Cynthia Ann Moylan | Scholars@Duke

Cynthia Ann Moylan
Associate Professor of Medicine

My research interests focus on the study of chronic liver disease and primary liver cancer, particularly from nonalcoholic fatty liver disease (NAFLD). As part of the NAFLD Research Team at Duke, I am investigating the role of epigenetics and genetics on the development of advanced fibrosis from NAFLD. The long term goal of our research is to develop non-invasive biomarkers to identify those patients at increased risk for cirrhosis and end stage liver disease in order to risk stratify patients as well as to develop better preventative and therapeutic strategies.

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2018
Associate Professor in Pathology, Pathology, Clinical Science Departments 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2014

Contact Information

905 S Lasalle St, Gsrb1, DUMC 3256, Durham, NC 27710
Duke Box 3256, 595 Lasalle GSRB 1, Durham, NC 27710
cynthia.moylan@duke.edu (919) 668-0401

Background
Education, Training, & Certifications
- Fellow in Gastroenterology, Medicine, Duke University 2005 - 2009
- Resident, Medicine, Duke University 2002 - 2005
- M.D., University of Miami 2002
Duke Appointment History
- Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2009 - 2018
Recognition
Awards & Honors
- Tyor Award. Division of Gastroenterology. 2017
Research
Selected Grants
- Hepatocellular Carcinoma, Epigenetics and Cadmium Exposure awarded by North Carolina State University 2019 - 2021
- Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease awarded by American Association for the Study of Liver Diseases 2018 - 2020
- Epigenetics and the Development of Nonalcoholic Fatty Liver Disease awarded by American College of Gastroenterology 2015 - 2019
- Role of the Stroma in Fibrolamellar Hepatocellular Carcinoma 2016 - 2019
- Lumena PSC 2014 - 2017
- Characterizing Alcohol's Effects on Repair of Liver Injury awarded by National Institutes of Health 2009 - 2012
External Relationships
- Gerson Lehrman Group
- Gilead Sciences, Inc.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Henson, Jacqueline B., Julius M. Wilder, Matthew R. Kappus, Andrew S. Barbas, Cynthia A. Moylan, Donna Niedzwiecki, Andrew J. Muir, Carl L. Berg, and Yuval A. Patel. “Transplant Outcomes in Older Patients With Nonalcoholic Steatohepatitis Compared to Alcohol-related Liver Disease and Hepatitis C.” Transplantation 104, no. 6 (June 2020): e164–73. https://doi.org/10.1097/TP.0000000000003219.
    Full Text Link to Item
  - Du, Kuo, Satish K. Chitneni, Ayako Suzuki, Ying Wang, Ricardo Henao, Jeongeun Hyun, Richard T. Premont, et al. “Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression.” Cell Mol Gastroenterol Hepatol 10, no. 1 (2020): 1–21. https://doi.org/10.1016/j.jcmgh.2019.12.006.
    Full Text Link to Item
  - Harrison, Stephen A., Mustafa R. Bashir, Cynthia D. Guy, Rong Zhou, Cynthia A. Moylan, Juan P. Frias, Naim Alkhouri, et al. “Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.” Lancet 394, no. 10213 (November 30, 2019): 2012–24. https://doi.org/10.1016/S0140-6736(19)32517-6.
    Full Text Link to Item
  - Wilder, Julius, Steve S. Choi, and Cynthia A. Moylan. “Evaluation for Fibrosis After Cure of Hepatitis C-Reply.” Jama 321, no. 15 (April 16, 2019): 1535. https://doi.org/10.1001/jama.2019.0873.
    Full Text Link to Item
  - Oloruntoba, Omobonike O., and Cynthia A. Moylan. “"Too Female" for Liver Transplantation.” Hepatology 68, no. 6 (December 2018): 2424–25. https://doi.org/10.1002/hep.30053.
    Full Text Link to Item
  - Wilder, Julius, Steve S. Choi, and Cynthia A. Moylan. “Vibration-Controlled Transient Elastography for Diagnosing Cirrhosis and Staging Hepatic Fibrosis.” Jama 320, no. 19 (November 20, 2018): 2031–32. https://doi.org/10.1001/jama.2018.13073.
    Full Text Link to Item
  - Glass, Oliver, Ricardo Henao, Keyur Patel, Cynthia D. Guy, Hans J. Gruss, Wing-Kin Syn, Cynthia A. Moylan, et al. “Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.” Hepatol Commun 2, no. 11 (November 2018): 1344–55. https://doi.org/10.1002/hep4.1237.
    Full Text Link to Item
  - Wildman-Tobriner, Benjamin, Michael M. Middleton, Cynthia A. Moylan, Stephen Rossi, Omar Flores, Zac Anchi Chang, Manal F. Abdelmalek, Claude B. Sirlin, and Mustafa R. Bashir. “Association Between Magnetic Resonance Imaging-Proton Density Fat Fraction and Liver Histology Features in Patients With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis.” Gastroenterology 155, no. 5 (November 2018): 1428-1435.e2. https://doi.org/10.1053/j.gastro.2018.07.018.
    Full Text Link to Item
  - Moylan, Cynthia A., and Manal F. Abdelmalek. “Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis.” Hepatology 68, no. 4 (October 2018): 1646–48. https://doi.org/10.1002/hep.29879.
