Daphne Ruth Friedman | Scholars@Duke

Daphne Ruth Friedman
Associate Professor of Medicine

My area of expertise is in leukemias and lymphomas, including Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. My research interests are focused on improving treatment options for patients with hematologic malignancies, through laboratory and clinical research. I am also a staff physician at the Durham VA Medical Center, and am deeply committed to expanding treatment options for veterans, including working on clinical trials for multiple myeloma, prostate cancer, and lung cancer at the Durham VA.

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Medical Oncology, Medicine 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013

Contact Information

508 Fulton Street (111g), Durham, NC 27705
508 Fulton Street (111g), Durham VA Medical Center, Durham, NC 27705
daphne.friedman@duke.edu (919) 286-6944

Background
Education, Training, & Certifications
- Fellow in Hematology-Oncology, Medicine, Duke University 2005 - 2008
- Medical Resident, Medicine, University of Maryland, College Park 2002 - 2005
- M.D., University of Maryland, College Park 2002
Duke Appointment History
- Assistant Professor of Medicine, Medicine, Medical Oncology, Medicine 2013 - 2017
- Medical Instructor in the Department of Medicine, Medicine, Medical Oncology, Medicine 2008 - 2013
- Instructor, Temporary in the Department of Medicine, Medicine, Medical Oncology, Medicine 2008
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Weinberg, JB, Brander, DM, Christensen, DJ, and Friedman, DR. "Post-translational regulation could be determine functional differences between SET alpha and beta isoform - Response to Cristóbal et al." British Journal of Haematology (May 2019). (Letter) Full Text
  - Brander, DM, Friedman, DR, Volkheimer, AD, Christensen, DJ, Rassenti, LZ, Kipps, TJ, Guadalupe, E, Chen, Y, Zhang, D, Wang, X, Davis, C, Owzar, K, and Weinberg, JB. "SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia." British Journal of Haematology 184, no. 4 (February 2019): 605-615. Full Text
  - Friedman, DR, Guadalupe, E, Volkheimer, A, Moore, JO, and Weinberg, JB. "Clinical outcomes in chronic lymphocytic leukaemia associated with expression of CD5, a negative regulator of B-cell receptor signalling." British Journal of Haematology 183, no. 5 (December 2018): 747-754. Full Text
  - Friedman, DR. "Lipids and Their Effects in Chronic Lymphocytic Leukemia." EBioMedicine 15 (February 2017): 2-3. (Letter) Full Text
  - Friedman, DR, Sibley, AB, Owzar, K, Chaffee, KG, Slager, S, Kay, NE, Hanson, CA, Ding, W, Shanafelt, TD, Weinberg, JB, and Wilcox, RA. "Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi-institutional study." American Journal of Hematology 91, no. 7 (July 2016): 687-691. Full Text
  - Holohan, B, Hagiopian, MM, Lai, T-P, Huang, E, Friedman, DR, Wright, WE, and Shay, JW. "Perifosine as a potential novel anti-telomerase therapy." Oncotarget 6, no. 26 (September 2015): 21816-21826. Full Text
  - Rempel, RE, Jiang, X, Fullerton, P, Tan, TZ, Ye, J, Lau, JA, Mori, S, Chi, J-T, Nevins, JR, and Friedman, DR. "Utilization of the Eμ-Myc mouse to model heterogeneity of therapeutic response." Molecular Cancer Therapeutics 13, no. 12 (December 2014): 3219-3229. Full Text
