David Joshua Whellan

Journal Article Contemp Clin Trials · January 2018 INTRODUCTION: Acute decompensated heart failure (ADHF) is the leading cause of hospitalization in older adults. Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial is a multi-site clinical trial to determine if physical rehabilita ... Full text Link to item Cite

Change Is Not Always Good.

Journal Article J Am Coll Cardiol · November 14, 2017 Full text Link to item Cite

Easy to Predict, Difficult to Prevent.

Journal Article JACC Heart Fail · March 2017 Full text Link to item Cite

Trends in Robotic-Assisted Coronary Artery Bypass Grafts: A Study of The Society of Thoracic Surgeons Adult Cardiac Surgery Database, 2006 to 2012.

Journal Article Ann Thorac Surg · July 2016 BACKGROUND: Robotic technology is one of the most recent technological changes in coronary artery bypass graft (CABG) operations. The current analysis was conducted to identify trends in the use and outcomes of robotic-assisted CABG (RA-CABG). METHODS: A r ... Full text Link to item Cite

Dichotomous Relationship Between Age and 30-Day Death or Rehospitalization in Heart Failure Patients Admitted With Acute Decompensated Heart Failure: Results From the ASCEND-HF Trial.

Journal Article J Card Fail · June 2016 BACKGROUND: Younger age as an independent predictor of death or all-cause rehospitalization at 30 days post-randomization for hospitalized heart failure (HF) patients has not been well described. METHODS AND RESULTS: ASCEND-HF enrolled 7141 hospitalized ac ... Full text Link to item Cite

Proton pump inhibitors and hypomagnesemia in patients with arrhythmias.

Journal Article Int J Clin Pract · December 2015 Full text Link to item Cite

Team-Based Care for Managing Cardiac Comorbidities in Heart Failure.

Journal Article Heart Fail Clin · July 2015 The need for HF management is predicted to increase as the HF population ages. Balancing HF and the multiple cardiac comorbidities remains difficult for any single provider, but becomes Fig. 6. Five-year rates of death or urgent heart transplantation by de ... Full text Link to item Cite

Authorship in a multicenter clinical trial: The Heart Failure-A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) Authorship and Publication (HAP) scoring system results.

Journal Article Am Heart J · April 2015 BACKGROUND: Few guidelines exist regarding authorship on manuscripts resulting from large multicenter trials. The HF-ACTION investigators devised a system to address assignment of authorship on trial publications and tested the outcomes in the course of co ... Full text Link to item Cite

PA32540 (a coordinated-delivery tablet of enteric-coated aspirin 325 mg and immediate-release omeprazole 40 mg) versus enteric-coated aspirin 325 mg alone in subjects at risk for aspirin-associated gastric ulcers: results of two 6-month, phase 3 studies.

Journal Article Am Heart J · October 2014 BACKGROUND: Discontinuations and/or interruptions in aspirin therapy for secondary cardioprotection due to upper gastrointestinal (UGI) complications or symptoms have been shown to increase the risk for subsequent cardiovascular events. PA32540 is a coordi ... Full text Link to item Cite

Development of a method to risk stratify patients with heart failure for 30-day readmission using implantable device diagnostics.

Journal Article Am J Cardiol · January 1, 2013 The aim of the present study was to evaluate whether diagnostic data collected after a heart failure (HF) hospitalization can identify patients with HF at risk of early readmission. The diagnostic data from cardiac resynchronization therapy defibrillator ( ... Full text Link to item Cite

Utilization of hospice and predicted mortality risk among older patients hospitalized with heart failure: findings from GWTG-HF.

Journal Article J Card Fail · June 2012 BACKGROUND: Guidelines recommend hospice care as a treatment option for end-stage heart failure (HF) patients. Little is known regarding utilization of hospice care in a contemporary cohort of patients hospitalized with HF and how this may vary by estimate ... Full text Link to item Cite

Change in intrathoracic impedance measures during acute decompensated heart failure admission: results from the Diagnostic Data for Discharge in Heart Failure Patients (3D-HF) Pilot Study.

Journal Article J Card Fail · February 2012 BACKGROUND: Despite the high number of admissions for acute decompensated heart failure (ADHF), there are no specific criteria for discharge readiness. A number of patients have implantable devices that might provide data to assist in determining readiness ... Full text Link to item Cite

Benefit of exercise therapy for systolic heart failure in relation to disease severity and etiology-findings from the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Training study.

