David Martin Murdoch
Associate Professor of Medicine
As a physician and researcher, my career has been driven by a passion for linking the basic and clinical sciences with the primary goal of understanding the disease pathogenesis. Through my training in epidemiology, basic science immunology, and clinical medicine, I have acquired a breadth of experience, knowledge, collaborators, and an adaptability which has culminated in a research focus on the reconstitution of immune responses and systemic inflammation in immunocompromised patients and vulnerable populations. My research focuses on T cell immunology utilizing a variety of platforms including polychromatic flow cytometry, cytokine multiplexing, and novel single cell assays. My initial research centered on the immune reconstitution syndrome (IRIS), with a focus on the mycobacterial precipitants of the disease, its epidemiology, and research efforts into elucidating the pathogenesis of the syndrome. Recently, I have translated my interest in co-infection immunology in the immunocompromised transplant population. With a career long interest in contrasting compartmental and peripheral immune responses, I have partnered with engineers in the Duke Pratt School of Engineering in order to develop novel single cell immune assays in order to comprehensively profile the immune response on limited specimens.
Current Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2018
Contact Information
- Duke Box 2629, MSRB 1, Durham, NC 27710
- MSRB I, Rm 259, 203 Research Dr, Durham, NC 27710
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david.murdoch@duke.edu
(919) 684-1106
- Background
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Education, Training, & Certifications
- Fellow in Pulmonary Medicine, Medicine, Duke University 2003 - 2007
- Medical Resident, Medicine, Vanderbilt University 1999 - 2002
- M.D., Medical University of South Carolina, College of Medicine 1999
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Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2016 - 2018
- Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2008 - 2016
- Medical Instructor in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2007 - 2008
- Instructor, Temporary in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2007
- Expertise
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Subject Headings
- AIDS-Related Opportunistic Infections
- Adult
- Anti-Retroviral Agents
- BK Virus
- Case-Control Studies
- Cytomegalovirus Infections
- Epidemiology--Research
- Flow Cytometry
- HIV Infections
- Health Resources
- Humans
- Immune Reconstitution Inflammatory Syndrome
- Immunocompromised Host
- Lung Diseases
- Mycobacterium avium-intracellulare Infection
- Phenotype
- Prospective Studies
- Research
- Smoking
- South Africa
- T cells
- T cells--Differentiation
- Tobacco Industry
- Transplantation Immunology
- Tuberculosis, Pulmonary
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Global Scholarship
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Research
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- Research
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Selected Grants
- Clinical and Mechanistic Factors Impacting Transplant Outcomes (U01) awarded by National Institutes of Health 2022 - 2027
- Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER) awarded by National Institutes of Health 2022 - 2026
- A machine learning approach to understanding the impact of cannabis on the HIV latent reservoir awarded by National Institutes of Health 2021 - 2026
- Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health 2010 - 2025
- Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users awarded by National Institutes of Health 2019 - 2025
- Characterization of CMV-specific T cell responses in immunocompromised hosts awarded by National Institutes of Health 2022 - 2024
- Trajectories of blood-based biomarkers of AD, their determinants, and ability to predict cognitive impairment awarded by National Institutes of Health 2022 - 2023
- 1/2 Doxycycline for Emphysema in People Living with HIV: The DEPTH Trial awarded by Weill Cornell Medicine 2022 - 2023
- Research Training in Allergy and Clinical Immunology awarded by University of North Carolina - Chapel Hill 2000 - 2023
