Cynthia Ann Moylan | Scholars@Duke

Cynthia Ann Moylan
Associate Professor of Medicine

My research interests focus on the study of chronic liver disease and primary liver cancer, particularly from nonalcoholic fatty liver disease (NAFLD). As part of the NAFLD Research Team at Duke, I am investigating the role of epigenetics and genetics on the development of advanced fibrosis from NAFLD. The long term goal of our research is to develop non-invasive biomarkers to identify those patients at increased risk for cirrhosis and end stage liver disease in order to risk stratify patients as well as to develop better preventative and therapeutic strategies.

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2018
Assoicate Professor in Pathology, Pathology, Clinical Science Departments 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2014

Contact Information

905 S Lasalle St, Gsrb1, DUMC 3256, Durham, NC 27710
Duke Box 3256, 595 Lasalle GSRB 1, Durham, NC 27710
cynthia.moylan@duke.edu (919) 668-0401

Background
Education, Training, & Certifications
- Fellow in Gastroenterology, Medicine, Duke University 2005 - 2009
- Resident, Medicine, Duke University 2002 - 2005
- M.D., University of Miami 2002
Duke Appointment History
- Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2009 - 2018
Recognition
Awards & Honors
- Tyor Award. Division of Gastroenterology. 2017
Research
Selected Grants
- Duke Training Grant in Digestive Diseases and Nutrition awarded by National Institutes of Health 1988 - 2021
- Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease awarded by American Association for the Study of Liver Diseases 2018 - 2019
- Epigenetics and the Development of Nonalcoholic Fatty Liver Disease awarded by American College of Gastroenterology 2015 - 2019
- Role of the Stroma in Fibrolamellar Hepatocellular Carcinoma awarded by Fibrolamellar Cancer Foundation 2016 - 2018
- Lumena PSC awarded by Lumena Pharmaceuticals, Inc. 2014 - 2017
- Characterizing Alcohol's Effects on Repair of Liver Injury awarded by National Institutes of Health 2009 - 2012
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Oloruntoba, OO, and Moylan, CA. ""Too Female" for Liver Transplantation." Hepatology (Baltimore, Md.) 68, no. 6 (December 2018): 2424-2425. Full Text
  - Glass, O, Henao, R, Patel, K, Guy, CD, Gruss, HJ, Syn, W-K, Moylan, CA, Streilein, R, Hall, R, Mae Diehl, A, and Abdelmalek, MF. "Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease." Hepatology Communications 2, no. 11 (November 2018): 1344-1355. Full Text
  - Wilder, J, Choi, SS, and Moylan, CA. "Vibration-Controlled Transient Elastography for Diagnosing Cirrhosis and Staging Hepatic Fibrosis." Jama 320, no. 19 (November 2018): 2031-2032. Full Text
  - Wildman-Tobriner, B, Middleton, MM, Moylan, CA, Rossi, S, Flores, O, Chang, ZA, Abdelmalek, MF, Sirlin, CB, and Bashir, MR. "Association Between Magnetic Resonance Imaging-Proton Density Fat Fraction and Liver Histology Features in Patients With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis." Gastroenterology 155, no. 5 (November 2018): 1428-1435.e2. Full Text
  - Moylan, CA, and Abdelmalek, MF. "Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis." Hepatology (Baltimore, Md.) 68, no. 4 (October 2018): 1646-1648. Full Text