    Full Text Link to Item
  - Patel, Yuval A., Elizabeth J. Gifford, Lisa M. Glass, Marsha J. Turner, Byungjoo Han, Cynthia A. Moylan, Steve Choi, Ayako Suzuki, Dawn Provenzale, and Christine M. Hunt. “Correction to: Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration.” Dig Dis Sci 63, no. 10 (October 2018): 2813–14. https://doi.org/10.1007/s10620-018-5213-2.
    Full Text Open Access Copy Link to Item
  - Kleinstein, Sarah E., Matthew Rein, Manal F. Abdelmalek, Cynthia D. Guy, David B. Goldstein, Anna Mae Diehl, and Cynthia A. Moylan. “Whole-Exome Sequencing Study of Extreme Phenotypes of NAFLD.” Hepatol Commun 2, no. 9 (September 2018): 1021–29. https://doi.org/10.1002/hep4.1227.
    Full Text Link to Item
  - Patel, Yuval A., Elizabeth J. Gifford, Lisa M. Glass, Marsha J. Turner, Byungjoo Han, Cynthia A. Moylan, Steve Choi, Ayako Suzuki, Dawn Provenzale, and Christine M. Hunt. “Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration.” Dig Dis Sci 63, no. 9 (September 2018): 2259–66. https://doi.org/10.1007/s10620-018-5123-3.
    Full Text Link to Item
  - Wegermann, Kara, Anna Mae Diehl, and Cynthia A. Moylan. “Disease pathways and molecular mechanisms of nonalcoholic steatohepatitis.” Clin Liver Dis (Hoboken) 11, no. 4 (April 2018): 87–91. https://doi.org/10.1002/cld.709.
    Full Text Link to Item
  - Patel, Y. A., E. J. Gifford, L. M. Glass, R. McNeil, M. J. Turner, B. Han, D. Provenzale, S. S. Choi, C. A. Moylan, and C. M. Hunt. “Risk factors for biopsy-proven advanced non-alcoholic fatty liver disease in the Veterans Health Administration.” Aliment Pharmacol Ther 47, no. 2 (January 2018): 268–78. https://doi.org/10.1111/apt.14411.
    Full Text Link to Item
  - Wegermann, Kara, Ricardo Henao, Anna Mae Diehl, Susan K. Murphy, Manal F. Abdelmalek, and Cynthia A. Moylan. “Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study.” Plos One 13, no. 9 (2018): e0204308. https://doi.org/10.1371/journal.pone.0204308.
    Full Text Link to Item
  - Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Reply to Kim et al.” Am J Gastroenterol 112, no. 5 (May 2017): 807–8. https://doi.org/10.1038/ajg.2017.45.
    Full Text Link to Item
  - Mwinyi, Jessica, Adrian E. Boström, Claudia Pisanu, Susan K. Murphy, Wiebke Erhart, Clemens Schafmayer, Jochen Hampe, Cynthia Moylan, and Helgi B. Schiöth. “NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition.” Biochim Biophys Acta Mol Cell Biol Lipids 1862, no. 3 (March 2017): 314–23. https://doi.org/10.1016/j.bbalip.2016.12.005.
    Full Text Link to Item
  - Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis.” Am J Gastroenterol 111, no. 11 (November 2016): 1591–98. https://doi.org/10.1038/ajg.2016.406.
    Full Text Link to Item
  - Wilder, Julius M., Omobonike O. Oloruntoba, Andrew J. Muir, and Cynthia A. Moylan. “Role of patient factors, preferences, and distrust in health care and access to liver transplantation and organ donation.” Liver Transpl 22, no. 7 (July 2016): 895–905. https://doi.org/10.1002/lt.24452.
    Full Text Open Access Copy Link to Item
  - Schiöth, Helgi B., Adrian Boström, Susan K. Murphy, Wiebke Erhart, Jochen Hampe, Cynthia Moylan, and Jessica Mwinyi. “A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease.” Bmc Genomics 17 (June 14, 2016): 462. https://doi.org/10.1186/s12864-016-2814-z.
    Full Text Link to Item
  - Hunt, Christine M., Lauren A. Beste, Elliott Lowy, Ayako Suzuki, Cynthia A. Moylan, Hans L. Tillmann, George N. Ioannou, Joseph K. Lim, Michael J. Kelley, and Dawn Provenzale. “Veterans health administration hepatitis B testing and treatment with anti-CD20 antibody administration.” World J Gastroenterol 22, no. 19 (May 21, 2016): 4732–40. https://doi.org/10.3748/wjg.v22.i19.4732.
    Full Text Open Access Copy Link to Item
  - Patel, Yuval A., Carl L. Berg, and Cynthia A. Moylan. “Nonalcoholic Fatty Liver Disease: Key Considerations Before and After Liver Transplantation.” Dig Dis Sci 61, no. 5 (May 2016): 1406–16. https://doi.org/10.1007/s10620-016-4035-3.
    Full Text Link to Item
  - Michelotti, Gregory A., Anikia Tucker, Marzena Swiderska-Syn, Mariana Verdelho Machado, Steve S. Choi, Leandi Kruger, Erik Soderblom, et al. “Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.” Gut 65, no. 4 (April 2016): 683–92. https://doi.org/10.1136/gutjnl-2014-308176.
