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David Martin Murdoch

Associate Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
Duke Box 2629, MSRB 1, Durham, NC 27710
MSRB I, Rm 259, 203 Research Dr, Durham, NC 27710


As a physician and researcher, my career has been driven by a passion for linking the basic and clinical sciences with the primary goal of understanding the disease pathogenesis. Through my training in epidemiology, basic science immunology, and clinical medicine, I have acquired a breadth of experience, knowledge, collaborators, and an adaptability which has culminated in a research focus on the reconstitution of immune responses and systemic inflammation in immunocompromised patients and vulnerable populations. My research focuses on T cell immunology utilizing a variety of platforms including polychromatic flow cytometry, cytokine multiplexing, and novel single cell assays. My initial research centered on the immune reconstitution syndrome (IRIS), with a focus on the mycobacterial precipitants of the disease, its epidemiology, and research efforts into elucidating the pathogenesis of the syndrome. Recently, I have translated my interest in co-infection immunology in the immunocompromised transplant population. With a career long interest in contrasting compartmental and peripheral immune responses, I have partnered with engineers in the Duke Pratt School of Engineering in order to develop novel single cell immune assays in order to comprehensively profile the immune response on limited specimens.

Current Appointments & Affiliations

Associate Professor of Medicine · 2018 - Present Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine

Education, Training & Certifications

Medical University of South Carolina, College of Medicine · 1999 M.D.