Journal Article Am Heart J · December 2011 BACKGROUND: This post hoc analysis of the HF-ACTION cohort explores the primary and secondary results of the HF-ACTION study by etiology and severity of illness. METHODS: HF-ACTION randomized stable outpatients with reduced left ventricular (LV) function a ... Full text Link to item Cite

Predictors of hospital length of stay in heart failure: findings from Get With the Guidelines.

Journal Article J Card Fail · August 2011 BACKGROUND: This study was undertaken to identify predictors of hospital length of stay (LOS) for heart failure (HF) patients using clinical variables available at the time of admission and hospital characteristics. METHODS AND RESULTS: A cohort of 70,094 ... Full text Link to item Cite

Review of advanced heart failure device diagnostics examined in clinical trials and the potential benefit from monitoring capabilities.

Journal Article Prog Cardiovasc Dis · 2011 Over the past decade, emerging clinical trial data supported the usefulness of implanted therapeutic cardiac devices (pacemakers and defibrillators) for the treatment of heart failure (HF). Interest has now developed in evaluating the potential of device d ... Full text Link to item Cite

Combined heart failure device diagnostics identify patients at higher risk of subsequent heart failure hospitalizations: results from PARTNERS HF (Program to Access and Review Trending Information and Evaluate Correlation to Symptoms in Patients With Heart Failure) study.

Journal Article J Am Coll Cardiol · April 27, 2010 OBJECTIVES: We sought to determine the utility of combined heart failure (HF) device diagnostic information to predict clinical deterioration of HF in patients with systolic left ventricular dysfunction. BACKGROUND: Some implantable devices continuously mo ... Full text Link to item Cite

Costs of inpatient care among Medicare beneficiaries with heart failure, 2001 to 2004.

Journal Article Circ Cardiovasc Qual Outcomes · January 2010 BACKGROUND: Inpatient care is the primary driver of costs for patients with heart failure. It is unclear whether recent advances in heart failure care have reduced the costs to Medicare for the care of inpatients with heart failure. METHODS AND RESULTS: In ... Full text Link to item Cite

QT as a safety biomarker in drug development.

Journal Article Clin Pharmacol Ther · July 2009 The cardiovascular safety of new drugs is an overarching concern for all stakeholders: the pharmaceutical industry and the US Food and Drug Administration (FDA) prior to approval and doctors and patients during postrelease drug use. Of the many cardiac saf ... Full text Link to item Cite

Introduction: Vasopressin therapy.

Journal Article Heart Fail Rev · June 2009 Full text Link to item Cite

Rationale, design, and baseline characteristics of a Program to Assess and Review Trending INformation and Evaluate CorRelation to Symptoms in Patients with Heart Failure (PARTNERS HF).

Journal Article Am Heart J · November 2008 BACKGROUND: Heart failure (HF) is a common medical problem with significant morbidity and mortality. Recently, device-based therapy, cardiac resynchronization therapy (CRT), implantable cardioverter-defibrillators (ICDs), and combined CRT and ICD have beco ... Full text Link to item Cite

Diastolic heart failure and continuous hemodynamic monitoring.

Journal Article Am Heart J · April 2007 Full text Link to item Cite

Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale.

Journal Article Am Heart J · February 2007 BACKGROUND: Although there are limited clinical data to support the use of exercise training as a means to reduce mortality and morbidity in patients with heart failure, current guidelines state that exercise is beneficial. TRIAL DESIGN: The objective of t ... Full text Link to item Cite

Financial implications of a model heart failure disease management program for providers, hospital, healthcare systems, and payer perspectives.

Journal Article Am J Cardiol · January 15, 2007 Although heart failure disease management (HFDM) programs improve patient outcomes, the implementation of these programs has been limited because of financial barriers. We undertook the present study to understand the economic incentives and disincentives ... Full text Link to item Cite

Metaanalysis and review of heart failure disease management randomized controlled clinical trials.

Journal Article Am Heart J · April 2005 BACKGROUND: The medical community has turned to disease management (DM) to bridge the gap between proven therapies and clinical practice for patients with heart failure (HF). The aim of this study was to assess the effectiveness of DM programs in reducing ... Full text Link to item Cite