- Defining the impact of cannabinoids on the latent HIV reservoir through multi-omic analysis awarded by University of North Carolina - Chapel Hill 2021 - 2023
- Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health 2017 - 2023
- Magnetically directed single cell transcriptome analysis in HIV latency awarded by National Institutes of Health 2014 - 2023
- Data-driven Approaches to Healthcare Provider Resilience & Burnout during COVID-19 awarded by Department of Defense 2021 - 2022
- 1/2 Doxycycline for Emphysema in People Living with HIV: The DEPTH Trial awarded by Weill Cornell Medicine 2022
- Characterization of CMV-specific T cell responses in immunocompromised hosts awarded by National Institutes of Health 2020 - 2022
- A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation awarded by National Institutes of Health 2016 - 2021
- The impact of HIV infection or exposure on the upper respiratory microbiome of children in Botswana awarded by Vanderbilt University Medical Center 2019 - 2021
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2021
- Magnetic single cell assay for epigenetic examination of latent HIV-1 infection awarded by University of Alabama at Birmingham 2014 - 2017
- HIV and Asthma in the Post- ART Era awarded by National Institutes of Health 2014 - 2016
- Longitudinal assessment of CMV and BK virus immunity in renal transplant patients awarded by National Institutes of Health 2013 - 2016
- ImmunosanT-Nexvax2-1002 awarded by ImmusanT 2014
- International Research Scientist Development Award awarded by National Institutes of Health 2007 - 2012
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Murdoch, David M., Richard Barfield, Cliburn Chan, Sheri L. Towe, Ryan P. Bell, Alicia Volkheimer, Joyce Choe, et al. “Neuroimaging and immunological features of neurocognitive function related to substance use in people with HIV.” J Neurovirol 29, no. 1 (February 2023): 78–93. https://doi.org/10.1007/s13365-022-01102-2.Full Text Link to Item
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DiSalvo, Matthew, Belén Cortés-Llanos, Cody A. LaBelle, David M. Murdoch, and Nancy L. Allbritton. “Scalable Additive Construction of Arrayed Microstructures with Encoded Properties for Bioimaging.” Micromachines (Basel) 13, no. 9 (August 25, 2022). https://doi.org/10.3390/mi13091392.Full Text Link to Item
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Fefer, Gilad, Wojciech K. Panek, Michael Z. Khan, Matthew Singer, Hans D. Westermeyer, Freya M. Mowat, David M. Murdoch, Beth Case, Natasha J. Olby, and Margaret E. Gruen. “Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population.” J Alzheimers Dis 87, no. 3 (2022): 1367–78. https://doi.org/10.3233/JAD-215562.Full Text Link to Item
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Chen, Lingye, Bryan D. Kraft, Victor L. Roggli, Zachary R. Healy, Christopher W. Woods, Ephraim L. Tsalik, Geoffrey S. Ginsburg, et al. “Heparin-based blood purification attenuates organ injury in baboons with Streptococcus pneumoniae pneumonia.” Am J Physiol Lung Cell Mol Physiol 321, no. 2 (August 1, 2021): L321–35. https://doi.org/10.1152/ajplung.00337.2020.Full Text Link to Item
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Navuluri, Neelima, Maria L. Srour, Peter S. Kussin, David M. Murdoch, Neil R. MacIntyre, Loretta G. Que, Nathan M. Thielman, and Eric D. McCollum. “Oxygen delivery systems for adults in Sub-Saharan Africa: A scoping review.” J Glob Health 11 (May 8, 2021): 04018. https://doi.org/10.7189/jogh.11.04018.Full Text Open Access Copy Link to Item
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Panek, Wojciech K., David M. Murdoch, Margaret E. Gruen, Freya M. Mowat, Robert D. Marek, and Natasha J. Olby. “Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs.” Mol Neurobiol 58, no. 2 (February 2021): 483–89. https://doi.org/10.1007/s12035-020-02140-9.Full Text Link to Item
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Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.Full Text Link to Item
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Panek, Wojciech K., Margaret E. Gruen, David M. Murdoch, Robert D. Marek, Alexandra F. Stachel, Freya M. Mowat, Korinn E. Saker, and Natasha J. Olby. “Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs.” Mol Neurobiol 57, no. 7 (July 2020): 3143–49. https://doi.org/10.1007/s12035-020-01951-0.Full Text Link to Item
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Healy, Zachary R., Kent J. Weinhold, and David M. Murdoch. “Transcriptional Profiling of CD8+ CMV-Specific T Cell Functional Subsets Obtained Using a Modified Method for Isolating High-Quality RNA From Fixed and Permeabilized Cells.” Front Immunol 11 (2020): 1859. https://doi.org/10.3389/fimmu.2020.01859.Full Text Open Access Copy Link to Item
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Berger, Miles, David M. Murdoch, Janet S. Staats, Cliburn Chan, Jake P. Thomas, Grant E. Garrigues, Jeffrey N. Browndyke, et al. “Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.” Anesth Analg 129, no. 5 (November 2019): e150–54. https://doi.org/10.1213/ANE.0000000000004179.Full Text Open Access Copy Link to Item
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Berger, Miles, Deborah Oyeyemi, Mobolaji O. Olurinde, Heather E. Whitson, Kent J. Weinhold, Marty G. Woldorff, Lewis A. Lipsitz, et al. “The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.” J Am Geriatr Soc 67, no. 4 (April 2019): 794–98. https://doi.org/10.1111/jgs.15770.Full Text Open Access Copy Link to Item
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Paul, D. W., D. K. Lagat, N. MacIntyre, J. R. Egger, D. M. Murdoch, L. G. Que, and P. S. Kussin. “Validation of spirometry prediction equations in western Kenya.” Int J Tuberc Lung Dis 22, no. 1 (January 1, 2018): 112–18. https://doi.org/10.5588/ijtld.17.0005.Full Text Link to Item
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Abedini-Nassab, Roozbeh, Daniel Y. Joh, Faris Albarghouthi, Ashutosh Chilkoti, David M. Murdoch, and Benjamin B. Yellen. “Magnetophoretic transistors in a tri-axial magnetic field.” Lab Chip 16, no. 21 (October 18, 2016): 4181–88. https://doi.org/10.1039/c6lc00878j.Full Text Link to Item
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Healy, Zachary R., and David M. Murdoch. “OMIP-036: Co-inhibitory receptor (immune checkpoint) expression analysis in human T cell subsets.” Cytometry A 89, no. 10 (October 2016): 889–92. https://doi.org/10.1002/cyto.a.22938.Full Text Link to Item
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Abedini-Nassab, Roozbeh, Daniel Y. Joh, Melissa Van Heest, Cody Baker, Ashutosh Chilkoti, David M. Murdoch, and Benjamin B. Yellen. “Magnetophoretic Conductors and Diodes in a 3D Magnetic Field.” Adv Funct Mater 26, no. 22 (June 14, 2016): 4026–34. https://doi.org/10.1002/adfm.201503898.Full Text Link to Item
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Van Rie, Annelies, Shobna Sawry, Ruth Link-Gelles, Shabir Madhi, Lee Fairlie, Charl Verwey, Nasreen Mahomed, David Murdoch, and Harry Moultrie. “Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome in children.” Pediatr Pulmonol 51, no. 2 (February 2016): 157–64. https://doi.org/10.1002/ppul.23221.Full Text Link to Item
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Abedini-Nassab, Roozbeh, Daniel Y. Joh, Melissa A. Van Heest, John S. Yi, Cody Baker, Zohreh Taherifard, David M. Margolis, et al. “Characterizing the Switching Thresholds of Magnetophoretic Transistors.” Adv Mater 27, no. 40 (October 28, 2015): 6176–80. https://doi.org/10.1002/adma.201502352.Full Text Open Access Copy Link to Item
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Bloomfield, Gerald S., Prateeti Khazanie, Alison Morris, Cristina Rabadán-Diehl, Laura A. Benjamin, David Murdoch, Virginia S. Radcliff, Eric J. Velazquez, and Charles Hicks. “HIV and noncommunicable cardiovascular and pulmonary diseases in low- and middle-income countries in the ART era: what we know and best directions for future research.” J Acquir Immune Defic Syndr 67 Suppl 1, no. 0 1 (September 1, 2014): S40–53. https://doi.org/10.1097/QAI.0000000000000257.Full Text Link to Item
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Shields, C Wyatt, Carissa E. Livingston, Benjamin B. Yellen, Gabriel P. López, and David M. Murdoch. “Magnetographic array for the capture and enumeration of single cells and cell pairs.” Biomicrofluidics 8, no. 4 (July 2014): 041101. https://doi.org/10.1063/1.4885840.Full Text Link to Item
