Daniel Bryce Landi | Scholars@Duke

Daniel Bryce Landi
Assistant Professor of Pediatrics

Current Appointments & Affiliations

Assistant Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2021

Contact Information

330 Trent Drive, Room 390, Durham, NC 27710
Box 102382, Durham, NC 27710
daniel.landi@duke.edu (919) 668-6288

Background
Education, Training, & Certifications
- Hemoatology/Oncology Fellowship, Pediatrics, Baylor College of Medicine 2013 - 2016
- Pediatric Internship and Residency, Pediatrics, Duke University School of Medicine 2009 - 2012
- M.D., University of Colorado School of Medicine 2009
Previous Appointments & Affiliations
- Assistant Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2017 - 2020
- Medical Instructor in the Department of Pediatrics, Pediatrics, Transplant and Cellular Therapy, Pediatrics 2012 - 2013
Research
Selected Grants
External Relationships
- Roche
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Thompson, Eric M., David Ashley, and Daniel Landi. “Current medulloblastoma subgroup specific clinical trials.” Transl Pediatr 9, no. 2 (April 2020): 157–62. https://doi.org/10.21037/tp.2020.03.03.
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  - Thompson, Eric M., Daniel Landi, David Ashley, Stephen T. Keir, and Darell Bigner. “Bevacizumab, irinotecan, temozolomide, tyrosine kinase inhibition, and MEK inhibition are effective against pleomorphic xanthoastrocytoma regardless of V600E status.” J Neurooncol 140, no. 2 (November 2018): 261–68. https://doi.org/10.1007/s11060-018-2975-5.
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  - Tan, Char-Loo, Daniel Landi, Herbert Fuchs, and Roger E. McLendon. “Novel case of recurrent intraventricular atypical central neurocytoma with prominent gangliogliomatous differentiation in a 10-year-old boy with 10 years of follow up.” Neuropathology 38, no. 5 (October 2018): 542–48. https://doi.org/10.1111/neup.12502.
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  - Landi, Daniel B., Eric M. Thompson, and David M. Ashley. “Immunotherapy for pediatric brain tumors.” Neuroimmunology and Neuroinflammation 5, no. 7 (July 23, 2018): 29–29. https://doi.org/10.20517/2347-8659.2018.35.
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  - Ahmed, Nabil, Vita Brawley, Meenakshi Hegde, Kevin Bielamowicz, Mamta Kalra, Daniel Landi, Catherine Robertson, et al. “HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma.” Jama Oncology 3, no. 8 (August 1, 2017): 1094–1094. https://doi.org/10.1001/jamaoncol.2017.0184.
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  - Hegde, Meenakshi, Malini Mukherjee, Zakaria Grada, Antonella Pignata, Daniel Landi, Shoba A. Navai, Amanda Wakefield, et al. “Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.” Journal of Clinical Investigation 126, no. 8 (July 18, 2016): 3036–52. https://doi.org/10.1172/jci83416.
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  - Wakefield, Amanda, Antonella Pignata, Alexia Ghazi, Aidin Ashoori, Meenakshi Hegde, Daniel Landi, Tara Gray, et al. “Is CMV a target in pediatric glioblastoma? Expression of CMV proteins, pp65 and IE1-72 and CMV nucleic acids in a cohort of pediatric glioblastoma patients.” Journal of Neuro Oncology 125, no. 2 (November 2015): 307–15. https://doi.org/10.1007/s11060-015-1905-z.
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  - Shah, Nirmish, Margo Rollins, Daniel Landi, Radhika Shah, Jonathan Bae, and Laura M. De Castro. “Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis.” Clin J Pain 30, no. 3 (March 2014): 266–68. https://doi.org/10.1097/AJP.0b013e318295ec04.