    Full Text Open Access Copy Link to Item
  - Michelotti, Gregory A., Anikia Tucker, Marzena Swiderska-Syn, Mariana Verdelho Machado, Steve S. Choi, Leandi Kruger, Erik Soderblom, et al. “Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.” Gut 65, no. 4 (April 2016): 683–92. https://doi.org/10.1136/gutjnl-2014-308176.
    Full Text Link to Item
  - Zhu, Ruixin, Susan S. Baker, Cynthia A. Moylan, Manal F. Abdelmalek, Cynthia D. Guy, Fausto Zamboni, Dingfeng Wu, et al. “Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers.” J Pathol 238, no. 4 (March 2016): 531–42. https://doi.org/10.1002/path.4650.
    Full Text Link to Item
  - Machado, Mariana Verdelho, Leandi Kruger, Mark L. Jewell, Gregory Alexander Michelotti, Thiago de Almeida Pereira, Guanhua Xie, Cynthia A. Moylan, and Anna Mae Diehl. “Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model.” Dig Dis Sci 61, no. 1 (January 2016): 137–48. https://doi.org/10.1007/s10620-015-3871-x.
    Full Text Link to Item
  - Oloruntoba, Omobonike O., and Cynthia A. Moylan. “Gender-based disparities in access to and outcomes of liver transplantation.” World J Hepatol 7, no. 3 (March 27, 2015): 460–67. https://doi.org/10.4254/wjh.v7.i3.460.
    Full Text Link to Item
  - Karaca, Gamze, Guanhua Xie, Cynthia Moylan, Marzena Swiderska-Syn, Cynthia D. Guy, Leandi Krüger, Mariana Verdelho Machado, et al. “Role of Fn14 in acute alcoholic steatohepatitis in mice.” Am J Physiol Gastrointest Liver Physiol 308, no. 4 (February 15, 2015): G325–34. https://doi.org/10.1152/ajpgi.00429.2013.
    Full Text Link to Item
  - Moylan, Cynthia A., Herbert Pang, Gregory Michelotti, and Anna Mae Diehl. “Reply: To PMID 23913408.” Hepatology 60, no. 4 (October 2014): 1445–46. https://doi.org/10.1002/hep.27038.
    Full Text Link to Item
  - Moylan, Cynthia A., Herbert Pang, Andrew Dellinger, Ayako Suzuki, Melanie E. Garrett, Cynthia D. Guy, Susan K. Murphy, et al. “Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.” Hepatology 59, no. 2 (February 2014): 471–82. https://doi.org/10.1002/hep.26661.
    Full Text Link to Item
  - Murphy, Susan K., Hyuna Yang, Cynthia A. Moylan, Herbert Pang, Andrew Dellinger, Manal F. Abdelmalek, Melanie E. Garrett, et al. “Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.” Gastroenterology 145, no. 5 (November 2013): 1076–87. https://doi.org/10.1053/j.gastro.2013.07.047.
    Full Text Link to Item
  - Garrett, Melanie E., Manal F. Abdelmalek, Allison Ashley-Koch, Michael A. Hauser, Cynthia A. Moylan, Herbert Pang, Anna Mae Diehl, and Hans L. Tillmann. “IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients.” J Hepatol 58, no. 2 (February 2013): 402–3. https://doi.org/10.1016/j.jhep.2012.09.035.
    Full Text Link to Item
  - Chen, Yuping, Steve S. Choi, Gregory A. Michelotti, Isaac S. Chan, Marzena Swiderska-Syn, Gamze F. Karaca, Guanhua Xie, et al. “Hedgehog controls hepatic stellate cell fate by regulating metabolism.” Gastroenterology 143, no. 5 (November 2012): 1319-1329.e11. https://doi.org/10.1053/j.gastro.2012.07.115.
    Full Text Link to Item
  - Moylan, Cynthia A., Ayako Suzuki, Julie I. Papay, Nancy A. Yuen, Michael Ames, and Christine M. Hunt. “A pre-marketing ALT signal predicts post-marketing liver safety.” Regul Toxicol Pharmacol 63, no. 3 (August 2012): 433–39. https://doi.org/10.1016/j.yrtph.2012.05.016.
    Full Text Link to Item
  - Thiele, Robert H., Jason Williams, Cynthia A. Moylan, Sunil V. Rao, and Elliott Bennett-Guerrero. “CASE 6--2012: suspected amiodarone hepatotoxicity after cardiac surgery.” J Cardiothorac Vasc Anesth 26, no. 4 (August 2012): 729–32. https://doi.org/10.1053/j.jvca.2012.02.002.
    Full Text Link to Item
  - Acharya, Chaitanya R., David S. Hsu, Carey K. Anders, Ariel Anguiano, Kelly H. Salter, Kelli S. Walters, Richard C. Redman, et al. “Retraction: Acharya CR, et al. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer. JAMA. 2008;299(13):1574-1587.” Jama 307, no. 5 (February 1, 2012): 453. https://doi.org/10.1001/jama.2012.2.
    Full Text Link to Item
  - Philips, George M., Isaac S. Chan, Marzena Swiderska, Vanessa T. Schroder, Cynthia Guy, Gamze F. Karaca, Cynthia Moylan, et al. “Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.” Plos One 6, no. 9 (2011): e23943. https://doi.org/10.1371/journal.pone.0023943.
