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Daniel Lee Gilstrap

Daniel Lee Gilstrap

Assistant Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
daniel.gilstrap@duke.edu
102355, Hanes House Room 101, Durham, NC 27710
102355, Hanes House Room 101, Durham, NC 27710

Selected Publications

Impact of Treatment Modalities on Intensive Care Unit Length of Stay for Patients Admitted With Severe Hyponatremia.

Conference Ann Pharmacother · May 2026 BACKGROUND: The diversity in presentation and cause of hyponatremia leads to a wide array of treatment modalities which are selected based on severity, chronicity, volume status, and putative cause. Due to the variability in treatment selection, it is pert ... Full text Link to item Cite

Impact of 25% Albumin on Vasopressor Requirements in Critically Ill Patients Receiving Continuous Renal Replacement Therapy.

Journal Article Ann Pharmacother · December 1, 2025 BACKGROUND: Critically ill patients receiving continuous renal replacement therapy (CRRT) commonly experience hypotension necessitating fluids, ultrafiltration (UF) adjustment, or vasopressors. There is limited evidence evaluating 25% albumin on vasopresso ... Full text Link to item Cite

Ventilator Management for Patients With Acute Respiratory Failure Supported With Venovenous ECMO: A Prospective, Pragmatic, Cluster-crossover Pilot Study

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRationale: The optimal ventilator management strategy for patients with acute respiratory failure (ARF) requiring venovenous extracorporeal membrane oxygenation (VV-ECMO) is unknown. Current guide ... Full text Cite

Clinical Utility of Plasma Microbial Cell-Free DNA Sequencing Among Immunocompromised Patients With Pneumonia.

Journal Article Open Forum Infect Dis · August 2024 BACKGROUND: Plasma microbial cell-free DNA (mcfDNA) sequencing can establish the etiology of multiple infectious syndromes by identifying microbial DNA in plasma. However, data are needed to define the clinical scenarios where this tool offers the highest ... Full text Link to item Cite

Reducing Clostridioides difficile Infections in a Medical Intensive Care Unit: A Multimodal Quality Improvement Initiative.

Journal Article Dimens Crit Care Nurs · July 2024 BACKGROUND: Clostridioides difficile (C. diff) infection causes significant morbidity for hospitalized patients. A large medical intensive care unit had an increase in C. diff infection rates. OBJECTIVES: The aim of this project was to reduce the C. diff p ... Full text Open Access Link to item Cite

Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Patients With Pneumonia: A Prospective Observational Study.

Journal Article Clin Infect Dis · March 20, 2024 BACKGROUND: Pneumonia is a common cause of morbidity and mortality, yet a causative pathogen is identified in a minority of cases. Plasma microbial cell-free DNA sequencing may improve diagnostic yield in immunocompromised patients with pneumonia. METHODS: ... Full text Link to item Cite

Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.

Journal Article Lancet Respir Med · September 2023 BACKGROUND: There is a clinical need for therapeutics for COVID-19 patients with acute hypoxemic respiratory failure whose 60-day mortality remains at 30-50%. Aviptadil, a lung-protective neuropeptide, and remdesivir, a nucleotide prodrug of an adenosine a ... Full text Link to item Cite

Incidence and associated risk factors for systemic drug levels with inhaled aminoglycoside therapy.

Journal Article J Antimicrob Chemother · February 1, 2023 OBJECTIVES: To characterize the incidence of and risk factors for a detectable drug level (DDL) in patients that received inhaled aminoglycoside therapy. METHODS: This retrospective, single-centre study included adult patients who received at least one dos ... Full text Link to item Cite

The ARREST Pneumonia Clinical Trial. Rationale and Design.

Journal Article Ann Am Thorac Soc · April 2021 Patients hospitalized for pneumonia are at high risk for mortality. Effective therapies are therefore needed. Recent randomized clinical trials suggest that systemic steroids can reduce the length of hospital stays among patients hospitalized for pneumonia ... Full text Link to item Cite

Effectiveness of Quetiapine as a Sedative Adjunct in Mechanically Ventilated Adults Without Delirium.

