David R. Sherwood
Jerry G. and Patricia Crawford Hubbard Professor
The Sherwood lab is interested in understanding mechanisms that drive dynamic cellular behaviors underlying normal development and human disease. We study 1) H
ow cells invade into tissues, 2) How stem cells interact with their niches, and 3) How cells control and interact with extracellular matrix
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Our lab primarily examines C. elegans development, in which simple cellular complexity, amenability to genetics/genomics/transgenics/molecular perturbations, and evolutionary comparisons facilitates powerful insights. One particular emphasis of our work is live-cell imaging, where we watch cellular behaviors and cell-extracellular matrix interactions unfold in real-time to understand their regulation and function. Cell invasion, stem cell regulation, and cell-matrix interactions are fundamental to development, regeneration, cancer, and aging. Our work aims to advance our understanding of these fascinating processes and positively influence human health.
Current Appointments & Affiliations
- Jerry G. and Patricia Crawford Hubbard Professor, Biology, Trinity College of Arts & Sciences 2019 - 2024
- Professor of Biology, Biology, Trinity College of Arts & Sciences 2017
- Associate Professor in Cell Biology, Cell Biology, Basic Science Departments 2016
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019
- Co-Director of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- Box 90338, Department of Biology, Durham, NC 27708
- Duke Box 90338, Durham, NC 27708-1000
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david.sherwood@duke.edu
(919) 613-8192
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http://sites.duke.edu/sherwoodlab
- Background
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Education, Training, & Certifications
- Ph.D., Duke University 1997
- B.A., Wesleyan University 1990
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Previous Appointments & Affiliations
- Associate Professor in the Department of Biology, Biology, Trinity College of Arts & Sciences 2012 - 2017
- Assistant Professor of Biology, Biology, Trinity College of Arts & Sciences 2005 - 2012
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Academic Positions Outside Duke
- Co-Director Embryology Course, Marine Biological Laboratory. 2021 - 2022
- Recognition
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In the News
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MAY 4, 2023 Duke Today -
MAR 22, 2022 -
JUL 14, 2020 -
JUL 7, 2020 -
MAR 6, 2020 Duke Research Blog -
JAN 24, 2019 -
NOV 27, 2017 -
NOV 1, 2016 -
FEB 19, 2016 Duke Research Blog -
JAN 4, 2016 Scientific American -
AUG 25, 2014 -
JUN 20, 2014 BBC News -
JUN 19, 2014
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Awards & Honors
- Expertise
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Subject Headings
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Global Scholarship
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Teaching
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- Research
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Selected Grants
- Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program awarded by National Institutes of Health 2022 - 2027
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Determining how basement membranes stretch and recover to support tissues awarded by Jane Coffin Childs Memorial Fund for Medical Research 2023 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Understanding how cells invade through basement membrane in vivo awarded by National Institutes of Health 2016 - 2026
- Understanding the Mechanisms and Consequences of Basement Membrane Aging in Vivo awarded by National Institutes of Health 2023 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Elucidating the Mechanisms Behind Basement Membrane Stretching awarded by National Institutes of Health 2021 - 2024
- Targeting invasive plasticity by inhibiting mitochondrial adaptations to matrix metalloproteinase loss awarded by National Institutes of Health 2022 - 2024
- A Comprehensive Endogenous Basement Membrane Toolkit to Elucidate how Basement Membranes Stretch on Mechanically Active Tissues and Decline during Aging awarded by National Institutes of Health 2022 - 2024
- A comprehensive toolkit to visualize endogenously tagged fluorescent basement membrane components in a living animal awarded by National Institutes of Health 2020 - 2023
- Understanding the role of the collagen receptor DDR-2 in germ stem cell niche formation awarded by National Institutes of Health 2019 - 2022
- Transmission electron microscope (TEM) awarded by National Institutes of Health 2019 - 2021
- Connecting human disease to basement membrane biology awarded by University of Manchester 2019 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Defining a Newly Identified Membrane Structure That Directs Cell Invasion awarded by American Cancer Society, Inc. 2016 - 2019
- Understanding a Novel Role for Gap Junctions in Directing Endogenous and Ectopic Stem Cell Niche Morphology awarded by National Institutes of Health 2016 - 2018
- Visualizing and Elucidating the Role of Force on Type IV Collagen in Development awarded by National Institutes of Health 2016 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- Elucidating Key Mechanisms Regulating Cell Invasion In Vivo awarded by National Institutes of Health 2007 - 2017
- Understanding How Invadosomes Breach Basement Membrane In Vivo awarded by National Institutes of Health 2012 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Understanding the Role of MMPs in Basement Membrane Breaching In vivo awarded by National Institutes of Health 2012 - 2015
- Understanding How Extrinsic Signals Direct a Rho GTPase Switch to Control Cell Invasion in Vivo awarded by Damon Runyon Cancer Research Foundation 2015
- Elucidating the Gene Regulatory Networks that Specify Invasive Behavior awarded by National Institutes of Health 2011 - 2014
- NRSA: Analysis of SPARC in Cell Invasion in C. Elegans awarded by National Institutes of Health 2007 - 2009
- NCI Howard Temin Award awarded by National Institutes of Health 2005 - 2009
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External Relationships
- Marine Biological Laboratory, Woods Hole, MA
- NIH
- Shanghai JiaoTong University
- Tesla
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Costa, Daniel S., Isabel W. Kenny-Ganzert, Qiuyi Chi, Kieop Park, Laura C. Kelley, Aastha Garde, David Q. Matus, et al. “The Caenorhabditis elegans anchor cell transcriptome: ribosome biogenesis drives cell invasion through basement membrane.” Development (Cambridge, England) 150, no. 9 (May 2023): dev201570. https://doi.org/10.1242/dev.201570.Full Text