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Abedini-Nassab, R., D. M. Murdoch, C. Kim, and B. B. Yellen. “Optimization of magnetic switches for single particle and cell transport.” Journal of Applied Physics 115, no. 24 (June 28, 2014). https://doi.org/10.1063/1.4884609.Full Text
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Link-Gelles, Ruth, Harry Moultrie, Shobna Sawry, David Murdoch, and Annelies Van Rie. “Tuberculosis Immune Reconstitution Inflammatory Syndrome in children initiating Antiretroviral Therapy for HIV infection: A systematic literature review.” Pediatr Infect Dis J 33, no. 5 (May 2014): 499–503. https://doi.org/10.1097/INF.0000000000000142.Full Text Link to Item
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Waweru, P., R. Anderson, H. Steel, W. D. F. Venter, D. Murdoch, and C. Feldman. “The prevalence of smoking and the knowledge of smoking hazards and smoking cessation strategies among HIV-positive patients in Johannesburg, South Africa.” South African Medical Journal 103, no. 11 (October 28, 2013): 858–60. https://doi.org/10.7196/SAMJ.7388.Full Text
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Piantadosi, Claude A., Raquel R. Bartz, Martha S. Carraway, Andrew J. Ghio, Timothy J. McMahon, David M. Murdoch, Victor L. Roggli, et al. “The opprobrium of Big Tobacco.” Am J Respir Crit Care Med 185, no. 9 (May 1, 2012): 1030. https://doi.org/10.1164/ajrccm.185.9.1030.Full Text Link to Item
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Murdoch, David M., Janet S. Staats, and Kent J. Weinhold. “OMIP-006: phenotypic subset analysis of human T regulatory cells via polychromatic flow cytometry.” Cytometry A 81, no. 4 (April 2012): 281–83. https://doi.org/10.1002/cyto.a.22024.Full Text Link to Item
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Buldeo, S., D. M. Murdoch, and M. S. Suchard. “Pulmonary immune-compartment-specific interferon gamma responses in HIV-infected individuals with active tuberculosis (TB) in an area of high TB prevalence.” Clin Dev Immunol 2012 (2012): 308473. https://doi.org/10.1155/2012/308473.Full Text Link to Item
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Wong, Emily B., Tanvier Omar, Gosetsemang J. Setlhako, Regina Osih, Charles Feldman, David M. Murdoch, Neil A. Martinson, David R. Bangsberg, and W. D. F. Venter. “Causes of death on antiretroviral therapy: a post-mortem study from South Africa.” Plos One 7, no. 10 (2012): e47542. https://doi.org/10.1371/journal.pone.0047542.Full Text Link to Item
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Worsley, Catherine M., Melinda S. Suchard, Wendy S. Stevens, Annelies Van Rie, and David M. Murdoch. “Multi-analyte profiling of ten cytokines in South African HIV-infected patients with Immune Reconstitution Inflammatory Syndrome (IRIS).” Aids Res Ther 7 (October 7, 2010): 36. https://doi.org/10.1186/1742-6405-7-36.Full Text Link to Item
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Gay, Cynthia L., Victor Mwapasa, David M. Murdoch, Jesse J. Kwiek, Susan A. Fiscus, Steven R. Meshnick, and Myron S. Cohen. “Acute HIV infection among pregnant women in Malawi.” Diagn Microbiol Infect Dis 66, no. 4 (April 2010): 356–60. https://doi.org/10.1016/j.diagmicrobio.2009.12.001.Full Text Link to Item
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Price, Patricia, David M. Murdoch, Upasna Agarwal, Sharon R. Lewin, Julian H. Elliott, and Martyn A. French. “Immune restoration diseases reflect diverse immunopathological mechanisms.” Clin Microbiol Rev 22, no. 4 (October 2009): 651–63. https://doi.org/10.1128/CMR.00015-09.Full Text Link to Item
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Murdoch, David M., Melinda S. Suchard, Willem D. F. Venter, Patrick Mhlangu, Janet S. Ottinger, Charles Feldman, Annelies Van Rie, Deborah K. Glencross, Wendy S. Stevens, and Kent J. Weinhold. “Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS).” Aids Res Ther 6 (July 16, 2009): 16. https://doi.org/10.1186/1742-6405-6-16.Full Text Link to Item
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Murdoch, D. M., M. S. Suchard, W. D. F. Venter, P. Mhlangu, J. S. Ottinger, C. Feldman, A. V. Rie, D. K. Glencross, W. S. Stevens, and K. J. Weinhold. “Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS).” Aids Research and Therapy 6 (2009). https://doi.org/10.1186/1742-6405-6-6.Full Text