    Full Text Open Access Copy Link to Item
  - Syn, Wing-Kin, Steve S. Choi, Evaggelia Liaskou, Gamze F. Karaca, Kolade M. Agboola, Ye Htun Oo, Zhiyong Mi, et al. “Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.” Hepatology 53, no. 1 (January 2011): 106–15. https://doi.org/10.1002/hep.23998.
    Full Text Link to Item
  - Pereira, Thiago de Almeida, Rafal P. Witek, Wing-Kin Syn, Steve S. Choi, Shelton Bradrick, Gamze F. Karaca, Kolade M. Agboola, et al. “Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma.” Lab Invest 90, no. 12 (December 2010): 1690–1703. https://doi.org/10.1038/labinvest.2010.147.
    Full Text Open Access Copy Link to Item
  - Choi, Steve S., Wing-Kin Syn, Gamze F. Karaca, Alessia Omenetti, Cynthia A. Moylan, Rafal P. Witek, Kolade M. Agboola, Youngmi Jung, Gregory A. Michelotti, and Anna Mae Diehl. “Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway.” J Biol Chem 285, no. 47 (November 19, 2010): 36551–60. https://doi.org/10.1074/jbc.M110.168542.
    Full Text Link to Item
  - Choi, Steve S., Rafal P. Witek, Liu Yang, Alessia Omenetti, Wing-Kin Syn, Cynthia A. Moylan, Youngmi Jung, et al. “Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells.” Hepatology 52, no. 1 (July 2010): 278–90. https://doi.org/10.1002/hep.23649.
    Full Text Link to Item
  - Choi, Steve S., Alessia Omenetti, Rafal P. Witek, Cynthia A. Moylan, Wing-Kin Syn, Youngmi Jung, Liu Yang, et al. “Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.” Am J Physiol Gastrointest Liver Physiol 297, no. 6 (December 2009): G1093–1106. https://doi.org/10.1152/ajpgi.00292.2009.
    Full Text Link to Item
  - Moylan, Cynthia A., Carla W. Brady, Jeffrey L. Johnson, Alastair D. Smith, Janet E. Tuttle-Newhall, and Andrew J. Muir. “Disparities in liver transplantation before and after introduction of the MELD score.” Jama 300, no. 20 (November 26, 2008): 2371–78. https://doi.org/10.1001/jama.2008.720.
    Full Text Link to Item
  - Herrenkohl, Todd I., Cynthia Sousa, Emiko A. Tajima, Roy C. Herrenkohl, and Carrie A. Moylan. “Intersection of child abuse and children's exposure to domestic violence.” Trauma Violence Abuse 9, no. 2 (April 2008): 84–99. https://doi.org/10.1177/1524838008314797.
    Full Text Link to Item
  - Morpeth, S. C., J. A. Crump, H. J. Shao, H. O. Ramadhani, P. R. Kisenge, C. A. Moylan, S. Naggie, et al. “Predicting CD4 lymphocyte count.” Aids Research and Human Retroviruses 23, no. 10 (October 2007): 1230–36.
  - Morpeth, Susan C., John A. Crump, Humphrey J. Shao, Habib O. Ramadhani, Peter R. Kisenge, Cindy A. Moylan, Susanna Naggie, et al. “Predicting CD4 lymphocyte count <200 cells/mm(3) in an HIV type 1-infected African population.” Aids Res Hum Retroviruses 23, no. 10 (October 2007): 1230–36. https://doi.org/10.1089/aid.2007.0053.
    Full Text Link to Item
  - Moylan, Cynthia A., and Andrew J. Muir. “Treatment of hepatitis C in special populations.” Clin Liver Dis 9, no. 4 (November 2005): 567–v. https://doi.org/10.1016/j.cld.2005.07.005.
    Full Text Link to Item
  - “Liver Transplantation for Nonalcoholic Fatty Liver Disease: Role of Bariatric Surgery for Comorbid Obesity.” Journal of Advanced Nutrition and Human Metabolism, n.d. https://doi.org/10.14800/janhm.1327.
    Full Text
- Book Sections
  - Moylan, C. A., and S. K. Murphy. “DNA Methylation: Basic Principles.” In Medical Epigenetics, 11–31, 2016. https://doi.org/10.1016/B978-0-12-803239-8.00002-8.
    Full Text
- Conference Papers
  - Benhammou, Jihane N., Joseph Pisegna, Feng Su, Philip Vutien, Cynthia A. Moylan, and George Ioannou. “THE ASSOCIATION BETWEEN OBESITY OR DIABETES AND LIVER DISEASE PROGRESSION AFTER ANTIVIRAL TREATMENT FOR HEPATITIS C.” In Hepatology, 70:179A-180A. WILEY, 2019.
    Link to Item
  - Bowlus, Christopher L., Bertus Eksteen, Angela Cheung, Douglas Thorburn, Cynthia A. Moylan, Paul J. Pockros, Lisa Forman, et al. “SAFETY AND EFFICACY OF MARALIXIBAT IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: AN OPEN-LABEL PROOF-OF-CONCEPT STUDY.” In Hepatology, 70:764A-765A. WILEY, 2019.