  - Patel, YA, Gifford, EJ, Glass, LM, Turner, MJ, Han, B, Moylan, CA, Choi, S, Suzuki, A, Provenzale, D, and Hunt, CM. "Correction to: Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration." Digestive Diseases and Sciences 63, no. 10 (October 2018): 2813-2814. Full Text Open Access Copy
  - Kleinstein, SE, Rein, M, Abdelmalek, MF, Guy, CD, Goldstein, DB, Mae Diehl, A, and Moylan, CA. "Whole-Exome Sequencing Study of Extreme Phenotypes of NAFLD." Hepatology Communications 2, no. 9 (September 5, 2018): 1021-1029. Full Text
  - Patel, YA, Gifford, EJ, Glass, LM, Turner, MJ, Han, B, Moylan, CA, Choi, S, Suzuki, A, Provenzale, D, and Hunt, CM. "Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration." Digestive Diseases and Sciences 63, no. 9 (September 2018): 2259-2266. Full Text
  - Wegermann, K, Diehl, AM, and Moylan, CA. "Disease pathways and molecular mechanisms of nonalcoholic steatohepatitis." Clinical Liver Disease 11, no. 4 (April 2018): 87-91. Full Text
  - Patel, YA, Gifford, EJ, Glass, LM, McNeil, R, Turner, MJ, Han, B, Provenzale, D, Choi, SS, Moylan, CA, and Hunt, CM. "Risk factors for biopsy-proven advanced non-alcoholic fatty liver disease in the Veterans Health Administration." Alimentary Pharmacology & Therapeutics 47, no. 2 (January 2018): 268-278. Full Text
  - Wegermann, K, Henao, R, Diehl, AM, Murphy, SK, Abdelmalek, MF, and Moylan, CA. "Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study." Plos One 13, no. 9 (January 2018): e0204308-null. Full Text
  - Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Reply to Kim et al." The American Journal of Gastroenterology 112, no. 5 (May 2017): 807-808. Full Text
  - Mwinyi, J, Boström, AE, Pisanu, C, Murphy, SK, Erhart, W, Schafmayer, C, Hampe, J, Moylan, C, and Schiöth, HB. "NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition." Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids 1862, no. 3 (March 2017): 314-323. Full Text
  - Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis." The American Journal of Gastroenterology 111, no. 11 (November 2016): 1591-1598. Full Text
  - Wilder, JM, Oloruntoba, OO, Muir, AJ, and Moylan, CA. "Role of patient factors, preferences, and distrust in health care and access to liver transplantation and organ donation." Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 22, no. 7 (July 2016): 895-905. Full Text Open Access Copy
  - Patel, YA, Berg, CL, and Moylan, CA. "Liver Transplantation for Nonalcoholic Fatty Liver Disease: Role of Bariatric Surgery for Comorbid Obesity." Journal of Advanced Nutrition and Human Metabolism (June 23, 2016). Full Text
  - Schiöth, HB, Boström, A, Murphy, SK, Erhart, W, Hampe, J, Moylan, C, and Mwinyi, J. "A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease." BMC genomics 17 (June 14, 2016): 462-. Full Text
  - Hunt, CM, Beste, LA, Lowy, E, Suzuki, A, Moylan, CA, Tillmann, HL, Ioannou, GN, Lim, JK, Kelley, MJ, and Provenzale, D. "Veterans health administration hepatitis B testing and treatment with anti-CD20 antibody administration." World Journal of Gastroenterology 22, no. 19 (May 2016): 4732-4740. Full Text Open Access Copy