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  - Boelens, Jaap Jan, Mieke Aldenhoven, Duncan Purtill, Annalisa Ruggeri, Todd Defor, Robert Wynn, Ed Wraith, et al. “Outcomes of transplantation using various hematopoietic cell sources in children with Hurler syndrome after myeloablative conditioning.” Blood 121, no. 19 (May 9, 2013): 3981–87. https://doi.org/10.1182/blood-2012-09-455238.
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  - Landi, Daniel, Michele G. Beckman, Nirmish R. Shah, Paula Bockenstedt, Althea M. Grant, John A. Heit, Nigel S. Key, et al. “Characteristics of abdominal vein thrombosis in children and adults.” Thromb Haemost 109, no. 4 (April 2013): 625–32. https://doi.org/10.1160/TH12-08-0568.
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  - Landi, Daniel, Evelyn Lockhart, Sara E. Miller, Michael Datto, Catherine Rehder, Angela Kanaly, and Courtney D. Thornburg. “Report of a young girl with MYH9 mutation and review of the literature.” J Pediatr Hematol Oncol 34, no. 7 (October 2012): 538–40. https://doi.org/10.1097/MPH.0b013e3182678fc9.
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  - Shah, Nirmish, Daniel Landi, Radhika Shah, Jennifer Rothman, Laura M. De Castro, and Courtney D. Thornburg. “Complications of implantable venous access devices in patients with sickle cell disease.” Am J Hematol 87, no. 2 (February 2012): 224–26. https://doi.org/10.1002/ajh.22230.
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  - Shah, Nirmish R., Daniel B. Landi, Susan G. Kreissman, Evan Kulbachi, and Cassandra Moran. “Presentation and outcomes for children with bone marrow necrosis and acute lymphoblastic leukemia: a literature review.” J Pediatr Hematol Oncol 33, no. 7 (October 2011): e316–19. https://doi.org/10.1097/MPH.0b013e318223fe9b.
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- Conference Papers
  - Batich, Kristen, Duane Mitchell, Patrick Healy, James Herndon, Gloria Broadwater, Gunn Michael, Min-Nung Huang, et al. “CTIM-10. REPRODUCIBILITY OF CLINICAL TRIALS USING CMV-TARGETED DENDRITIC CELL VACCINES IN PATIENTS WITH GLIOBLASTOMA.” In Neuro Oncology, 23:vi51–vi51. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.202.
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  - Desjardins, Annick, Matthias Gromeier, Henry Friedman, Daniel Landi, Allan Friedman, David M. Ashley, William Curry, et al. “IMMU-26. SAFETY AND EFFICACY OF PVSRIPO IN RECURRENT GLIOBLASTOMA: LONG-TERM FOLLOW-UP AND INITIAL MULTICENTER RESULTS.” In Neuro Oncology, 23:vi97–vi97. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.385.
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  - Johnson, Margaret, Mustafa Khasraw, Jung-Young Kim, Nicole Cort, James Herndon, Luis Ramirez, Eric Lipp, et al. “QOLP-28. COMPARING KNOWLEDGE OF AND BELIEFS ABOUT PALLIATIVE CARE AMONG NEURO-ONCOLOGY PATIENTS, CAREGIVERS, PROVIDERS AND A NATIONALLY-REPRESENTATIVE U.S. SAMPLE.” In Neuro Oncology, 23:vi189–vi189. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.748.
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  - Peters, Katherine, Mallika Patel, Candice Alford, Gerardo Chavez, Jung-Young Kim, Jennifer Durling, Tracy Novack, et al. “INNV-20. RADIOGRAPHIC RESPONSE AND SEIZURE CONTROL IN IDH1 MUTANT GLIOMA PATIENTS USING IVOSIDENIB.” In Neuro Oncology, 23:vi109–vi109. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.431.
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  - Peters, Katherine, Mary Affronti, Jung-Young Kim, Mallika Patel, Margaret Johnson, David Bartlett, Nicole Cort, et al. “QOLP-10. A LONGITUDINAL OBSERVATIONAL STUDY OF EXERCISE BEHAVIOR IN GLIOBLASTOMA PATIENTS TREATED WITH TUMOR-TREATING FIELDS.” In Neuro Oncology, 23:vi184–85. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.731.
