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David Martin Murdoch

Associate Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
Duke Box 2629, MSRB 1, Durham, NC 27710
MSRB I, Rm 259, 203 Research Dr, Durham, NC 27710

Overview


As a physician and researcher, my career has been driven by a passion for linking the basic and clinical sciences with the primary goal of understanding the disease pathogenesis. Through my training in epidemiology, basic science immunology, and clinical medicine, I have acquired a breadth of experience, knowledge, collaborators, and an adaptability which has culminated in a research focus on the reconstitution of immune responses and systemic inflammation in immunocompromised patients and vulnerable populations. My research focuses on T cell immunology utilizing a variety of platforms including polychromatic flow cytometry, cytokine multiplexing, and novel single cell assays. My initial research centered on the immune reconstitution syndrome (IRIS), with a focus on the mycobacterial precipitants of the disease, its epidemiology, and research efforts into elucidating the pathogenesis of the syndrome. Recently, I have translated my interest in co-infection immunology in the immunocompromised transplant population. With a career long interest in contrasting compartmental and peripheral immune responses, I have partnered with engineers in the Duke Pratt School of Engineering in order to develop novel single cell immune assays in order to comprehensively profile the immune response on limited specimens.

Current Appointments & Affiliations


Associate Professor of Medicine · 2018 - Present Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine

Recent Publications


The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Prospective Cohort Study.

Journal Article Anesth Analg · January 1, 2025 BACKGROUND: Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of ... Full text Link to item Cite

Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy.

Journal Article Elife · September 9, 2024 Understanding the interplay between the HIV reservoir and the host immune system may yield insights into HIV persistence during antiretroviral therapy (ART) and inform strategies for a cure. Here, we applied machine learning (ML) approaches to cross-sectio ... Full text Link to item Cite

Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy

Journal Article eLife · September 9, 2024 Understanding the interplay between the HIV reservoir and the host immune system may yield insights into HIV persistence during antiretroviral therapy (ART) and inform strategies for a cure. Here, we applied machine learning (ML) approaches to cros ... Full text Cite
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Recent Grants


Stimulating Access to Research in Residency (StARR) - NIAID

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2029

The impact of the oral microbiome on pulmonary function among people with HIV in Botswana

ResearchMentor · Awarded by National Heart, Lung, and Blood Institute · 2024 - 2029

Clinical and Mechanistic Factors Impacting Transplant Outcomes (U01)

ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027

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Education, Training & Certifications


Medical University of South Carolina, College of Medicine · 1999 M.D.