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David Isaias Ortiz-Melo

Associate Professor of Medicine
Medicine, Nephrology
2424 Erwin Rd, Suite 605, DUMC Box 2747, Durham, NC 27705
2424 Erwin Rd, Suite 605, DUMC Box 2747, Durham, NC 27705

Overview


I enjoy practicing nephrology and taking care of patient with kidney disorders. As a clinician-educator in the Division of Nephrology, my clinical practice mainly focuses on the management of uncontrolled high blood pressure, chronic kidney disease, acute kidney injury and fluid and electrolyte disorders. I have particular interest in the evaluation and management of kidney disease affecting patients with cancer (onco-nephrology). In the inpatient setting, my clinical activities are focused on consultative nephrology and maintenance dialysis.  In the outpatient setting, I see patients two days weekly through the Private Diagnostic Clinic. In addition, I am a rounding nephrologist at three outpatient dialysis units.

Current Appointments & Affiliations


Associate Professor of Medicine · 2024 - Present Medicine, Nephrology, Medicine

Recent Publications


A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant.

Journal Article Kidney Int · July 2021 Immune checkpoint inhibitors (ICIs) are widely used for various malignancies. However, their safety and efficacy in patients with a kidney transplant have not been defined. To delineate this, we conducted a multicenter retrospective study of 69 patients wi ... Full text Link to item Cite

Angiotensin converting enzyme 2 and the kidney.

Journal Article Current opinion in nephrology and hypertension · January 2016 Purpose of reviewAngiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that metabolizes angiotensin II (AngII). AngII levels can be modulated by ACE2 in tissues where the enzyme is highly expressed, such as the kidney. In the kidney, AC ... Full text Cite
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Education, Training & Certifications


Instituto Tecnologico de Santo Domingo (Dominican Republic) · 2004 M.D.