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Gianakas, Claire A., Daniel P. Keeley, William Ramos-Lewis, Kieop Park, Ranjay Jayadev, Isabel W. Kenny, Qiuyi Chi, and David R. Sherwood. “Hemicentin-mediated type IV collagen assembly strengthens juxtaposed basement membrane linkage.” The Journal of Cell Biology 222, no. 1 (January 2023): e202112096. https://doi.org/10.1083/jcb.202112096.Full Text
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Garde, Aastha, and David R. Sherwood. “Visualizing cytoplasmic ATP in C. elegans larvae using PercevalHR.” Star Protocols 3, no. 2 (June 2022): 101429. https://doi.org/10.1016/j.xpro.2022.101429.Full Text
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Jayadev, Ranjay, Mychel R. P. T. Morais, Jamie M. Ellingford, Sandhya Srinivasan, Richard W. Naylor, Craig Lawless, Anna S. Li, et al. “A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations.” Science Advances 8, no. 20 (May 2022): eabn2265. https://doi.org/10.1126/sciadv.abn2265.Full Text
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Garde, Aastha, Isabel W. Kenny, Laura C. Kelley, Qiuyi Chi, Ayse Sena Mutlu, Meng C. Wang, and David R. Sherwood. “Localized glucose import, glycolytic processing, and mitochondria generate a focused ATP burst to power basement-membrane invasion.” Developmental Cell 57, no. 6 (March 2022): 732-749.e7. https://doi.org/10.1016/j.devcel.2022.02.019.Full Text
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Smith, Jayson J., Isabel W. Kenny, Carsten Wolff, Rachel Cray, Abhishek Kumar, David R. Sherwood, and David Q. Matus. “A light sheet fluorescence microscopy protocol for Caenorhabditis elegans larvae and adults.” Frontiers in Cell and Developmental Biology 10 (January 2022): 1012820. https://doi.org/10.3389/fcell.2022.1012820.Full Text
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Gianakas, Claire A., Daniel P. Keeley, William Ramos-Lewis, Kieop Park, Ranjay Jayadev, Qiuyi Chi, and David R. Sherwood. “Hemicentin mediated type IV collagen assembly strengthens juxtaposed basement membrane linkage,” December 23, 2021. https://doi.org/10.1101/2021.12.21.473673.Full Text
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Sherwood, David R. “Basement membrane remodeling guides cell migration and cell morphogenesis during development.” Current Opinion in Cell Biology 72 (October 2021): 19–27. https://doi.org/10.1016/j.ceb.2021.04.003.Full Text
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Garde, Aastha, and David R. Sherwood. “Fueling Cell Invasion through Extracellular Matrix.” Trends in Cell Biology 31, no. 6 (June 2021): 445–56. https://doi.org/10.1016/j.tcb.2021.01.006.Full Text
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Keeley, Daniel P., Eric Hastie, Ranjay Jayadev, Laura C. Kelley, Qiuyi Chi, Sara G. Payne, Jonathan L. Jeger, Brenton D. Hoffman, and David R. Sherwood. “Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding.” Developmental Cell 54, no. 1 (July 2020): 60-74.e7. https://doi.org/10.1016/j.devcel.2020.05.022.Full Text
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Gordon, Kacy L., Jay W. Zussman, Xin Li, Camille Miller, and David R. Sherwood. “Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche.” Elife 9 (July 2020): e56383. https://doi.org/10.7554/elife.56383.Full Text
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Hartman, Jessica H., Christopher T. Richie, Kacy L. Gordon, Danielle F. Mello, Priscila Castillo, April Zhu, Yun Wang, et al. “MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa.” European Journal of Cell Biology 98, no. 5–8 (December 2019): 151043. https://doi.org/10.1016/j.ejcb.2019.05.002.Full Text
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Chen, David, Eric Hastie, and David Sherwood. “Endogenous expression of UNC-59/Septin in C.elegans.” Micropublication Biology 2019 (December 2019). https://doi.org/10.17912/micropub.biology.000200.Full Text
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Jayadev, Ranjay, Qiuyi Chi, Daniel P. Keeley, Eric L. Hastie, Laura C. Kelley, and David R. Sherwood. “α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes.” The Journal of Cell Biology 218, no. 9 (September 2019): 3098–3116. https://doi.org/10.1083/jcb.201903124.Full Text
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Sherwood, David R. “Breaching the Basement Membrane David R. Sherwood.” Developmental Cell 49, no. 4 (May 20, 2019): 498–498.Link to Item
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Gordon, Kacy L., Sara G. Payne, Lara M. Linden-High, Ariel M. Pani, Bob Goldstein, E Jane Albert Hubbard, and David R. Sherwood. “Ectopic Germ Cells Can Induce Niche-like Enwrapment by Neighboring Body Wall Muscle.” Current Biology : Cb 29, no. 5 (March 2019): 823-833.e5. https://doi.org/10.1016/j.cub.2019.01.056.Full Text
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Kelley, Laura C., Qiuyi Chi, Rodrigo Cáceres, Eric Hastie, Adam J. Schindler, Yue Jiang, David Q. Matus, Julie Plastino, and David R. Sherwood. “Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs.” Developmental Cell 48, no. 3 (February 2019): 313-328.e8. https://doi.org/10.1016/j.devcel.2018.12.018.Full Text
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Keeley, Daniel P., and David R. Sherwood. “Tissue linkage through adjoining basement membranes: The long and the short term of it.” Matrix Biology : Journal of the International Society for Matrix Biology 75–76 (January 2019): 58–71. https://doi.org/10.1016/j.matbio.2018.05.009.Full Text
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Hastie, Eric, Ryan Sellers, Bruno Valan, and David R. Sherwood. “A Scalable CURE Using a CRISPR/Cas9 Fluorescent Protein Knock-In Strategy in Caenorhabditis elegans.” Journal of Microbiology & Biology Education 20, no. 3 (January 2019): 20.3.60. https://doi.org/10.1128/jmbe.v20i3.1847.Full Text
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Hibshman, Jonathan D., Tess C. Leuthner, Chelsea Shoben, Danielle F. Mello, David R. Sherwood, Joel N. Meyer, and L Ryan Baugh. “Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans.” American Journal of Physiology. Cell Physiology 315, no. 6 (December 2018): C781–92. https://doi.org/10.1152/ajpcell.00109.2018.Full Text
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Cáceres, Rodrigo, Nagagireesh Bojanala, Laura C. Kelley, Jes Dreier, John Manzi, Fahima Di Federico, Qiuyi Chi, et al. “Forces drive basement membrane invasion in Caenorhabditis elegans.” Proceedings of the National Academy of Sciences of the United States of America 115, no. 45 (November 2018): 11537–42. https://doi.org/10.1073/pnas.1808760115.Full Text