  - Patel, YA, Berg, CL, and Moylan, CA. "Nonalcoholic Fatty Liver Disease: Key Considerations Before and After Liver Transplantation." Digestive Diseases and Sciences 61, no. 5 (May 2016): 1406-1416. (Review) Full Text
  - Michelotti, GA, Tucker, A, Swiderska-Syn, M, Machado, MV, Choi, SS, Kruger, L, Soderblom, E, Thompson, JW, Mayer-Salman, M, Himburg, HA, Moylan, CA, Guy, CD, Garman, KS, Premont, RT, Chute, JP, and Diehl, AM. "Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches." Gut 65, no. 4 (April 2016): 683-692. Full Text Open Access Copy
  - Michelotti, GA, Tucker, A, Swiderska-Syn, M, Machado, MV, Choi, SS, Kruger, L, Soderblom, E, Thompson, JW, Mayer-Salman, M, Himburg, HA, Moylan, CA, Guy, CD, Garman, KS, Premont, RT, Chute, JP, and Diehl, AM. "Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches." GUT 65, no. 4 (April 2016): 683-692. Full Text Link to Item
  - Zhu, R, Baker, SS, Moylan, CA, Abdelmalek, MF, Guy, CD, Zamboni, F, Wu, D, Lin, W, Liu, W, Baker, RD, Govindarajan, S, Cao, Z, Farci, P, Diehl, AM, and Zhu, L. "Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers." The Journal of Pathology 238, no. 4 (March 2016): 531-542. Full Text
  - Machado, MV, Kruger, L, Jewell, ML, Michelotti, GA, Pereira, TDA, Xie, G, Moylan, CA, and Diehl, AM. "Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model." Digestive diseases and sciences 61, no. 1 (January 2016): 137-148. Full Text
  - Oloruntoba, OO, and Moylan, CA. "Gender-based disparities in access to and outcomes of liver transplantation." World journal of hepatology 7, no. 3 (March 2015): 460-467. (Review) Full Text
  - Karaca, G, Xie, G, Moylan, C, Swiderska-Syn, M, Guy, CD, Krüger, L, Machado, MV, Choi, SS, Michelotti, GA, Burkly, LC, and Diehl, AM. "Role of Fn14 in acute alcoholic steatohepatitis in mice." American Journal of Physiology. Gastrointestinal and Liver Physiology 308, no. 4 (February 2015): G325-G334. Full Text
  - Moylan, CA, Pang, H, Michelotti, G, and Diehl, AM. "Reply: To PMID 23913408." Hepatology (Baltimore, Md.) 60, no. 4 (October 2014): 1445-1446. (Letter) Full Text
  - Moylan, CA, Pang, H, Dellinger, A, Suzuki, A, Garrett, ME, Guy, CD, Murphy, SK, Ashley-Koch, AE, Choi, SS, Michelotti, GA, Hampton, DD, Chen, Y, Tillmann, HL, Hauser, MA, Abdelmalek, MF, and Diehl, AM. "Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease." Hepatology 59, no. 2 (February 2014): 471-482. Full Text Link to Item
  - Moylan, CA, Pang, H, Michelotti, G, and Diehl, AM. "Reply." Hepatology 60, no. 4 (January 1, 2014): 1445-1446. (Letter) Full Text
  - Murphy, SK, Yang, H, Moylan, CA, Pang, H, Dellinger, A, Abdelmalek, MF, Garrett, ME, Ashley-Koch, A, Suzuki, A, Tillmann, HL, Hauser, MA, and Diehl, AM. "Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease." Gastroenterology 145, no. 5 (November 2013): 1076-1087. Full Text Link to Item
  - Garrett, ME, Abdelmalek, MF, Ashley-Koch, A, Hauser, MA, Moylan, CA, Pang, H, Diehl, AM, and Tillmann, HL. "IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients." J Hepatol 58, no. 2 (February 2013): 402-403. (Letter) Full Text Link to Item
  - Garrett, ME, Abdelmalek, MF, Ashley-Koch, A, Hauser, MA, Moylan, CA, Pang, H, Diehl, AM, and Tillmann, HL. "IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients." Journal of Hepatology 58, no. 2 (2013): 402-403. Full Text
