Daniel Len Edmonston | Scholars@Duke

Daniel Len Edmonston
Assistant Professor of Medicine

My primary research focus lies at the intersection of kidney and cardiovascular disease including pulmonary hypertension, heart failure, and atherosclerotic disease in patients with chronic kidney disease.

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Nephrology, Medicine 2021
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2019

Contact Information

daniel.edmonston@duke.edu

Background
Education, Training, & Certifications
- Fellowship, Nephrology, Duke University 2016 - 2019
- Residency, Medicine, New York Presbyterian Hospital 2013 - 2016
- M.D., Mercer University School of Medicine 2013
Medical Licensure
- #2016-00878. North Carolina. 2016
Previous Appointments & Affiliations
- Medical Instructor in the Department of Medicine, Medicine, Nephrology, Medicine 2019 - 2021
Leadership & Clinical Positions at Duke
- President, Mercer University School of Medicine Class of 2013                   2009 - 2012
  
  Vice President, Mercer University School of Medicine Student Council       2011 – 2012
  
  Assistant Chief Resident, Weill Cornell Department of Medicine                  2015 - 2016
  
  Editor, American Society of Nephrology Kidney News Fellow’s Corner       2017 - 2018
Recognition
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Novel Mechanisms and Therapeutic Targets for Pulmonary Hypertension in End-Stage Renal Disease (K23) awarded by National Institutes of Health 2021 - 2026
- "HiLo": Pragmatic trial of higher vs. lower serum phosphate targets in patients undergoing hemodialysis awarded by National Institutes of Health 2018 - 2023
- The Role of Klotho and Serotonin in Cardiovascular Outcomes and Mortality in CKD awarded by University of Pennsylvania 2021 - 2023
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Edmonston, Daniel, Matthew Sparks, Sudarshan Rajagopal, and Myles Wolf. “Sildenafil and Kidney Function in Heart Failure with Preserved Ejection Fraction.” Kidney360 4, no. 5 (May 1, 2023): 631–40. https://doi.org/10.34067/KID.0000000000000103.
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  - Shavadia, Jay S., Jonathan Wilson, Daniel Edmonston, Alyssa Platt, Patti Ephraim, Rasheeda Hall, Benjamin A. Goldstein, et al. “Corrigendum to "Statins and atherosclerotic cardiovascular outcomes in patients on incident dialysis and with atherosclerotic heart disease" [Am Heart J (2021) 231:36-44].” Am Heart J 253 (November 2022): 99–100. https://doi.org/10.1016/j.ahj.2022.06.009.
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  - Sata, Suchita Shah, Susan E. Spratt, Daniel L. Edmonston, and Neha Pagidipati. “Clinical progress note: Indications for and management of sodium-glucose cotransporter-2 (SGLT-2) inhibitors in hospitalized patients.” J Hosp Med 17, no. 5 (May 2022): 360–63. https://doi.org/10.1002/jhm.12798.
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  - Hsu, Caroline M., Shruti Gupta, Hocine Tighiouart, Nitender Goyal, Anthony J. Faugno, Asma Tariq, Ritesh Raichoudhury, et al. “Kidney Recovery and Death in Critically Ill Patients With COVID-19-Associated Acute Kidney Injury Treated With Dialysis: The STOP-COVID Cohort Study.” Am J Kidney Dis 79, no. 3 (March 2022): 404-416.e1. https://doi.org/10.1053/j.ajkd.2021.11.004.
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  - Edmonston, Daniel L., Roland Matsouaka, Svati H. Shah, Sudarshan Rajagopal, and Myles Wolf. “Noninvasive Risk Score to Screen for Pulmonary Hypertension With Elevated Pulmonary Vascular Resistance in Diseases of Chronic Volume Overload.” Am J Cardiol 159 (November 15, 2021): 113–20. https://doi.org/10.1016/j.amjcard.2021.08.016.
