Current Duke Appointments & Affiliations
Associate Professor of Pediatrics
·
2025 - Present
Pediatrics, Hematology-Oncology,
Pediatrics
Associate Professor in Neurosurgery
·
2026 - Present
Neurosurgery,
Neurosurgery
Member of the Duke Cancer Institute
·
2023 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
A phase 2 PBTC study of selumetinib for recurrent/progressive pediatric low-grade glioma: Strata 2, 5, and 6 with long-term outcomes on strata 1, 3, and 4.
Journal article Neuro Oncol · October 14, 2025 BACKGROUND: PBTC-029B was a phase 2 trial evaluating efficacy of selumetinib in children with recurrent/progressive low-grade glioma. We report results of strata 2, 5, and 6 with updated survivals for strata 1, 3, and 4. METHODS: Stratum 2 included recurre ... Full text Link to item CiteA peptide vaccine targeting the CMV antigen pp65 in children and young adults with recurrent high-grade glioma and medulloblastoma: a phase 1 trial.
Journal article Nat Cancer · September 2025 The human cytomegalovirus (CMV) antigen pp65 is expressed in high-grade glioma (HGG) and medulloblastoma but not in the adjacent brain. This single-arm phase 1 trial ( NCT03299309 ) assessed the safety and immunogenicity of a peptide vaccine (PEP-CMV) targ ... Full text Open Access Link to item CiteRecent Grants
TarGeT-D: Phase 2 Study of Olutasidenib with Temozolomide as Maintenance Therapy in Pediatric and Young Adult Patients Newly Diagnosed with High-Grade Glioma (HGG), including Diffuse Intrinsic Pontine Glioma (DIPG), which Harbor IDH1 Mutations
Clinical TrialPrincipal Investigator · Awarded by Research Institute at Nationwide Children's Hospital · 2026 - 2031PNOC041: A Target Validation and Efficacy Study of Metformin in Patients with Recurrent or Progressive Posterior Fossa Group A (PFA) Ependymoma
Clinical TrialPrincipal Investigator · Awarded by The Regents of the University of California · 2026 - 2031CONNECT1905: Phase 2 Study of Systemic IL-6 Receptor Antagonist ACTEMRA® (tocilizumab) for the treatment of Progressive/Recurrent Pediatric Adamantinomatous Craniopharyngioma
Clinical TrialPrincipal Investigator · Awarded by Research Institute at Nationwide Children's Hospital · 2024 - 2029View All Grants
Education
University of Colorado, School of Medicine ·
2009
M.D.