  - Chen, Y, Choi, SS, Michelotti, GA, Chan, IS, Swiderska-Syn, M, Karaca, GF, Xie, G, Moylan, CA, Garibaldi, F, Premont, R, Suliman, HB, Piantadosi, CA, and Diehl, AM. "Hedgehog controls hepatic stellate cell fate by regulating metabolism." Gastroenterology 143, no. 5 (November 2012): 1319-1329.e11. Full Text
  - Moylan, CA, Suzuki, A, Papay, JI, Yuen, NA, Ames, M, and Hunt, CM. "A pre-marketing ALT signal predicts post-marketing liver safety." Regul Toxicol Pharmacol 63, no. 3 (August 2012): 433-439. Full Text Link to Item
  - Thiele, RH, Williams, J, Moylan, CA, Rao, SV, and Bennett-Guerrero, E. "CASE 6--2012: suspected amiodarone hepatotoxicity after cardiac surgery." J Cardiothorac Vasc Anesth 26, no. 4 (August 2012): 729-732. Full Text Link to Item
  - Acharya, CR, Hsu, DS, Anders, CK, Anguiano, A, Salter, KH, Walters, KS, Redman, RC, Tuchman, SA, Moylan, CA, Mukherjee, S, Barry, WT, Dressman, HK, Ginsburg, GS, Marcom, KP, Garman, KS, Lyman, GH, Nevins, JR, and Potti, A. "Retraction: Acharya CR, et al. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer. JAMA. 2008;299(13):1574-1587." JAMA 307, no. 5 (February 1, 2012): 453-. Full Text Link to Item
  - Philips, GM, Chan, IS, Swiderska, M, Schroder, VT, Guy, C, Karaca, GF, Moylan, C, Venkatraman, T, Feuerlein, S, Syn, W-K, Jung, Y, Witek, RP, Choi, S, Michelotti, GA, Rangwala, F, Merkle, E, Lascola, C, and Diehl, AM. "Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer." Plos One 6, no. 9 (January 2011): e23943-null. Full Text Open Access Copy
  - Syn, W-K, Choi, SS, Liaskou, E, Karaca, GF, Agboola, KM, Oo, YH, Mi, Z, Pereira, TA, Zdanowicz, M, Malladi, P, Chen, Y, Moylan, C, Jung, Y, Bhattacharya, SD, Teaberry, V, Omenetti, A, Abdelmalek, MF, Guy, CD, Adams, DH, Kuo, PC, Michelotti, GA, Whitington, PF, and Diehl, AM. "Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis." Hepatology (Baltimore, Md.) 53, no. 1 (January 2011): 106-115. Full Text
  - Pereira, TDA, Witek, RP, Syn, W-K, Choi, SS, Bradrick, S, Karaca, GF, Agboola, KM, Jung, Y, Omenetti, A, Moylan, CA, Yang, L, Fernandez-Zapico, ME, Jhaveri, R, Shah, VH, Pereira, FE, and Diehl, AM. "Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma." Laboratory Investigation; a Journal of Technical Methods and Pathology 90, no. 12 (December 2010): 1690-1703. Full Text Open Access Copy
  - Choi, SS, Syn, W-K, Karaca, GF, Omenetti, A, Moylan, CA, Witek, RP, Agboola, KM, Jung, Y, Michelotti, GA, and Diehl, AM. "Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway." The Journal of Biological Chemistry 285, no. 47 (November 2010): 36551-36560. Full Text
  - Choi, SS, Witek, RP, Yang, L, Omenetti, A, Syn, W-K, Moylan, CA, Jung, Y, Karaca, GF, Teaberry, VS, Pereira, TA, Wang, J, Ren, X-R, and Diehl, AM. "Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells." Hepatology 52, no. 1 (July 2010): 278-290. Full Text Link to Item
  - Choi, SS, Omenetti, A, Witek, RP, Moylan, CA, Syn, W-K, Jung, Y, Yang, L, Sudan, DL, Sicklick, JK, Michelotti, GA, Rojkind, M, and Diehl, AM. "Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis." American Journal of Physiology. Gastrointestinal and Liver Physiology 297, no. 6 (December 2009): G1093-G1106. Full Text
  - Moylan, CA, Brady, CW, Johnson, JL, Smith, AD, Tuttle-Newhall, JE, and Muir, AJ. "Disparities in liver transplantation before and after introduction of the MELD score." Jama 300, no. 20 (November 2008): 2371-2378. Full Text
  - Herrenkohl, TI, Sousa, C, Tajima, EA, Herrenkohl, RC, and Moylan, CA. "Intersection of child abuse and children's exposure to domestic violence." Trauma, Violence & Abuse 9, no. 2 (April 2008): 84-99. (Review) Full Text
  - Morpeth, SC, Crump, JA, Shao, HJ, Ramadhani, HO, Kisenge, PR, Moylan, CA, Naggie, S, Caram, LB, Landman, KZ, Sam, NE, Itemba, DK, Shao, JF, Bartlett, JA, and Thielman, NM. "Predicting CD4 lymphocyte count." AIDS research and human retroviruses 23, no. 10 (October 2007): 1230-1236. (Academic Article)
  - Morpeth, SC, Crump, JA, Shao, HJ, Ramadhani, HO, Kisenge, PR, Moylan, CA, Naggie, S, Caram, LB, Landman, KZ, Sam, NE, Itemba, DK, Shao, JF, Bartlett, JA, and Thielman, NM. "Predicting CD4 lymphocyte count <200 cells/mm(3) in an HIV type 1-infected African population." Aids Research and Human Retroviruses 23, no. 10 (October 2007): 1230-1236. Full Text
  - Moylan, CA, and Muir, AJ. "Treatment of hepatitis C in special populations." Clin Liver Dis 9, no. 4 (November 2005): 567-v. (Review) Full Text Link to Item
- Book Sections
  - Moylan, CA, and Murphy, SK. "DNA Methylation: Basic Principles." In Medical Epigenetics, 11-31. July 1, 2016. Full Text
- Conference Papers
  - Chaudhry, M, Moylan, CA, Middleton, MS, Farjat, A, Chaudhury, KR, Guy, CD, Abdelmalek, MF, Loomba, R, Sirlin, CB, and Bashir, M. "Quantifying the Placebo Effect on Liver Fat Using Magnetic Resonance Imaging-Proton Density Fat Fraction in NAFLD Clinical Trials." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018. Link to Item
  - Harrison, SA, Guy, CD, Bashir, M, Frias, JP, Alkhouri, N, Baum, S, Taub, RA, Moylan, CA, Bansal, MB, Neuschwander-Tetri, BA, and Moussa, S. "In a Placebo-Controlled 36-Week Phase 2 Trial, Treatment with Mgl-3196 Compared to Placebo Results in Significant Reductions in Hepatic Fat (MRI-PDFF), Liver Enzymes, Fibrosis Biomarkers, Atherogenic Lipids, and Improvement in Nash on Serial Liver Biopsy." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018. Link to Item
  - Moylan, CA, Sorrow, PA, Mavis, A, Bashir, M, Jima, D, Maguire, R, Bozdogan, E, Buie, S, Murphy, SK, Diehl, AM, Hoyo, C, and Abdelmalek, MF. "Obesity and Nonalcoholic Fatty Liver Disease in Childhood Associate with Altered DNA Methylation in Early Life." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018. Link to Item
  - Patel, Y, Henson, J, Wilder, J, Kappus, MR, Barbas, AS, Moylan, CA, Niedzwiecki, D, Muir, AJ, and Berg, CL. "The Impact of Advanced Age on Waiting List and Post-Transplantation Outcomes for NAFLD Patients." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018. Link to Item
  - Bae, A, Henao, R, Suzuki, A, Moylan, CA, Guy, CD, Diehl, AM, and Abdelmalek, MF. "STATIN USE AND LIVER INJURY IN NONALCOHOLIC FATTY LIVER DISEASE: RESULTS OF A PAIRED CLINICAL AND GENE EXPRESSION PROFILE ANALYSIS." Annual Meeting of the American-Society-for-Gastrointestinal-Endoscopy / Digestive Disease Week. Washington, DC. June 2, 2018 - June 5, 2018.: W B SAUNDERS CO-ELSEVIER INC, May 1, 2018. Link to Item
  - Du, K, Premont, R, Hyun, J, Machado, MV, Moylan, CA, Abdelmalek, MF, Guy, CD, and Diehl, AM. "PATHPHYSIOLOGICAL ROLE OF GLUTAMINOLYSIS IN HUMAN NAFLD PROGRESSION." Annual Meeting of the American-Society-for-Gastrointestinal-Endoscopy / Digestive Disease Week. Washington, DC. June 2, 2018 - June 5, 2018.: W B SAUNDERS CO-ELSEVIER INC, May 1, 2018. Link to Item
  - Li, X, Moylan, CA, Baker, SS, Liu, W, Baker, RD, Murphy, SK, Abdelmalek, MF, Zhu, R, Diehl, AM, and Zhu, L. "Altered liver methylome and transcriptome provide evidence for epigenetic contribution to NAFLD pathogenesis." October 2017. Link to Item
  - Moylan, CA, Mavis, AM, Bashir, MR, Malik, D, Bozdogan, E, Buie, S, Hoyo, C, Diehl, AM, Murphy, SK, and Abdelmalek, MF. "Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children." October 2017. Link to Item
  - Patel, YA, Gifford, E, Glass, LM, McNeil, R, Turner, MJ, Han, B, Provenzale, DT, Choi, SS, Moylan, CA, and Hunt, CM. "Diet/exercise programs are used by only one in five severely obese patients with biopsy-defined Nonalcoholic Fatty Liver Disease (NAFLD) advanced fibrosis in the Veterans Health Administration (VHA)." October 2017. Link to Item
  - Wegermann, K, Moylan, CA, Zheng, J, Abdelmalek, MF, Chow, S-C, Guy, CD, Diehl, AM, and Suzuki, A. "Gender and menopause significantly modify effects of metabolism-related SNPs on fibrosis stage in adult patients with nonalcoholic fatty liver disease (NAFLD)." October 2017. Link to Item
  - Moylan, CA, Giraldo, RH, Murphy, SK, Diehl, AM, and Abdelmalek, MF. "Differential DNA Methylation in Whole Blood Reflects that in Liver and Distinguishes Patients with Advanced NAFLD Fibrosis from Those with Normal Histology: A Potential Non-Invasive Tool." April 2017. Full Text
  - Moylan, CA, Wegermann, KJ, Henao, RG, Murphy, SK, Diehl, AM, and Abdelmalek, MF. "BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study." October 2016. Link to Item
  - Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Vitamin D is Not Associated with Histologic Severity in NAFLD: Results of a Paired Clinical and Hepatic Gene Expression Profile Analysis." October 2016. Link to Item
  - Suzuki, A, Spencer, HJ, Moylan, CA, Dranoff, JA, Abdelmalek, MF, Guy, CD, and Diehl, AM. "Hepatic estrogen transcriptional activity and estrogen receptor a gene expression are negatively correlated with fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD)." October 2016. Link to Item
  - Wegermann, K, Henao, R, Pan, Y, Diehl, AM, Abdelmalek, MF, and Moylan, CA. "BCAT1 is Associated with Clinical Decompensation in NAFLD: A Pilot Study." October 2016. Link to Item
  - Henao, R, Hasanaliyeva, N, Bell, LN, Wulff, J, Perichon, R, Moylan, CA, Lu, JT, Guy, CD, Diehl, AM, and Abdelmalek, MF. "Plasma Metabolomic Profiles Predict Advanced Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease." October 2015. Link to Item
  - Hunt, CM, Beste, LA, Ioannou, GN, Lowy, E, Provenzale, DT, Kelley, MJ, Suzuki, A, Moylan, CA, Oloruntoba, OO, Tillmann, HL, Lim, JK, and Ross, D. "Hepatitis B Testing Prior to Administration of Rituximab, Ofatumumab and Obinutuzumab in the National Veterans Affairs Health Healthcare System, 2002-2014." October 2015. Link to Item
  - Moylan, CA, Murphy, SK, Grenier, C, Abdelmalek, MF, and Diehl, AM. "DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease." October 2015. Link to Item
  - Rabatin, A, Hashem, M, Townsend, ML, Bryan, WE, Moylan, CA, Choi, SS, and Naggie, S. "Treatment Outcomes of Veterans with Decompensated Cirrhosis Receiving All Oral Direct Acting Antiviral Hepatitis C Therapy." October 2015. Link to Item
  - Zhu, R, Baker, SS, Moylan, CA, Abdelmalek, MF, Guy, CD, Zamboni, F, Wu, D, Lin, W, Liu, W, Baker, RD, Govindarajan, S, Cao, Z, Farci, P, Diehl, AM, and Zhu, L. "Systematic Analysis of NAFLD Transcriptome Revealed Elevated Expression of Alcohol Metabolizing Genes in Mild and Severe NAFLD Livers." April 2015. Link to Item
  - Naqvi, IA, White, RR, Moylan, CA, Diehl, AM, and Choi, SS. "Abstract 4117: Utilizing RNA aptamers for biomarker discovery in a novel cell culture system for hepatocellular carcinoma." October 1, 2014. Full Text
  - Moylan, CA, Owzar, K, Muir, AJ, Cauchy, F, Belghiti, J, Diehl, AM, and Paradis, V. "Gene Expression and Pathway Analyses Reveal Distinctions Between Hepatocellular Carcinoma Arising in Fibrotic and Non-Fibrotic Nonalcoholic Fatty Liver Disease." May 2014. Link to Item
  - Oloruntoba, OO, Wilder, JM, Smith, AD, Muir, AJ, and Moylan, CA. "The Influence of Race on Patient Preferences and Access to Orthotopic Liver Transplantation and Organ Donation." 2014. Link to Item
  - Urban, TJ, Moylan, CA, Rein, M, Abdelmalek, MF, Goldstein, DB, and Diehl, AM. "Whole Exome Sequencing of Extreme Phenotypes of NAFLD Identifies Potential Genetic Risk Factors for Advanced Hepatic Fibrosis." 2014. Link to Item
  - Chen, Y, Michelotti, GA, Xie, G, Moylan, CA, and Diehl, AM. "Hedgehog-Induced Serine Biogenesis is Required for Activation of Hepatic Stellate Cells." October 2013. Link to Item
  - Garrett, ME, Moylan, CA, Gibson, J, Yang, H, Pang, H, Dellinger, A, Suzuki, A, Tillmann, HL, Guy, CD, Abdelmalek, MF, Murphy, SK, Diehl, AM, Hauser, M, and Ashley-Koch, AE. "Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease." October 2012. Link to Item
  - Moylan, CA, Yang, H, Pang, H, Dellinger, A, Suzuki, A, Tillmann, HL, Guy, CD, Ashley-Koch, AE, Garrett, ME, Abdelmalek, MF, Hauser, MA, Murphy, SK, and Diehl, AM. "Epigenetic Regulation of Gene Expression in NAFLD." May 2012. Link to Item
  - Chan, IS, Philips, GM, Zdanowicz, M, Teaberry, V, Karaca, G, Rangwala, F, Guy, CD, Moylan, CA, Venkatraman, T, Feuerlein, S, Syn, W-K, Jung, Y, Witek, RP, Michelotti, GA, Choi, SS, Merkle, EM, Lascola, C, and Diehl, AM. "HEDGEHOG PATHWAY INHIBITION BY GDC-0449 CAUSES REGRESSION OF HEPATOCELLULAR CARCINOMAS AND IMPROVES LIVER FIBROSIS IN MDR2-DEFICIENT MICE." October 2011. Link to Item
  - Chen, Y, Choi, SS, Michelotti, GA, Moylan, CA, Karaca, G, Zdanowicz, M, Xie, G, Kruger, L, and Diehl, AM. "TRANSITION OF QUIESCENT STELLATE CELLS INTO MYOFIBROBLASTS REQUIRES HEDGEHOG-MEDIATED INDUCTION OF GLYCOLYSIS." October 2011. Link to Item
  - Philips, GM, Chan, IS, Choi, SS, Xie, G, Michelotti, GA, Zdanowicz, M, Teaberry, V, Rangwala, F, Guy, CD, Karaca, G, Venkatraman, T, Feuerlein, S, Moylan, CA, Syn, W-K, Jung, Y, Witek, RP, Merkle, EM, Lascola, C, and Diehl, AM. "HEDGEHOG PATHWAY INHIBITION INDUCES HCC TUMOR NECROSIS BY REPRESSING EXPRESSION OF ANGIOPOIETIN-2 AND ITS COGNATE RECEPTOR, TIE-2." October 2011. Link to Item
  - Moylan, CA, Dellinger, A, Pang, H, Suzuki, A, Tillmann, HL, Hampton, D, Chen, Y, Choi, SS, Hauser, MA, Abdelmalek, MF, and Diehl, AM. "Modest Alcohol Consumption Attenuates Expression of Fibrosis-Associated Genes in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD)." May 2011. Link to Item
  - Tillmann, HL, Pang, H, Dellinger, A, Suzuki, A, Guy, CD, Moylan, CA, Piercy, D, Smith, M, Hauser, MA, Diehl, AM, and Abdelmalek, ME. "Coffee's Beneficial Effect on Liver Disease Confirmed in NASH Cohort, but Only Partially Confirmation of In Vitro Pre-Described Differentially Expressed Genes in This Patient Cohort." May 2011. Link to Item
  - Tillmann, H, Suzuki, A, Pang, H, Dellinger, A, Guy, CD, Moylan, CA, Piercy, D, Smith, M, Hauser, MA, Diehl, AME, and Abdelmalek, MF. "869 COFFEE CONSUMPTION INCREASES HEPATIC EXPRESSION OF CYTOCHROME P450S AND SIGNIFICANTLY REDUCES LIVER FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE (NAFLD)." : Elsevier BV, March 2011. Full Text
  - Choi, SS, Pereira, TA, Syn, W-K, Agboola, KM, Moylan, CA, Omenetti, A, Karaca, GF, Rangwala, F, Jhaveri, R, and Diehl, AM. "CO-CULTURE OF LIVER EPITHELIAL CELLS STABLY TRANSFECTED WITH HEPATITIS B VIRUS X PROTEIN PROMOTES MYOFIBROBLASTIC ACTIVATION AND ACCUMULATION VIA A HEDGEHOG-MEDIATED PROCESS IN RAT HEPATIC STELLATE CELLS." October 2010. Link to Item
  - Forssen, U, Kobayashi, M, Moylan, CA, Ludema, CM, and Theodore, D. "NASH INCREASES THE RISK OF PORTAL VEIN THROMBOSIS IN PATIENTS ON THE LIVER TRANSPLANT WAITING LIST." October 2010. Link to Item
  - Moylan, CA, Abdelmalek, MF, Pang, H, Dellinger, A, Choi, SS, Omenetti, A, Chen, Y, Hampton, D, Syn, W-K, Suzuki, A, Tillmann, HL, Acharya, CR, Potti, A, Hauser, MA, and Diehl, AM. "SIGNALS FROM THE FIBROTIC LIVER IN PATIENTS WITH NAFLD MAY PROMOTE DIABETES AND OBESITY." October 2010. Link to Item
  - Moylan, CA, Choi, SS, Dellinger, A, Pang, H, Abdelmalek, MF, Hampton, D, Chen, Y, Omenetti, A, Suzuki, A, Tillmann, HL, Acharya, CR, Potti, A, Hauser, MA, and Diehl, AM. "CONSERVED GENE EXPRESSION PATTERNS IN MYOFIBROBLASTIC MURINE AND HUMAN HEPATIC STELLATE CELLS AND NAFLD PATIENTS WITH LIVER FIBROSIS COMPATIBLE WITH EPITHELIAL-TO-MESENCHYMAL LIKE TRANSITION." October 2010. Link to Item
  - Syn, W-K, Choi, SS, Liaskou, E, Karaca, GF, Oo, YH, Pereira, TA, Bhattacharya, SD, Moylan, CA, Agboola, KM, Omenetti, A, Schroder, VT, Mi, Z, Guy, CD, Abdelmalek, MF, Potti, A, Kuo, PC, Michelotti, GA, Adams, DH, and Diehl, AM. "OSTEOPONTIN PROMOTES NONALCOHOLIC FATTY LIVER DISEASE PROGRESSION." October 2010. Link to Item
  - Moylan, CA, Choi, SS, Acharya, CR, Salter, K, Muir, AJ, Potti, A, and Diehl, AM. "GENE EXPRESSION PROFILES COUPLED WITH SIGNATURES OF ONCOGENIC PATHWAY DYSREGULATION PROVIDE A RATIONAL APPROACH TO DISSECTING THE MOLECULAR HETEROGENEITY OF HEPATOCELLULAR CARCINOMA." October 2008. Link to Item
  - Robertson, KD, Moylan, CA, Brady, CW, and Muir, AJ. "Factors Influencing Participation in Hepatitis C Research Trials." : Ovid Technologies (Wolters Kluwer Health), September 2007. Full Text

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