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  - Petitt, Zoey, James Herndon, Oren Gottfried, Christina Cone, Daniel Landi, Mustafa Khasraw, Henry Friedman, et al. “INNV-31. NEURO-ONCOLOGY OUTPATIENT SATISFACTION IS MAINTAINED IN THE ERA OF COVID-19 TELEMEDICINE.” In Neuro Oncology, 23:vi112–vi112. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.442.
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  - Sloan, Andrew, Robin Buerki, Daniel Landi, Annick Desjardins, Allan Friedman, Prakash Ambady, Kevin Becker, et al. “CTIM-18. LUMINOS-101: INITIAL SAFETY AND TOLERABILITY OF PVSRIPO AND PEMBROLIZUMAB COMBINATION THERAPY IN RECURRENT GLIOBLASTOMA.” In Neuro Oncology, 23:vi53–54. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.210.
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  - Wilkinson, Daniel, Katherine Ryan, Vidyalakshmi Chandramohan, Daniel Landi, Darell Bigner, and Peter Fecci. “EXTH-59. GENERATION OF A THIRD GENERATION CAR T CELL THAT SIMULTANEOUSLY TARGETS WILDTYPE EGFR AND ITS MUTANT ISOFORM EGFRVIII FOR TREATMENT OF GLIOBLASTOMA.” In Neuro Oncology, 23:vi176–vi176. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.698.
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  - Hanzlik, Emily, Bridget Archambault, Mays Dairi, Kristin Schroeder, Mallika Patel, Eric S. Lipp, Song Boucree, Katherine Peters, David Ashley, and Daniel Landi. “LGG-08. TREATMENT OUTCOMES AND TOLERABILITY OF TRAMETINIB IN PROGRESSIVE CIRCUMSCRIBED LOW-GRADE GLIOMAS.” In Neuro Oncology, 23:i32–33. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab090.132.
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  - Thompson, Eric, Daniel Landi, Gerald Archer, Eric Lipp, Ashley Walter, Bridget Archambault, Bea Balajonda, et al. “EPCT-01. A NOVEL PEPTIDE VACCINE DIRECTED TO CMV PP65 FOR TREATMENT OF RECURRENT MALIGNANT GLIOMA AND MEDULLOBLASTOMA IN CHILDREN AND YOUNG ADULTS: PRELIMINARY RESULTS OF A PHASE I TRIAL.” In Neuro Oncology, 23:i46–i46. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab090.187.
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  - Kilburn, Lindsay Baker, Nada Jabado, Andrea Franson, Susan N. Chi, Michael J. Fisher, Darren R. Hargrave, Jordan R. Hansford, et al. “FIREFLY-1: A phase 2 study of the pan-RAF inhibitor DAY101 in pediatric patients with low-grade glioma.” In Journal of Clinical Oncology, 39:TPS10056–TPS10056. American Society of Clinical Oncology (ASCO), 2021. https://doi.org/10.1200/jco.2021.39.15_suppl.tps10056.
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  - Sloan, Andrew E., Robin Arthur Buerki, Christopher Murphy, Andrea True Kelly, Prakash Ambady, Michael Brown, Nicholas A. Butowski, et al. “LUMINOS-101: Phase 2 study of PVSRIPO with pembrolizumab in recurrent glioblastoma.” In Journal of Clinical Oncology, 39:TPS2065–TPS2065. American Society of Clinical Oncology (ASCO), 2021. https://doi.org/10.1200/jco.2021.39.15_suppl.tps2065.
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  - Cohen, Kenneth, Susan Chi, Cynthia Hawkins, Fausto Rodriguez, Wendy London, Robert Craig Castellino, Dolly Aguilera, et al. “MBCL-25. PILOT STUDY OF A SURGERY AND CHEMOTHERAPY-ONLY APPROACH IN THE UPFRONT THERAPY OF CHILDREN WITH WNT-POSITIVE STANDARD RISK MEDULLOBLASTOMA: UPDATED OUTCOMES.” In Neuro Oncology, 22:iii393–94. Oxford University Press (OUP), 2020. https://doi.org/10.1093/neuonc/noaa222.501.