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Hartman, Jessica H., Latasha L. Smith, Kacy L. Gordon, Ricardo Laranjeiro, Monica Driscoll, David R. Sherwood, and Joel N. Meyer. “Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity.” Scientific Reports 8, no. 1 (May 2018): 8359. https://doi.org/10.1038/s41598-018-26552-9.Full Text Open Access Copy
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Sherwood, David R., and Julie Plastino. “Invading, Leading and Navigating Cells in Caenorhabditis elegans: Insights into Cell Movement in Vivo.” Genetics 208, no. 1 (January 2018): 53–78. https://doi.org/10.1534/genetics.117.300082.Full Text
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Naegeli, Kaleb M., Eric Hastie, Aastha Garde, Zheng Wang, Daniel P. Keeley, Kacy L. Gordon, Ariel M. Pani, et al. “Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain.” Developmental Cell 43, no. 4 (November 2017): 403-417.e10. https://doi.org/10.1016/j.devcel.2017.10.024.Full Text
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Kelley, Laura C., Zheng Wang, Elliott J. Hagedorn, Lin Wang, Wanqing Shen, Shijun Lei, Sam A. Johnson, and David R. Sherwood. “Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans.” Nature Protocols 12, no. 10 (October 2017): 2081–96. https://doi.org/10.1038/nprot.2017.093.Full Text
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Jayadev, Ranjay, and David R. Sherwood. “Morphogenesis: Shaping Tissues through Extracellular Force Gradients.” Current Biology : Cb 27, no. 17 (September 2017): R850–52. https://doi.org/10.1016/j.cub.2017.07.040.Full Text
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Linden, Lara M., Kacy L. Gordon, Ariel M. Pani, Sara G. Payne, Aastha Garde, Dane Burkholder, Qiuyi Chi, Bob Goldstein, and David R. Sherwood. “Identification of regulators of germ stem cell enwrapment by its niche in C. elegans.” Developmental Biology 429, no. 1 (September 2017): 271–84. https://doi.org/10.1016/j.ydbio.2017.06.019.Full Text
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Jayadev, Ranjay, and David R. Sherwood. “Basement membranes.” Current Biology : Cb 27, no. 6 (March 2017): R207–11. https://doi.org/10.1016/j.cub.2017.02.006.Full Text
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Hastie, Eric L., and David R. Sherwood. “A new front in cell invasion: The invadopodial membrane.” European Journal of Cell Biology 95, no. 11 (November 2016): 441–48. https://doi.org/10.1016/j.ejcb.2016.06.006.Full Text
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Maurer, Laura L., Xinyu Yang, Adam J. Schindler, Ross K. Taggart, Chuanjia Jiang, Heileen Hsu-Kim, David R. Sherwood, and Joel N. Meyer. “Intracellular trafficking pathways in silver nanoparticle uptake and toxicity in Caenorhabditis elegans.” Nanotoxicology 10, no. 7 (September 2016): 831–35. https://doi.org/10.3109/17435390.2015.1110759.Full Text
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McClatchey, Shelly Th, Zheng Wang, Lara M. Linden, Eric L. Hastie, Lin Wang, Wanqing Shen, Alan Chen, Qiuyi Chi, and David R. Sherwood. “Boundary cells restrict dystroglycan trafficking to control basement membrane sliding during tissue remodeling.” Elife 5 (September 2016): e17218. https://doi.org/10.7554/elife.17218.Full Text
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Jayadev, Ranjay, and David R. Sherwood. “Tissue Sculpting by Fibrils.” Developmental Cell 38, no. 1 (July 2016): 1–3. https://doi.org/10.1016/j.devcel.2016.06.028.Full Text
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Morrissey, Meghan A., Ranjay Jayadev, Ginger R. Miley, Catherine A. Blebea, Qiuyi Chi, Shinji Ihara, and David R. Sherwood. “SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane.” Plos Genetics 12, no. 2 (February 2016): e1005905. https://doi.org/10.1371/journal.pgen.1005905.Full Text
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Lohmer, Lauren L., Matthew R. Clay, Kaleb M. Naegeli, Qiuyi Chi, Joshua W. Ziel, Elliott J. Hagedorn, Jieun E. Park, Ranjay Jayadev, and David R. Sherwood. “A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation.” Plos Genetics 12, no. 1 (January 2016): e1005786. https://doi.org/10.1371/journal.pgen.1005786.Full Text
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Matus, David Q., Lauren L. Lohmer, Laura C. Kelley, Adam J. Schindler, Abraham Q. Kohrman, Michalis Barkoulas, Wan Zhang, Qiuyi Chi, and David R. Sherwood. “Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression.” Developmental Cell 35, no. 2 (October 2015): 162–74. https://doi.org/10.1016/j.devcel.2015.10.002.Full Text
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Sherwood, David R. “A developmental biologist's "outside-the-cell" thinking.” The Journal of Cell Biology 210, no. 3 (August 2015): 369–72. https://doi.org/10.1083/jcb.201501083.Full Text
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Wei, Xing, Audrey S. Howell, Xintong Dong, Caitlin A. Taylor, Roshni C. Cooper, Jianqi Zhang, Wei Zou, David R. Sherwood, and Kang Shen. “The unfolded protein response is required for dendrite morphogenesis.” Elife 4 (June 2015): e06963. https://doi.org/10.7554/elife.06963.Full Text
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Morrissey, Meghan A., and David R. Sherwood. “An active role for basement membrane assembly and modification in tissue sculpting.” Journal of Cell Science 128, no. 9 (May 2015): 1661–68. https://doi.org/10.1242/jcs.168021.Full Text
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Clay, Matthew R., and David R. Sherwood. “Basement Membranes in the Worm: A Dynamic Scaffolding that Instructs Cellular Behaviors and Shapes Tissues.” Current Topics in Membranes 76 (January 2015): 337–71. https://doi.org/10.1016/bs.ctm.2015.08.001.Full Text
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Zou, Wei, Smita Yadav, Laura DeVault, Yuh Nung Jan, and David R. Sherwood. “RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization.” Plos Genetics 11, no. 9 (January 2015): e1005484. https://doi.org/10.1371/journal.pgen.1005484.Full Text
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Armenti, Stephen T., Lauren L. Lohmer, David R. Sherwood, and Jeremy Nance. “Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins.” Development (Cambridge, England) 141, no. 23 (December 2014): 4640–47. https://doi.org/10.1242/dev.115048.Full Text
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Morrissey, Meghan A., Daniel P. Keeley, Elliott J. Hagedorn, Shelly T. H. McClatchey, Qiuyi Chi, David H. Hall, and David R. Sherwood. “B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes.” Developmental Cell 31, no. 3 (November 2014): 319–31. https://doi.org/10.1016/j.devcel.2014.08.024.Full Text
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Schindler, Adam J., and David R. Sherwood. “Should I stay or should I go? Identification of novel nutritionally regulated developmental checkpoints in C. elegans.” Worm 3, no. 4 (October 2014): e979658. https://doi.org/10.4161/21624054.2014.979658.Full Text