Journal Article Ann Pharmacother · February 2021 BACKGROUND: Quetiapine is an atypical antipsychotic that is commonly used in the Intensive Care Unit (ICU). The utility of quetiapine as a sedative adjunct has not yet been evaluated, but has been described previously in studies evaluating quetiapine for d ... Full text Link to item Cite

Operationalizing needs-focused palliative care for older adults in intensive care units: Design of and rationale for the PCplanner randomized clinical trial.

Journal Article Contemp Clin Trials · November 2020 INTRODUCTION: The number of older adults who receive life support in an intensive care unit (ICU), now 2 million per year, is increasing while survival remains unchanged. Because the quality of ICU-based palliative care is highly variable, we developed a m ... Full text Link to item Cite

Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in the Diagnosis of Breast Cancer Thoracic Metastases and Detection of Receptor Discordance.

Journal Article J Bronchology Interv Pulmonol · July 2018 BACKGROUND: Metastasis of breast cancer to mediastinal lymph nodes is common and biopsy of suspicious lesions can have important diagnostic, prognostic, and therapeutic implications, particularly with respect to tumor receptor status. Our aim was to show t ... Full text Link to item Cite

Predictors of Vasopressin Responsiveness in Critically Ill Adults.

Journal Article Ann Pharmacother · February 2018 BACKGROUND: Vasopressin is commonly used as an adjunct vasopressor in shock. However, response to vasopressin varies among critically ill patients. OBJECTIVE: To identify patient-specific factors that are associated with vasopressin responsiveness in criti ... Full text Link to item Cite

Discharge prescribing of enteral opioids after initiation as a weaning strategy from continuous opioid infusions in the Intensive Care Unit.

Conference J Opioid Manag · 2018 OBJECTIVE: To evaluate the proportion of patients receiving a hospital discharge prescription for a scheduled enteral opioid following initiation as a weaning strategy from a continuous opioid infusion in the Intensive Care Unit (ICU). DESIGN: Retrospectiv ... Full text Link to item Cite

Patient-Ventilator Interactions.

Journal Article Clin Chest Med · December 2016 Ventilatory muscle fatigue is a reversible loss of the ability to generate force or velocity of contraction in response to increased elastic and resistive loads. Mechanical ventilation should provide support without imposing additional loads from the venti ... Full text Link to item Cite

Mechanical Ventilator Discontinuation Process.

Journal Article Clin Chest Med · December 2016 The goal of this article is to discuss approaches to discontinuing invasive mechanical ventilation in a general intensive care unit (ICU) population. It considers approaches in which the clinician expects patient survival, as well as those that do not. Add ... Full text Link to item Cite

Comparative effectiveness and safety of drug therapy for pulmonary arterial hypertension: a systematic review and meta-analysis.

Journal Article Chest · May 2014 BACKGROUND: Current treatments for pulmonary arterial hypertension (PAH) have been shown to improve dyspnea, 6-min walk distance (6MWD), and pulmonary hemodynamics, but few studies were designed to compare treatment regimens or assess the impact of treatme ... Full text Link to item Cite

Patient-ventilator interactions. Implications for clinical management.

Journal Article Am J Respir Crit Care Med · November 1, 2013 Assisted/supported modes of mechanical ventilation offer significant advantages over controlled modes in terms of ventilator muscle function/recovery and patient comfort (and sedation needs). However, assisted/supported breaths must interact with patient d ... Full text Link to item Cite

Asthma and the host-microbe interaction.

Journal Article J Allergy Clin Immunol · May 2013 Full text Link to item Cite

Predictors of short-term mortality in patients undergoing percutaneous dilatational tracheostomy.

Journal Article J Crit Care · August 2012 PURPOSE: The purpose of the study was to identify the predictors of short-term mortality in patients undergoing percutaneous dilatational tracheostomy (PDT). MATERIALS AND METHODS: Retrospective analysis of data pertaining to adult patients who underwent P ... Full text Link to item Cite