    Link to Item
  - Moylan, Cynthia A., Kuo Du, Jeongeun Hyun, Kara Wegermann, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia D. Guy. “EXPRESSION OF BRANCHED CHAIN AMINO ACID TRANSAMINASE 1 (BCAT1) IS INCREASED IN NAFLD FIBROSIS AND CIRRHOSIS AND HEPATOCELLULAR CARCINOMA.” In Hepatology, 70:1335A-1336A. WILEY, 2019.
    Link to Item
  - Wegermann, Kara, Catherine Howe, Ricardo Henao, Ying Wang, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “PRIMARY BILE ACID AND BRANCHED CHAIN AMINO ACID METABOLITES ASSOCIATE WITH DIASTOLIC HEART FAILURE IN NON-ALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 70:1039A-1039A. WILEY, 2019.
    Link to Item
  - Lee, Tzu-Hao, Austin Chan, William E. Bryan, Lawrence Park, Mohamed Hashem, Mary Townsend, Cynthia A. Moylan, Rachel B. Britt, Steve S. Choi, and Susanna Naggie. “USAGE OF PPI REDUCES THE SVR RATE FOR HIV-HCV COINFECTED PATIENTS USING LEDIPASVIR/SOFOSBUVIR: A REAL-WORLD STUDY FROM MULTICENTER VA COHORT.” In Gastroenterology, 156:S1345–S1345. W B SAUNDERS CO-ELSEVIER INC, 2019.
    Link to Item
  - Moylan, Cynthia A., Carole Grenier, Jeongeun Hyun, Kuo Du, Ricardo Henao, Manal F. Abdelmalek, Susan K. Murphy, and Anna Mae Diehl. “DYSREGULATED DNA METHYLATION OF FGFR2, CASP1, AND BCAT1 ASSOCIATES WITH NONALCOHOLIC FATTY LIVER DISEASE SEVERITY AND CAN BE IDENTIFIED IN PERIPHERAL BLOOD.” In Gastroenterology, 156:S1360–61. W B SAUNDERS CO-ELSEVIER INC, 2019.
    Link to Item
  - Wegermann, Kara, Catherine Howe, Ricardo Henao, Ying Wang, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “BRANCHED CHAIN AMINO ACID AND BILE ACID METABOLITES ASSOCIATE WITH FUTURE CLINICAL DECOMPENSATION IN NONALCOHOLIC FATTY LIVER DISEASE.” In Gastroenterology, 156:S1223–S1223. W B SAUNDERS CO-ELSEVIER INC, 2019.
    Link to Item
  - Chaudhry, Mohammad, Cynthia A. Moylan, Michael S. Middleton, Alfredo Farjat, Kingshuk Roy Chaudhury, Cynthia D. Guy, Manal F. Abdelmalek, Rohit Loomba, Claude B. Sirlin, and Mustafa Bashir. “Quantifying the Placebo Effect on Liver Fat Using Magnetic Resonance Imaging-Proton Density Fat Fraction in NAFLD Clinical Trials.” In Hepatology, 68:68A-68A. WILEY, 2018.
    Link to Item
  - Harrison, Stephen A., Cynthia D. Guy, Mustafa Bashir, Juan Pablo Frias, Naim Alkhouri, Seth Baum, Rebecca A. Taub, et al. “In a Placebo-Controlled 36-Week Phase 2 Trial, Treatment with Mgl-3196 Compared to Placebo Results in Significant Reductions in Hepatic Fat (MRI-PDFF), Liver Enzymes, Fibrosis Biomarkers, Atherogenic Lipids, and Improvement in Nash on Serial Liver Biopsy.” In Hepatology, 68:9A-10A. WILEY, 2018.
    Link to Item
  - Moylan, Cynthia A., Patricia A. Sorrow, Alisha Mavis, Mustafa Bashir, Dereje Jima, Rachel Maguire, Erol Bozdogan, et al. “Obesity and Nonalcoholic Fatty Liver Disease in Childhood Associate with Altered DNA Methylation in Early Life.” In Hepatology, 68:949A-950A. WILEY, 2018.
    Link to Item
  - Patel, Yuval, Jacqueline Henson, Julius Wilder, Matthew R. Kappus, Andrew S. Barbas, Cynthia A. Moylan, Donna Niedzwiecki, Andrew Joseph Muir, and Carl L. Berg. “The Impact of Advanced Age on Waiting List and Post-Transplantation Outcomes for NAFLD Patients.” In Hepatology, 68:683A-683A. WILEY, 2018.
    Link to Item
  - Bae, Andrew, Ricardo Henao, Ayako Suzuki, Cynthia A. Moylan, Cynthia D. Guy, Anna Mae Diehl, and Manal F. Abdelmalek. “STATIN USE AND LIVER INJURY IN NONALCOHOLIC FATTY LIVER DISEASE: RESULTS OF A PAIRED CLINICAL AND GENE EXPRESSION PROFILE ANALYSIS.” In Gastroenterology, 154:S1085–86. W B SAUNDERS CO-ELSEVIER INC, 2018.