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Wang, Lin, Wanqing Shen, Shijun Lei, David Matus, David Sherwood, and Zheng Wang. “MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans.” Biochemical and Biophysical Research Communications 452, no. 3 (September 2014): 328–33. https://doi.org/10.1016/j.bbrc.2014.08.049.Full Text
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Wang, Zheng, Lara M. Linden, Kaleb M. Naegeli, Joshua W. Ziel, Qiuyi Chi, Elliott J. Hagedorn, Natasha S. Savage, and David R. Sherwood. “UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity.” The Journal of Cell Biology, August 25, 2014. https://doi.org/10.1083/jcb.201405026.Full Text Open Access Copy
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Matus, David Q., Emily Chang, Sasha C. Makohon-Moore, Mary A. Hagedorn, Qiuyi Chi, and David R. Sherwood. “Cell division and targeted cell cycle arrest opens and stabilizes basement membrane gaps.” Nature Communications 5 (June 2014): 4184. https://doi.org/10.1038/ncomms5184.Full Text
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Schindler, Adam J., L Ryan Baugh, and David R. Sherwood. “Identification of late larval stage developmental checkpoints in Caenorhabditis elegans regulated by insulin/IGF and steroid hormone signaling pathways.” Plos Genetics 10, no. 6 (June 2014): e1004426. https://doi.org/10.1371/journal.pgen.1004426.Full Text Open Access Copy
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Lohmer, Lauren L., Laura C. Kelley, Elliott J. Hagedorn, and David R. Sherwood. “Invadopodia and basement membrane invasion in vivo.” Cell Adhesion & Migration 8, no. 3 (May 2014): 246–55. https://doi.org/10.4161/cam.28406.Full Text
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Lacroix, Benjamin, Karine G. Bourdages, Jonas F. Dorn, Shinji Ihara, David R. Sherwood, Paul S. Maddox, and Amy S. Maddox. “In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics.” Developmental Cell 29, no. 2 (April 2014): 203–16. https://doi.org/10.1016/j.devcel.2014.03.007.Full Text
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Wang, Zheng, Qiuyi Chi, and David R. Sherwood. “MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans.” Development (Cambridge, England) 141, no. 6 (March 2014): 1342–53. https://doi.org/10.1242/dev.102434.Full Text
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Hagedorn, Elliott J., Laura C. Kelley, Kaleb M. Naegeli, Zheng Wang, Qiuyi Chi, and David R. Sherwood. “ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo.” The Journal of Cell Biology 204, no. 7 (March 2014): 1209–18. https://doi.org/10.1083/jcb.201312098.Full Text
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Kelley, Laura C., Lauren L. Lohmer, Elliott J. Hagedorn, and David R. Sherwood. “Traversing the basement membrane in vivo: a diversity of strategies.” The Journal of Cell Biology 204, no. 3 (February 2014): 291–302. https://doi.org/10.1083/jcb.201311112.Full Text
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Morrissey, Meghan A., Elliott J. Hagedorn, and David R. Sherwood. “Cell invasion through basement membrane: The netrin receptor DCC guides the way.” Worm 2, no. 3 (July 2013): e26169. https://doi.org/10.4161/worm.26169.Full Text
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Hagedorn, Elliott J., Joshua W. Ziel, Meghan A. Morrissey, Lara M. Linden, Zheng Wang, Qiuyi Chi, Sam A. Johnson, and David R. Sherwood. “The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo.” The Journal of Cell Biology 201, no. 6 (June 2013): 903–13. https://doi.org/10.1083/jcb.201301091.Full Text
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Schindler, Adam J., and David R. Sherwood. “Morphogenesis of the caenorhabditis elegans vulva.” Wiley Interdisciplinary Reviews. Developmental Biology 2, no. 1 (January 2013): 75–95. https://doi.org/10.1002/wdev.87.Full Text
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Hagedorn, Elliott J., Joshua W. Ziel, Meghan A. Morrissey, Lara Linden, Zheng Wang, Qiuyi Chi, Sam A. Johnson, and David R. Sherwood. “The UNC-40(DCC) Receptor Mediates a Morphogenetic Switch that Directs C. elegans Anchor Cell Invasion Across Basement Membrane (Submitted).” Nature Cell Biology, 2012.
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Wang, Zheng, Joshua W. Ziel, Qiu Chi, Elliott J. Hagedorn, and David R. Sherwood. “Netrin Stabilizes UNC-40(DCC)-Generated Oscillatory Polarity to Direct Anchor Cell Invasion in C. elegans (In preparation).” Cell, 2012.
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Hagedorn, Elliott J., and David R. Sherwood. “Cell invasion through basement membrane: the anchor cell breaches the barrier.” Current Opinion in Cell Biology 23, no. 5 (October 2011): 589–96. https://doi.org/10.1016/j.ceb.2011.05.002.Full Text
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Schindler, Adam J., and David R. Sherwood. “The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans.” Developmental Biology 357, no. 2 (September 2011): 380–91. https://doi.org/10.1016/j.ydbio.2011.07.012.Full Text
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Ihara, S., E. J. Hagedorn, M. A. Morrissey, Q. Chi, F. Motegi, J. M. Kramer, and D. R. Sherwood. “Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans.” Nature Cell Biology 13, no. 6 (June 2011): 641–51. https://doi.org/10.1038/ncb2233.Full Text
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Wang, Zheng, and David R. Sherwood. “Dissection of genetic pathways in C. elegans.” Methods in Cell Biology 106 (January 2011): 113–57. https://doi.org/10.1016/b978-0-12-544172-8.00005-0.Full Text
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Matus, D. Q., D. R. Sherwood, and A. M. Vanhook. “Science signaling podcast: 11 May 2010.” Science Signaling 3, no. 121 (May 11, 2010). https://doi.org/10.1126/scisignal.3121pc10.Full Text
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Ziel, Joshua W., and David R. Sherwood. “Roles for netrin signaling outside of axon guidance: a view from the worm.” Developmental Dynamics : An Official Publication of the American Association of Anatomists 239, no. 5 (May 2010): 1296–1305. https://doi.org/10.1002/dvdy.22225.Full Text
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Matus, D. Q., X. Y. Li, S. Durbin, D. Agarwal, Q. Chi, S. J. Weiss, and D. R. Sherwood. “In vivo identification of regulators of cell invasion across basement membranes.” Science Signaling 3, no. 120 (2010): ra35. https://doi.org/10.1126/scisignal.2000654.Full Text
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Matus, David Q., David R. Sherwood, and Annalisa M. VanHook. “Science Signaling Podcast: 11 May 2010.” Science Signaling 3 (121), no. pc10 (2010).