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Murdoch, David M., Willem D. F. Venter, Charles Feldman, and Annelies Van Rie. “HIV immune reconstitution syndrome in sub-Saharan Africa.” Aids 22, no. 13 (August 20, 2008): 1689–90. https://doi.org/10.1097/QAD.0b013e328308de33.Full Text Link to Item
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Meintjes, Graeme, Stephen D. Lawn, Fabio Scano, Gary Maartens, Martyn A. French, William Worodria, Julian H. Elliott, et al. “Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings.” Lancet Infect Dis 8, no. 8 (August 2008): 516–23. https://doi.org/10.1016/S1473-3099(08)70184-1.Full Text Link to Item
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Murdoch, David M., Willem D. F. Venter, Charles Feldman, and Annelies Van Rie. “Incidence and risk factors for the immune reconstitution inflammatory syndrome in HIV patients in South Africa: a prospective study.” Aids 22, no. 5 (March 12, 2008): 601–10. https://doi.org/10.1097/QAD.0b013e3282f4a607.Full Text Link to Item
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Murdoch, David M., Sonia Napravnik, Joseph J. Eron, and Annelies Van Rie. “Smoking and predictors of pneumonia among HIV-infected patients receiving care in the HAART era.” Open Respir Med J 2 (2008): 22–28. https://doi.org/10.2174/1874306400802010022.Full Text Link to Item
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Tabatabaei, N., J. Stout, P. Goldschmidt-Clermont, and D. Murdoch. “Central nervous system infection and cutaneous lymphadenitis due to Mycobacterium kansasii in an immunocompetent patient.” Infection 35, no. 4 (June 2007): 291–94. https://doi.org/10.1007/s15010-007-6208-7.Full Text Link to Item
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Murdoch, David M., Willem D. F. Venter, Annelies Van Rie, and Charles Feldman. “Immune reconstitution inflammatory syndrome (IRIS): review of common infectious manifestations and treatment options.” Aids Res Ther 4 (May 8, 2007): 9. https://doi.org/10.1186/1742-6405-4-9.Full Text Link to Item
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Murdoch, David M., and Jay R. McDonald. “Mycobacterium avium-intracellulare cellulitis occurring with septic arthritis after joint injection: a case report.” Bmc Infect Dis 7 (February 26, 2007): 9. https://doi.org/10.1186/1471-2334-7-9.Full Text Link to Item
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Joos, T. J., W. C. Miller, and D. M. Murdoch. “Tuberculin reactivity in bacille Calmette-Guérin vaccinated populations: a compilation of international data.” Int J Tuberc Lung Dis 10, no. 8 (August 2006): 883–91.Link to Item
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Miller, D. L., S. Brazer, D. Murdoch, L. B. Reller, and G. R. Corey. “Significance of Clostridium tertium bacteremia in neutropenic and nonneutropenic patients: review of 32 cases.” Clin Infect Dis 32, no. 6 (March 15, 2001): 975–78. https://doi.org/10.1086/319346.Full Text Link to Item
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Journal Issues
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Paul, Devon W., Nigel B. Neely, Meredith Clement, Isaretta Riley, Mashael Al-Hegelan, Matthew Phelan, Monica Kraft, et al. “Development and validation of an electronic medical record (EMR)-based computed phenotype of HIV-1 infection.” J Am Med Inform Assoc, February 1, 2018. https://doi.org/10.1093/jamia/ocx061.Full Text Link to Item
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Conference Papers
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Navuluri, N., L. G. Que, D. M. Murdoch, N. Thielman, N. R. MacIntyre, J. A. Krishnan, D. K. Lagat, and P. S. Kussin. “Evaluation of Hypoxemia Among Patients Admitted to a Tertiary Referral Hospital in Western Kenya.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.Link to Item
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- Teaching & Mentoring
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Advising & Mentoring
Available to mentor:
- Fellow
- Masters
- PhD
- Resident
- Undergraduate
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