    Link to Item
  - Du, Kuo, Richard Premont, Jeongeun Hyun, Mariana V. Machado, Cynthia A. Moylan, Manal F. Abdelmalek, Cynthia D. Guy, and Anna Mae Diehl. “PATHPHYSIOLOGICAL ROLE OF GLUTAMINOLYSIS IN HUMAN NAFLD PROGRESSION.” In Gastroenterology, 154:S950–51. W B SAUNDERS CO-ELSEVIER INC, 2018.
    Link to Item
  - Li, Xiaoyi, Cynthia A. Moylan, Susan S. Baker, Wensheng Liu, Robert D. Baker, Susan K. Murphy, Manal F. Abdelmalek, Ruixin Zhu, Anna Mae Diehl, and Lixin Zhu. “Altered liver methylome and transcriptome provide evidence for epigenetic contribution to NAFLD pathogenesis.” In Hepatology, 66:1071A-1072A. WILEY, 2017.
    Link to Item
  - Moylan, Cynthia A., Alisha M. Mavis, Mustafa R. Bashir, David Malik, Erol Bozdogan, Stephanie Buie, Cathrine Hoyo, Anna Mae Diehl, Susan K. Murphy, and Manal F. Abdelmalek. “Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children.” In Hepatology, 66:665A-665A. WILEY, 2017.
    Link to Item
  - Patel, Yuval A., Elizabeth Gifford, Lisa M. Glass, Rebecca McNeil, Marsha J. Turner, Byungjoo Han, Dawn T. Provenzale, Steve S. Choi, Cynthia A. Moylan, and Christine M. Hunt. “Diet/exercise programs are used by only one in five severely obese patients with biopsy-defined Nonalcoholic Fatty Liver Disease (NAFLD) advanced fibrosis in the Veterans Health Administration (VHA).” In Hepatology, 66:1164A-1164A. WILEY, 2017.
    Link to Item
  - Wegermann, Kara, Cynthia A. Moylan, Jiayin Zheng, Manal F. Abdelmalek, Shein-Chung Chow, Cynthia D. Guy, Anna Mae Diehl, and Ayako Suzuki. “Gender and menopause significantly modify effects of metabolism-related SNPs on fibrosis stage in adult patients with nonalcoholic fatty liver disease (NAFLD).” In Hepatology, 66:55A-55A. WILEY, 2017.
    Link to Item
  - Moylan, Cynthia A., Ricardo Henao Giraldo, Susan K. Murphy, Anna Mae Diehl, and Manal F. Abdelmalek. “Differential DNA Methylation in Whole Blood Reflects that in Liver and Distinguishes Patients with Advanced NAFLD Fibrosis from Those with Normal Histology: A Potential Non-Invasive Tool.” In Gastroenterology, 152:S1069–70. Elsevier BV, 2017. https://doi.org/10.1016/s0016-5085(17)33611-9.
    Full Text
  - Moylan, Cynthia A., Kara J. Wegermann, Ricardo G. Henao, Susan K. Murphy, Anna Mae Diehl, and Manal F. Abdelmalek. “BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study.” In American Journal of Gastroenterology, 111:S381–S381. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.14309/00000434-201610001-00871.
    Full Text
  - Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated with Histologic Severity in NAFLD: Results of a Paired Clinical and Hepatic Gene Expression Profile Analysis.” In Hepatology, 64:577A-577A. WILEY, 2016.
    Link to Item
  - Suzuki, Ayako, Horace J. Spencer, Cynthia A. Moylan, Jonathan A. Dranoff, Manal F. Abdelmalek, Cynthia D. Guy, and Anna Mae Diehl. “Hepatic estrogen transcriptional activity and estrogen receptor a gene expression are negatively correlated with fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD).” In Hepatology, 64:105A-105A. WILEY, 2016.
    Link to Item
  - Wegermann, Kara, Ricardo Henao, Yiping Pan, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “BCAT1 is Associated with Clinical Decompensation in NAFLD: A Pilot Study.” In Hepatology, 64:577A-577A. WILEY, 2016.
    Link to Item
  - Henao, Ricardo, Nigar Hasanaliyeva, Lauren N. Bell, Jacob Wulff, Regis Perichon, Cynthia A. Moylan, James T. Lu, Cynthia D. Guy, Anna Mae Diehl, and Manal F. Abdelmalek. “Plasma Metabolomic Profiles Predict Advanced Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:290A-291A. WILEY-BLACKWELL, 2015.
    Link to Item
  - Hunt, Christine M., Lauren A. Beste, George N. Ioannou, Elliott Lowy, Dawn T. Provenzale, Michael J. Kelley, Ayako Suzuki, et al. “Hepatitis B Testing Prior to Administration of Rituximab, Ofatumumab and Obinutuzumab in the National Veterans Affairs Health Healthcare System, 2002-2014.” In Hepatology, 62:478A-479A. WILEY-BLACKWELL, 2015.
    Link to Item
  - Moylan, Cynthia A., Susan K. Murphy, Carole Grenier, Manal F. Abdelmalek, and Anna Mae Diehl. “DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:648A-649A. WILEY-BLACKWELL, 2015.
    Link to Item
  - Rabatin, Abigail, Mohamed Hashem, Mary L. Townsend, William E. Bryan, Cynthia A. Moylan, Steve S. Choi, and Susanna Naggie. “Treatment Outcomes of Veterans with Decompensated Cirrhosis Receiving All Oral Direct Acting Antiviral Hepatitis C Therapy.” In Hepatology, 62:773A-773A. WILEY-BLACKWELL, 2015.
