest Endosc 82, no. 4 (October 2015): 742. https://doi.org/10.1016/j.gie.2015.05.005.
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    • Machado, M. V., G. A. Michelotti, T de Almeida Pereira, J. Boursier, L. Kruger, M. Swiderska-Syn, G. Karaca, et al. “Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.” Gut 64, no. 7 (July 2015): 1148–57. https://doi.org/10.1136/gutjnl-2014-307362.
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    • Guy, Cynthia, Ayako Suzuki, Manal Abdelmalek, James Burchette, and Anna Mae Diehl. “Reply: To PMID 24849310.” Hepatology 61, no. 5 (May 2015): 1770–71. https://doi.org/10.1002/hep.27430.
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    • Yang, Ju Dong, Cynthia D. Guy, and Ayako Suzuki. “Reply: To PMID 24123276.” Hepatology (Baltimore, Md.) 61, no. 3 (March 2015): 1094. https://doi.org/10.1002/hep.27335.
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    • Karaca, Gamze, Guanhua Xie, Cynthia Moylan, Marzena Swiderska-Syn, Cynthia D. Guy, Leandi Krüger, Mariana Verdelho Machado, et al. “Role of Fn14 in acute alcoholic steatohepatitis in mice.” Am J Physiol Gastrointest Liver Physiol 308, no. 4 (February 15, 2015): G325–34. https://doi.org/10.1152/ajpgi.00429.2013.
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    • Machado, Mariana Verdelho, Gregory Alexander Michelotti, Guanhua Xie, Thiago Almeida Pereira, Jerome Boursier, Brittany Bohnic, Cynthia D. Guy, and Anna Mae Diehl. “Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.” Plos One 10, no. 5 (2015): e0127991. https://doi.org/10.1371/journal.pone.0127991.
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    • Nightingale, Kathryn R., Ned C. Rouze, Stephen J. Rosenzweig, Michael H. Wang, Manal F. Abdelmalek, Cynthia D. Guy, and Mark L. Palmeri. “Derivation and analysis of viscoelastic properties in human liver: impact of frequency on fibrosis and steatosis staging.” Ieee Trans Ultrason Ferroelectr Freq Control 62, no. 1 (January 2015): 165–75. https://doi.org/10.1109/TUFFC.2014.006653.
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    • Guy, Cynthia D., Ayako Suzuki, Manal F. Abdelmalek, James L. Burchette, Anna Mae Diehl, and Anna Mae NASH CRN. “Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity.” Hepatology 61, no. 1 (January 2015): 98–107. https://doi.org/10.1002/hep.27235.
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    • Machado, Mariana Verdelho, Gregory Alexander Michelotti, Guanhua Xie, Thiago Pereira de Almeida, Jerome Boursier, Brittany Bohnic, Cynthia D. Guy, and Anna Mae Diehl. “Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease.” Plos One 10, no. 6 (2015): e0132315. https://doi.org/10.1371/journal.pone.0132315.
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    • Bohinc, Brittany N., Gregory Michelotti, Guanhua Xie, Herbert Pang, Ayako Suzuki, Cynthia D. Guy, Dawn Piercy, et al. “Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism.” Endocrinology 155, no. 11 (November 2014): 4591–4601. https://doi.org/10.1210/en.2014-1302.
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    • Siddique, Asma, James E. Nelson, Bradley Aouizerat, Matthew M. Yeh, Kris V. Kowdley, and Kris V. NASH Clinical Research Network. “Iron deficiency in patients with nonalcoholic Fatty liver disease is associated with obesity, female gender, and low serum hepcidin.” Clin Gastroenterol Hepatol 12, no. 7 (July 2014): 1170–78. https://doi.org/10.1016/j.cgh.2013.11.017.
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    • Choi, Steve S., Lee C. Claridge, Ravi Jhaveri, Marzena Swiderska-Syn, Paul Clark, Ayako Suzuki, Thiago A. Pereira, et al. “Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication.” Clin Sci (Lond) 126, no. 12 (June 2014): 845–55. https://doi.org/10.1042/CS20130473.
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    • Chan, Isaac S., Cynthia D. Guy, Mariana V. Machado, Abigail Wank, Vishnu Kadiyala, Gregory Michelotti, Steve Choi, et al. “Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis.” Alcohol Clin Exp Res 38, no. 3 (March 2014): 787–800. https://doi.org/10.1111/acer.12279.
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    • Moylan, Cynthia A., Herbert Pang, Andrew Dellinger, Ayako Suzuki, Melanie E. Garrett, Cynthia D. Guy, Susan K. Murphy, et al. “Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.” Hepatology 59, no. 2 (February 2014): 471–82. https://doi.org/10.1002/hep.26661.
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    • Black, Tyler, Cynthia D. Guy, and Rebecca A. Burbridge. “Retroperitoneal cystic lymphangioma diagnosed by endoscopic ultrasound-guided fine needle aspiration.” Clin Endosc 46, no. 5 (September 2013): 595–97. https://doi.org/10.5946/ce.2013.46.5.595.
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    • Youssef, Nagy A., Manal F. Abdelmalek, Martin Binks, Cynthia D. Guy, Alessia Omenetti, Alastair D. Smith, Anna Mae E. Diehl, and Ayako Suzuki. “Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease.” Liver Int 33, no. 7 (August 2013): 1062–70. https://doi.org/10.1111/liv.12165.
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    • Swiderska-Syn, Marzena, Ayako Suzuki, Cynthia D. Guy, Jeffrey B. Schwimmer, Manal F. Abdelmalek, Joel E. Lavine, and Anna Mae Diehl. “Hedgehog pathway and pediatric nonalcoholic fatty liver disease.” Hepatology 57, no. 5 (May 2013): 1814–25. https://doi.org/10.1002/hep.26230.
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    • Corbin, Karen D., Manal F. Abdelmalek, Melanie D. Spencer, Kerry-Ann da Costa, Joseph A. Galanko, Wei Sha, Ayako Suzuki, et al. “Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.” Faseb J 27, no. 4 (April 2013): 1674–89. https://doi.org/10.1096/fj.12-219097.
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    • Chan, Isaac S., Cynthia D. Guy, Yuping Chen, Jiuyi Lu, Marzena Swiderska-Syn, Gregory A. Michelotti, Gamze Karaca, et al. “Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma.” Cancer Res 72, no. 24 (December 15, 2012): 6344–50. https://doi.org/10.1158/0008-5472.CAN-12-1068.
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    • Nelson, James E., Elizabeth M. Brunt, Kris V. Kowdley, and Kris V. Nonalcoholic Steatohepatitis Clinical Research Network. “Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations.” Hepatology 56, no. 5 (November 2012): 1730–40. https://doi.org/10.1002/hep.25856.
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    • Syn, Wing-Kin, Kolade M. Agboola, Marzena Swiderska, Gregory A. Michelotti, Evaggelia Liaskou, Herbert Pang, Guanhua Xie, et al. “NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease.” Gut 61, no. 9 (September 2012): 1323–29. https://doi.org/10.1136/gutjnl-2011-301857.
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    • Zagar, Timothy M., Rebekah R. White, Christopher G. Willett, Douglas S. Tyler, Paulie Papavassiliou, Katia T. Papalezova, Cynthia D. Guy, Gloria Broadwater, Robert W. Clough, and Brian G. Czito. “Resected pancreatic neuroendocrine tumors: patterns of failure and disease-related outcomes with or without radiotherapy.” Int J Radiat Oncol Biol Phys 83, no. 4 (July 15, 2012): 1126–31. https://doi.org/10.1016/j.ijrobp.2011.09.041.
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    • Suzuki, Ayako, Manal F. Abdelmalek, Jeffrey B. Schwimmer, Joel E. Lavine, Ann O. Scheimann, Aynur Unalp-Arida, Katherine P. Yates, et al. “Association between puberty and features of nonalcoholic fatty liver disease.” Clin Gastroenterol Hepatol 10, no. 7 (July 2012): 786–94. https://doi.org/10.1016/j.cgh.2012.01.020.
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    • Guy, Cynthia D., Ayako Suzuki, James L. Burchette, Elizabeth M. Brunt, Manal F. Abdelmalek, Diana Cardona, Shannon J. McCall, et al. “Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease.” Hum Pathol 43, no. 6 (June 2012): 790–800. https://doi.org/10.1016/j.humpath.2011.07.007.
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    • Guy, Cynthia D., Ayako Suzuki, Marzena Zdanowicz, Manal F. Abdelmalek, James Burchette, Aynur Unalp, Anna Mae Diehl, and Anna Mae NASH CRN. “Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease.” Hepatology 55, no. 6 (June 2012): 1711–21. https://doi.org/10.1002/hep.25559.
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    • Levine, Edward A., Dan G. Blazer, Mickey K. Kim, Perry Shen, John H. Stewart, Cynthia Guy, and David S. Hsu. “Gene expression profiling of peritoneal metastases from appendiceal and colon cancer demonstrates unique biologic signatures and predicts patient outcomes.” J Am Coll Surg 214, no. 4 (April 2012): 599–606. https://doi.org/10.1016/j.jamcollsurg.2011.12.028.
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    • Vos, Miriam B., Ryan Colvin, Patricia Belt, Jean P. Molleston, Karen F. Murray, Philip Rosenthal, Jeffrey B. Schwimmer, et al. “Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD.” J Pediatr Gastroenterol Nutr 54, no. 1 (January 2012): 90–96. https://doi.org/10.1097/MPG.0b013e318229da1a.
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    • Tillmann, Hans L., Keyur Patel, Andrew J. Muir, Cynthia D. Guy, Josephine H. Li, Xiang Qian Lao, Alexander Thompson, et al. “Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C.” J Hepatol 55, no. 6 (December 2011): 1195–1200. https://doi.org/10.1016/j.jhep.2011.03.015.
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    • Terry, Neil, Yizheng Zhu, Julie K. M. Thacker, John Migaly, Cynthia Guy, Christopher R. Mantyh, and Adam Wax. “Detection of intestinal dysplasia using angle-resolved low coherence interferometry.” J Biomed Opt 16, no. 10 (October 2011): 106002. https://doi.org/10.1117/1.3631799.
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    • Palmeri, Mark L., Michael H. Wang, Ned C. Rouze, Manal F. Abdelmalek, Cynthia D. Guy, Barry Moser, Anna Mae Diehl, and Kathryn R. Nightingale. “Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease.” J Hepatol 55, no. 3 (September 2011): 666–72. https://doi.org/10.1016/j.jhep.2010.12.019.
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    • Rangwala, Fatima, Cynthia D. Guy, Jiuyi Lu, Ayako Suzuki, James L. Burchette, Manal F. Abdelmalek, Wei Chen, and Anna Mae Diehl. “Increased production of sonic hedgehog by ballooned hepatocytes.” J Pathol 224, no. 3 (July 2011): 401–10. https://doi.org/10.1002/path.2888.
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    • Omenetti, Alessia, Lee M. Bass, Robert A. Anders, Maria G. Clemente, Heather Francis, Cynthia D. Guy, Shannon McCall, et al. “Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia.” Hepatology 53, no. 4 (April 2011): 1246–58. https://doi.org/10.1002/hep.24156.
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    • Speliotes, Elizabeth K., Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Cameron D. Palmer, Vilmundur Gudnason, et al. “Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.” Plos Genet 7, no. 3 (March 2011): e1001324. https://doi.org/10.1371/journal.pgen.1001324.
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    • Omenetti, Alessia, Liu Yang, Raul R. Gainetdinov, Cynthia D. Guy, Steve S. Choi, Wei Chen, Marc G. Caron, and Anna Mae Diehl. “Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults.” Am J Physiol Gastrointest Liver Physiol 300, no. 2 (February 2011): G303–15. https://doi.org/10.1152/ajpgi.00368.2010.
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    • Philips, George M., Isaac S. Chan, Marzena Swiderska, Vanessa T. Schroder, Cynthia Guy, Gamze F. Karaca, Cynthia Moylan, et al. “Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.” Plos One 6, no. 9 (2011): e23943. https://doi.org/10.1371/journal.pone.0023943.
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    • Syn, Wing-Kin, Steve S. Choi, Evaggelia Liaskou, Gamze F. Karaca, Kolade M. Agboola, Ye Htun Oo, Zhiyong Mi, et al. “Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.” Hepatology 53, no. 1 (January 2011): 106–15. https://doi.org/10.1002/hep.23998.
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    • Suzuki, Ayako, Manal F. Abdelmalek, Aynur Unalp-Arida, Katherine Yates, Arun Sanyal, Cynthia Guy, and Anna Mae Diehl. “Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease.” Clin Gastroenterol Hepatol 8, no. 12 (December 2010): 1062–69. https://doi.org/10.1016/j.cgh.2010.08.005.
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    • Abdelmalek, Manal F., Ayako Suzuki, Cynthia Guy, Aynur Unalp-Arida, Ryan Colvin, Richard J. Johnson, Anna Mae Diehl, and Anna Mae Nonalcoholic Steatohepatitis Clinical Research Network. “Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease.” Hepatology 51, no. 6 (June 2010): 1961–71. https://doi.org/10.1002/hep.23535.
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    • Syn, Wing-Kin, Ye Htun Oo, Thiago A. Pereira, Gamze F. Karaca, Youngmi Jung, Alessia Omenetti, Rafal P. Witek, et al. “Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease.” Hepatology 51, no. 6 (June 2010): 1998–2007. https://doi.org/10.1002/hep.23599.
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    • Jung, Youngmi, Rafal P. Witek, Wing-Kin Syn, Steve S. Choi, Alessia Omenetti, Richard Premont, Cynthia D. Guy, and Anna Mae Diehl. “Signals from dying hepatocytes trigger growth of liver progenitors.” Gut 59, no. 5 (May 2010): 655–65. https://doi.org/10.1136/gut.2009.204354.
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    • Lavine, Joel E., Jeffrey B. Schwimmer, Jean P. Molleston, Ann O. Scheimann, Karen F. Murray, Stephanie H. Abrams, Philip Rosenthal, et al. “Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.” Contemp Clin Trials 31, no. 1 (January 2010): 62–70. https://doi.org/10.1016/j.cct.2009.09.001.
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    • Witek, Rafal P., W Carl Stone, F Gamze Karaca, Wing-Kin Syn, Thiago A. Pereira, Kolade M. Agboola, Alessia Omenetti, et al. “Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis.” Hepatology 50, no. 5 (November 2009): 1421–30. https://doi.org/10.1002/hep.23167.
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    • Wang, Michael H., Mark L. Palmeri, Cynthia D. Guy, Liu Yang, Laurence W. Hedlund, Anna Mae Diehl, and Kathryn R. Nightingale. “In vivo quantification of liver stiffness in a rat model of hepatic fibrosis with acoustic radiation force.” Ultrasound Med Biol 35, no. 10 (October 2009): 1709–21. https://doi.org/10.1016/j.ultrasmedbio.2009.04.019.
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    • Shah, Amy G., Alison Lydecker, Karen Murray, Brent N. Tetri, Melissa J. Contos, Arun J. Sanyal, and Arun J. Nash Clinical Research Network. “Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease.” Clin Gastroenterol Hepatol 7, no. 10 (October 2009): 1104–12. https://doi.org/10.1016/j.cgh.2009.05.033.
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    • Syn, Wing-Kin, Youngmi Jung, Alessia Omenetti, Manal Abdelmalek, Cynthia D. Guy, Liu Yang, Jiangbo Wang, et al. “Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.” Gastroenterology 137, no. 4 (October 2009): 1478-1488.e8. https://doi.org/10.1053/j.gastro.2009.06.051.
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    • David, Kristin, Kris V. Kowdley, Aynur Unalp, Fasiha Kanwal, Elizabeth M. Brunt, Jeffrey B. Schwimmer, and Jeffrey B. NASH CRN Research Group. “Quality of life in adults with nonalcoholic fatty liver disease: baseline data from the nonalcoholic steatohepatitis clinical research network.” Hepatology 49, no. 6 (June 2009): 1904–12. https://doi.org/10.1002/hep.22868.
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    • Brunt, Elizabeth M., David E. Kleiner, Laura A. Wilson, Aynur Unalp, Cynthia E. Behling, Joel E. Lavine, Brent A. Neuschwander-Tetri, and Brent A. NASH Clinical Research NetworkA list of members of the Nonalcoholic Steatohepatitis Clinical Research Network can be found in the Appendix. “Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network.” Hepatology 49, no. 3 (March 2009): 809–20. https://doi.org/10.1002/hep.22724.
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    • Waugh, Michael S., Cynthia D. Guy, Susan J. Maygarden, Chad A. Livasy, Claudia K. Jones, and Keith E. Volmar. “Use of the ThinPrep method in bile duct brushings: analysis of morphologic parameters associated with malignancy and determination of interobserver reliability.” Diagn Cytopathol 36, no. 9 (September 2008): 651–56. https://doi.org/10.1002/dc.20855.
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    • Teitelman, Melissa, Joanne A. P. Wilson, and Cynthia D. Guy. “Image of the month. Syphilitic proctitis.” Clin Gastroenterol Hepatol 6, no. 4 (April 2008): xxvi. https://doi.org/10.1016/j.cgh.2007.12.031.
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    • “Image of the month. Syphilitic proctitis.” Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association 6, no. 4 (April 1, 2008).
    • Wang, M. H., L. W. Hedlund, M. L. Palmeri, C. D. Guy, L. Yang, A. M. Diehl, and K. R. Nightingale. “In-vivo staging of liver fibrosis in a rat model using acoustic radiation force.” Proceedings  Ieee Ultrasonics Symposium, December 1, 2007, 562–65. https://doi.org/10.1109/ULTSYM.2007.146.
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    • Guy, C. D., S. Yuan, and M. S. Ballo. “Spindle-cell lesions of the liver: diagnosis by fine-needle aspiration biopsy.” Diagn Cytopathol 25, no. 2 (August 2001): 94–100. https://doi.org/10.1002/dc.2011.
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    • Cokgor, I., G. Akabani, H. S. Friedman, A. H. Friedman, M. R. Zalutsky, L. M. Zehngebot, J. M. Provenzale, C. D. Guy, C. J. Wikstrand, and D. D. Bigner. “Long term response in a patient with neoplastic meningitis secondary to melanoma treated with (131)I-radiolabeled antichondroitin proteoglycan sulfate Mel-14 F(ab')(2): a case study.” Cancer 91, no. 9 (May 1, 2001): 1809–13.
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    • Guy, C. D., and C. K. Jones. “Abdominal fat pad aspiration biopsy for tissue confirmation of systemic amyloidosis: specificity, positive predictive value, and diagnostic pitfalls.” Diagn Cytopathol 24, no. 3 (March 2001): 181–85. https://doi.org/10.1002/1097-0339(200103)24:3<181::aid-dc1037>3.0.co;2-d.
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    • Ballo, M. S., and C. D. Guy. “Percutaneous fine-needle aspiration of gastrointestinal wall lesions with image guidance.” Diagn Cytopathol 24, no. 1 (January 2001): 16–20. https://doi.org/10.1002/1097-0339(200101)24:1<16::aid-dc1002>3.0.co;2-t.
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    • Guy, C. D., and M. S. Ballo. “Fine needle aspiration biopsy of the liver.” Adv Anat Pathol 6, no. 6 (November 1999): 303–16. https://doi.org/10.1097/00125480-199911000-00001.
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    • Chung, C. J., R. Lorenzo, S. Rayder, E. Schemankewitz, C. D. Guy, J. Cutting, and M. Munden. “Rhabdoid tumors of the kidney in children: CT findings.” Ajr Am J Roentgenol 164, no. 3 (March 1995): 697–700. https://doi.org/10.2214/ajr.164.3.7863897.
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  • Conference Papers

    • Yang, Ju Dong, Manal F. Abdelmalek, Herbert Pang, Cynthia D. Guy, Alastair D. Smith, Anna Mae Diehl, and Ayako Suzuki. “Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis.” In Hepatology, 59:1406–14, 2014. https://doi.org/10.1002/hep.26761.
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