  - Friedman, DR, Lanasa, MC, Davis, PH, Allgood, SD, Matta, KM, Brander, DM, Chen, Y, Davis, ED, Volkheimer, AD, Moore, JO, Gockerman, JP, Sportelli, P, and Weinberg, JB. "Perifosine treatment in chronic lymphocytic leukemia: results of a phase II clinical trial and in vitro studies." Leuk Lymphoma 55, no. 5 (May 2014): 1067-1075. Full Text Link to Item
  - Nipp, RD, Volkheimer, AD, Davis, ED, Chen, Y, Weinberg, JB, and Friedman, DR. "CD38 variation as a prognostic factor in chronic lymphocytic leukemia." Leuk Lymphoma 55, no. 1 (January 2014): 191-194. (Letter) Full Text Link to Item
  - Friedman, DR. ""Primum non nocere": the addition of granulocyte-macrophage colony stimulating factor to alemtuzumab in chronic lymphocytic leukemia." Leuk Lymphoma 54, no. 3 (March 2013): 441-442. Full Text Link to Item
  - DiLillo, DJ, Weinberg, JB, Yoshizaki, A, Horikawa, M, Bryant, JM, Iwata, Y, Matsushita, T, Matta, KM, Chen, Y, Venturi, GM, Russo, G, Gockerman, JP, Moore, JO, Diehl, LF, Volkheimer, AD, Friedman, DR, Lanasa, MC, Hall, RP, and Tedder, TF. "Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function." Leukemia 27, no. 1 (January 2013): 170-182. Full Text Link to Item
  - Dilillo, DJ, Weinberg, JB, Yoshizaki, A, Horikawa, M, Bryant, JM, Iwata, Y, Matsushita, T, Matta, KM, Chen, Y, Venturi, GM, Russo, G, Gockerman, JP, Moore, JO, Diehl, LF, Volkheimer, AD, Friedman, DR, Lanasa, MC, Hall, RP, and Tedder, TF. "Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function." Leukemia 27, no. 1 (2013): 170-182. Full Text
  - Friedman, DR, Lucas, JE, and Weinberg, JB. "Clinical and biological relevance of genomic heterogeneity in chronic lymphocytic leukemia." Plos One 8, no. 2 (2013): e57356-null. Full Text Link to Item
  - Lanasa, MC, Davis, PH, Datto, M, Li, Z, Gockerman, JP, Moore, JO, DeCastro, CM, Friedman, DR, Diehl, LF, Rehder, C, Cook, H, Daugherty, FJ, Matta, KMB, Weinberg, JB, and Rizzieri, D. "Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia." Leukemia & Lymphoma 53, no. 2 (February 2012): 218-224. Full Text
  - Christensen, DJ, Chen, Y, Oddo, J, Matta, KM, Neil, J, Davis, ED, Volkheimer, AD, Lanasa, MC, Friedman, DR, Goodman, BK, Gockerman, JP, Diehl, LF, de Castro, CM, Moore, JO, Vitek, MP, and Weinberg, JB. "SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target." Blood 118, no. 15 (October 13, 2011): 4150-4158. Full Text Link to Item
  - Jima, DD, Zhang, J, Jacobs, C, Richards, KL, Dunphy, CH, Choi, WWL, Au, WY, Srivastava, G, Czader, MB, Rizzieri, DA, Lagoo, AS, Lugar, PL, Mann, KP, Flowers, CR, Bernal-Mizrachi, L, Naresh, KN, Evens, AM, Gordon, LI, Luftig, M, Friedman, DR, Weinberg, JB, Thompson, MA, Gill, JI, Liu, Q, How, T, Grubor, V, Gao, Y, Patel, A, Wu, H, Zhu, J, Blobe, GC, Lipsky, PE, Chadburn, A, Dave, SS, and Hematologic Malignancies Research Consortium, . "Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs." Blood 116, no. 23 (December 2, 2010): e118-e127. Full Text Link to Item
  - Mowery, YM, Weinberg, JB, Kennedy, MN, Bond, KM, Moore, JO, Lanasa, MC, Gockerman, JP, Diehl, LF, Pizzo, SV, Cianciolo, GJ, and Friedman, DR. "LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells." Leukemia 24, no. 9 (September 2010): 1580-1587. Full Text Link to Item
  - Friedman, DR, Coan, AD, Smith, SK, Herndon, JE, and Abernethy, AP. "Informational needs assessment of non-Hodgkin lymphoma survivors and their physicians." Am J Hematol 85, no. 7 (July 2010): 528-532. (Letter) Full Text Link to Item