    Link to Item
  - Zhu, Ruixin, Susan S. Baker, Cynthia A. Moylan, Manal F. Abdelmalek, Cynthia D. Guy, Fausto Zamboni, Dingfeng Wu, et al. “Systematic Analysis of NAFLD Transcriptome Revealed Elevated Expression of Alcohol Metabolizing Genes in Mild and Severe NAFLD Livers.” In Gastroenterology, 148:S1054–S1054. W B SAUNDERS CO-ELSEVIER INC, 2015.
    Link to Item
  - Naqvi, Ibtehaj A., Rebekah R. White, Cynthia A. Moylan, Anna Mae Diehl, and Steve S. Choi. “Abstract 4117: Utilizing RNA aptamers for biomarker discovery in a novel cell culture system for hepatocellular carcinoma.” In Prevention Research. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-4117.
    Full Text
  - Moylan, Cynthia A., Kouros Owzar, Andrew J. Muir, Francois Cauchy, Jacques Belghiti, Anna Mae Diehl, and Valerie Paradis. “Gene Expression and Pathway Analyses Reveal Distinctions Between Hepatocellular Carcinoma Arising in Fibrotic and Non-Fibrotic Nonalcoholic Fatty Liver Disease.” In Gastroenterology, 146:S998–99. W B SAUNDERS CO-ELSEVIER INC, 2014.
    Link to Item
  - Oloruntoba, Omobonike O., Julius M. Wilder, Alastair D. Smith, Andrew J. Muir, and Cynthia A. Moylan. “The Influence of Race on Patient Preferences and Access to Orthotopic Liver Transplantation and Organ Donation.” In Hepatology, 60:963A-963A. WILEY-BLACKWELL, 2014.
    Link to Item
  - Urban, Thomas J., Cynthia A. Moylan, Matthew Rein, Manal F. Abdelmalek, David B. Goldstein, and Anna Mae Diehl. “Whole Exome Sequencing of Extreme Phenotypes of NAFLD Identifies Potential Genetic Risk Factors for Advanced Hepatic Fibrosis.” In Hepatology, 60:744A-744A. WILEY-BLACKWELL, 2014.
    Link to Item
  - Chen, Yuping, Gregory A. Michelotti, Guanhua Xie, Cynthia A. Moylan, and Anna Mae Diehl. “Hedgehog-Induced Serine Biogenesis is Required for Activation of Hepatic Stellate Cells.” In Hepatology, 58:572A-572A. WILEY-BLACKWELL, 2013.
    Link to Item
  - Garrett, Melanie E., Cynthia A. Moylan, Jason Gibson, Hyuna Yang, Herbert Pang, Andrew Dellinger, Ayako Suzuki, et al. “Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease.” In Hepatology, 56:267A-268A. WILEY-BLACKWELL, 2012.
    Link to Item
  - Moylan, Cynthia A., Hyuna Yang, Herbert Pang, Andrew Dellinger, Ayako Suzuki, Hans L. Tillmann, Cynthia D. Guy, et al. “Epigenetic Regulation of Gene Expression in NAFLD.” In Gastroenterology, 142:S929–S929. W B SAUNDERS CO-ELSEVIER INC, 2012.
    Link to Item
  - Chan, Isaac S., George M. Philips, Marzena Zdanowicz, Vanessa Teaberry, Gamze Karaca, Fatima Rangwala, Cynthia D. Guy, et al. “HEDGEHOG PATHWAY INHIBITION BY GDC-0449 CAUSES REGRESSION OF HEPATOCELLULAR CARCINOMAS AND IMPROVES LIVER FIBROSIS IN MDR2-DEFICIENT MICE.” In Hepatology, 54:1278A-1278A. WILEY-BLACKWELL, 2011.
    Link to Item
  - Chen, Yuping, Steve S. Choi, Gregory A. Michelotti, Cynthia A. Moylan, Gamze Karaca, Marzena Zdanowicz, Guanhua Xie, Leandi Kruger, and Anna Mae Diehl. “TRANSITION OF QUIESCENT STELLATE CELLS INTO MYOFIBROBLASTS REQUIRES HEDGEHOG-MEDIATED INDUCTION OF GLYCOLYSIS.” In Hepatology, 54:422A-422A. WILEY-BLACKWELL, 2011.
    Link to Item
  - Philips, George M., Isaac S. Chan, Steve S. Choi, Guanhua Xie, Gregory A. Michelotti, Marzena Zdanowicz, Vanessa Teaberry, et al. “HEDGEHOG PATHWAY INHIBITION INDUCES HCC TUMOR NECROSIS BY REPRESSING EXPRESSION OF ANGIOPOIETIN-2 AND ITS COGNATE RECEPTOR, TIE-2.” In Hepatology, 54:1280A-1280A. WILEY-BLACKWELL, 2011.
    Link to Item
  - Moylan, Cynthia A., Andrew Dellinger, Herbert Pang, Ayako Suzuki, Hans L. Tillmann, Daniel Hampton, Yuping Chen, et al. “Modest Alcohol Consumption Attenuates Expression of Fibrosis-Associated Genes in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD).” In Gastroenterology, 140:S914–15. W B SAUNDERS CO-ELSEVIER INC, 2011.