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Ziel, Joshua W., David Q. Matus, and David R. Sherwood. “An expression screen for RhoGEF genes involved in C. elegans gonadogenesis.” Gene Expression Patterns : Gep 9, no. 6 (September 2009): 397–403. https://doi.org/10.1016/j.gep.2009.06.005.Full Text
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Hagedorn, Elliott J., Hanako Yashiro, Joshua W. Ziel, Shinji Ihara, Zheng Wang, and David R. Sherwood. “Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.” Developmental Cell 17, no. 2 (August 2009): 187–98. https://doi.org/10.1016/j.devcel.2009.06.006.Full Text
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Ziel, Joshua W., and David R. Sherwood. “Mechanisms of UNC-40/DCC signaling during cell invasion in C. elegans.” Developmental Biology 331, no. 2 (July 2009): 475–475. https://doi.org/10.1016/j.ydbio.2009.05.332.Full Text
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Sherwood, D. “David Sherwood: invasive procedures. Interview by Ben Short.” The Journal of Cell Biology 185, no. 4 (May 2009): 568–69.
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Ziel, Joshua W., Elliott J. Hagedorn, Anjon Audhya, and David R. Sherwood. “UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans.” Nature Cell Biology 11, no. 2 (February 2009): 183–89. https://doi.org/10.1038/ncb1825.Full Text
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Sherwood, David R. “Cell invasion through basement membranes: an anchor of understanding.” Trends in Cell Biology 16, no. 5 (May 2006): 250–56. https://doi.org/10.1016/j.tcb.2006.03.004.Full Text
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Sherwood, D. R., J. A. Butler, J. M. Kramer, and P. W. Sternberg. “FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans.” Cell 121, no. 6 (June 2005): 951–62.
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Sherwood, David R., and Paul W. Sternberg. “Anchor cell invasion into the vulval epithelium in C. elegans.” Developmental Cell 5, no. 1 (July 2003): 21–31. https://doi.org/10.1016/s1534-5807(03)00168-0.Full Text
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Inoue, Takao, David R. Sherwood, Gudrun Aspöck, James A. Butler, Bhagwati P. Gupta, Martha Kirouac, Minqin Wang, et al. “Gene expression markers for Caenorhabditis elegans vulval cells.” Mechanisms of Development 119 Suppl 1 (December 2002): S203–9. https://doi.org/10.1016/s0925-4773(03)00117-5.Full Text
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Inoue, Takao, David R. Sherwood, Gudrun Aspöck, James A. Butler, Bhagwati P. Gupta, Martha Kirouac, Minqin Wang, et al. “Gene expression markers for Caenorhabditis elegans vulval cells.” Gene Expression Patterns : Gep 2, no. 3–4 (December 2002): 235–41. https://doi.org/10.1016/s1567-133x(02)00055-8.Full Text
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Palmer, Robert E., Takao Inoue, David R. Sherwood, Lily I. Jiang, and Paul W. Sternberg. “Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development.” Developmental Biology 252, no. 2 (December 2002): 202–13. https://doi.org/10.1006/dbio.2002.0850.Full Text
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Sherwood, D. R., and D. R. McClay. “LvNotch signaling plays a dual role in regulating the position of the ectoderm-endoderm boundary in the sea urchin embryo.” Development (Cambridge, England) 128, no. 12 (June 2001): 2221–32. https://doi.org/10.1242/dev.128.12.2221.Full Text
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Sherwood, D. R., and D. R. McClay. “LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo.” Development (Cambridge, England) 126, no. 8 (April 1999): 1703–13. https://doi.org/10.1242/dev.126.8.1703.Full Text
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Sherwood, D. R., and D. R. McClay. “Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation.” Development (Cambridge, England) 124, no. 17 (September 1997): 3363–74. https://doi.org/10.1242/dev.124.17.3363.Full Text
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McClay, D. R., J. R. Miller, C. Y. Logan, P. L. Hertzler, E. S. Bachman, J. C. Matese, D. R. Sherwood, and N. A. Armstrong. “Cell adhesion and cell signaling at gastrulation in the sea urchin.” Theriogenology 44, no. 8 (January 1, 1995): 1145–65. https://doi.org/10.1016/0093-691X(95)00326-4.Full Text
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Book Sections
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Keeley, Daniel, and David R. Sherwood. “Breaching and Opening Basement Membrane Barriers: The Anchor Cell Leads the Way.” In Extracellular Matrix in Tumor Biology, 91–115. Springer International Publishing, 2017. https://doi.org/10.1007/978-3-319-60907-2_6.Full Text
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Conference Papers
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Hartman, Jessica, Latasha Smith, Kacy Gordon, David Sherwood, Ricardo Laranjeiro, Monica Driscoll, and Joel Meyer. “Chemical-induced toxicity is ameliorated by swimming exercise in caenorhabditis elegans.” In Drug Metabolism and Pharmacokinetics, 34:S30–S30. Elsevier BV, 2019. https://doi.org/10.1016/j.dmpk.2018.09.117.Full Text
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Garde, A., Y. Li, and D. R. Sherwood. “The role of lipid metabolism in anchor cell invasion in C.elegans.” In Molecular Biology of the Cell, 29:238–39. AMER SOC CELL BIOLOGY, 2018.Link to Item
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Hartman, Jessica Helene, Kacy L. Gordon, David R. Sherwood, and Joel N. Meyer. “Humanized, transgenic worms to study the role of mitochondrial CYP2E1 in toxicant-induced mitochondrial dysfunction and neurodegeneration.” In Drug Metabolism and Pharmacokinetics, 33:S35–S35. Elsevier BV, 2018. https://doi.org/10.1016/j.dmpk.2017.11.130.Full Text
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Caceres, R., N. Bojanala, L. C. Kelley, J. Dreier, J. Manzi, F. Di Federico, Q. Chi, et al. “WASP and WAVE activate the Arp2/3 complex for actin-based force production during basement membrane invasion.” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.Link to Item
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Keeley, D. P., and D. R. Sherwood. “Type IV Collagen stabilizes the connection of juxtaposed tissues at the B-LINK complex.” In Molecular Biology of the Cell, Vol. 27. AMER SOC CELL BIOLOGY, 2016.Link to Item
