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David Harold Harpole Jr.

George Barth Geller Distinguished Professor for Research in Cancer
Surgery, Cardiovascular and Thoracic Surgery
Box 3627 Med Ctr, Durham, NC
MSRB I, Room 455-B, Durham, NC 27710

Overview


A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Current Appointments & Affiliations


George Barth Geller Distinguished Professor for Research in Cancer · 2022 - Present Surgery, Cardiovascular and Thoracic Surgery, Surgery
Professor of Surgery · 2003 - Present Surgery, Cardiovascular and Thoracic Surgery, Surgery
Professor in Pathology · 2018 - Present Pathology, Clinical Science Departments
Member of the Duke Cancer Institute · 1987 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published May 18, 2022
University Awards 24 New Distinguished Professorships

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Recent Publications


Going to MARS may shorten our patient's survival.

Journal Article J Thorac Cardiovasc Surg · June 2025 Full text Link to item Cite

The influence of the American Association for Thoracic Surgery on clinical trial development by cardiothoracic surgeons.

Journal Article J Thorac Cardiovasc Surg · May 2025 OBJECTIVE: Clinical trials play a critical role in the rapidly evolving field of cardiothoracic surgery and the American Association for Thoracic Surgery Clinical Trials Methods Course has provided a biannual symposium led by preeminent surgeons with vast ... Full text Link to item Cite

Initial patient characteristics of Thoracic Surgical Oncology Group 102: A multicenter prospective registry of active surveillance in patients with multiple ground-glass opacities.

Journal Article J Thorac Cardiovasc Surg · April 2025 OBJECTIVE: Presentation with multiple ground-glass opacities (GGOs) is an increasingly common occurrence, and the optimal management of these lesions is unclear. Active surveillance has been increasingly adopted as a management strategy for other low-grade ... Full text Link to item Cite
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Recent Grants


Stimulating Access to Research in Residency (StARR) - NIAID

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2029

Duke Research Training Program in Surgical Oncology

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029

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Education, Training & Certifications


University of Virginia · 1984 M.D.