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  - Landi, Daniel, Gary Archer, Timothy Driscoll, Eric Lipp, Bridget Archambault, Eric Thompson, Charlene Flahiff, et al. “EPCT-13. CMV PP65 RNA-PULSED DENDRITIC CELL VACCINES FOR PEDIATRIC GLIOBLASTOMA AND MEDULLOBLASTOMA: PHASE I TRIAL RESULTS.” In Neuro Oncology, 22:iii306–iii306. Oxford University Press (OUP), 2020. https://doi.org/10.1093/neuonc/noaa222.136.
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  - Mosaheb, Mubeen, Daniel Landi, Elena Dobrikova, Michael Brown, Yuanfan Yang, Jana Cable, Hideho Okada, et al. “THER-05. GENETICALLY STABLE POLIOVIRUS VECTOR CARRYING H3.3K27M ANTIGEN FOR TREATMENT OF DIFFUSE MIDLINE GLIOMA BY INTRAMUSCULAR INJECTION.” In Neuro Oncology, 22:iii472–iii472. Oxford University Press (OUP), 2020. https://doi.org/10.1093/neuonc/noaa222.855.
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  - Noyd, David, Claire Howell, Kevin Oeffinger, Daniel Landi, and Kristin Schroeder. “EPID-16. INTEGRATION OF EHR AND CANCER REGISTRY DATA TO CONSTRUCT A PEDIATRIC NEURO-ONCOLOGY SURVIVORSHIP COHORT AND IMPROVE LONG-TERM FOLLOW-UP CARE.” In Neuro Oncology, 22:iii322–iii322. Oxford University Press (OUP), 2020. https://doi.org/10.1093/neuonc/noaa222.202.
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  - Desjardins, Annick, Dina Randazzo, Vidya Chandramohan, Katherine Peters, Margaret Johnson, Daniel Landi, Mustafa Khasraw, et al. “CTIM-23. A PHASE 1 TRIAL OF D2C7-IT IN COMBINATION WITH ATEZOLIZUMAB IN RECURRENT WHO GRADE IV MALIGNANT GLIOMA (MG).” In Neuro Oncology, 22:ii38–ii38. Oxford University Press (OUP), 2020. https://doi.org/10.1093/neuonc/noaa215.157.
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  - Randazzo, Dina, Evan Buckley, James Herndon, Nicole Cort, Mary Affronti, Eric Lipp, Annick Desjardins, et al. “QOLP-20. A FEASIBILITY STUDY UTILIZING MINDFULNESS MEDITATION DURING CONCOMITANT CHEMORADIATION IN MALIGNANT GLIOMA PATIENTS: HEALTH-REPORTED QUALITY OF LIFE (HRQOL) RESULTS.” In Neuro Oncology, 22:ii179–ii179. Oxford University Press (OUP), 2020. https://doi.org/10.1093/neuonc/noaa215.745.
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  - Ryan, Katherine, Daniel Wilkinson, Daniel Landi, and Peter Fecci. “DDRE-20. GENERATION OF A HIGH-AFFINITY EGFR/EGFRvIII-TARGETED D2C7 CAR-T CELL.” In Neuro Oncology, 22:ii65–66. Oxford University Press (OUP), 2020. https://doi.org/10.1093/neuonc/noaa215.265.
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  - Thompson, Eric, Daniel Landi, Eric Lipp, Bea Balajonda, James Herndon, Evan Buckley, Charlene Flahiff, et al. “CTIM-21. PEPTIDE VACCINE DIRECTED TO CMV pp65 FOR TREATMENT OF RECURRENT MALIGNANT GLIOMA AND MEDULLOBLASTOMA IN CHILDREN AND YOUNG ADULTS: PRELIMINARY RESULTS OF A PHASE I TRIAL.” In Neuro Oncology, 22:ii37–ii37. Oxford University Press (OUP), 2020. https://doi.org/10.1093/neuonc/noaa215.155.
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  - Walsh, Kyle, Joanne Xiu, Giselle López, Daniel Landi, Zachary Reitman, Sandeep Mittal, Andrew Brenner, et al. “BIOM-17. BRAF MUTATION IS AN EARLY EVENT IN THE EVOLUTION OF A SUBSET OF GLIOBLASTOMAS AND IS ASSOCIATED WITH INCREASED PD-L1 EXPRESSION.” In Neuro Oncology, 22:ii5–ii5. Oxford University Press (OUP), 2020. https://doi.org/10.1093/neuonc/noaa215.017.
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  - Archambault, Bridget, Daniel Landi, and Kristin Schroeder. “QOLP-34. DOSE FREQUENCY MODIFICATION OF TRAMETINIB TO MITIGATE SEVERE RASH AND IMPROVE QUALITY OF LIFE IN PEDIATRIC LOW-GRADE GLIOMA PATIENTS.” In Neuro Oncology, 21:vi205–vi205. Oxford University Press (OUP), 2019. https://doi.org/10.1093/neuonc/noz175.854.
