Scholars@Duke
Dana Most

Dana Most

Assistant Professor of Neurology
Hospital Neurology
dana.most@duke.edu
40 Medicine Circle, Clinic 1L, Durham, NC 27710
40 Medicine Circle, Clinic 1L, Durham, NC 27710

Selected Publications

Silencing synaptic MicroRNA-411 reduces voluntary alcohol consumption in mice.

Journal Article Addict Biol · July 2019 Chronic alcohol consumption alters the levels of microRNAs and mRNAs in the brain, but the specific microRNAs and processes that target mRNAs to affect cellular function and behavior are not known. We examined the in vivo manipulation of previously identif ... Full text Link to item Cite

Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption.

Journal Article Neuropsychopharmacology · January 2016 Local translation of mRNAs in the synapse has a major role in synaptic structure and function. Chronic alcohol use causes persistent changes in synaptic mRNA expression, possibly mediated by microRNAs localized in the synapse. We profiled the transcriptome ... Full text Link to item Cite

The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol.

Journal Article Pharmacogenomics J · April 2015 Chronic alcohol consumption changes gene expression, likely causing persistent remodeling of synaptic structures via altered translation of mRNAs within synaptic compartments of the cell. We profiled the transcriptome from synaptoneurosomes (SNs) and paire ... Full text Link to item Cite

PPAR agonists regulate brain gene expression: relationship to their effects on ethanol consumption.

Journal Article Neuropharmacology · November 2014 Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists also possess anti-addictive characteristics. PPAR ... Full text Link to item Cite

Synaptic adaptations by alcohol and drugs of abuse: changes in microRNA expression and mRNA regulation.

Journal Article Front Mol Neurosci · 2014 Local translation of mRNAs is a mechanism by which cells can rapidly remodel synaptic structure and function. There is ample evidence for a role of synaptic translation in the neuroadaptations resulting from chronic drug use and abuse. Persistent and coord ... Full text Link to item Cite

Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans.

Journal Article Int Rev Neurobiol · 2014 Immune or brain proinflammatory signaling has been linked to some of the behavioral effects of alcohol. Immune signaling appears to regulate voluntary ethanol intake in rodent models, and ethanol intake activates the immune system in multiple models. This ... Full text Link to item Cite

Molecular basis of alcoholism.

Journal Article Handb Clin Neurol · 2014 Acute alcohol intoxication causes cellular changes in the brain that last for hours, while chronic alcohol use induces widespread neuroadaptations in the nervous system that can last a lifetime. Chronic alcohol use and the progression into dependence invol ... Full text Link to item Cite