    Link to Item
  - Tillmann, Hans L., Herbert Pang, Andrew Dellinger, Ayako Suzuki, Cynthia D. Guy, Cynthia A. Moylan, Dawn Piercy, et al. “Coffee's Beneficial Effect on Liver Disease Confirmed in NASH Cohort, but Only Partially Confirmation of In Vitro Pre-Described Differentially Expressed Genes in This Patient Cohort.” In Gastroenterology, 140:S987–S987, 2011.
    Link to Item
  - Tillmann, H., A. Suzuki, H. Pang, A. Dellinger, C. D. Guy, C. A. Moylan, D. Piercy, et al. “869 COFFEE CONSUMPTION INCREASES HEPATIC EXPRESSION OF CYTOCHROME P450S AND SIGNIFICANTLY REDUCES LIVER FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE (NAFLD).” In Journal of Hepatology, 54:S346–47. Elsevier BV, 2011. https://doi.org/10.1016/s0168-8278(11)60871-4.
    Full Text
  - Choi, Steve S., Thiago A. Pereira, Wing-Kin Syn, Kolade M. Agboola, Cynthia A. Moylan, Alessia Omenetti, Gamze F. Karaca, Fatima Rangwala, Ravi Jhaveri, and Anna Mae Diehl. “CO-CULTURE OF LIVER EPITHELIAL CELLS STABLY TRANSFECTED WITH HEPATITIS B VIRUS X PROTEIN PROMOTES MYOFIBROBLASTIC ACTIVATION AND ACCUMULATION VIA A HEDGEHOG-MEDIATED PROCESS IN RAT HEPATIC STELLATE CELLS.” In Hepatology, 52:977A-978A. WILEY-BLACKWELL, 2010.
    Link to Item
  - Forssen, Ulla, Monica Kobayashi, Cynthia A. Moylan, Christina M. Ludema, and Dickens Theodore. “NASH INCREASES THE RISK OF PORTAL VEIN THROMBOSIS IN PATIENTS ON THE LIVER TRANSPLANT WAITING LIST.” In Hepatology, 52:911A-911A. WILEY-BLACKWELL, 2010.
    Link to Item
  - Moylan, Cynthia A., Manal F. Abdelmalek, Herbert Pang, Andrew Dellinger, Steve S. Choi, Alessia Omenetti, Yuping Chen, et al. “SIGNALS FROM THE FIBROTIC LIVER IN PATIENTS WITH NAFLD MAY PROMOTE DIABETES AND OBESITY.” In Hepatology, 52:1049A-1050A. WILEY-BLACKWELL, 2010.
    Link to Item
  - Moylan, Cynthia A., Steve S. Choi, Andrew Dellinger, Herbert Pang, Manal F. Abdelmalek, Daniel Hampton, Yuping Chen, et al. “CONSERVED GENE EXPRESSION PATTERNS IN MYOFIBROBLASTIC MURINE AND HUMAN HEPATIC STELLATE CELLS AND NAFLD PATIENTS WITH LIVER FIBROSIS COMPATIBLE WITH EPITHELIAL-TO-MESENCHYMAL LIKE TRANSITION.” In Hepatology, 52:1286A-1287A. WILEY-BLACKWELL, 2010.
    Link to Item
  - Syn, Wing-Kin, Steve S. Choi, Evaggelia Liaskou, Gamze F. Karaca, Ye H. Oo, Thiago A. Pereira, Syamal D. Bhattacharya, et al. “OSTEOPONTIN PROMOTES NONALCOHOLIC FATTY LIVER DISEASE PROGRESSION.” In Hepatology, 52:350A-351A. WILEY-BLACKWELL, 2010.
    Link to Item
  - Moylan, Cynthia A., Steve S. Choi, Chaitanya R. Acharya, Wing-Kin Syn, Alessia Omenetti, Youngmi Jung, Debra L. Sudan, Andrew J. Muir, Anil Potti, and Anna Mae Diehl. “Gene Expression Profiles During Activation of Human Hepatic Stellate Cells Suggest an Epithelial-to-Mesenchymal Transition-Like Process.” In Gastroenterology, 138:S838–S838. W B SAUNDERS CO-ELSEVIER INC, 2010.
    Link to Item
  - Moylan, Cynthia A., Steve S. Choi, Chaitanya R. Acharya, Kelly Salter, Andrew J. Muir, Anil Potti, and Anna Mae Diehl. “GENE EXPRESSION PROFILES COUPLED WITH SIGNATURES OF ONCOGENIC PATHWAY DYSREGULATION PROVIDE A RATIONAL APPROACH TO DISSECTING THE MOLECULAR HETEROGENEITY OF HEPATOCELLULAR CARCINOMA.” In Hepatology, 48:1120A-1120A. JOHN WILEY & SONS INC, 2008.
    Link to Item
  - Robertson, Katina D., Cynthia A. Moylan, Carla W. Brady, and Andrew J. Muir. “Factors Influencing Participation in Hepatitis C Research Trials.” In American Journal of Gastroenterology, 102:S224–S224. Ovid Technologies (Wolters Kluwer Health), 2007. https://doi.org/10.14309/00000434-200709002-00296.
    Full Text

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Awards & Honors

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers