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Cynthia Dianne Guy

Professor of Pathology
Pathology
Duke Box 3712, Durham, NC 27710
206 A Davison Bldg, Durham, NC

Overview


My research interests include:
Fine Needle Aspiration of Liver, Gastrointestinal Tract, and Pancreatic Lesions
Biliary Duct Brushings
Nonalcoholic Fatty Liver Disease/NASH
Liver Fibrogenesis

Current Appointments & Affiliations


Professor of Pathology · 2021 - Present Pathology, Clinical Science Departments
Professor of Medicine · 2020 - Present Medicine, Gastroenterology, Medicine

Recent Publications


Consensus position statements for the standardized application of histological grading and staging systems in MASH clinical trials.

Journal Article J Hepatol · October 8, 2025 BACKGROUND & AIMS: Assessment of histologic disease activity (grading) and fibrosis (staging) is a prerequisite for patient selection and evaluation of treatment response in clinical trials of metabolic dysfunction-associated steatohepatitis (MASH). The la ... Full text Link to item Cite

Clinical associations of portal-based disease in MASLD: proposal of a new histological scoring system.

Journal Article Virchows Arch · August 2025 Portal inflammation (PI) and ductular reaction (DR) in metabolic dysfunction-associated steatotic liver disease (MASLD) have shown associations with disease severity. We developed a histologic categorization of these features to correlate with known featur ... Full text Link to item Cite

Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage.

Journal Article Toxins (Basel) · January 24, 2025 Anthrax represents a disease resulting from infection by toxin-secreting bacteria, Bacillus anthracis. This research aimed to identify new therapeutic targets to combat anthrax. We performed assays to assess cell viability, apoptosis, glycogen consumption, ... Full text Link to item Cite
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Recent Grants


Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)

ResearchPathologist · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2004 - 2027

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Education, Training & Certifications


Medical University of South Carolina, College of Medicine · 1993 M.D.
University of North Carolina, Chapel Hill · 1985 B.A.