Scholars@Duke
Danielle Elliott Range

Danielle Elliott Range

Associate Professor of Pathology
Pathology
danielle.range@duke.edu
Rm 3419 Duke South Hospital, Durham, NC 27708

Selected Publications

Use of Machine Learning-Based Software for the Screening of Thyroid Cytopathology Whole Slide Images.

Journal Article Arch Pathol Lab Med · July 1, 2022 CONTEXT.—: The use of whole slide images (WSIs) in diagnostic pathology presents special challenges for the cytopathologist. Informative areas on a direct smear from a thyroid fine-needle aspiration biopsy (FNAB) smear may be spread across a large area com ... Full text Link to item Cite

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in The Bethesda System for the Reporting of Thyroid Cytopathology.

Journal Article Diagn Cytopathol · June 2020 INTRODUCTION: The Bethesda System for the Reporting of Thyroid Cytopathology (TBSRTC) is used to categorize and diagnose thyroid nodules by fine needle aspiration biopsy (FNAB). Each category in TBSRTC is associated with an estimated risk of malignancy (RO ... Full text Link to item Cite

Application of a machine learning algorithm to predict malignancy in thyroid cytopathology.

Journal Article Cancer Cytopathol · April 2020 BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) comprises 6 categories used for the diagnosis of thyroid fine-needle aspiration biopsy (FNAB). Each category has an associated risk of malignancy, which is important in the manage ... Full text Link to item Cite

Practical Head and Neck Pathology Frequently Asked Questions

Book · November 14, 2019 This book answers some of the difficult, prevailing and emerging questions in head and neck pathology that arise in everyday practice. While such challenges may not always be frequent, they have tremendous impact on clinical practice. ... Cite

Treatment Outcomes in Anaplastic Thyroid Cancer.

Journal Article J Thyroid Res · 2019 BACKGROUND: Anaplastic thyroid cancer (ATC) is rare, accounting for 1-2% of thyroid malignancies. Median survival is only 3-10 months, and the optimal therapeutic approach has not been established. This study aimed to evaluate outcomes in ATC based on trea ... Full text Link to item Cite

Thyroid Cancer Malignancy Prediction From Whole Slide Cytopathology Images

Journal Article Proceedings of Machine Learning Research · January 1, 2019 We consider preoperative prediction of thyroid cancer based on ultra-high-resolution whole-slide cytopathology images. Inspired by how human experts perform diagnosis, our approach first identifies and classifies diagnostic image regions containing informa ... Cite

Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer.

Journal Article Clin Cancer Res · September 1, 2018 Purpose: Sixty percent of papillary thyroid cancers (PTC) have an oncogenic (V600E) BRAF mutation. Inhibitors of BRAF and its substrates MEK1/2 are showing clinical promise in BRAFV600E PTC. PTC progression can be decades long, which is challenging in term ... Full text Link to item Cite

An update on noninvasive follicular thyroid neoplasm with papillary-like nuclear features.

Journal Article Curr Opin Oncol · January 2018 PURPOSE OF REVIEW: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) has been established in the literature as a clinically indolent tumor. Despite this, it was traditionally treated like all other PTCs. In an attempt to redu ... Full text Link to item Cite

Evaluation and management of anaplastic thyroid carcinoma

Chapter · May 14, 2014 Edited by outstanding leaders in the field of surgical oncology, this book offers expert advice on prevention, diagnosis, treatment and reconstruction by recognized authorities. ... Cite

Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas.

Journal Article Hum Pathol · September 2011 The classification of follicular thyroid neoplasms requires surgical resection for histologic evaluation of malignancy. Because variable clinical behavior exists, genomic expression profiling may lead to the identification of novel markers that facilitate ... Full text Link to item Cite

Growth factor receptors expression in anaplastic thyroid carcinoma: potential markers for therapeutic stratification.

Journal Article Hum Pathol · January 2008 Anaplastic thyroid carcinoma is a rare and universally fatal disease. Therefore, novel biomarkers are needed as surrogate end points in triaging patients for novel and selective biologic treatments. Up-regulation of several growth factor receptors has been ... Full text Link to item Cite

Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland: A cytomorphologic study of 139 cases with statistical analysis.

Journal Article Cancer · April 25, 2006 BACKGROUND: Lesions of the thyroid gland composed of Hurthle cells encompass pathologic entities ranging from hyperplastic nodules with Hurthle cell metaplasia to Hurthle cell carcinomas. The cytologic distinction between these entities can be diagnostical ... Full text Link to item Cite

Determining optimal clinical target volume margins in head-and-neck cancer based on microscopic extracapsular extension of metastatic neck nodes.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2006 PURPOSE: To determine the optimal clinical target volume margins around the gross nodal tumor volume in head-and-neck cancer by assessing microscopic tumor extension beyond cervical lymph node capsules. METHODS AND MATERIALS: Histologic sections of 96 diss ... Full text Link to item Cite

Langerhans cell histiocytosis presenting as a thyroid gland mass.

Journal Article Ann Diagn Pathol · October 2005 We report 2 cases of Langerhans cell histiocytosis (LCH) presenting as a thyroid mass. The first case is a 45-year-old woman with a 13-year history of diabetes insipidus who presented with an enlarging thyroid mass with substernal extension. The second cas ... Full text Link to item Cite

Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance.

Journal Article Mod Pathol · March 2005 Sinonasal adenocarcinomas, a relatively rare entity, are composed of distinctly different morphologic subtypes with variable biological behavior. To investigate the genetic events associated with their development and clinicopathologic features, we analyze ... Full text Link to item Cite

Metastatic acinic cell carcinoma in a neurofibroma mistaken for carcinosarcoma.

Journal Article Head Neck · January 2005 BACKGROUND: Tumor-to-tumor metastasis is a rare, but well-recognized, entity most commonly involving metastatic carcinoma to a mesenchymal neoplasm. We report a case of acinic cell carcinoma of the parotid gland metastatic to a neurofibroma. METHODS AND RE ... Full text Link to item Cite

Gene expression profiling of differentiated thyroid neoplasms: diagnostic and clinical implications.

Journal Article Clin Cancer Res · October 1, 2004 PURPOSE: The purpose of this research was to identify novel genes that can be targeted as diagnostic and clinical markers of differentiated thyroid tumors. EXPERIMENTAL DESIGN: Gene expression analysis using microarray platform was performed on 6 pathologi ... Full text Link to item Cite

Malignant melanoma with a myxoid stroma: a diagnostic pitfall on fine-needle aspiration biopsy.

Journal Article Diagn Cytopathol · September 2001 Malignant melanoma (MM), both primary and metastatic, may be associated with a prominent myxoid stromal reaction causing diagnostic confusion on fine-needle aspiration biopsy (FNAB), most often with sarcomas that demonstrate a myxoid stroma, particularly m ... Full text Link to item Cite