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  - Landi, Daniel, Gary Archer, Timothy Driscoll, James Herndon, John Sampson, and David Ashley. “PDCT-10. FEASIBILITY OF LEUKAPHERESIS FOR HARVESTING MONOCYTES AND GENERATING AUTOLOGOUS DENDRITIC CELL VACCINES IN CHILDREN WITH MALIGNANT BRAIN TUMORS.” In Neuro Oncology, 21:vi185–vi185. Oxford University Press (OUP), 2019. https://doi.org/10.1093/neuonc/noz175.772.
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  - Randazzo, Dina, Jenny Jackman, James Herndon, Mary Affronti, Eric Lipp, Nicole Cort, Annick Desjardins, et al. “QOLP-29. MINDFULNESS MEDITATION PRACTICE IN MALIGNANT GLIOMA PATIENTS THROUGHOUT CONCOMITANT RADIATION AND TEMOZOLOMIDE: A FEASIBILITY STUDY.” In Neuro Oncology, 21:vi204–vi204. Oxford University Press (OUP), 2019. https://doi.org/10.1093/neuonc/noz175.849.
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  - Thompson, Eric, Daniel Landi, David Ashley, Steve Keir, and Darell Bigner. “EXTH-79. BEVACIZUMAB, IRINOTECAN, TEMOZOLOMIDE, TYROSINE KINASE INHIBITION, AND MEK INHIBITION ARE EFFECTIVE AGAINST PLEOMORPHIC XANTHOASTROCYTOMA REGARDLESS OF V600E STATUS.” In Neuro Oncology, 20:vi102–vi102. Oxford University Press (OUP), 2018. https://doi.org/10.1093/neuonc/noy148.426.
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  - Ashley, David M., Eric M. Thompson, Daniel Landi, Annick Desjardins, Allan H. Friedman, Stevie Threatt, James E. Herndon, II, et al. “HGG-22. PHASE 1b STUDY POLIO VACCINE SABIN-RHINOVIRUS POLIOVIRUS (PVSRIPO) FOR RECURRENT MALIGNANT GLIOMA IN CHILDREN.” In Neuro Oncology, 20:i93–i93. Oxford University Press (OUP), 2018. https://doi.org/10.1093/neuonc/noy059.294.
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  - Landi, Daniel, Eric Thompson, James Herndon, John Sampson, and David Ashley. “IMMU-23. CMV pp65 RNA-PULSED DENDRITIC CELL VACCINES FOR PEDIATRIC GLIOBLASTOMA AND MEDULLOBLASTOMA: A PHASE I TRIAL.” In Neuro Oncology, 20:i103–i103. Oxford University Press (OUP), 2018. https://doi.org/10.1093/neuonc/noy059.339.
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  - Landi, Daniel, Eric Thompson, Roger McLendon, Annick Desjardins, Vidya Chandramohan, David Ashley, and Darell Bigner. “IMMU-21. TARGETING EGFR IN HYPOMUTATED PEDIATRIC BRAIN TUMORS USING THE D2C7 IMMUNOTOXIN.” In Neuro Oncology, 20:i103–i103. Oxford University Press (OUP), 2018. https://doi.org/10.1093/neuonc/noy059.337.
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  - Landi, D. B., J. T. Rahkola, and E. N. Janoff. “MEASURING ANTIBODY-SECRETING B-CELL RESPONSES TO IMMUNOLOGICAL STIMULI.” In Journal of Investigative Medicine, 55:S121–S121. SAGE Publications, 2007. https://doi.org/10.1097/00042871-200701010-00279.
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  - Liu, C. C., M. F. Diaz-Aguado, D. B. Landi, and T. J. Moon. “Micromechanics applied to cytoskeleton dynamics: Actin substructure modeling.” In Biophysical Journal, 86:301A-302A. BIOPHYSICAL SOCIETY, 2004.
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  - Frost, Erin I., Andrew Bellantoni, and Daniel Landi. “A Sheep in Wolf’s Clothing: An Atypical Etiology of a Cerebellar Lesion. (Accepted),” n.d.
  - Frost, Erin I., Andrew Bellantoni, and Daniel Landi. “A Sheep in Wolf’s Clothing: An Atypical Etiology of a Cerebellar Lesion. (Accepted),” n.d.

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Education, Training, & Certifications

Previous Appointments & Affiliations

Selected Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers