David Michael Stepien

Journal Article Aesthetic Plast Surg · October 2024 BACKGROUND: Plastic surgeons increasingly use social media to market their practices and educate prospective patients. Previous studies have investigated plastic surgery content on Instagram from the angle of hashtags and most popular plastic surgeons. How ... Full text Link to item Cite

Art and Safety of Gluteal Augmentation: Future Directions.

Journal Article Clin Plast Surg · October 2023 Gluteal augmentation is a quickly evolving field that continues to grow in the realms of patient safety, surgical education, and technological advancement. This article discusses innovation in gluteal augmentation and suggests potential new pathways for de ... Full text Link to item Cite

NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma.

Journal Article Nat Commun · August 16, 2021 Pain is a central feature of soft tissue trauma, which under certain contexts, results in aberrant osteochondral differentiation of tissue-specific stem cells. Here, the role of sensory nerve fibers in this abnormal cell fate decision is investigated using ... Full text Link to item Cite

Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification.

Journal Article JCI Insight · July 9, 2020 Heterotopic ossification (HO) is defined as abnormal differentiation of local stromal cells of mesenchymal origin, resulting in pathologic cartilage and bone matrix deposition. Cyr61, CTGF, Nov (CCN) family members are matricellular proteins that have dive ... Full text Link to item Cite

Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis.

Journal Article J Immunol · April 15, 2020 Myeloid cells are critical to the development of fibrosis following muscle injury; however, the mechanism of their role in fibrosis formation remains unclear. In this study, we demonstrate that myeloid cell-derived TGF-β1 signaling is increased in a profib ... Full text Link to item Cite

Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification

Journal Article Bone Research · December 1, 2019 Heterotopic ossification (HO) is a debilitating condition characterized by the pathologic formation of ectopic bone. HO occurs commonly following orthopedic surgeries, burns, and neurologic injuries. While surgical excision may provide palliation, the proc ... Full text Cite

Antagonism of the Neurokinin-1 Receptor Improves Survival in a Mouse Model of Sepsis by Decreasing Inflammation and Increasing Early Cardiovascular Function.

Journal Article Crit Care Med · February 2017 OBJECTIVES: Sepsis remains a serious clinical problem despite intensive research efforts and numerous attempts to improve outcome by modifying the inflammatory response. Substance P, the principal ligand for the neurokinin-1 receptor, is a potent proinflam ... Full text Link to item Cite

The Role of Substance P in Pulmonary Clearance of Bacteria in Comparative Injury Models.

Journal Article Am J Pathol · December 2016 Neural input to the immune system can alter its ability to clear pathogens effectively. Patients suffering mild traumatic brain injury (mTBI) have shown reduced rates of pneumonia and a murine model replicated these findings, with better overall survival o ... Full text Link to item Cite

Substance P mediates reduced pneumonia rates after traumatic brain injury.

Journal Article Crit Care Med · September 2014 OBJECTIVES: Traumatic brain injury results in significant morbidity and mortality and is associated with infectious complications, particularly pneumonia. However, whether traumatic brain injury directly impacts the host response to pneumonia is unknown. T ... Full text Link to item Cite

Early murine polymicrobial sepsis predominantly causes renal injury.

Journal Article Shock · February 2014 Multiple organ failure in sepsis substantially increases mortality. This study examined if there was greater hepatic, pancreatic, splenic, or renal injury in mice that would die during sepsis induced by cecal ligation and puncture (CLP) compared with that ... Full text Link to item Cite

Reduction of eotaxin production and eosinophil recruitment by pulmonary autologous macrophage transfer in a cockroach allergen-induced asthma model.

Journal Article Am J Physiol Lung Cell Mol Physiol · December 2013 We sought to investigate the effects of cockroach allergen (CRA) exposure on the lung macrophage population to determine how different macrophage phenotypes influence exacerbation of disease. CRA exposure caused significantly reduced expression of CD86 on ... Full text Link to item Cite

A murine model of mild traumatic brain injury exhibiting cognitive and motor deficits.

Journal Article J Surg Res · October 2013 BACKGROUND: Mild traumatic brain injury (TBI) is a serious public health concern affecting more than 1.7 million people in the United States annually. Mild TBI is difficult to diagnose and is clinically associated with impaired motor coordination and cogni ... Full text Link to item Cite

Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding.

Journal Article Physiol Rev · July 2013 Sepsis represents the host's systemic inflammatory response to a severe infection. It causes substantial human morbidity resulting in hundreds of thousands of deaths each year. Despite decades of intense research, the basic mechanisms still remain elusive. ... Full text Link to item Cite

Cecal ligation and puncture-induced murine sepsis does not cause lung injury.

Journal Article Crit Care Med · January 2013 OBJECTIVE: The cause of death in murine models of sepsis remains unclear. The primary purpose of this study was to determine if significant lung injury develops in mice predicted to die after cecal ligation and puncture-induced sepsis compared with those p ... Full text Link to item Cite