  - Friedman, DR, Magura, LA, Warren, HAC, Harrison, JD, Diehl, LF, and Weinberg, JB. "Statin use and need for therapy in chronic lymphocytic leukemia." Leukemia and Lymphoma 51, no. 12 (2010): 2295-2298. Full Text
  - Friedman, DR, Weinberg, JB, Barry, WT, Goodman, BK, Volkheimer, AD, Bond, KM, Chen, Y, Jiang, N, Moore, JO, Gockerman, JP, Diehl, LF, Decastro, CM, Potti, A, and Nevins, JR. "A genomic approach to improve prognosis and predict therapeutic response in chronic lymphocytic leukemia." Clin Cancer Res 15, no. 22 (November 15, 2009): 6947-6955. Full Text Link to Item
  - Friedman, DR, Dupont, AH, Coan, AD, Herndon, JE, Rowe, KL, and Abernethy, AP. "Survivorship care planning needs in diffuse large B-cell lymphoma (DLBCL)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27, no. 15_suppl (May 2009): e20703-.
  - Zhang, J, Jima, DD, Jacobs, C, Fischer, R, Gottwein, E, Huang, G, Lugar, PL, Lagoo, AS, Rizzieri, DA, Friedman, DR, Weinberg, JB, Lipsky, PE, and Dave, SS. "Patterns of microRNA expression characterize stages of human B-cell differentiation." Blood 113, no. 19 (May 2009): 4586-4594. Full Text
  - Weinberg, JB, Volkheimer, AD, Chen, Y, Beasley, BE, Jiang, N, Lanasa, MC, Friedman, D, Vaccaro, G, Rehder, CW, Decastro, CM, Rizzieri, DA, Diehl, LF, Gockerman, JP, Moore, JO, Goodman, BK, and Levesque, MC. "Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia." American Journal of Hematology 82, no. 12 (December 2007): 1063-1070. Full Text
  - Friedman, DR, and Abernethy, AP. "Review of targeted cancer therapies for the palliative care provider Part 1: Small molecules." Progress in Palliative Care 15, no. 4 (October 29, 2007): 171-176. (Review) Full Text
  - Friedman, DR, and Abernethy, AP. "Review of targeted cancer therapies for the palliative care provider PART 2: Antibodies and conjugated agents." Progress in Palliative Care 15, no. 5 (October 29, 2007): 225-232. (Review) Full Text
  - Friedman, DR, and Wolfsthal, SD. "Cocaine-induced pseudovasculitis." Mayo Clin Proc 80, no. 5 (May 2005): 671-673. Full Text Link to Item
  - Vázquez, N, Walsh, TJ, Friedman, D, Chanock, SJ, and Lyman, CA. "Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans." Infection and Immunity 66, no. 1 (1998): 145-150.
- Conference Papers
  - Chanfreau, C, Lynch, KE, Chang, JW, Becker, DJ, Friedman, DR, Rivera, DR, DuVall, SL, and Lynch, JA. "Chronic myeloid leukemia among veterans from 2006 to 2015: Trends in utilization of tyrosine kinase inhibitors." : WILEY, August 1, 2018. Link to Item
  - Friedman, DR, Guadeloupe, E, Volkheimer, A, and Weinberg, JB. "Surface CD5 Protein Risk Stratifies Chronic Lymphocytic Leukemia." 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH). San Diego, CA. December 3, 2016 - December 6, 2016.: AMER SOC HEMATOLOGY, December 2, 2016. Link to Item
  - Vakkalanka, S, Penmetsa, KV, Chasse, D, Chen, Y, Viswanadha, S, Friedman, DR, and Weinberg, JB. "Abstract A24: The dual PI3K δ/γ inhibitor, RP6530, in combination with ibrutinib or fludarabine, synergistically enhances cytotoxicity in primary CLL cells in vitro." Abstracts: AACR Special Conference on Hematologic Malignancies: Translating Discoveries to Novel Therapies; September 20-23, 2014; Philadelphia, PA.: American Association for Cancer Research, September 1, 2015. Full Text
  - Friedman, DR, Stewart, T, Guadalupe, E, Brander, DM, Pisetsky, DS, and Weinberg, JB. "Pan-caspase peptide inhibitor to induce primary chronic lymphocytic leukemia (CLL) cell death through a non-apoptotic and non-necroptotic mechanism." : American Society of Clinical Oncology (ASCO), May 20, 2015. Full Text
  - Friedman, DR, Simms, T, Allgood, SD, Brander, DM, Sportelli, P, Miskin, HP, Vakkalanka, S, Viswanadha, S, Weinberg, JB, and Lanasa, MC. "Abstract 4518: The PI3K-δ inhibitor TGR-1202 induces cytotoxicity and inhibits phosphorylation of AKT in 17p deleted and non-17p deleted CLL cells in vitro." October 1, 2014. Full Text
  - Beri, N, Friedman, DR, Simms, TM, Kuchibhatla, M, Weinberg, JB, and Lanasa, MC. "Molecular and Clinical Associations Between Vitamin D and Chronic Lymphocytic Leukemia." November 15, 2013. Link to Item
  - Friedman, DR, Rempel, RE, Jiang, X, and Nevins, JR. "Modeling Variation in the Human Lymphoma Microenvironment with the E mu-Myc Mouse Model." November 16, 2012. Link to Item
  - Nipp, RD, Weinberg, JB, Volkheimer, AD, Davis, ED, Chen, Y, and Friedman, DR. "CD38 Variation in Chronic Lymphocytic Leukemia." 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH). Atlanta, GA. December 8, 2012 - December 11, 2012.: AMER SOC HEMATOLOGY, November 16, 2012. Link to Item
  - Friedman, DR, and Nevins, JR. "Genomic Heterogeneity in B-Cell Malignancies." November 18, 2011. Link to Item
  - Weinberg, JB, DiLillo, DJ, Iwata, Y, Matushita, T, Matta, KM, Venturi, GM, Russo, G, Chen, Y, Gockerman, JP, Moore, JO, Diehl, LF, Volkheimer, AD, Friedman, DR, Lanasa, MC, Hall, RP, and Tedder, TJ. "Chronic Lymphocytic Leukemia Shares a Common Cellular Origin with Regulatory B10 Cells." November 18, 2011. Link to Item
  - Friedman, DR, Davis, PH, Lanasa, MC, Moore, JO, Gockerman, JP, Nelson, T, Bond, KM, Jiang, N, Davis, ED, Allgood, SD, Chen, Y, Sportelli, P, and Weinberg, JB. "Pre-Clinical and Interim Results of a Phase II Trial of Perifosine In Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)." 52nd Annual Meeting of the American-Society-of-Hematology (ASH). Orlando, FL. December 4, 2010 - December 7, 2010.: AMER SOC HEMATOLOGY, November 19, 2010. Link to Item
  - Friedman, DR, Harrison, JD, Magura, LA, Warren, HA, Diehl, LF, and Weinberg, JB. "Influence of Statin Therapy On the Clinical Course of Chronic Lymphocytic Leukemia." November 20, 2009. Link to Item
  - Friedman, DR, Mowery, Y, Kennedy, M, Bond, KM, Weinberg, JB, and Cianciolo, GJ. "The Anti-Inflammatory Investigational Agent LMP-420 Demonstrates in Vitro Cytotoxic Activity against Chronic Lymphocytic Leukemia Cells." November 20, 2009. Link to Item
  - Jacobs, CL, Jima, DD, Zhang, J, Dunphy, C, Richards, KL, Choi, WWL, Srivastava, G, Evens, AM, Gordon, LI, Czader, M, Rizzieri, DA, Lagoo, AS, Mann, KP, Flowers, CR, Naresh, K, Luftig, M, Friedman, DR, Weinberg, JB, Thompson, MA, Gill, J, Kahl, BS, Chadburn, A, and Dave, S. "A Comprehensive Identification of the Microrna Transcriptome and Its Application in B Cell Malignancies." November 20, 2009. Link to Item
  - Friedman, DR, Dupont, AH, Coan, AD, II, HJE, Rowe, KL, and Abernethy, AP. "Survivorship care planning needs in diffuse large B-cell lymphoma (DLBCL)." May 20, 2009. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Publications

Academic Articles

Conference Papers