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  - Friedman, Allon N., John Guirguis, Rajat Kapoor, Shruti Gupta, David E. Leaf, Lava R. Timsina, and Lava R. STOP-COVID Investigators. “Obesity, inflammatory and thrombotic markers, and major clinical outcomes in critically ill patients with COVID-19 in the US.” Obesity (Silver Spring) 29, no. 10 (October 2021): 1719–30. https://doi.org/10.1002/oby.23245.
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  - Jezmir, Julia L., Maheetha Bharadwaj, Alexander Chaitoff, Bradford Diephuis, Conor P. Crowley, Sandeep P. Kishore, Eric Goralnick, et al. “Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States.” Cell Rep Med 2, no. 9 (September 21, 2021): 100376. https://doi.org/10.1016/j.xcrm.2021.100376.
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  - Vasquez, Charles R., Shruti Gupta, Todd A. Miano, Meaghan Roche, Jesse Hsu, Wei Yang, Daniel N. Holena, et al. “Identification of Distinct Clinical Subphenotypes in Critically Ill Patients With COVID-19.” Chest 160, no. 3 (September 2021): 929–43. https://doi.org/10.1016/j.chest.2021.04.062.
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  - Edmonston, Daniel L., Tamara Isakova, Laura M. Dember, Steven Brunelli, Amy Young, Rebecca Brosch, Srinivasan Beddhu, Hrishikesh Chakraborty, and Myles Wolf. “Design and Rationale of HiLo: A Pragmatic, Randomized Trial of Phosphate Management for Patients Receiving Maintenance Hemodialysis.” Am J Kidney Dis 77, no. 6 (June 2021): 920-930.e1. https://doi.org/10.1053/j.ajkd.2020.10.008.
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  - Herbek, Savannah, Daniel L. Edmonston, and Tomokazu Souma. “Hypoxia signaling in renal pericytes-is it safe to activate?” Kidney Int 99, no. 6 (June 2021): 1267–69. https://doi.org/10.1016/j.kint.2021.02.014.
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  - Cohen, Jordana B., Thomas C. Hanff, Preethi William, Nancy Sweitzer, Nelson R. Rosado-Santander, Carola Medina, Juan E. Rodriguez-Mori, et al. “Continuation versus discontinuation of renin-angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial.” Lancet Respir Med 9, no. 3 (March 2021): 275–84. https://doi.org/10.1016/S2213-2600(20)30558-0.
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  - Flythe, Jennifer E., Magdalene M. Assimon, Matthew J. Tugman, Emily H. Chang, Shruti Gupta, Jatan Shah, Marie Anne Sosa, et al. “Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States.” Am J Kidney Dis 77, no. 2 (February 2021): 190-203.e1. https://doi.org/10.1053/j.ajkd.2020.09.003.
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  - Shaefi, Shahzad, Samantha K. Brenner, Shruti Gupta, Brian P. O’Gara, Megan L. Krajewski, David M. Charytan, Sobaata Chaudhry, et al. “Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19.” Intensive Care Med 47, no. 2 (February 2021): 208–21. https://doi.org/10.1007/s00134-020-06331-9.
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  - Gupta, Shruti, Steven G. Coca, Lili Chan, Michal L. Melamed, Samantha K. Brenner, Salim S. Hayek, Anne Sutherland, et al. “AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.” J Am Soc Nephrol 32, no. 1 (January 2021): 161–76. https://doi.org/10.1681/ASN.2020060897.
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  - Shavadia, Jay S., Jonathan Wilson, Daniel Edmonston, Alyssa Platt, Patti Ephraim, Rasheeda Hall, Benjamin A. Goldstein, et al. “Statins and atherosclerotic cardiovascular outcomes in patients on incident dialysis and with atherosclerotic heart disease.” Am Heart J 231 (January 2021): 36–44. https://doi.org/10.1016/j.ahj.2020.10.055.
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  - Edmonston, Daniel L., Matthew T. Roe, Geoffrey Block, Paul T. Conway, Laura M. Dember, Peter M. DiBattiste, Tom Greene, et al. “Drug Development in Kidney Disease: Proceedings From a Multistakeholder Conference.” Am J Kidney Dis 76, no. 6 (December 2020): 842–50. https://doi.org/10.1053/j.ajkd.2020.05.026.
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  - Edmonston, Daniel L., Sudarshan Rajagopal, and Myles Wolf. “Echocardiography to Screen for Pulmonary Hypertension in CKD.” Kidney Int Rep 5, no. 12 (December 2020): 2275–83. https://doi.org/10.1016/j.ekir.2020.09.033.
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  - Hung, Anna, Matthew Sinclair, Marion Hemmersbach-Miller, Daniel Edmonston, and Christina Wyatt. “Prescribing rates and characteristics of recipients of tenofovir-containing regimens before and after market entry of tenofovir alafenamide.” J Manag Care Spec Pharm 26, no. 12 (December 2020): 1582–88. https://doi.org/10.18553/jmcp.2020.26.12.1582.
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  - Cohen, Jordana B., Thomas C. Hanff, Vicente Corrales-Medina, Preethi William, Nicolas Renna, Nelson R. Rosado-Santander, Juan E. Rodriguez-Mori, et al. “Randomized elimination and prolongation of ACE inhibitors and ARBs in coronavirus 2019 (REPLACE COVID) Trial Protocol.” J Clin Hypertens (Greenwich) 22, no. 10 (October 2020): 1780–88. https://doi.org/10.1111/jch.14011.
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  - Edmonston, Daniel L., and Matthew A. Sparks. “Therapeutic options for chronic kidney disease-associated pulmonary hypertension.” Curr Opin Nephrol Hypertens 29, no. 5 (September 2020): 497–507. https://doi.org/10.1097/MNH.0000000000000624.
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  - Edmonston, Daniel L., Andrew M. South, Matthew A. Sparks, and Jordana B. Cohen. “Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System.” Adv Chronic Kidney Dis 27, no. 5 (September 2020): 404–11. https://doi.org/10.1053/j.ackd.2020.07.002.
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  - South, Andrew M., Laurie Tomlinson, Daniel Edmonston, Swapnil Hiremath, and Matthew A. Sparks. “Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic.” Nat Rev Nephrol 16, no. 6 (June 2020): 305–7. https://doi.org/10.1038/s41581-020-0279-4.
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  - Edmonston, Daniel L., Kishan S. Parikh, Sudarshan Rajagopal, Linda K. Shaw, Dennis Abraham, Alexander Grabner, Matthew A. Sparks, and Myles Wolf. “Pulmonary Hypertension Subtypes and Mortality in CKD.” Am J Kidney Dis 75, no. 5 (May 2020): 713–24. https://doi.org/10.1053/j.ajkd.2019.08.027.
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  - Edmonston, Daniel L., and Patrick H. Pun. “Coronary artery disease in chronic kidney disease: highlights from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.” Kidney Int 97, no. 4 (April 2020): 642–44. https://doi.org/10.1016/j.kint.2019.12.010.
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  - Edmonston, Daniel, and Myles Wolf. “FGF23 at the crossroads of phosphate, iron economy and erythropoiesis.” Nat Rev Nephrol 16, no. 1 (January 2020): 7–19. https://doi.org/10.1038/s41581-019-0189-5.
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  - Edmonston, Daniel, Daniel Wojdyla, Rupal Mehta, Xuan Cai, Claudia Lora, Debbie Cohen, Raymond R. Townsend, et al. “Single Measurements of Carboxy-Terminal Fibroblast Growth Factor 23 and Clinical Risk Prediction of Adverse Outcomes in CKD.” Am J Kidney Dis 74, no. 6 (December 2019): 771–81. https://doi.org/10.1053/j.ajkd.2019.05.026.
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  - Edmonston, Daniel L., Christina M. Wyatt, and Sana M. Al-Khatib. “Atrial fibrillation and kidney disease: stuck outside the CABANA.” Kidney Int 96, no. 5 (November 2019): 1054–55. https://doi.org/10.1016/j.kint.2019.05.023.
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  - Edmonston, Daniel L., Jingjing Wu, Roland A. Matsouaka, Clyde Yancy, Paul Heidenreich, Ileana L. Piña, Adrian Hernandez, Gregg C. Fonarow, and Adam D. DeVore. “Association of post-discharge specialty outpatient visits with readmissions and mortality in high-risk heart failure patients.” Am Heart J 212 (June 2019): 101–12. https://doi.org/10.1016/j.ahj.2019.03.005.
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  - Hein, Aaron M., Julia J. Scialla, Daniel Edmonston, Lauren B. Cooper, Adam D. DeVore, and Robert J. Mentz. “Medical Management of Heart Failure With Reduced Ejection Fraction in Patients With Advanced Renal Disease.” Jacc Heart Fail 7, no. 5 (May 2019): 371–82. https://doi.org/10.1016/j.jchf.2019.02.009.
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  - Edmonston, Daniel, and Myles Wolf. “Good Guys, Bad Guys, Guesses, and Near Misses in Nephrology.” Clin J Am Soc Nephrol 14, no. 1 (January 7, 2019): 7–9. https://doi.org/10.2215/CJN.13801118.
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  - Edmonston, Daniel, Myles Wolf, and Michael Pencina. “Statins at Dialysis Transition-Supportive but Not Sufficient.” Jama Netw Open 1, no. 6 (October 5, 2018): e182411. https://doi.org/10.1001/jamanetworkopen.2018.2411.
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  - Edmonston, Daniel, Jessica D. Morris, and John P. Middleton. “Working Toward an Improved Understanding of Chronic Cardiorenal Syndrome Type 4.” Adv Chronic Kidney Dis 25, no. 5 (September 2018): 454–67. https://doi.org/10.1053/j.ackd.2018.08.010.
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  - McHugh, Kelly R., Adam D. DeVore, Robert J. Mentz, Daniel Edmonston, Jennifer B. Green, and Adrian F. Hernandez. “The emerging role of novel antihyperglycemic agents in the treatment of heart failure and diabetes: A focus on cardiorenal outcomes.” Clin Cardiol 41, no. 9 (September 2018): 1259–67. https://doi.org/10.1002/clc.23054.
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  - Edmonston, Daniel L., and Guy D. Foulkes. “Infection rate and risk factor analysis in an orthopaedic ambulatory surgical center.” J Surg Orthop Adv 19, no. 3 (2010): 174–76.
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Teaching & Mentoring
Teaching Activities
- Diabetic Nephropathy (1-3 Lectures/Year)                                                     2018 – Present
  
  Duke Internal Medicine Resident Academic Half-Day
  
  Secondary Hypertension (1-3 Lectures/Year)                                                2018 – Present
  
  Duke Internal Medicine Resident Academic Half-Day
  
  End-Stage Renal Disease Options (1-3 Lectures/Year)
  
  Duke Internal Medicine Resident Academic Half-Day                                  2020 – Present
  
  Diabetic Kidney Disease (1 Lecture/Year)
  
  Duke Nephrology Fellowship Academic Conference                                    2020 – Present
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Academic & Administrative Activities
- Attending Nephrologist, Duke University Hosptial, Durham, NC 2019-Present
  Attending Nephrologist, Duke Private Diagnostic Clinic, Durham, NC 2019-Present
  Attending Nephrologist, Durham Veterans Affairs Medical Center, Durham, NC 2019-Present

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Education, Training, & Certifications

Medical Licensure

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Teaching Activities

Presentations & Appearances

Academic & Administrative Activities