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Jayadev, R., and D. R. Sherwood. “Visualizing and elucidating the regulation of type IV collagen assembly in developing basement membranes.” In Molecular Biology of the Cell, Vol. 26. AMER SOC CELL BIOLOGY, 2015.Link to Item
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Naegeli, K. M., Q. Chi, and D. R. Sherwood. “Rapid exocytosis of an endolysosome-derived membrane domain forms a polarized invasive protrusion that clears basement membrane during cell invasion.” In Molecular Biology of the Cell, Vol. 26. AMER SOC CELL BIOLOGY, 2015.Link to Item
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Clay, M. R., LR Lilley Lohmer, J. W. Ziel, Q. Chi, and D. R. Sherwood. “Cell invasion through basement membrane requires multiple GTPases and is initiated by CDC-42 directed invadopodia formation.” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.Link to Item
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Keeley, D. P., M. Morrissey, and D. R. Sherwood. “Investigating the B-LINK: an adhesion system that links neighboring basement membranes.” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.Link to Item
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Matus, D. Q., L. L. Lohmer, L. C. Kelley, and D. R. Sherwood. “Cell cycle arrest is required for cell invasive behavior.” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.Link to Item
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Matus, D. Q., E. Chang, S. C. Makohon-Moore, and D. R. Sherwood. “Targeted cell cycle arrest halts basement membrane gap expansion during nematode uterine-vulval attachment.” In Integrative and Comparative Biology, 54:E134–E134. OXFORD UNIV PRESS INC, 2014.Link to Item
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Schindler, A. J., L. R. Baugh, and D. R. Sherwood. “Identification of two novel insulin- and hormone-regulated nutritional checkpoints in C. elegans development.” In Integrative and Comparative Biology, 54:E185–E185. OXFORD UNIV PRESS INC, 2014.Link to Item
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Chang, E., M. Yang, D. R. Sherwood, and D. Q. Matus. “The evolution of anchor cell invasion during rhabditid nematode vulval development.” In Integrative and Comparative Biology, 53:E262–E262. OXFORD UNIV PRESS INC, 2013.Link to Item
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Matus, D. Q., E. Chang, and D. R. Sherwood. “Patterning of cell cycle arrest during formation of the nematode uterine-vulval connection.” In Integrative and Comparative Biology, 53:E139–E139. OXFORD UNIV PRESS INC, 2013.Link to Item
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Kelley, L. C., D. Q. Matus, and D. R. Sherwood. “MMP-Independent Mechanisms of Basement Membrane Breaching In Vivo.” In Molecular Biology of the Cell, Vol. 24. AMER SOC CELL BIOLOGY, 2013.Link to Item
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Lacroix, B., J. F. Dorn, K. G. Bourdages, S. Ihara, D. R. Sherwood, P. S. Maddox, and A. S. Maddox. “In situ imaging in C. elegans reveals developmental and subcellular regulation of microtubule dynamics.” In Molecular Biology of the Cell, Vol. 24. AMER SOC CELL BIOLOGY, 2013.Link to Item
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Lohmer, L. R., J. W. Ziel, Q. Chi, and D. R. Sherwood. “Characterizing the role of CDC-42 in cell invasion through basement membrane.” In Molecular Biology of the Cell, Vol. 24. AMER SOC CELL BIOLOGY, 2013.Link to Item
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Sherwood, D. R., and Z. Wang. “The receptor DCC mediates oscillatory, self-organizing polarity to orient towards netrin.” In Molecular Biology of the Cell, Vol. 24. AMER SOC CELL BIOLOGY, 2013.Link to Item
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Kelley, L. C., D. Q. Matus, and D. R. Sherwood. “MMP-Independent Mechanisms of Basement Membrane Breaching In Vivo.” In Molecular Biology of the Cell, Vol. 24, 2013.Link to Item
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Matus, D. Q., M. Yang, E. Chang, and D. R. Sherwood. “Anchor cell invasion across the Nematoda: a highly conserved cell biological process required for establishing the uterine-vulval connection.” In Integrative and Comparative Biology, 52:E115–E115. OXFORD UNIV PRESS INC, 2012.Link to Item
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Lacroix, B., S. Ihara, K. Bourdages, J. Dorn, D. R. Sherwood, P. S. Maddox, and A. S. Maddox. “Exploring microtubule dynamics in vivo and its role in tissue biogenesis.” In Molecular Biology of the Cell, Vol. 23. AMER SOC CELL BIOLOGY, 2012.Link to Item
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Matus, D. Q., L. C. Kelley, A. J. Schindler, Q. Chi, and D. R. Sherwood. “Cell Cycle Arrest is Required For Cell Invasion Through Basement Membranes.” In Molecular Biology of the Cell, Vol. 23. AMER SOC CELL BIOLOGY, 2012.Link to Item
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Hagedorn, E. J., and D. R. Sherwood. “Imaging the Cell-Basement Membrane Interface during Anchor Cell Invasion in C. elegans.” In Molecular Biology of the Cell, Vol. 22. AMER SOC CELL BIOLOGY, 2011.Link to Item
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Lacroix, B., J. Dorn, S. Ihara, D. R. Sherwood, P. S. Maddox, and A. S. Maddox. “In vivo imaging of microtubule dynamics throughout tissue biogenesis and cell differentiation.” In Molecular Biology of the Cell, Vol. 22. AMER SOC CELL BIOLOGY, 2011.Link to Item
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Morrissey, M. A., and D. R. Sherwood. “HIM-4/Hemicentin Links the Uterine and Vulval Basement Membranes during Anchor Cell Invasion in C. elegans.” In Molecular Biology of the Cell, Vol. 22. AMER SOC CELL BIOLOGY, 2011.Link to Item
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McClay, D. R., M. J. Ferkowicz, D. R. Sherwood, and C. Y. Logan. “Specification of mesoderm and endoderm during cleavage in sea urchin embryos.” In Regulatory Processes in Development, edited by L. Olsson and C. O. Jacobson, 76:19–30. PORTLAND PRESS LTD, 2000.Link to Item
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Sherwood, D. R., and D. R. McClay. “Notch signaling positions germ-layer boundaries in the sea urchin embryo.” In Developmental Biology, 198:202–202. ACADEMIC PRESS INC, 1998.Link to Item
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Sherwood, D. R., and D. R. McClay. “Notch signaling positions germ-layers in the sea urchin embryo.” In Molecular Biology of the Cell, 8:1904–1904. AMER SOC CELL BIOLOGY, 1997.Link to Item
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McClay, D. R., D. R. Sherwood, and C. Y. Logan. “Axial specification in the sea urchin embryo.” In Developmental Biology, 186:P5–P5. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 1997.Link to Item
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Sherwood, D. R., and D. R. McClay. “A novel shift in subcellular distribution of notch defines the presumptive endoderm-mesoderm boundary in the sea urchin embryo.” In Molecular Biology of the Cell, 7:637–637. AMER SOC CELL BIOLOGY, 1996.Link to Item
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Hertzler, P. L., C. Y. Logan, D. R. Sherwood, and D. R. McClay. “A sea urchin hedgehog homolog.” In Developmental Biology, 175:40–40. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 1996.Link to Item
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SHERWOOD, D. R., and D. R. MCCLAY. “A HOMOLOG OF NOTCH IS EXPRESSED IN THE VEGETAL PLATE, DEVELOPING GUT AND ECTODERM OF THE SEA-URCHIN, LYTECHINUS-VARIEGATUS.” In Developmental Biology, 170:745–745. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 1995.Link to Item
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SHERWOOD, D. R., and D. R. MCCLAY. “THE IDENTIFICATION, CLONING AND EXPRESSION PATTERN OF A NOTCH HOMOLOG IN THE SEA-URCHIN, LYTECHINUS-VARIEGATUS.” In Developmental Biology, 163:545–545. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 1994.Link to Item
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Preprints
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Park, Kieop, Ranjay Jayadev, Sara G. Payne, Isabel W. Kenny-Ganzert, Qiuyi Chi, Daniel S. Costa, William Ramos-Lewis, Siddharthan Balachandar Thendral, and David R. Sherwood. “Reciprocal discoidin domain receptor signaling strengthens integrin adhesion to connect adjacent tissues.,” May 16, 2023. https://doi.org/10.1101/2023.03.14.532639.Full Text Link to Item
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Park, Kieop, Ranjay Jayadev, Sara G. Payne, Isabel W. Kenny-Ganzert, Qiuyi Chi, Daniel S. Costa, William Ramos-Lewis, Siddharthan Balachandar Thendral, and David R. Sherwood. “Reciprocal discoidin domain receptor signaling strengthens integrin adhesion to connect adjacent tissues.” ELife Sciences Publications, Ltd, May 11, 2023. https://doi.org/10.7554/elife.87037.1.Full Text
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Park, Kieop, Ranjay Jayadev, Sara G. Payne, Isabel W. Kenny-Ganzert, Qiuyi Chi, Daniel S. Costa, William Ramos-Lewis, Siddharthan Balachandar Thendral, and David R. Sherwood. “Reciprocal discoidin domain receptor signaling strengthens integrin adhesion to connect adjacent tissues.” ELife Sciences Publications, Ltd, May 11, 2023. https://doi.org/10.7554/elife.87037.Full Text
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- Teaching & Mentoring
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Recent Courses
- BIOLOGY 220: Cell Biology 2023
- BIOLOGY 293: Research Independent Study 2023
- BIOLOGY 415S: Developmental and Stem Cell Biology Colloquium 2023
- BIOLOGY 493: Research Independent Study 2023
- BIOLOGY 792: Research 2023
- CELLBIO 830: Developmental Biology Colloquium 2023
- CMB 710A: Cell & Molecular Biology Module I 2023
- UPGEN 778C: University Program in Genetics and Genomics Biological Solutions Module Ill 2023
- BIOLOGY 220: Cell Biology 2022
- BIOLOGY 293: Research Independent Study 2022
- BIOLOGY 415S: Developmental and Stem Cell Biology Colloquium 2022
- BIOLOGY 493: Research Independent Study 2022
- BIOLOGY 791T: Tutorial 2022
- BIOLOGY 792: Research 2022
- CELLBIO 830: Developmental Biology Colloquium 2022
- CMB 710B: Cell & Molecular Biology Module II 2022
- UPGEN 778D: University Program in Genetics and Genomics Biological Solutions Module IV 2022
- BIOLOGY 220: Cell Biology 2021
- BIOLOGY 293: Research Independent Study 2021
- BIOLOGY 415S: Developmental and Stem Cell Biology Colloquium 2021
- CELLBIO 830: Developmental Biology Colloquium 2021
- CMB 710B: Cell & Molecular Biology Module II 2021
- UPGEN 778D: University Program in Genetics and Genomics Biological Solutions Module IV 2021
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Basement membranes: a new visual toolkit reveals dynamic properties. Biology seminar, Duke Department of Biology. November 29, 2021 2021
- Looking outside the cell: The basement membrane toolkit in C. elegans. MIT Department of Biology, Biology Colloquium. October 19, 2021 2021
- The B-LINK: A Basement membrane-Basement Membrane Adhesion that Connects Adjacent Tissues. September 14, 2021 2021
- Linking Adjacent Basement Membranes-Insights from C. elegans. 13th International Podocyte Conference, Manchester England. July 28, 2021 2021
- The C. elegans model system and basement membrane biology. Marine Biological Laboratory, Embryology Course. May 27, 2021 2021
- An inclusive view of Developmental Biology. Marine Biological Laboratory, Embryology Course. May 25, 2021 2021
- C. elegans-a model for insights into regeneration and tissue renewal. Ken Poss Symposium on Regeneration. Duke University. April 7, 2021 2021
- Powering Cell Invasion through Basement Membrane. Mount Sinai, Dept., of Cell, Development, and Regenerative Biology. April 1, 2021 2021
- Powering Cell Invasion through Basement Membrane. University of British Colombia, Vancouver, Canada, Dept., of Cellular and Physiological Sciences . February 21, 2021 2021
- UTSE-Seam B-LINK: Linking Basement Membranes. International Worm Skin Meeting. February 17, 2021 2021
- Powering Cell Invasion through Basement Membrane. University College London, Dept., of Cell and Developmental Biology. January 14, 2021 2021
- Fueling Cell Invasion through Basement Membrane. Cornell University, Dept. of Molecular Biology and Genetics. December 4, 2020 2020
- Basement membrane dynamics-a view from the worm. American Society for Matrix Biology. November 18, 2020 2020
- Fueling Cell Invasion through Basement Membranes. BioSciences at Rice seminar. Rice University. October 5, 2020 2020
- Fueling Cell Invasion through Basement Membrane. NIEHS. October 1, 2020 2020
- An Adhesion System for Linking Basement Membranes. British Society for Matrix Biology. September 1, 2020 2020
- Basement Membrane Study in the Worm. Embryology Course. Marine Biological Laboratory. June 7, 2020 2020
- Introduction to the C. elegans Model System. Embryology Course. Marine Biological Laboratory. June 7, 2020 2020
- Ask Me Anything. Regeneration Next, Duke University. June 2, 2020 2020
- Cell invasion and basement membrane dynamics-a view from the worm. University of British Columbia. April 2, 2020 2020
- Cell Invasion & Basement Membrane Dynamics. Institute of Biosciences and Technology Texas A&M University Health Science Center. January 6, 2020 2020
- AC invasion in C. elegans. University of Colorado, Health Sciences Center Center. February 5, 2014 2014
- Polarizing Invasion: Netrin Receptor Oscillations Lead the Way. December 15, 2013 2013
- MMP Function During Anchor Cell Invasion in C. elegans. December 14, 2013 2013
- Anchor Cell Invasion in C. elegans, Columbia University, New York, Departments of Pharmacology and Physiology and Cellular Biophysics. October 22, 2013 2013
- Anchor Cell Invasion in C. elegans, Max Planck Institute (MPI) for Cell Biology and Genetics in Dresden, Germany. September 19, 2013 2013
- Anchor Cell Invasion in C. elegans, FASEB Summer Meeting, “Matricellular Proteins in Development, Health and Disease”, Invited Speaker, Vermont Academy, Saxtons River, VT. July 28, 2013 2013
- Cell Invasion: what can we learn from one cell in a worm?. June 6, 2013 2013
- Polarizing Invasion: Netrin Receptor Oscillations Lead the Way. June 6, 2013 2013
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. February 18, 2013 2013
- Anchor Cell Invasion in C. elegans. February 10, 2013 2013
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. January 30, 2013 2013
- Invadopodia in vivo: Anchor cell invasion in C. elegans. January 25, 2013 2013
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. November 30, 2012 2012
- Anchor Cell Invasion in C. elegans: Cell Cycle Progression Antagonizes Invasion. November 5, 2012 2012
- Anchor Cell Invasion in C. elegans. July 25, 2012 2012
- Analysis of Cell Invasive Behavior Using C. elegans. July 10, 2012 2012
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. July 2, 2012 2012
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. June 9, 2012 2012
- Nutritional Regulation of Late Larval Development in C. elegans. June 9, 2012 2012
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. May 23, 2012 2012
- Understanding Cell Invasion Using C. elegans. April 26, 2012 2012
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. February 20, 2012 2012
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. January 24, 2012 2012
- Cellular and Genetic Analysis of Cell Invasion: Anchor Cell Invasion in C. elegans. December 8, 2011 2011
- Anchor cell Invasion in C. elegans. November 21, 2011 2011
- Nutritional Control of Late Larval Development in C. elegans. September 9, 2011 2011
- Pushing the Basement Membrane Aside: Anchor Cell Invasion in C. elegans. July 17, 2011 2011
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. June 11, 2011 2011
- Nutritional Control of Late Larval Development in C. elegans. June 11, 2011 2011
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. May 3, 2011 2011
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. April 13, 2011 2011
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. April 6, 2011 2011
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. March 30, 2011 2011
- Anchor cell Invasion in C. elegans. March 15, 2011 2011
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. February 25, 2011 2011
- Anchor cell Invasion in C. elegans. February 17, 2011 2011
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. November 30, 2010 2010
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. November 15, 2010 2010
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. October 26, 2010 2010
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. October 13, 2010 2010
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. October 12, 2010 2010
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. July 25, 2010 2010
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. July 9, 2010 2010
- C. elegans Uterine-Vulval Development: Vulval patterning and Anchor Cell Invasion. June 18, 2010 2010
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. June 8, 2010 2010
- AACR Methods Workshop: Anchor cell invasion in Caenorhabditis elegans: Dissecting cell invation through basement membrane in vivo. April 17, 2010 2010
- Anchor cell invasion in Caenorhabditis elegans: Dissecting cell invation through basement membrane in vivo. April 17, 2010 2010
- Pew Scholars Meeting. March 20, 2010 2010
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. February 24, 2010 2010
- Breaching the Basement Membrane: Anchor Cell Invasion in C. Elegans. February 21, 2010 2010
- Targeting Cancer Invasion and Metastasis; Breaching the Basement Membrane: Anchor Cell Invasion in C. Elegans. February 21, 2010 2010
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. February 15, 2010 2010
- Breaching the Basement Membrane: Lessons Learned from C. elegans Anchor Cell Invasion. December 11, 2009 2009
- Breaching the Basement Membrane: Lessons Learned from C. elegans Anchor Cell Invasion. October 19, 2009 2009
- Time-Lapse Analysis of Cell Invasion through Basement Membrane in C. elegans.. September 30, 2009 2009
- Cell Invasion through basement membrane. July 1, 2009 2009
- Anchor Cell Invasion in C. elegans. June 19, 2009 2009
- Chalk Talk on Cell Invasion through Basement Membrane, Pew Meeting, Puerto Rico. March 11, 2009 2009
- Anchor Cell Invasion as a model for Implantation. January 26, 2009 2009
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. November 14, 2008 2008
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. November 13, 2008 2008
- Anchor Cell Invasion in C. elegans. July 1, 2008 2008
- UNC-6 (netrin) Orients the Invasive Membrane of the Anchor Cell in C. elegans. June 29, 2008 2008
- Breaching the Basement Membrane: Anchor Cell Invasion in C. elegans. June 23, 2008 2008
- Anchor Cell Invasion in C. elegans. June 19, 2008 2008
- Establishing the Invasive Membrane of the Anchor Cell. March 8, 2008 2008
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Outreach & Engaged Scholarship
- Unknown. Invite a Scientist, Two Lectures at Chapel Hill High School. April 26, 2012 2012
- Unknown. Invite a Scientist, Two Lectures at Chapel Hill High School. April 26, 2012 2012
- Unknown. Forest View Elementary School Science Share. December 19, 2011 2011
- Unknown. Forest View Elementary School Science Share. December 19, 2011 2011
- Unknown. NPR Academic Minute Interview. October 18, 2010 2010
- Unknown. NPR Academic Minute Interview. October 18, 2010 2010
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Service to the Profession
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.
